GEN-005 / Genocea - LARVOL DELTA

Cholecystectomy Association with Kidney Stone Occurrence (KIDNEY WEEK 2024) - "We hypothesize that this potential post-surgical bile acid malabsorption could be associated with the occurrence of nephrolithiasis. We used the National Inpatient Database (NIS), between 2016 and 2020, to identify patients with diagnoses of urinary tract calculus (CCSR: GEN005) and cholecystectomy (CCSR: HEP006) through the appropriate ICD-10 codes... The association between cholecystectomy and urinary tract calculus and the percentage increase in risk in patients that underwent the surgery highlights the underappreciated impact of bile acid physiology on lipid digestion and its potential link with kidney stone disease. Further analysis involving prospective cohorts will be necessary to confirm and better elucidate this association."

Addiction (Opioid and Alcohol) • Diabetes • Gout • Inflammatory Arthritis • Metabolic Disorders • Nephrology • Renal Calculi • Rheumatology • Urolithiasis