dipiperidine (SQ-609) / Sequella - LARVOL DELTA

New protocols for the synthesis of 5-amino-7-(4-phenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate esters using an efficient additive. (PubMed, Turk J Chem) - "The current methodology has several advantages: (a) it avoids the use of hazardous materials, as well as toxic, volatile, and flammable solvents, (b) it does not entail tedious processes, harsh conditions, and the multistep preparation of catalysts, (c) it uses a metal-free and noncorrosive catalyst, and (d) reduces the generation of hazardous waste and simple work-up processes. The most important result of this study is that 4,4'-trimethylenedipiperidine can be a promising alternative for toxic, volatile, and flammable base reagents in organic synthesis owing to its unique properties."

Clinical • Journal

Synthesis, H-labelling and in vitro evaluation of a substituted dipiperidine alcohol as a potential ligand for chemokine receptor 2. (PubMed, J Labelled Comp Radiopharm) - "The preparation of a tritium labelled analogue for the autoradiography (ARG) study gave rise to an intriguing and unexpected side reaction profile, through a novel amination of ethanol and methanol in the presence of tritium. After successful preparation of the tritiated radioligand, in vitro autoradiography measurements on human brain sections revealed non-specific binding properties of the selected antagonist in the CNS."

Journal • Preclinical • CNS Disorders

Interlinking supertetrahedral chalcogenolate clusters with bipyridines to form two-dimensional coordination polymers for photocatalytic degradation of organic dye. (PubMed, Dalton Trans) - "...Further interlinking the clusters with organic linker 4,4'-trimethylenedipiperidine in the stepwise assembly approach forms two-dimensional coordination polymers. The clusters and the coordination polymers show tunable band gaps and efficient photocatalytic activities for the degradation of aqueous dye solution. This study demonstrates the great potential of using chalcogenolate clusters and their coordination polymers in photocatalysis applications."

Journal