CK-103 / Jubilant Pharmova, TG Therap, Sun Pharma - LARVOL DELTA

Venoarterial Extracorporeal Membrane Oxygenation for Propofol-related Infusion Syndrome: A Case Report (ATS 2023) - "Despite multiple antiepileptics he required intubation and high-dose midazolam (30 mg/hr) and propofol (100 mcg/kg/hr) infusions to achieve 80% burst suppression...He developed rhabdomyolysis (peak CK 103,000 Units/L) and right lower extremity compartment syndrome managed with a 4-compartment fasciotomy...Despite multiple antiepileptics he required intubation and high-dose midazolam (30 mg/hr) and propofol (100 mcg/kg/hr) infusions to achieve 80% burst suppression...He developed rhabdomyolysis (peak CK 103,000 Units/L) and right lower extremity compartment syndrome managed with a 4-compartment fasciotomy...Patients requiring high dose of propofol for more than 48 hours, particularly those with neurologic injury, should be closely monitored for PRIS. In cases with hemodynamic instability, early VA-ECMO should be considered as a bridge to recovery if no contraindications are present."

Clinical • Cardiovascular • CNS Disorders • Cognitive Disorders • Dyslipidemia • Epilepsy • Hypotension • Metabolic Disorders • Nephrology • Renal Disease • Transplantation

Effect of atorvastatin on skeletal muscles of patients with knee osteoarthritis: post-hoc analysis of a randomised controlled trial (EULAR 2022) - "There were no significant differences in CK and AST levels between atorvastatin and placebo groups at 4 weeks (CK median 107 vs 110, p=0.76; AST 22 vs 21, p=0.14), 6 (CK 109 vs 101.5, p=0.37; AST 21 vs 20, p=0.45), 12 (CK 103 vs 103, p=0.93; AST 22 vs 21, p=0.99), and 24 (CK 103 vs 93.5, p=0.17; AST 22 vs 21, p=0.34) months. In those with symptomatic knee osteoarthritis, despite a trend for more myalgia, there was no clear evidence of an adverse effect of atorvastatin on skeletal muscles, including those most relevant to knee joint health."

Clinical • Retrospective data • Immunology • Musculoskeletal Pain • Osteoarthritis • Pain • Rheumatology