engineered destabilized 3’UTR of TEAD1 therapeutic / UTR Therap - LARVOL DELTA

Engineered destabilized 3'UTR of TEAD1 therapeutically inhibits and degrades TEAD1 mRNA and YAP1 interactors across multiple cancers (AACR 2024) - "We found evidence that suggests that the engineered destabilized 3'UTR of TEAD1 is superior. Mechanistically, the loss of TEAD1 led to the loss of TEAD2,3 and YAP1 and FOSL1 , JUN and c-MYC."

Breast Cancer • Gastrointestinal Cancer • Genito-urinary Cancer • Oncology • Ovarian Cancer • Pancreatic Cancer • Prostate Cancer • Solid Tumor • FOSL1 • MYC • TEAD1 • TEAD2 • YAP1