Surfacten (bovine surfactant) / Tanabe Pharma - LARVOL DELTA

Outcomes of 22-Week Gestation Infants Following a Survival-Focused Care Approach in the UAE: A Cohort Analysis (PAS 2026) - "Bovine surfactant use correlated with higher 48-h mortality (61.5%) than porcine (25.0%)... Preliminary findings suggest that implementing a 'survival-focused approach' improved cohort outcomes. Mortality remained high, especially among males, infants < 500 g, and those with EOS. All survivors had major morbidity, highlighting the intensive resource use and ethical complexity of proactive care at the limits of viability."

Bronchopulmonary Dysplasia • Gastrointestinal Disorder • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Retinal Disorders • Retinopathy of Prematurity • Septic Shock

Less Invasive Surfactant Administration (LISA) versus Intubation Surfactant Extubation (InSurE) technique using higher volume surfactant in management of neonates with respiratory distress syndrome: an open-label randomized controlled trial. (PubMed, Eur J Pediatr) - "LISA and InSurE are equally feasible strategies for surfactant administration in the treatment of neonatal RDS using NIPPV as primary respiratory support. Both groups had comparable outcomes using larger volume, cost effective bovine lipid extract surfactant with no added advantage of LISA as compared to InSurE technique."

Clinical • Intubation • Journal • Acute Respiratory Distress Syndrome • Bronchopulmonary Dysplasia • Cardiovascular • Pulmonary Disease • Respiratory Diseases

Reflections on the Introduction of Surfactant Therapy for Neonates with Respiratory Distress. (PubMed, Am J Physiol Lung Cell Mol Physiol) - "However, in 1980, Fujiwara demonstrated that a modified bovine surfactant promoted gaseous exchange with infants suffering from RDS...The present review relates some of the key scientific findings and significant clinical contributions responsible for reducing the neonatal morbidity and mortality associated with RDS. It further describes some of the more recent findings on the biological, biophysical and physiological significance of pulmonary surfactant in health and disease."

Journal • Review • Acute Respiratory Distress Syndrome • Respiratory Diseases

Comparison of porcine versus bovine surfactant in preterm respiratory distress syndrome: Evidence from real-world data. A multicentre collaboration from Karnataka. (PubMed, Pediatr Pulmonol) - "We could not find a difference in the outcomes of BPD and redosing using porcine surfactant at 200 mg/kg compared to bovine surfactant. Considering the cost burden in the developing world, efficacy needs to be evaluated in randomized clinical trials."

Clinical • Journal • Preclinical • Real-world • Real-world evidence • Acute Respiratory Distress Syndrome • Pulmonary Disease • Respiratory Diseases

A new tractable method for generating human alveolar macrophage-like cells in vitro to study lung inflammatory processes and diseases. (PubMed, mBio) - "We developed cell culture conditions that mimic the lung alveolar environment in humans using lung lipids, that is, Infasurf (calfactant, natural bovine surfactant) and lung-associated cytokines (granulocyte macrophage colony-stimulating factor, transforming growth factor-β, and interleukin 10) that facilitate the conversion of blood-obtained monocytes to an AM-like (AML) phenotype and function in tissue culture. We have applied this model to early studies of M. tuberculosis and SARS-CoV-2. This model will significantly advance respiratory biology research."

Journal • Preclinical • Acute Myelogenous Leukemia • Infectious Disease • Inflammation • Novel Coronavirus Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis • IL10