Veregen (sinecatechins) / Sinphar Pharma, Medigene - LARVOL DELTA

To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring (clinicaltrials.gov) - P2 | N=360 | Active, not recruiting | Sponsor: ECOG-ACRIN Cancer Research Group | Trial completion date: Dec 2032 ➔ Dec 2027 | Trial primary completion date: Dec 2032 ➔ Dec 2026

Biomarker • Trial completion date • Trial primary completion date • Genito-urinary Cancer • Oncology • Prostate Adenocarcinoma • Prostate Cancer • Solid Tumor

International Papillomavirus Society statement on reputed treatments for human papillomavirus infection and human papillomavirus-related diseases: evidence, risks, and standards for clinical evaluation. (PubMed, Int J Gynecol Cancer) - "Some agents, including immune modulators and sinecatechins, are approved for external anogenital warts but do not reliably eliminate underlying human papillomavirus infection. Selected topical therapies, particularly 5-fluorouracil, have demonstrated efficacy in randomized trials for regression of cervical intraepithelial neoplasia in specific clinical contexts, but do not represent validated antiviral eradication therapies...In the absence of proven therapies that eradicate human papillomavirus infection, current management relies on surveillance, evidence-based treatment of precancerous lesions, vaccination, and screening. The proposed framework may support professional societies in evaluating emerging interventions and providing clear, evidence-based guidance to health care professionals, policymakers, patients, and the public."

Journal • Review • Cervical Cancer • Dermatology • Gynecology • Head and Neck Cancer • Human Papillomavirus Infection • Infectious Disease • Oncology • Oropharyngeal Cancer • Solid Tumor

Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous (clinicaltrials.gov) - P3 | N=6 | Completed | Sponsor: Centre Hospitalier Universitaire de Nice | Unknown status ➔ Completed

Trial completion • Atopic Dermatitis • Dermatology • Immunology • Vitiligo

Drugs for sexually transmitted infections. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Infectious Disease

To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring (clinicaltrials.gov) - P2 | N=360 | Active, not recruiting | Sponsor: ECOG-ACRIN Cancer Research Group | Recruiting ➔ Active, not recruiting

Biomarker • Enrollment closed • Genito-urinary Cancer • Oncology • Prostate Adenocarcinoma • Prostate Cancer • Solid Tumor

Anthraquinones from the Endophytic Streptomyces griseoincarnatus SB03 (Ocimum basilicum): Isolation and Evaluation of Antibacterial and Cytotoxic Activities. (PubMed, Pak J Biol Sci) - "Importantly, they showed a higher selectivity index against the HepG2 line than the control, doxorubicin. Its anthraquinone metabolites possess valuable dual antibacterial and selective anticancer properties. These compounds are excellent lead candidates for future drug development against infectious diseases and hepatocellular carcinoma."

Journal • Hepatocellular Cancer • Hepatology • Infectious Disease • Oncology • Solid Tumor

EXACT-1: Phase 3 - Evaluation of Veregen® 10% Ointment as New Herbal Topical Treatment for Actinic Keratosis (clinicaltrials.gov) - P3 | N=280 | Recruiting | Sponsor: Aresus Pharma GmbH

New P3 trial • Actinic Keratosis • Dermatology

Interventions for anal canal intraepithelial neoplasia. (PubMed, Cochrane Database Syst Rev) - "All included studies focused on people living with HIV. This may limit the applicability of the results to HIV-negative people. We assessed the certainty of evidence as very low for all outcomes across all nine comparisons, highlighting a lack of high-quality evidence on interventions for AIN. Our findings suggest that HRA-guided treatment may lower anal cancer risk, but the evidence is very uncertain. We evaluated the efficacy of cidofovir, sinecatechins, infrared coagulation, HRA-guided electrocautery, imiquimod, and fluorouracil in eradicating AIN. With eradication rates between 14% and 62% and follow-up periods ranging from four weeks to 33 months, the evidence on the effectiveness of these treatments is very uncertain. Further studies on interventions for AIN with sufficient power and duration are required to determine the efficacy of interventions. Studies addressing treatments in HIV-negative cohorts are also needed."

Journal • Review • Anal Carcinoma • Human Immunodeficiency Virus • Human Papillomavirus Infection • Infectious Disease • Oncology • Pain • Rare Diseases • Solid Tumor • CD4

Genetic diversity and genome-wide associations for frost survival in sorghum. (PubMed, BMC Plant Biol) - "A good overview regarding the suitability of the tested genotypes for early sowing was obtained due to the large diversity investigated in this study, with surprisingly high survival rates of numerous genotypes after frost stress. These results will contribute to the breeding of cultivars with improved cold and frost tolerance, facilitating better adaptation for production in high-latitude temperate areas, as well as earlier sowing to avoid summer drought."

