reproxalap topical (ADX-102 topical) / Aldeyra - LARVOL DELTA

Ameliorative Role of Ethanolic Nigella sativa Seed Extract in Chlorpyrifos-Induced Neurotoxicity and Testicular Toxicity. (PubMed, Vet Med Int) - "A total of 36 male Wistar rats were divided into six groups, which included Group 1 as Control group, Group 2 as CPF 7.5 mg/kg, Group 3 as CPF 7.5 mg/kg + ATR 10 mg/kg, Group 4 as CPF 7.5 mg/kg + NS 2.5 mg/kg, Group 5 as CPF 7.5 mg/kg + NS 5 mg/kg, and Group 6 as CPF 7.5 mg/kg + NS 10 mg/kg...However, the NS extract did not show any significant protective effect against CPF-induced testicular toxicity. These results indicate the potential therapeutic role of NS in mitigating OP-induced neurological damage, justifying further studies to elucidate its mechanisms and extended benefits."

Journal • Cardiovascular • CNS Disorders • Dermatology • Pain • IL1B

Long-Term Risk of Type 2 Diabetes Associated With Topical Corticosteroid Use: A Nationwide Population-Based Cohort Study in Korea. (PubMed, Adv Pharmacol Pharm Sci) - "A nationwide, population-based cohort study was conducted using data from the Korea National Health Insurance Service National Sample Cohort Database (NHIS-NSC2)...In this study, the use of topical corticosteroids was significantly associated with the incidence of Type 2 diabetes. These findings highlight the importance of considering diabetes risk factors when prescribing topical corticosteroids."

Journal • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Porcine deltacoronavirus nonstructural protein 2 inhibits type I and III IFN production by targeting STING for degradation. (PubMed, Vet Res) - "Furthermore, K150 and K236 of pSTING were identified as crucial residues for nsp2-mediated ubiquitination and degradation. In summary, our findings provide a basis for elucidating the immune evasion mechanism of PDCoV and will contribute to the development of targets for anti-coronavirus drugs."

Journal • Preclinical • Infectious Disease • Novel Coronavirus Disease • Targeted Protein Degradation • KEAP1 • STING

Genomes of the autonomous parvovirus minute virus of mice induce replication stress through RPA exhaustion. (PubMed, PLoS Pathog) - "Ectopically expressed viral non-structural proteins NS1 and NS2 are sufficient to cause host-cell replication stress, as is the presence of UV-inactivated non-replicative MVM genomes...Overexpressing RPA in host cells prior to UV-MVM infection rescues DNA fiber lengths and increases MVM replication, confirming that MVM genomes deplete RPA stores to cause replication stress. Together, these results indicate that parvovirus genomes induce replication stress through RPA exhaustion, rendering the host genome vulnerable to additional DNA breaks."

Journal • Preclinical • Infectious Disease • RPA1

RESET Trial - Part 1 (Followed by Reset Trial - Part 2) - A Phase 3 Trial in Subjects With Sjögren-Larsson Syndrome (SLS) (clinicaltrials.gov) - P3; N=11; Completed; Sponsor: Aldeyra Therapeutics, Inc.; Suspended ➔ Completed; N=39 ➔ 11; Trial completion date: Dec 2020 ➔ Jan 2020; Trial primary completion date: Dec 2020 ➔ Jan 2020

Clinical • Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Complement-mediated Rare Disorders

RESET Trial - Part 1 (Followed by Reset Trial - Part 2) - A Phase 3 Trial in Subjects With Sjögren-Larsson Syndrome (SLS) (clinicaltrials.gov) - P3; N=39; Suspended; Sponsor: Aldeyra Therapeutics, Inc.; Recruiting ➔ Suspended

Clinical • Trial suspension