Lu AF90103
/ Lundbeck
- LARVOL DELTA
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November 20, 2024
Advancements in NMDA Receptor-Targeted Antidepressants: From d-Cycloserine Discovery to Preclinical Efficacy of Lu AF90103.
(PubMed, J Med Chem)
- "The discovery of d-cycloserine (DCS), a partial agonist of the NMDA receptor that exhibits antidepressant effects without the psychotomimetic effects of ketamine, has fueled interest in new NMDA-targeting antidepressants. Subsequent investigations led us to 42e (Lu AF90103), a methyl ester prodrug of 42d capable of penetrating the blood-brain barrier, as confirmed by rat microdialysis studies. In different rat in vivo models relevant to neuropsychiatric diseases, administering 42e led to 42d demonstrating both acute effects, observed in a seizure model and EEG, and lasting effects in the stress-sensitive hippocampal pathway and an antidepressant-sensitive model."
Journal • Preclinical • CNS Disorders • Epilepsy • Mental Retardation • Psychiatry • GRIN2B
December 20, 2022
A Study to Evaluate Lu AF90103 in Healthy Men
(clinicaltrials.gov)
- P1 | N=15 | Terminated | Sponsor: H. Lundbeck A/S | N=92 ➔ 15 | Recruiting ➔ Terminated; The study was terminated based on new safety data.
Enrollment change • Trial termination
July 14, 2022
A Brain Imaging PET Study of [11C]-Lu AF90103 in Healthy Adult Male Participants
(clinicaltrials.gov)
- P1 | N=8 | Completed | Sponsor: H. Lundbeck A/S | Recruiting ➔ Completed
Trial completion
June 21, 2022
A Study to Evaluate Lu AF90103 in Healthy Men
(clinicaltrials.gov)
- P1 | N=92 | Recruiting | Sponsor: H. Lundbeck A/S | Trial completion date: Aug 2022 ➔ Nov 2022 | Trial primary completion date: Apr 2022 ➔ Nov 2022
Trial completion date • Trial primary completion date
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