dexketoprofen trometamol / Generic mfg. - LARVOL DELTA

Adjunctive Wet Cupping for Acute Non-Specific Low Back Pain (clinicaltrials.gov) - P=N/A | N=80 | Completed | Sponsor: Ataturk University

New trial • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Stereoselective Differences in the Percutaneous Permeation of Ketoprofen Enantiomers and the Underlying Chiral Recognition Mechanisms. (PubMed, Chirality) - "The transdermal superiority of dexketoprofen within the chiral skin barrier is synergistically attributed to its high thermodynamic activity, driven by a lower lattice energy, and its stronger microscopic stereoselective interactions with SC components. This study systematically elucidates the stereoselective mechanisms underlying the transdermal permeation of chiral drugs, thereby providing a scientific basis for the development of transdermal formulations containing a single enantiomer."

Journal

Effect of Intravenous Methylprednisolone Versus NSAIDs on Early Soft Tissue Recovery in High-Energy Pilon and Foot Fractures: A Prospective Cohort Study. (PubMed, Foot Ankle Spec) - "Patients received either intravenous methylprednisolone (1 mg/kg/day, tapered every 3 days) or dexketoprofen (50 mg every 8 hours) starting at admission and based on the routine clinical practice of each hospital (treatment allocation was not randomized). No surgical site infections occurred in the CG, while 2 superficial infections were reported in the NG. Median hospital stay was shorter in the CG (11.5 vs 17.5 days), though not statistically significant (P = .277).ConclusionsIn our sample, intravenous methylprednisolone was associated with a higher probability of achieving surgical readiness within 10 days in high-energy tibial pilon, hindfoot, and midfoot fractures, while maintaining a comparable safety profile.Level of Evidence:Level II."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

The impact of psychoemotional state on the intensity and nature of pain after hysteroscopic myomectomy. (PubMed, Wiad Lek) - " Wartime stress significantly modulates pain perception by lowering the pain threshold even during hysteroscopic myomectomy. State anxiety correlates with acute postoperative pain intensity, while depressive states are associated with prolonged pain and the risk of chronification. These findings support personalised analgesia that considers patients' psychoemotional profiles."

Journal • CNS Disorders • Depression • Gynecology • Musculoskeletal Pain • Pain • Psychiatry • Solid Tumor • Uterine Leiomyoma • Women's Health

Pain Characteristics, Analgesic Use Patterns, and Reliability of the Short-Form McGill Pain Questionnaire in Community-Dwelling Older Adults: A Cross-Sectional Study. (PubMed, Pain Manag Nurs) - "Routine pain assessment and nurse involvement may contribute to more informed analgesic use in older adults. The SF-MPQ may serve as a practical assessment tool in older adults."

Journal • Observational data • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

Naproxen and Lidocaine Gel Combination for Rib Fracture (clinicaltrials.gov) - P=N/A | N=110 | Completed | Sponsor: Ankara City Hospital Bilkent

New trial • Musculoskeletal Diseases • Orthopedics • Pain

Norfloxacin-NSAID Pharmaceutical Salts: Structure-Property Relationships for Enhanced Solubility and Stability. (PubMed, Cryst Growth Des) - "To overcome these limitations, this work presents three novel drug-drug pharmaceutical salts of NOR with the anti-inflammatory drugs ketoprofen (KET), dexketoprofen (DKT), and niflumic acid (NIF). Moreover, NOR-KET and NOR-DKT significantly enhanced the solubility of both NOR and the corresponding NSAIDs in PBS at pH 6.8, while all salts provided a more controlled NOR dissolution profile under acidic conditions. These findings demonstrate that salt formation is an effective strategy to overcome the solubility and stability limitations in NOR and NSAIDs, offering a framework for improving the performance not only of NOR but also of other APIs facing similar challenges."

Journal

Perioperative analgesia and clinical safety of dexketoprofen in dogs undergoing ovariohysterectomy. (PubMed, Open Vet J) - "Blood count and chemistry values in both groups showed no changes indicative of hematological, hepatic, or renal toxicity. Dexketoprofen offers effective pain relief with short-term (48 hours) clinical safety similar to that of meloxicam in dogs undergoing OVH, highlighting its potential as a dependable option for multimodal pain management during elective surgical procedures."

