IrniCann (cannabidiol/cannabigerol) / Argent BioPharma - LARVOL DELTA

Evaluation of Biophysical Parameters of the Skin of Patients With Atopic Dermatitis After Application of an Ointment Containing 30% Cannabidiol and 5% Cannabigerol. (PubMed, Clin Cosmet Investig Dermatol) - "The results we achieved included improved skin hydration, sebum level, and TEWL as well as reduced erythema in the studied areas (forearms). Our results demonstrate that topical cannabinoid therapy is effective in reducing itching and improving the quality of life of patients with AD, leading to symptom remission in some cases."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Cannabis: Zone Aspects of Raw Plant Components in Sport-A Narrative Review. (PubMed, Nutrients) - "Despite many recent studies on cannabis species, there is very little research on the beneficial effects in active athletes, especially on large groups compared to placebo. These studies may complete the current vision of this topic and clarify the hypotheses launched as discussions in this review."

Journal • Review • CNS Disorders • Psychiatry

Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids. (PubMed, Proc Natl Acad Sci U S A) - "In particular, CBG shows significant promise due to its ability to effectively inhibit excitability of peripheral sensory neurons. These findings highlight the therapeutic potential of cannabinoids, particularly CBG, as agents that may attenuate pain via block of Nav1.8, warranting further in vivo studies."

Journal • Pain • NAV1

Role of cannabidiolic acid or the combination of cannabigerol/cannabidiol in pain modulation and welfare improvement in horses with chronic osteoarthritis. (PubMed, Front Vet Sci) - "No subject required rescue analgesia or showed any adverse effects. The results of this study showed that oral administration of both CBDA and CBG/CBD oil may promote pain reduction in adult horses affected by chronic OA."

Journal • Immunology • Musculoskeletal Pain • Osteoarthritis • Pain • Rheumatology • CD4

Exploring Cannabidiol (CBD) and Cannabigerol (CBG) Safety Profile and Skincare Potential. (PubMed, Int J Mol Sci) - "Specifically, they reduced the levels of pro-inflammatory cytokines, making them valuable in combating environmental skin damage. Overall, our results validate the safety of topical use of cannabinoids, while paving the way for further research in the beauty and personal care market as soothing agents."

Journal • Dermatology • Inflammation

Exploring the Potential of Nonpsychoactive Cannabinoids in the Development of Materials for Biomedical and Sports Applications. (PubMed, ACS Appl Bio Mater) - "The review also addresses innovative approaches to enhance NPC delivery including the use of computational tools and explores their potential in both biomedical and sports science contexts. By providing a comprehensive overview of the current state of research, this review aims to outline future directions, emphasizing the potential of NPCs in biomaterial science and regenerative medicine."

Journal • Review • Pain

Effect of Hemp Extraction Procedures on Cannabinoid and Terpenoid Composition. (PubMed, Plants (Basel)) - "This work aimed to compare cannabinoid and terpene profiles using the three primary commercial procedures, using hemp inflorescence from a CBD/CBG dominant Cannabis sativa L. cultivar. Ethanol extracts contained the most acidic cannabinoids with 3.2-4.1 mg/g of CBDA along with minor terpene levels. The resulting extracts demonstrated substantially different chemical profiles and highlight how the process used to extract hemp can play a large role in product composition and potential biological effects."

Journal

Single and Combined Effects of Cannabigerol (CBG) and Cannabidiol (CBD) in Mouse Models of Oxaliplatin-Associated Mechanical Sensitivity, Opioid Antinociception, and Naloxone-Precipitated Opioid Withdrawal. (PubMed, Biomedicines) - "We have previously demonstrated that treatment with the psychoactive CB1/CB2 cannabinoid receptor agonist Δ9-tetrahydrocannabinol (Δ9-THC) or the non-psychoactive, minor phytocannabinoid cannabidiol (CBD) can attenuate paclitaxel-induced mechanical sensitivity in a mouse model of CIPN...Most recently, it was reported that another minor cannabinoid, cannabigerol (CBG), attenuated cisplatin-associated mechanical sensitivity in mice...CBG and CBD decreased naloxone-precipitated jumping behavior alone and acted synergistically in combination, while CBG attenuated the acute antinociceptive effects of morphine and CBD. Taken together, CBG may have therapeutic effects like CBD as demonstrated in rodent models, and its interactive effects with opioids or other phytocannabinoids should continue to be characterized."

