CC003 / Chupu Chuang (Wuhan) Pharmaceutical Technology - LARVOL DELTA

Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003. (PubMed, J Clin Oncol) - "Although the study did not meet its primary end point of DR preservation, HA during PCI reduces the risk of overall neurocognitive toxicity with noninferior ICR risk and similar survival."

Journal • P2/3 data • Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor

Comment on "Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003". (PubMed, Pract Radiat Oncol) - No abstract available

Journal • P2/3 data • Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor

Advances in the research on radiotherapy for lung cancer: a 2025 review. (PubMed, Transl Lung Cancer Res) - "In locally advanced NSCLC, EA5181 and SKYSCRAPER-03 trials identified that durvalumab administered concurrently with definitive chemoradiotherapy (dCRT) or atezolizumab + tiragolumab combination following concurrent chemoradiation therapy (cCRT) failed to improve PFS. NRG-CC003 trial indicated that hippocampal avoidance prophylactic cranial irradiation (HA-PCI) reduced neurocognitive function (NCF) failure in comparison with PCI. This review provides references for clinical decision-making in lung cancer radiotherapy and future research directions."

Journal • Review • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor

A mouse model for studying chronic Salmonella Typhi infection and anti-biofilm interventions. (PubMed, mBio) - "Additionally, we show that novel anti-biofilm compounds, in combination with ciprofloxacin, are able to reduce S. Typhi burden within the CC003/Unc gallbladder. This study establishes and characterizes a new murine model of chronic S. Typhi carriage and demonstrates its utility with the identification of novel anti-biofilm compounds that disperse S. Typhi biofilms from gallbladder gallstones. This new model will provide a means for further studies into S. Typhi chronic infection."

Journal • Preclinical • Gastroenterology • Infectious Disease