acitretin / Generic mfg. - LARVOL DELTA

Psoriasis flare confused with drug allergy: A collaborative effort is required to treat tuberculosis in the setting of severe psoriasis. (PubMed, Respir Med Case Rep) - "The patients were treated with acitretin and cyclosporine systemically along with topical agents to achieve psoriasis control. Treatment of TB disease in patients with severe psoriasis requires a collaborative effort between the TB treatment team and dermatology. A balanced approach, including treatment of both diseases, is necessary to avoid confusion of psoriasis flare versus drug induced skin reactions from TB medications."

Journal • Allergy • Dermatology • Immunology • Infectious Disease • Psoriasis • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Sporadic Diffuse Palmoplantar Keratoderma in a Pediatric Patient With Early Onset: A Case Report. (PubMed, Cureus) - "Treatment with low-dose acitretin (10 mg twice weekly) combined with topical keratolytic agents over three months resulted in significant clinical improvement, with marked reduction in hyperkeratosis and resolution of painful fissuring. This case highlights the importance of distinguishing isolated PPK from syndromic forms in pediatric patients. Systemic retinoid therapy proved effective in this case of early-onset sporadic PPK, significantly improving the patient's quality of life and mobility."

Journal • Pain • Pediatrics

Drug Survival of Acitretin and Methotrexate in Adult Psoriasis Patients. (PubMed, Indian J Dermatol) - "Survival rates of acitretin and methotrexate were generally low in practice compared with published data on biological treatments, but as a response to treatment increased, the survival of both drugs improved. Better strategies need to be developed to increase treatment response and survival."

Journal • Dermatology • Immunology • Psoriasis • Rheumatology

Acitretin and Methotrexate in Vulvar Lichen Sclerosus. (PubMed, J Am Acad Dermatol) - No abstract available

Journal • Dermatology • Women's Health

Lipoid Proteinosis in a Pediatric Patient. (PubMed, J Craniofac Surg) - "The treatment regimen included topical carbon dioxide laser therapy and oral administration of acitretin at a dose of 10 mg daily. This case report may contribute to improved clinical recognition of lipoid proteinosis and aid in reducing diagnostic errors."

Journal • Metabolic Disorders • Otorhinolaryngology • Pediatrics

Localized palmar mycosis fungoides: A case report. (PubMed, Medicine (Baltimore)) - "This case highlights the diagnostic pitfalls of palmar MF and underscores the necessity of early biopsy in patients with persistent, treatment-resistant palm dermatoses. Raising clinical awareness of this rare entity may prevent misdiagnosis, facilitate timely therapy, and ultimately improve patient prognosis."

Journal • Cutaneous T-cell Lymphoma • Dermatology • Hematological Malignancies • Immunology • Lymphoma • Mycosis Fungoides • Oncology • Psoriasis • T Cell Non-Hodgkin Lymphoma

Acitretin Negatively Regulates Osteogenic Differentiation of Rat Bone Marrow Derived Mesenchymal Stem Cells Running head: Retinoid Effect on Bone Differentiation. (PubMed, Can J Physiol Pharmacol) - "These findings demonstrate that acitretin suppresses osteogenic differentiation of BMD-MSCs under in vitro conditions, suggesting potential implications for bone metabolism in patients receiving retinoid therapy. Further studies should focus on elucidating the mechanism of this effect, determining frequency of skeletal system-related side effects in patients using retinoids, and determining the conditions of use of acitretin in high-risk patients."

Journal • Preclinical • CD44 • ICAM1 • ITGB1 • PTPRC • SPP1 • THY1 • VCAM1

Efficacy of acitretin, cryotherapy, and tirbanibulin combination therapy for recalcitrant plantar and periungual warts: a case series of 30 patients. (PubMed, Ital J Dermatol Venerol) - No abstract available

Journal • Dermatology

Acitretin-induced psoriasis and Darier disease treated with adalimumab. (PubMed, An Bras Dermatol) - No abstract available

Journal • Dermatology • Immunology • Psoriasis

Effective Treatment of Darier Disease With Abrocitinib Combined and Acitretin Capsules: A Case Report. (PubMed, Am J Ther) - No abstract available

Journal

Novel homozygous pathogenic AP1B1 variant in autosomal recessive keratitis-ichthyosis-deafness syndrome treated with acitretin. (PubMed, BMJ Case Rep) - "Initiation of acitretin therapy led to significant dermatologic improvement without adverse effects so far. This case underscores the rarity of autosomal recessive KID syndrome and highlights acitretin's potential as a therapeutic option."