Journal • Preclinical • Pain

Modulation of Redox and Inflammatory Signaling in Human Skin Cells Using Phytocannabinoids Applied after UVA Irradiation: In Vitro Studies. (PubMed, Cells) - "Modification of antioxidant signalling (Nrf2/HO-1) through the administration of CBG+CBD has been proven to be associated with reduced proinflammatory signalling (NFκB/TNFα). Differential metabolic responses of keratinocytes and fibroblasts to the effects of the UVA and phytocannabinoids have indicated possible beneficial protective and regenerative effects of the phytocannabinoids, suggesting their possible application for the purpose of limiting the harmful impact of the UVA on skin cells."

Journal • Preclinical • Inflammation • TNFA

CHONDROPROTECTIVE AND ANALGESIC EFFECTS OF NATURAL AND SYNTHETIC CANNABINOIDS IN MURINE OSTEOARTHRITIS (OARSI 2024) - "Our recently published data showed that non-euphorigenic cannabis extract with high CBG and cannabidiol (CBD) content (CBG:CBD oil) reduces pain and slows down OA development in male mice when administered at the time of traumatic injury, resembling early OA. In this study, we aim to determine the efficacy of cannabis extracts in ongoing OA and whether the effect is sex-dependent; in addition, we will explore the possibility of an entourage effect by comparing the efficacy of natural cannabis extracts to those of pure synthetic cannabinoids. We hypothesize that CBG (pure or in cannabis extracts) possess potent analgesic effects and is chondroprotective when used during ongoing OA."

Preclinical • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Osteoarthritis • Pain • Rheumatology

Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In Vitro Cytotoxicity in 2D and 3D Colon Cancer Cell Models. (PubMed, Curr Issues Mol Biol) - "In this study, we tested the anticancer potential of selected cannabinoids CBD (cannabidiol) and its quinone derivative CBD-HQ (cannabidiol hydroquinone), CBG (cannabigerol) and its acid derivative CBG-A (cannabigerolic acid), as well as a combination of CBD+CBG on the colon cancer cell line SW-620. Our results suggest that cannabinoids represent an interesting research direction with great implementation potential. These preliminary results represent the beginning of research into the potential of these substances for anticancer treatment and underscore the potential for further research."

Journal • Preclinical • Colon Cancer • Colorectal Cancer • Gastrointestinal Cancer • Mood Disorders • Oncology • Pain • Palliative care • Psychiatry • Solid Tumor

Antibiofilm and Immune-Modulatory Activity of Cannabidiol and Cannabigerol in Oral Environments-In Vitro Study. (PubMed, Antibiotics (Basel)) - "Both CBG and CBD inhibit S. mutans; they also moderately lower the metabolic activity of multispecies biofilms that form; however, CBD had an effect on biofilms that had already developed. This, together with the production of anti-inflammatory mediators and the maintenance of the viability of mammalian cells from the oral cavity, make these substances promising for clinical use and should be taken into account for future studies."

Journal • Preclinical • Dental Disorders • Immunology • Periodontitis • IFNG • IL4 • TGFB1

Host status and susceptibility of Cannabis sativa cultivars to root-knot nematodes. (PubMed, J Nematol) - "Root-knot nematode host status of hemp cultivars of different uses (fiber, dual, CBD/CBG) and from different regions (Europe, China, US) were evaluated in five different greenhouse trials. While no negative impact on hemp shoot growth was seen in trials where nematodes were added to pasteurized soil, a significant and visible negative effect on hemp growth was noted when two CBG hemp cultivars were planted in heavily naturally root-knot infested soil. This result indicates that hemp is not only a good host to root-knot nematodes, but also that root-knot can be a limiting factor for hemp production in Florida and other places with high abundance and pressure of root-knot nematodes."

