KAR-2581 / Valerio Therap - LARVOL DELTA

Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors (Cell Death Differ) - Pubmed ID: 23222458; "...interrogation of the CMap revealed an unexpected association between HDACIs and AnxA1 that translated in mechanistic findings with particular impact on the processes that regulate the resolution of inflammation. We propose non-genomic modulation of AnxA1 in immune cells as a novel mechanism of action for HDACIs, which may underlie their reported efficacy in models of chronic inflammatory pathologies."

Preclinical • Psoriasis • Rheumatoid Arthritis