Journal • Atopic Dermatitis • Dermatology • Dermatopathology • Developmental Disorders • Immunology • Keratitis • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Vitiligo

Erythroderma, Alopecia, Anhidrosis, and Vitiligo as Complications of a Red Ink Tattoo-A Case Report. (PubMed, Clin Pract) - " After months of ineffective treatment with glucocorticosteroids, cyclosporine, methotrexate, and acitretin, patch tests confirmed hypersensitivity to possible components of the red tattoo ink, prompting surgical removal of the inflamed tattoo fragments. Only after the complete removal of the red tattoo ink from the same series that caused the sensitization and the use of immunosuppressive and immunomodulatory drugs, including JAK inhibitors, was hair growth restored and the progression of vitiligo halted, but with no effect on anhidrosis. This case highlights the challenges in managing systemic reactions to tattoo ink and the importance of thorough evaluation and treatment strategies."

Journal • Alopecia • Atopic Dermatitis • Dermatology • Dermatopathology • Immunology • Vitiligo

P10 Treatment-refractory psoriasiform dermatitis resulting from a rare genetic alteration in MSMO1 with marked improvement with combined cholesterol and statin use. (PubMed, Br J Dermatol) - "This progressed to become erythrodermic despite multiple topical treatments as well as systemic treatments including ciclosporin and zinc supplements...Oral acitretin reduced skin severity significantly...Topical (2% simvastatin/2% cholesterol cream) and oral statin was commenced to reduce the toxic accumulation of methylsterols, along with cholesterol replacement to replace the downstream deficiency. Improvement in her skin, with almost complete clearance after only after a few months of treatment has been life changing. Awareness of potential genetic metabolic causes of childhood skin conditions is key to ensure appropriate support and early effective treatments."

Journal • Cataract • Dermatitis • Dermatology • Developmental Disorders • Immunology • Ophthalmology • Psoriasis

BI18 Skin conditions in immunocompromised individuals: a service evaluation. (PubMed, Br J Dermatol) - "Tacrolimus, mycophenolate mofetil and prednisolone accounted for 76% of all immunosuppressive medications prescribed...For patients at high risk of further keratinocyte carcinomas, only 42% were receiving chemoprevention with acitretin or nicotinamide. There were 45 recurrences of squamous cell carcinoma (SCC) and basal cell carcinoma, and seven patients required treatment for metastatic SCC or sarcomatoid carcinoma - these were managed with cemiplimab, radiotherapy and surgical excision...Severe inflammatory conditions and a range of undiagnosed cutaneous lesions add to the complex dermatological burden in this population. Multidisciplinary collaboration between dermatology, transplant and haematology teams remains crucial to optimizing outcomes for these patients."

Journal • Retrospective data • Atopic Dermatitis • Basal Cell Carcinoma • Dermatitis • Dermatology • Genetic Disorders • Hematological Disorders • Hematological Malignancies • Human Immunodeficiency Virus • Immunology • Infectious Disease • Melanoma • Non-melanoma Skin Cancer • Oncology • Rheumatology • Sarcoma • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma • Transplantation

Successful Treatment of Severe Plaque Psoriasis in an Adolescent With a Combination of Methotrexate and Acitretin: A Case Report. (PubMed, Cureus) - "The case presents a young adolescent with severe plaque psoriasis who was successfully treated with a combination of methotrexate and acitretin. This combination is not routinely used in daily practice due to concerns that it may cause serious hepatotoxicity."

Journal • Dermatology • Immunology • Inflammation • Psoriasis

The role of phototherapy in reducing the risk of psoriatic arthritis among psoriasis patients in the era of biologics - A single center exploratory retrospective cohort study. (PubMed, J Dtsch Dermatol Ges) - "Phototherapy, especially in combination with systemic treatments, demonstrates synergistic potential in mitigating PsA risk."

Journal • Retrospective data • Dermatology • Immunology • Inflammatory Arthritis • Psoriasis • Psoriatic Arthritis • Rheumatology • Seronegative Spondyloarthropathies • IL12A • IL17A • IL23A

SG05 The use of oral methotrexate in a case of Ferguson-Smith syndrome. (PubMed, Br J Dermatol) - "Despite 3 years of acitretin therapy, surgical excisions, imiquimod and repeated cryotherapy, the lesions remained poorly controlled. This case, along with her sister's experience, highlights oral methotrexate as a potential therapeutic option for refractory cases. Further studies are needed to explore its role in the management of this challenging condition."

