myrtleciclib (VS2-370) / ViroStatics - LARVOL DELTA

CDK Inhibition as a new Potential Target Approach in Pleural Mesothelioma Models (IMIG 2025) - " PM clones resistant to cisplatin and pemetrexed were obtained by exposing the H2452 epithelioid cell line to increasing concentrations of the drug combination over a period of more than six months. The mechanisms underlying chemo-resistance in PM patients are poorly understood, and no effective treatment has yet been developed to treat these patients and ameliorate their survival. Overall, our results demonstrated the therapeutic potential of CDK inhibitors in chemo-resistant PM cells, which is consistent with the recent positive results of the MiST2 arm in abemaciclib-treated patients."

Malignant Pleural Mesothelioma • Mesothelioma • Pleural Mesothelioma • Solid Tumor • CDKN2A • MYC

Differences in clinical characteristics and quantitative lung CT features between vaccinated and not vaccinated hospitalized COVID-19 patients in Italy. (PubMed, Ann Intensive Care) - "Hospitalized vaccinated patients with COVID-19, although older and with more comorbidities, presented a similar impairment in gas exchange and lung CT scan compared to non-vaccinated patients, but were at a lower risk of mortality."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases