recombinant human Interleukin-12 (AM0012) / Eli Lilly - LARVOL DELTA

Discovery of Novel Inhibitors for Mycobacterium tuberculosis D-alanine: D-alanine Ligase through Virtual Screening. (PubMed, FASEB J) - "The highest-ranking ligand targeting the ATP site from GOLD, SAM001246657, came from the National Institutes of Health's Clinical Collection library (NIH) and received an overall fitness score of 104.4...Both ligands are from the Zinc ChemBridge library. The inhibitory effects of these top-scoring ligands may be further validated through wet-lab research using binding assays and enzyme inhibition assays."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

[VIRTUAL] Phase 3 Study of Pomalidomide with Cyclophosphamide and Dexamethasone Versus Pomalidomide and Dexamethasone in Asian Patients with Relapsed/Refractory Myeloma (RRMM) – Interim Analysis of a Trial By the Asian Myeloma Network (AMN) (ASH 2020) - P3 | "In our prior study, AMN0012, we should that in patients with sub-optimal response to pomalidomide and dexamethasone, the addition of cyclophosphamide can increase response resulting in improvement of progression free survival...All patients are refractory to lenalidomide and 96% have prior exposure to bortezomib. In addition, 12 patients (26%) and 5 (11%) have been treated with Carfilzomib and Ixazomib respectively. 15 (33%) patients had prior high dose melphalan and autologous stem cell transplant...Conclusion In this interim analysis of a prospective randomized study of pomalidomide and dexamethasone with or without cyclophosphamide in Asian patients, we demonstrated the feasibility and efficacy of this combination. Longer follow-up and final analysis of the study will be needed to ascertain the therapeutic advantage of PCD over PD in relapse and refractory myeloma that is refractory to lenalidomide."

Clinical • P3 data • P3 data: top line • Cardiovascular • Hematological Disorders • Hematological Malignancies • Immune Modulation • Infectious Disease • Inflammation • Multiple Myeloma • Neutropenia • Oncology • Pain • Pneumonia • Renal Disease • Respiratory Diseases • Transplantation • Venous Thromboembolism