Journal

Treatment Interventions for Usual-Type Vulvar Intraepithelial Neoplasia: A Systematic Review and Meta-analysis. (PubMed, J Low Genit Tract Dis) - "Imiquimod 5% is an effective treatment for uVIN with comparable results to surgery. Cidofovir 1% is another effective option. Less invasive treatments are beneficial for multifocal or extensive lesions but combining medical and surgical approaches has not been studied."

Journal • Retrospective data • Oncology

Treatment of Condyloma Acuminata with Tirbanibulin 1% Ointment in People Living with HIV: A Case Series with Literature Review. (PubMed, Infect Dis Rep) - "While in need of larger studies, it is possible to hypothesize tirbanibulin 1% ointment as a therapeutic alternative for people living with HIV, especially for condylomas smaller than 1 cm in size."

Journal • Review • Actinic Keratosis • Dermatology • Human Immunodeficiency Virus • Human Papillomavirus Infection • Infectious Disease • Oncology

Growth responses of Aspergillus and Penicillium species under modified atmospheric conditions: An in vitro and partially baked roll study. (PubMed, J Food Sci) - "Growth of P. crustosum SB20 and P. paneum SB14; and A. clavatus SB03 and A. oryzae SB02 on partially baked rolls was delayed by 7 and 14 days, respectively, under 80% CO2 and 20% O2 compared to normal atmosphere...PRACTICAL APPLICATION: The influence of CO2 on the growth and sporulation of mold varies depending on the tested strain and species. To analyze the effects of packaging conditions (modified atmosphere packaging or O2 scavengers) on the mold-free shelf-life of bakery products/food products, it is essential to utilize molds that have been isolated from either the product being tested or the manufacturing environment."

Journal • Preclinical

Effectiveness of electrocautery, topical cidofovir and topical sinecatechins for the Treatment of Anal High-grade Squamous Intraepithelial Lesions in Persons with HIV: an open-label, randomized controlled trial. (PubMed, Clin Infect Dis) - P3 | "No statistically significant difference was observed in efficacy between treatments; in contrast, sinecatechins was the most accepted and well-tolerated treatment."

Journal • Anal Carcinoma • Human Immunodeficiency Virus • Human Papillomavirus Infection • Infectious Disease • Oncology • Solid Tumor

Genital Warts: Rapid Evidence Review. (PubMed, Am Fam Physician) - "All treatment strategies are associated with some recurrence, but most successfully treated warts do not recur. Use of podofilox, imiquimod, and sinecatechins should be avoided in pregnancy."

Journal • Review • Dermatology • Oncology

Condylomata Acuminata Successfully Treated with Topical Glycyrrhizic Acid after Failure Treatment of 80% Trichloroacetic Acid and 25% Podophyllin : A case report (EADV 2024) - "There are developing herbal medicines used to treat CA such as sinecatechins ointment and glycyrrhizic acid solution... Glycyrrhizic acid topical is a simple, safe, effective, and patient friendly in treating genital warts. It can be regarded as an alternative therapy for CA. It can be used if standard therapy cannot give good clinical response or as a combination home therapy."

Case report • Clinical • Dermatology • Human Immunodeficiency Virus • Infectious Disease • Oncology

Early exposure to phosphorus starvation induces genetically determined responses in Sorghum bicolor roots. (PubMed, Theor Appl Genet) - "Association studies identified quantitative trait loci in chromosomes Sb02, Sb03, Sb04, Sb06 and Sb09 linked with genes potentially involved in P transport and stress responses. The genetic dissection of key factors underlying RSA responses to P deficiency could enable early identification of P-efficient sorghum genotypes. Genotypes with interesting RSA traits for low P environments will be incorporated into current sorghum breeding programs for later growth stages and field-based evaluations."

Journal

TreatAIN: Clinical Trial for Evaluating the Efficacy and Safety of Electrocoagulation vs Topic Sinecatechins vs Topic Cidofovir Within the Treatment to High-grade Anal Intraepithelial Neoplasia in HIV Homosexual Males (clinicaltrials.gov) - P3 | N=108 | Completed | Sponsor: Hospital Universitari Vall d'Hebron Research Institute | Unknown status ➔ Completed | Trial completion date: Apr 2022 ➔ Jul 2024 | Trial primary completion date: Sep 2021 ➔ Jan 2024

Trial completion • Trial completion date • Trial primary completion date • Human Immunodeficiency Virus • Infectious Disease • Oncology

Protective effects of several tyndallized probiotics against UVs‑induced photodamage in epidermal keratinocytes cells (EADV-Sp 2024) - "Materials & The present work explores the potential of five tyndalized probiotics (Lactiplantibacillus plantarum SKINBAC™ SB01, Limosilactobacillus reuteri SKINBAC™ SB02, Bifidobacterium breve SKINBAC™ SB03, Ligilactobacillus salivarius SKINBAC™ SB04, and Bifidobacterium animalis spp... With this work we aim to contribute valuable insights that may pave the way for innovative skincare strategies centered around probiotic-based formulations for enhanced skin protection against UV-induced damage."