Journal • Infectious Disease

Spray-Dried Powder Containing Cannabigerol: A New Extemporaneous Emulgel for Topical Administration. (PubMed, Pharmaceutics) - "Thermogravimetric analysis (TGA), attenuated total reflection-Fourier transformed infrared spectroscopy (ATR-FTIR), x-ray powder diffraction (XRPD), and high-performance liquid chromatography (HPLC) analyses demonstrated that the spray-drying treatment did not alter the chemical properties of CBG. This product can represent a metered-dosage form for the localized treatment of cutaneous afflictions such as acne and psoriasis."

Journal • Acne Vulgaris • Dermatology • Immunology • Psoriasis

Investigation of the cytotoxicity induced by cannabinoids on human ovarian carcinoma cells. (PubMed, Pharmacol Res Perspect) - "Both CBD and CBG induced stronger cytotoxicity than afforded by carboplatin in resistant cells. The cytotoxicity induced by CBD was not CB or CB receptor dependent in both carcinoma cells, however, CBG-induced cytotoxicity may involve CB receptor activity in cisplatin-resistant carcinoma cells...Further studies are required to investigate whether these results are translatable in the clinic. Combination therapies with conventional cancer treatments using cannabinoids are suggested."

Journal • Oncology • Ovarian Cancer • Solid Tumor • ANXA5 • CASP3 • CASP7

Proof of Concept Open Label Trial of CBD/CBG Oral Tincture in the Management of Symptoms in Adult Patients with Irritable Bowel Syndrome (ACG 2023) - "5 of the 6 patients had a reduction in pain scale from baseline using a Likert Pain Scale of 0-10. Mean pain score 6.6 at baseline and 3.7 at Day 14, a decrease of 33.4%. 1 male patient had a worse pain score Day 14 (5) than Baseline (1)."

Clinical • Gastrointestinal Disorder • Pain • Women's Health • RSPO1

Cannabis-Based Formulations: Clinical and Economic Results Promising Savings and Sustainability (ISPOR-EU 2023) - "PD on rasagiline(n=10); Ache-inhibitors: DBL (n=4 rivastigmine, n=1 donepezil) PD (n=2 rivastigmine, n=1galantamine).PD under 2 or more dopaminergic drugs:(n=13). CBD/CBG PGF demonstrated efficacy in several non-motor symptoms in sleep disorders and anxiety. Data points benefits of pain control in formulations with full-spectrum of cannabinoids. CBD and CBD/CBG combinations appear to have antipsychotic effect as an add-on therapy."

Clinical • CNS Disorders • Insomnia • Mood Disorders • Pain • Psychiatry • Sleep Disorder

Nonlinear liquid-liquid chromatography: Modeling a binary mixture separation. (PubMed, J Chromatogr A) - "The approach was demonstrated and validated for CBD and CBG as model compounds and n-hexane/methanol/water 10/7.5/2.5 (v/v/v) as the biphasic solvent system. It should be noted that the applicability of the proposed approach is system-dependent, and hence, it should be evaluated for each separation task individually."

Journal

Cannabidiol and cannabigerol, non-psychotropic cannabinoids, as analgesics that effectively manage bone fracture pain and promote healing in mice. (PubMed, J Bone Miner Res) - "These effects culminated in higher bone volume fraction, higher bone mineral density, and improved mechanical quality of the newly formed bone. Together, our data suggest CBD and CBG as therapeutic agents that can replace NSAIDs in managing post-fracture pain as both cannabinoids exert potent analgesic effects and, at the same time, promote bone healing."

Journal • Preclinical • Musculoskeletal Diseases • Orthopedics • Pain

Cannabidiol and Cannabigerol Modify the Composition and Physicochemical Properties of Keratinocyte Membranes Exposed to UVA. (PubMed, Int J Mol Sci) - "The phytocannabinoids, especially in combination (CBD+CBG), partially prevented increased levels of phosphatidylinositols and sialic acid from occurring and sphingomyelinase activity after the UVA exposure of keratinocytes. This was accompanied by a reduction in the formation of lipid rafts and malondialdehyde, which correlated with the parameters responsible for the integrity and functionality of the keratinocyte membrane (membrane fluidity and permeability and the activity of transmembrane transporters), compared to UVA-irradiated cells. This suggests that the simultaneous use of two phytocannabinoids may have a protective effect on healthy cells, without significantly reducing the therapeutic effect of UV radiation used to treat skin diseases such as psoriasis."

