P2X4 Antagonist / Bayer - LARVOL DELTA

P2X4 Receptor Antagonist Ameliorates Ocular Pain in Rats After Lacrimal Gland Removal. (PubMed, Transl Vis Sci Technol) - "The purinergic receptor P2X4 is critical to transduction of ocular pain. The results indicate that BAY-776 effectively reduced chronic ocular pain in rats, showing efficacy similar to that of cyclosporine and underscoring its therapeutic potential for managing ocular pain. These results suggest that BAY-776 may be a promising option for managing chronic ocular pain."

Journal • Preclinical • Ocular Inflammation • Pain • P2RX4

Effects of the P2RX4 antagonist BR11595 in a guinea pig model of chronic asthma. (PubMed, Br J Pharmacol) - "The P2X4-receptor antagonist BR11595 acutely inhibits AHR, eosinophilia, and Goblet cell hyperplasia after 12 weeks, indicating its potential as a therapeutic target for acute intervention of chronic asthma attacks or exacerbations."

Journal • Preclinical • Asthma • Eosinophilia • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • P2RX4