QGC606 / Quantum Genomics - LARVOL DELTA

Orally active brain aminopeptidase A inhibitors on heart failure after myocardial infarction: Their development up to phase II clinical trials (PubMed, Biol Aujourdhui) - "These studies revealed the key role of brain AngIII in blood pressure regulation and cardiac function, highlighting brain aminopeptidase A, the enzyme responsible for brain AngIII formation, as a potential therapeutic target for treating arterial hypertension and myocardial infarction-induced heart failure. This led to the development of two, orally active, centrally acting, aminopeptidase A inhibitors, firibastat and QGC606, which were tested in various experimental models of arterial hypertension and heart failure, and demonstrated therapeutic potentialities up to phase 2 clinical trials in patients after myocardial infarction."

Journal • P2 data • Review • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Myocardial Infarction • Pulmonary Arterial Hypertension

QGC606, a best-in-class orally active centrally acting aminopeptidase A inhibitor prodrug, for treating heart failure following myocardial infarction. (PubMed, Can J Cardiol) - "Chronic oral QGC606 administration in post-MI mice showed beneficial effects in improving cardiac function and reducing cardiac remodeling and fibrosis but, unlike ramipril, without lowering BP."

Journal • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Immunology • Myocardial Infarction • CTGF

European Society of Cardiology (ESC) Congress 2021 (August 27-30, 2021 - Virtual Meeting). (PubMed, Drugs Today (Barc)) - "The 2021 Congress of the European Society of Cardiology (ESC) was again held as a digital experience, providing poster and oral sessions highlighting the latest developments in cardiovascular science, including therapeutics for a range of related conditions and updates on ongoing trials, as well as guideline updates."

Journal • Cardiovascular

[VIRTUAL] QGC606, a novel drug for treating heart failure (ESC 2021) - No abstract available

Late-breaking abstract • Cardiovascular • Congestive Heart Failure • Heart Failure