Undisclosed X-Zyme / 1E Therap - LARVOL DELTA

DISCOVERY OF A FIRST-IN-CLASS ALLELE-SELECTIVE XNAZYME THAT KNOCKS DOWN MUTANT JAK2 V617F MRNA IN A MOUSE MODEL OF POLYCYTHEMIA VERA (EHA 2026) - "X-Zymes were delivered to erythroid progenitors and demonstrated median knockdown of mutant JAK2 V617F mRNA by 70% . These data support a potentially disease-modifying strategy for V617F-driven myeloproliferative neoplasms."

Preclinical • Bone Marrow Transplantation • Hematological Disorders • Hematological Malignancies • Myeloproliferative Neoplasm • Polycythemia Vera • Solid Tumor • JAK2