Journal • Brain Cancer • Dermatology • Immunology • Inflammatory Arthritis • Neuralgia • Oncology • Ophthalmology • Pain • Psoriasis • Psoriatic Arthritis • Rheumatology • Seronegative Spondyloarthropathies • Solid Tumor • TGFBR1

P086 Management of severe psoriasis in patients with concomitant malignancy: a retrospective observational study. (PubMed, Br J Dermatol) - "Prior psoriasis treatments included ultraviolet B phototherapy, methotrexate, ciclosporin and acitretin. At cancer diagnosis, 10 patients (20%) were on tumour necrosis factor (TNF)-α inhibitors, 8 (16%) on interleukin (IL)-17 inhibitors, five (10%) on IL-12/23 inhibitors, 5 (10%) on IL-23 inhibitors, 6 (12%) on methotrexate, 2 (4%) on apremilast and 1 (2%) on ciclosporin...Multidisciplinary collaboration and shared decision making are essential. Clinicians should consider biologic therapies for patients with both malignancy and uncontrolled psoriasis, tailoring treatments to patient-specific factors and malignancy type."

Journal • Observational data • Retrospective data • Breast Cancer • Colon Cancer • Colorectal Cancer • Dermatology • Hematological Malignancies • Immunology • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • Psoriasis • Rectal Cancer • Solid Tumor • IL12A • IL17A • IL23A

PA15 Harlequin ichthyosis: a multidisciplinary journey from antenatal to neonatal care. (PubMed, Br J Dermatol) - "Dermatologists commenced oral acitretin at 0.5 mg kg-1 per day at 2 days of life, increasing to 1 mg kg-1 per day on day 30...Several expert centres provide support upon request. We hope that this case will add to the impetus for a national MDT framework for congenital ichthyosis to standardize care, ensure equitable access to specialized services, establish a national register and provide dedicated nursing support to improve patient outcomes."

Journal • Atopic Dermatitis • Dermatology • Hematological Disorders • Immunology • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Septic Shock • Transplantation • Vitiligo • ABCA1

SG14 Homozygous pathogenic variant in transgradient palmoplantar keratoderma: causative, contributory or irrelevant? (PubMed, Br J Dermatol) - "He is currently managed on acitretin 25 mg once daily and psoralen plus ultraviolet A. Acitretin at 50 mg alone was effective but was discontinued due to side-effects. Previous treatment with secukinumab and adalimumab was not beneficial...However, 10% of individuals with European ancestry are heterozygous carriers of loss-of-function variants in the FLG gene. This high carrier frequency in the general population suggests that FLG may be only a contributing factor, and other variants or environmental factors are important in the manifestation of PPK, if FLG variants are found in so many unaffected individuals."

Journal • Asthma • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Pulmonary Disease • Respiratory Diseases • Vitiligo • FLG

O07 Serious infection risk with systemic treatments for psoriasis: a cohort study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR). (PubMed, Br J Dermatol) - "Inclusion criteria were adults who received at least one of the biologics, apremilast or conventional nonbiologics (acitretin, ciclosporin and methotrexate) for ≥ 6 months. All biologics licensed for psoriasis were analysed except for infliximab, which had higher prescription criteria...The certolizumab group had a low mean age of 37.4 years (SD 10.3), the ustekinumab group had a significantly longer median treatment duration of over 4 years (IQR 1.83-6.73), and more patients in the ixekizumab (42.6%) and certolizumab (40.6%) groups had concomitant psoriatic arthritis...IRs (95% CIs) of other tumour necrosis factor-α inhibitors were 15.7 (14.5-17.1) for adalimumab and 16.7 (13.8-20.0) for etanercept. For interleukin-17 inhibitors the IRs (95% CIs) were 18.4 (15.9-21.2) for secukinumab, 7.63 (0.92-27.6) for bimekizumab, 14.5 (7.73-24.8) for brodalumab and 18.5 (14.0-24.0) for ixekizumab. For interleukin-23 inhibitors the IRs (95% CIs) were 13.5 (9.97-17.8) for guselkumab,..."

