P 1055 / Parion Sciences, Vertex - LARVOL DELTA

Genomic Loci for Sclerotinia Stem Rot Resistance and Chlorophyll Stability in Brassica napus: Integrating GWAS With Microbiome Insights. (PubMed, Plant Environ Interact) - "Among the SNPs significantly linked to lesion length were Bn-A04-p10555408, Bn-A07-p12487549, Bn-A09-p4652268, Bn-A09-p4916858 and, to our knowledge, these SNPs have not been previously linked to SSR resistance in oilseed rape...The SNPs linked to lesion length showed consistent haplotype variation between these selected accessions. Given the absence of complete resistance against SSR, the study provides insights into the significance of maintaining chlorophyll levels and considering microbiome composition for enhancing the level of existing partial resistance to SSR in oilseed rape."

Journal • Infectious Disease

First Report of Stem Blight of Mungbean (Vigna radiata) Caused by Diaporthe longicolla in the United States. (PubMed, Plant Dis) - "GenBank accession numbers for the ITS region were PP105598 and PP105599; PP108254 and PP108255 for TUB sequences...To our knowledge, this is the first report of Diaporthe longicolla causing disease on mungbean within the U.S. and worldwide. The presence of this disease in two locations suggests the potential for Diaporthe longicolla to be a serious disease of mungbean in the future."

Journal

Tregs are important to maintain CD4+ Tconv hypofunction in allograft tolerance. (P1055) (IMMUNOLOGY 2023) - "Gene set enrichment analysis revealed that B cell-mediated immune response related pathways were enriched in differentially expressed genes between graft-specific Tconvs from tolerant and Treg-depleted mice. Tconvs from Treg-depleted mice expressed significantly higher levels of genes associated with Tfh cell differentiation compared to both tolerant and naïve graft-reactive Tconvs. This indicates a unique state of potential reinvigoration and implicates Tregs in actively maintaining dysfunction of graft-specific Tconvs, and also suggests that hypofunctional graft-reactive Tconvs may become Tfh cells when reinvigorated by Treg depletion."

Cardiovascular • Immune Modulation • Infectious Disease • Transplantation • CD4 • FOXP3

Naive phenotype antigen-specific CD4+ T cells persist in the memory repertoire after vaccination (P1055) (IMMUNOLOGY 2023) - "In conclusion, our results provided the surprising finding that the post-exposure T cell repertoire contains naïve antigen-specific T cells. We plan to test the possibility that the thymus continues to add new T cells into the adult immune repertoire in future experiments."

Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • CCR7 • CD31 • CD4 • PECAM1

Development of a reusable metal 3D-printed Heat and Moisture Exchanger (ECHNO-ICHNO 2023) - "CONFLICT OF INTERESTS AND FUNDING Mobius 3D Technologies (Nieuw-Vennep, The Netherlands) has filed a patent application for the additive manufacturing of HMEs (P6105500NL). The authors have no other funding or conflicts of interest to disclose."

Laryngeal Cancer

Symptom Profiles of CD and ODD Among Youth With Perinatally Acquired HIV. (PubMed, J Pediatr Psychol) - "Findings suggest that homogeneous classes of CD/ODD symptoms can be identified among youth with PHIV, and these profiles differ in terms of family processes, consistent with previous work among chronically ill youth."

Journal