Journal • Dermatology • Immunology • Psoriasis

Determining Antioxidant Activity of Cannabis Leaves Extracts from Different Varieties-Unveiling Nature's Treasure Trove. (PubMed, Antioxidants (Basel)) - "The results revealed that the selection of extractant and extraction conditions significantly influenced the active compounds' extraction efficiency and antioxidant activity. Among the tested conditions, ultrasound-assisted extraction using methanol yielded the highest cannabinoid profile: CBD = 184.51 ± 5.61; CBG = 6.10 ± 0.21; Δ9-THC = 0.51 ± 0.01; and CBC = 0.71 ± 0.01 μg/g antioxidant potential in Białobrzeska leaf extracts."

Journal

Cannabinoid compounds in combination with curcumin and piperine display an anti-tumorigenic effect against colon cancer cells. (PubMed, Front Pharmacol) - "In this study, we investigated a plausible therapeutic synergism of a triple combination of CBD/CBG, curcumin, and piperine in the colon adenocarcinoma using HCT116 and HT29 cell lines. Our findings revealed that different genetic backgrounds of HCT116 and HT29 cell lines resulted in divergent responses to the combination treatments. Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line."

Combination therapy • Journal • Colon Cancer • Colorectal Adenocarcinoma • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Phase III ATALANTE/ov29 trial: Atezolizumab (Atz) versus placebo with platinum-based chemotherapy (Cx) plus bevacizumab (bev) in patients (pts) with platinum-sensitive relapse (PSR) of epithelial ovarian cancer (OC) (ESMO 2022) - P3 | "Background Standard Cx for PSROC (> 6 months after last platinum dose) includes carboplatin plus pegylated liposomal doxorubicin (CbD) or gemcitabine (CbG) or paclitaxel (CbP) with or without bev...Pts were randomised 2:1 to Atz (1200 mg, d1, q3w or 800 mg, d1&15, q4w with CbD up to 24 months [m]) or placebo (Pbo) with Cx at investigator-choice (CbD/CbG/CbP, 6 cycles) plus bev (15 mg/kg, d1, q3w or 10 mg/kg, d1&15, q4w), stratified by platinum-free interval, PD-L1 status on biopsy at study entry and Cx cohort...Encouraging OS data warrant further analyses with longer follow-up. Further research on ATALANTE biopsy samples is warranted to better decipher the immunological landscape of PSROC."

Clinical • Late-breaking abstract • P3 data • Oncology • Ovarian Cancer • Solid Tumor • PD-L1

Safety Assessment and Redox Status in Rats after Chronic Exposure to Cannabidiol and Cannabigerol. (PubMed, Toxicology) - "Based on liquid chromatography-mass spectrometry analysis, CBD/CBG accumulated in rat tissues (in the liver, brain, muscle, heart, kidney and skin) at a low ng level per gram. In CBG, there is an extra dimethyloctadienyl structural pattern, which is most likely responsible for the disruption to the redox status and hepatic environment. The results are valuable to further investigation of the effects of CBD on redox status and should contribute towards opening up critical discussion on the applicability of other non-psychotropic cannabinoids."

Journal • Preclinical • Gastrointestinal Disorder • Hepatology

Cannabidiol and Cannabigerol Exert Antimicrobial Activity without Compromising Skin Microbiota. (PubMed, Int J Mol Sci) - "Our results suggest that phytocannabinoids can be promising topical antimicrobial agents when searching for novel therapeutic candidates for different skin conditions. Additional research is needed to clarify phytocannabinoids' mechanisms of action, aiming to develop practical applications in dermatological use."

Journal • Dermatology