R-baclofen / SRI International, Nagoya University - LARVOL DELTA

Propranolol Effective in Suppressing Paroxysmal Sympathetic Hyperactivity Attacks Occurring in the Acute Phase of Diffuse Axonal Injury: A Case Report. (PubMed, Cureus) - "Baclofen and dantrolene slightly improved muscle stiffness, but the continuous intravenous infusion of sedatives could not be discontinued for more than 40 days because it caused a recurrence of attacks. Therefore, sedatives could be discontinued and the patient was transferred to a rehabilitation hospital. Propranolol, an oral β-adrenergic blocker, is one of the effective treatments for paroxysmal sympathetic hyperactivity."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Hypertension • Infectious Disease • Pain • Septic Shock • Vascular Neurology

Efficacy and safety of alcohol reduction pharmacotherapy according to treatment duration in patients with alcohol dependence or alcohol use disorder: A systematic review and network meta-analysis. (PubMed, Addiction) - "Nalmefene, topiramate and baclofen may be effective as alcohol reduction pharmacotherapy; however, only nalmefene has demonstrated long-term efficacy, and nalmefene and topiramate have a significantly higher frequency of adverse events compared with placebo."

Journal • Retrospective data • Review • Addiction (Opioid and Alcohol)

GABA receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice. (PubMed, Sci Rep) - "Baclofen also suppressed the activation of drd1-expressing neurons in the CPu, but not in the NAc, during binge-like eating in WT mice. Thus, our data suggest that GABAR signaling in CPu neurons expressing drd1 suppresses binge-like consumption during a HFD in mice."

Journal • Preclinical • CNS Disorders • Genetic Disorders • Obesity