MPE-001 / Mperia Therap - LARVOL DELTA

The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress. (PubMed, Oxid Med Cell Longev) - "The cytoprotective effect of MPE-001 was completely abolished by the autophagy inhibitors wortmannin and bafilomycin A1. In conclusion, we report for the first time an autophagy-dependent protection of RPE cells from oxidative stress by a CD36 ligand."

Journal • Age-related Macular Degeneration • Complement-mediated Rare Disorders • Macular Degeneration • Ophthalmology • Retinal Disorders • CD36

Immunometabolic modulation of retinal inflammation by CD36 ligand. (PubMed, Sci Rep) - "Accordingly, PPAR-γ inhibition blocked the cytoprotective effect of MPE-001 on photoreceptor apoptosis elicited by activated MP. By altering activated MP metabolism, MPE-001 decreased immune responses to alleviate subsequent inflammation-dependent neuronal injury characteristic of various vision-threatening retinal disorders."

IO Biomarker • Journal • Immunology • Inflammation • Ocular Inflammation • Ophthalmology • Retinal Disorders

Atheroprotective and atheroregressive potential of azapeptide derivatives of GHRP-6 as selective CD36 ligands in apolipoprotein E-deficient mice. (PubMed, Atherosclerosis) - "Azapeptides MPE-001 and MPE-003 diminished aortic lesion progression and reduced, below pre-existing levels, lesions in the aortic sinus of atherosclerotic mice. A relative increase of M2-like macrophages was observed in lesions, associated with reduced systemic inflammation. Development of CD36-selective azapeptide ligands merits consideration for treating atherosclerotic disease."

Journal • Preclinical • Atherosclerosis • Cardiovascular • Dyslipidemia • Immunology • APOE • CD36

ATHEROREGRESSIVE POTENTIAL OF AZAPEPTIDES ANALOGUES OF GHRP-6 AS SELECTIVE CD36 LIGANDS IN APOLIPOPROTEIN E-DEFICIENT MICE (EAS 2019) - "...From week 19, daily s.c. injections of MPE-001 or MPE-003 (300 nmol/kg) or of 0.9% NaCl (n=12 per group) were administered... Azapeptides feature atheroregressive effect associated with reduced numbers of pro-inflammatory macrophages in BCA lesions of ApoE-/- mice, supporting the potential of selective CD36 ligands in the treatment of atherosclerosis."

Preclinical