Journal • Anesthesia • Gynecology • Hematological Disorders • Pain

Preemptive Analgesia With Steroidal and Nonsteroidal Anti-Inflammatory Drugs in Dental Implant Surgeries: A Systematic Review. (PubMed, J Oral Implantol) - "Seven RCTs (n = 589 patients) evaluated aceclofenac 100 mg (in combination with acetaminophen), dexamethasone 4 mg, dexketoprofen 25 mg, etoricoxib 90 mg, ibuprofen 600 mg, ketorolac 10 mg, meloxicam 15 mg, nimesulide 100 mg, piroxicam 40 mg, and tenoxicam 20 mg. Owing to the heterogeneity in protocols, drug regimens, and outcome measures, definitive conclusions regarding the most effective and safest preemptive agents could not be drawn. Future trials should emphasize methodological standardization and focus on widely used drugs to support evidence-based decisions in implant dentistry."

Clinical • Journal • Review • Pain

Effect of acupuncture on postoperative nausea and vomiting in lumbar disc herniation surgery. (PubMed, Acupunct Med) - P=N/A | "Although this study was negative in its primary endpoint, multiple significant secondary findings suggest that acupuncture with standard antiemetic therapy was associated with lower early PONV and reduced rescue antiemetic use."

Journal • Anesthesia • Musculoskeletal Diseases • Pain

A Dual-Drug Nanocarrier Strategy for Ocular Fungal Infections: Micelles Embedded in Electrospun Nanofibers. (PubMed, Molecules) - "Posaconazole (PSC), a broad-spectrum triazole antifungal agent, and dexketoprofen trometamol (DKP), a rapidly acting nonsteroidal anti-inflammatory drug, were co-loaded onto polymeric micelles and then incorporated into electrospun poly(vinyl alcohol)/poly(vinylpyrrolidone) (PVA/PVP) nanofiber intraocular implants. In vitro antifungal activity tests demonstrated efficacy against Candida albicans, and HET-CAM toxicity tests showed that the micelle-loaded nanofibers were non-irritating and suitable for ocular application. Overall, the micelle-loaded electrospun nanofiber ocular inserts developed in this study represent a promising platform for combined antifungal and anti-inflammatory ocular therapy."

Journal • Infectious Disease • Ocular Inflammation • Pain

Impact of Erector Spinae Plane Block on Postoperative Analgesia and Perioperative Stress Response in Sleeve Gastrectomy: A Prospective Randomized Clinical Trial. (PubMed, Medicina (Kaunas)) - "All patients received dexketoprofen as baseline analgesia, with tramadol HCl administered as rescue analgesic. Additionally, ESPB appears to attenuate the postoperative stress response, as reflected by smaller increases in cortisol levels. These findings support the routine incorporation of ESPB in perioperative pain management strategies for gastric sleeve surgery."

Clinical • Journal • Anesthesia • Gastrointestinal Disorder • Hematological Disorders • Obesity • Pain

1042/25;DEXO-0125/BE: Study to compare drug availability in the bloodstream of two oral formulations of dexketoprofen in healthy volunteers under fasting conditions. (clinicaltrialsregister.eu) - P1 | N=48 | Recruiting | Sponsor: Faes Farma S.A.

New P1 trial

A Robust LC-MS/MS Bioanalytical Strategy for Simultaneous Quantification of Tramadol HCl and Dexketoprofen Trometamol and Its Use in Pharmacokinetic Studies. (PubMed, Biomed Chromatogr) - "All validation parameters met acceptable criteria. The method is suitable for evaluating pharmacokinetic parameters that indicate drug efficacy and safety."

Journal • PK/PD data

Dexketoprofen-mediated attenuation of ischemia-reperfusion injury in a rat model of lower limb ischemia. (PubMed, Cir Esp (Engl Ed)) - "Functional recovery improved from day 5 onwards in treated animals. Prophylactic DEX administration effectively attenuated biochemical and functional damage secondary to IRI-LL, supporting its potential as a protective therapy against reperfusion injury."