Dermatology • Genetic Disorders • Oncology • Skin Cancer • CDH1 • CLDN1 • CLDN4 • HMOX1 • IL6 • OCLN

Treatment of Pediatric Anogenital Warts in the Era of HPV-Vaccine: A Literature Review. (PubMed, J Clin Med) - "Among available therapies for AWs, topical therapies, such as immunomodulating-agents (topical imiquimod 5% and 3.75% cream, sinecatechins 15% ointment) and cytotoxic agents (podophyllotoxin and cidofovir) are considered manageable in children because of their low aggressiveness. In particular, podofillotoxin gel 5% and imiquimod 5% cream have been reported to be safe and efficacious in children. Currently, HPV vaccination is not recommended as a treatment for established HPV infection and AWs, yet a possible therapeutic role of HPV vaccination was recently suggested in the literature and deserves mention."

Journal • Review • Dermatology • Human Papillomavirus Infection • Immune Modulation • Infectious Disease • Pediatrics

Tirbanibulin 1% ointment – a potential new treatment option for recurrent anogenital warts (WCD 2023) - "OBSERVATIONS: All our patients suffered from recurrent AGW in the genito-anal area for several years and had undergone multiple surgical therapies and topical treatments with imiquimod, trichloroacetic acid, podophyllotoxin and sinecatechins. KEY MESSAGE: Due to its short application time and mild local skin reactions, tirbanibulin may represent a new first-in-class treatment for AGW. Especially patients with chronic recurrent lesions could benefit from the therapy in a home application"

Actinic Keratosis • Dermatology • Inflammation • Pain

To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring (clinicaltrials.gov) - P2 | N=360 | Recruiting | Sponsor: ECOG-ACRIN Cancer Research Group | Trial completion date: Jun 2026 ➔ Dec 2032 | Trial primary completion date: Jun 2026 ➔ Dec 2032

Biomarker • Trial completion date • Trial primary completion date • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring (clinicaltrials.gov) - P2 | N=360 | Recruiting | Sponsor: ECOG-ACRIN Cancer Research Group | Trial completion date: Oct 2024 ➔ Jun 2026 | Trial primary completion date: Oct 2024 ➔ Jun 2026

Biomarker • Trial completion date • Trial primary completion date • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Recent advances in chemical composition and transdermal delivery systems for topical bio-actives in skin cancer. (PubMed, Curr Top Med Chem) - "The most commonly used topical agents for treating skin carcinoma are- 5-fluorouracil, imiquimod, sonidegib, dacarbazine, etc. However, drug physicochemical characteristics and skin physiological barriers limit the anticancer potency of topical as well as transdermal drug delivery. In particular, significant studies have been made, including modification of bio-actives, permeability enhancers, incorporation of advanced nano and microcarriers, and physical enhancement devices. This critical review summarizes the advancement in the chemical composition of bioactives used in skin cancer, such as sinecatechins, BIL-010t, patidegib, gingerol, curcumin, remetinostat, epigallocatechin-3-gallate, etc. Furthermore, this review, specifically addresses the progress in transdermal delivery systems for melanoma and non-melanoma cancer therapy, emphasizing advances in physical and chemical penetration enhancement and nanocarrier-assisted transdermal systems."

Journal • Basal Cell Carcinoma • Genetic Disorders • Non-melanoma Skin Cancer • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma

Inhibition of Cell Proliferation and Cell Viability by Sinecatechins in Cutaneous SCC Cells Is Related to an Imbalance of ROS and Loss of Mitochondrial Membrane Potential. (PubMed, Antioxidants (Basel)) - "Thus, sinecatechins inhibited cell proliferation and viability of cSCC cells, which could suggest the use of PE for AK treatment. The mechanisms appear as linked to an imbalance of ROS levels."

IO biomarker • Journal • Actinic Keratosis • Dermatology • Non-melanoma Skin Cancer • Oncology • Squamous Cell Carcinoma • Squamous Cell Skin Cancer • BCL2 • CASP3

To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring (clinicaltrials.gov) - P2; N=360; Recruiting; Sponsor: ECOG-ACRIN Cancer Research Group; Not yet recruiting ➔ Recruiting

Biomarker • Clinical • Enrollment open • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • MRI