Journal • Observational data • Dermatology • Immunology • Infectious Disease • Inflammatory Arthritis • Oncology • Psoriasis • Psoriatic Arthritis • Rheumatology • Seronegative Spondyloarthropathies • IL12A • IL17A

SG01 Naltrexone: not a one-trick pony for opioid overdose. The use of naltrexone to successfully treat severe Hailey-Hailey disease. (PubMed, Br J Dermatol) - "In 2022, acitretin was commenced and uptitrated to 25 mg once daily...Other immunosuppressive agents such as methotrexate, ciclosporin and azathioprine have been described in the literature with varying efficacy...Naltrexone is postulated to work due to analgesic and anti-inflammatory effects. It is a well-tolerated treatment for severe HHD that has drastically improved both our patient's skin and his quality of life."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Dermatology • Genetic Disorders • Oncology • Pain • IL6 • TLR4

BI16 The COAST (Contemporary Outcomes After cutaneous SCC in Transplant recipients) study: final results and implications for management following the first cutaneous squamous cell carcinoma in kidney transplant recipients. (PubMed, Br J Dermatol) - "Within 6 months of the first cSCC, 21% of KTRs were using topical chemoprevention (mainly 5-fluorouracil cream), 6% started systemic chemoprevention (acitretin or nicotinamide) and 5% used destructive therapies...Immunosuppression reduction strategies varied both within and between centres and were more frequently undertaken in patients with high-risk CSCC or in those on azathioprine (P = 0.01)...These data highlight the urgent need for prospective studies to identify optimal management of KTR following a first cSCC. Here we propose a risk stratification approach that may be used to guide prevention strategies."

Journal • Retrospective data • Dermatology • Non-melanoma Skin Cancer • Oncology • Solid Organ Transplantation • Squamous Cell Carcinoma • Squamous Cell Skin Cancer • Transplantation

P048 Lenalidomide use in recalcitrant inflammatory dermatoses: a trio of successes. (PubMed, Br J Dermatol) - "A 36-year-old woman with recurrent aphthous stomatitis had not responded to treatment with colchicine, pentoxifylline, azathioprine, dapsone or mycophenolate mofetil...A 49-year-old woman with severe recalcitrant cutaneous discoid lupus erythematosus (CDLE), systemic lupus and Raynaud phenomenon with chilblains had not responded to, had intolerance to or had adverse side-effects with multiple systemic agents including hydroxychloroquine, mepacrine, dapsone, rituximab biosimilar, mycophenolate mofetil, fumaric acid esters, acitretin, ciclosporin, thalidomide (tremor/loss of concentration), belimumab and methotrexate...Baseline and renal function monitoring is required for dose adjustment, and strict adherence to pregnancy prevention programmes is necessitated due to teratogenicity. Our three cases demonstrate lenalidomide to be a clinically beneficial, fast-acting and well-tolerated alternative off-label option for recalcitrant inflammatory dermatoses."

Journal • Cardiovascular • Cataract • Dental Disorders • Dermatology • Discoid Lupus Erythematosus • Hematological Disorders • Hematological Malignancies • Immunology • Inflammatory Arthritis • Lupus • Lymphoma • Movement Disorders • Multiple Myeloma • Myelodysplastic Syndrome • Neutropenia • Oncology • Ophthalmology • Pain • Peripheral Neuropathic Pain • Rheumatology • Stomatitis • Systemic Lupus Erythematosus • Thrombocytopenia • IL12A • IL6

BI21 Intermittent and progressive pustular psoriasis during chemotherapy cycles in a toddler. (PubMed, Br J Dermatol) - "Just before his next chemotherapy cycle (cisplatin and etoposide), the rash recurred as a pruritic pustular eruption across the frontal and retroauricular scalp; skin biopsy suggested nonspecific subacute eczematous dermatitis...Topical ivermectin and ketoconazole did not help...A second biopsy was taken due to clinical suspicion of psoriasis, and 10 days of oral prednisolone was given to try to clear his skin for autologous stem cell transplantation (HSCT)...He was treated with topical calcipotriol and mometasone 0.1%, with consideration of acitretin should he not improve. Fortunately, the rash settled with topical therapy and time. After completing proton radiotherapy prior to tumour resection, he had six cycles of maintenance immunotherapy (dinutuximab) with no recurrence of the rash, despite monthly GCSF, and good cell counts, and has now completed his oncological therapy."

Journal • Atopic Dermatitis • Bone Marrow Transplantation • Contact Dermatitis • Dermatitis • Dermatology • Epstein-Barr Virus Infections • Herpes Simplex • Herpes Zoster • Immunology • Neuroblastoma • Oncology • Psoriasis • Pustular Psoriasis • Solid Tumor • Transplantation • Varicella Zoster