Journal • Preclinical • Cardiovascular • Hepatology • Immunology • Inflammation • Liver Failure • Reperfusion Injury • Systemic Inflammatory Response Syndrome

Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (clinicaltrials.gov) - P4 | N=120 | Recruiting | Sponsor: Medical University of Silesia | Not yet recruiting ➔ Recruiting | Trial completion date: Feb 2026 ➔ Jun 2026 | Trial primary completion date: Feb 2026 ➔ Jun 2026

Enrollment open • Trial completion date • Trial primary completion date • Anesthesia • Orthopedics • Pain

Clinical application of dexketoprofen trometamol injection in patients undergoing hysteroscopic surgery without opioid anesthesia: A prospective, randomized, controlled trial (ChiCTR) - P=N/A | N=70 | Not yet recruiting | Sponsor: Baiyun District People's Hospital of Guangzhou; Baiyun District People's Hospital of Guangzhou

New trial • Anesthesia

Dexketoprofen Time-Dependent Administration After Third Molar Extraction: A Pilot Randomized Cross-Over Controlled Trial. (PubMed, Clin Exp Dent Res) - P=N/A | "Daytime administration of NSAIDs might be sufficient to manage postoperative pain after third molar extraction, and complications were similar between both groups."

Clinical • Journal • Pain • IL10 • IL13 • IL1A • IL1B • IL2 • IL4 • IL6 • IL7

2025 guideline update to acute treatment of migraine for adults in the emergency department: The American Headache Society evidence assessment of parenteral pharmacotherapies. (PubMed, Headache) - "Prochlorperazine IV and GONB must be offered to eligible adults presenting to the ED with a migraine attack for treatment of headache requiring parenteral therapy (level A - must offer) in those without contraindications, while hydromorphone IV must not be offered (level A - must not offer). Treatments that should be offered when appropriate (level B - should offer) include dexketoprofen IV, ketorolac IV, metoclopramide IV, sumatriptan SC, and SONB. Chlorpromazine IV, dexamethasone IV, and valproate IV may be offered (level C - may offer). Paracetamol IV may not be offered (level C - should not offer). Eptinezumab should be offered (level B) only for patients matching the clinical trial population but is rated level U - no recommendation for an ED-specific population. Additional evidence is needed for caffeine, granisetron, ibuprofen, ketamine, lidocaine, normal saline, propofol, and SPG blocks, all currently rated level U - no recommendation."

Journal • CNS Disorders • Migraine • Pain

IVMAG: IV Magnesium in the Treatment of Acute Dysmenorrhea (clinicaltrials.gov) - P=N/A | N=60 | Recruiting | Sponsor: Havva Betül Bacak

New trial • Women's Health

VRPAIN: Virtual Reality for Pain and Anxiety Relief During Peripheral Angioplasty (clinicaltrials.gov) - P2/3 | N=52 | Completed | Sponsor: Kastamonu University | Not yet recruiting ➔ Completed

Trial completion • Mood Disorders • Pain • Psychiatry

Dexketoprofen enhances NLRP3 activation via ATPase activity after canonical stimuli. (PubMed, Inflammopharmacology) - "Furthermore, treatment with DXK in combination with nigericin further increased IL-1β secretion, while the NLRP3 inhibitor MCC950 reduced the effects of DXK. These findings suggest that DXK amplifies inflammation in macrophages via NLRP3 activation, emphasizing the importance of caution in prolonged use, especially in autoinflammatory diseases where inflammasomes play a significant role."

Journal • Inflammation • IL1B • NLRP3

Analgesic Efficacy of Transcutaneous Electrical Nerve Stimulation and Dexketoprofen in Renal Colic (clinicaltrials.gov) - P4 | N=128 | Not yet recruiting | Sponsor: Adiyaman University Research Hospital

New P4 trial • Pain • Renal Calculi

Efficacy of preemptive intravenous ibuprofen and dexketoprofen on postoperative opioid consumption in laparoscopic cholecystectomy: Randomized controlled study. (PubMed, PLoS One) - "Preemptive ibuprofen and dexketoprofen administration reduce pain scores and opioid consumption compared with the control group, however, they are non-inferiority to each other."

Clinical • Journal • Pain

Rapid in vitro and computer-aided method for assessing synergistic interactions between NSAIDs and analgesics. (PubMed, Methods) - "Furthermore, to better understand the results obtained from previous experiments, we analysed the anti-inflammatory effects of ketoprofen and dexketoprofen in combination with metamizole and paracetamol through quantitative real-time PCR (qRT-PCR). This work could be the first step for the study of the mechanisms behind the synergistic interactions between NSAIDs and analgesics for the treatment of pain, mainly when inflammatory processes are involved. Consequently, this study aims to contribute to the exploration of non-opioid drug combinations, addressing the urgent need for alternative analgesic strategies that minimize opioid use."

Journal • Preclinical • Pain