NV103 / NanoValent Pharma - LARVOL DELTA

Enhanced therapeutic efficacy of ApoA1-Anti CD99 antibody fusion protein for treatment of Ewing sarcoma (AACR 2026) - "Much better tumor reduction has been observed at doses as low as 0.5 mg/kg irinotecan, treated twice per week, which was superior to 1 mg/kg NV103 treated biweekly. In conclusion, HPLN/Ir formulated with anti-CD99 antibodies fused with ApoA1 demonstrated substantially greater efficacy against Ewing Sarcoma. We anticipate that this approach will enhance tumor cell binding and drug targeting broadly for other antibodies and nanoparticle formulations."

Clinical • Late-breaking abstract • Ewing Sarcoma • Oncology • Sarcoma • Solid Tumor • APOA1 • CD99

Enhancing GBM therapy with tumor-targeted nanoparticles (AACR 2025) - "NV103 employs liposomal nanoparticles with tumor antigen targeted antibodies specifically engineered to deliver otherwise ineffective drugs like irinotecan directly to tumor. These findings underscore NV103's potential to effectively target heterogeneous GBMs, including those with variable CD99 expression levels, not unlike HER2-low tumors treated with HER2-directed ADCs. Further, preclinical data suggest that NV103 dose escalation will amplify its therapeutic impact, positioning this platform as a potential groundbreaking approach to overcome treatment resistant GBM."

Late-breaking abstract • Glioblastoma • Oncology • CD99 • EGFR • HER-2

[VIRTUAL] Targeted NanoSpheres (TNS) (AACR 2021) - "We have developedNV103, a first-in-class anti-CD99 TNS (CD99-TNS/Irinotecan), for the treatment of Ewing Sarcoma (EWS), a highly lethal pediatric and young adult bone and soft tissue tumor driven by a fusion protein, typically EWS/FLI1 in over 85% of cases. The results from our salvage/rescue studies with NV103 suggested that successful dose intensification schedules with NV103 could be used to treat relapsed or resistant patients in future clinical trials. Furthermore, Targeted Nanosphere (TNS) can be used to overcome drug resistance of various cancers.This platform is also being investigated for other types of cancer that either express CD99, or other tumor antigens like GD2 and B7-H3."

Ewing Sarcoma • Oncology • Sarcoma • Solid Tumor • CD276 • CD99 • EWSR1 • FLI1