Undisclosed anti-MICA/B antibody / BMS - LARVOL DELTA

Antibody targeting NKG2D ligands MICA/B to unleash anti-tumor immunity of NK and ILC1 cells (SITC 2022) - "Conclusions Our data elucidated the functional heterogeneity of type I ILCs in prostate tumor microenvironment in a murine model, which has not been previously characterized. Moreover, we showed that targeting MIC with B10G5 could increase heterogeneity of type I innate lymphoid cells in vivo , which potentially contribute to better overall anti-tumor responses."

Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • CD8 • GZMB • IFNG • NKG2D • PRF1 • PTPRC • TNFSF10

[VIRTUAL] Selective inhibition of tyrosine kinase 2 prevents and restores interleukin-12- induced hair follicle immune privilege collapse: a novel approach to alopecia areata therapy? (ESDR 2021) - "Given the critical role of interleukin (IL)-12 in priming Th1 responses, we investigated whether IL-12 could be directly involved in inducing HF-IP collapse and whether the selective tyrosine kinase 2 (TYK2) inhibitor, BMS-986202, could prevent or reverse the process. By quantitative immunohistomorphometry, we showed that ex vivo treatment of microdissected HFs with IL-12 (3 ng/mL) + IL-18 (20 ng/mL) upregulated MHC-I and II as well as MICA/B expression in the hair bulb (cardinal features of IP collapse), increased the numbers of CD3+ or CD56+ cells in HF epithelium and mesenchyme, and selectively enriched IFNginducible genes...Therefore, our data demonstrate that local IL-12 directly promotes perifollicular immune cell expansion, IFNg secretion, and HF-IP collapse. These findings support a potential role of IL12 signaling in AA pathogenesis and highlight IL-12 as a potential new target for pharmacologic AA therapy"

Alopecia • Inflammation • IFNG • IL12A • IL18 • NCAM1 • TYK2