dexketoprofen trometamol / Generic mfg. - LARVOL DELTA

2025 guideline update to acute treatment of migraine for adults in the emergency department: The American Headache Society evidence assessment of parenteral pharmacotherapies. (PubMed, Headache) - "Prochlorperazine IV and GONB must be offered to eligible adults presenting to the ED with a migraine attack for treatment of headache requiring parenteral therapy (level A - must offer) in those without contraindications, while hydromorphone IV must not be offered (level A - must not offer). Treatments that should be offered when appropriate (level B - should offer) include dexketoprofen IV, ketorolac IV, metoclopramide IV, sumatriptan SC, and SONB. Chlorpromazine IV, dexamethasone IV, and valproate IV may be offered (level C - may offer). Paracetamol IV may not be offered (level C - should not offer). Eptinezumab should be offered (level B) only for patients matching the clinical trial population but is rated level U - no recommendation for an ED-specific population. Additional evidence is needed for caffeine, granisetron, ibuprofen, ketamine, lidocaine, normal saline, propofol, and SPG blocks, all currently rated level U - no recommendation."

Journal • CNS Disorders • Migraine • Pain

IVMAG: IV Magnesium in the Treatment of Acute Dysmenorrhea (clinicaltrials.gov) - P=N/A | N=60 | Recruiting | Sponsor: Havva Betül Bacak

New trial • Women's Health

VRPAIN: Virtual Reality for Pain and Anxiety Relief During Peripheral Angioplasty (clinicaltrials.gov) - P2/3 | N=52 | Completed | Sponsor: Kastamonu University | Not yet recruiting ➔ Completed

Trial completion • Mood Disorders • Pain • Psychiatry

Dexketoprofen enhances NLRP3 activation via ATPase activity after canonical stimuli. (PubMed, Inflammopharmacology) - "Furthermore, treatment with DXK in combination with nigericin further increased IL-1β secretion, while the NLRP3 inhibitor MCC950 reduced the effects of DXK. These findings suggest that DXK amplifies inflammation in macrophages via NLRP3 activation, emphasizing the importance of caution in prolonged use, especially in autoinflammatory diseases where inflammasomes play a significant role."

Journal • Inflammation • IL1B • NLRP3

Analgesic Efficacy of Transcutaneous Electrical Nerve Stimulation and Dexketoprofen in Renal Colic (clinicaltrials.gov) - P4 | N=128 | Not yet recruiting | Sponsor: Adiyaman University Research Hospital

New P4 trial • Pain • Renal Calculi

Efficacy of preemptive intravenous ibuprofen and dexketoprofen on postoperative opioid consumption in laparoscopic cholecystectomy: Randomized controlled study. (PubMed, PLoS One) - "Preemptive ibuprofen and dexketoprofen administration reduce pain scores and opioid consumption compared with the control group, however, they are non-inferiority to each other."

Clinical • Journal • Pain

Rapid in vitro and computer-aided method for assessing synergistic interactions between NSAIDs and analgesics. (PubMed, Methods) - "Furthermore, to better understand the results obtained from previous experiments, we analysed the anti-inflammatory effects of ketoprofen and dexketoprofen in combination with metamizole and paracetamol through quantitative real-time PCR (qRT-PCR). This work could be the first step for the study of the mechanisms behind the synergistic interactions between NSAIDs and analgesics for the treatment of pain, mainly when inflammatory processes are involved. Consequently, this study aims to contribute to the exploration of non-opioid drug combinations, addressing the urgent need for alternative analgesic strategies that minimize opioid use."

Journal • Preclinical • Pain

VRPAIN: Virtual Reality for Pain and Anxiety Relief During Peripheral Angioplasty (clinicaltrials.gov) - P2/3 | N=52 | Not yet recruiting | Sponsor: Kastamonu University

New P2/3 trial • Mood Disorders • Pain • Psychiatry

From Chemistry to Pharmacology: Exploring the Anti-Inflammatory and Antioxidant Potential of Novel Dexketoprofen Amide Derivatives. (PubMed, Antioxidants (Basel)) - "Furthermore, compounds 2 and 5 demonstrated efficacy comparable to the parent drug in restoring redox balance, indicating their potential antioxidant properties under acute inflammatory conditions. The findings of this study underscore the therapeutic potential of the novel dexketoprofen amide derivatives as dual-function agents with the capacity to modulate both inflammatory responses and oxidative stress."

Journal • Inflammation

Formulation of zein nanoparticles for augmenting the anti-inflammatory activity of dexketoprofen. (PubMed, Front Pharmacol) - "These findings highlight the effectiveness of zein nanoparticles as a promising topical delivery system for Dexketoprofen. The optimized ZNs not only improved drug entrapment and stability but also provided superior anti-inflammatory efficacy and excellent skin tolerability, suggesting their potential for the treatment of inflammatory skin conditions."

Journal • Inflammation

Design of a Dual-Drug Delivery System for Local Release of Chlorhexidine and Dexketoprofen. (PubMed, Polymers (Basel)) - "This novel dual-action DDS showed promising characteristics and a favorable release profile, supporting its potential as a therapeutic alternative for post-operative pain and infection control in oral surgical procedures."

Journal • Infectious Disease • Pain

The Choice of Anti-Inflammatory Influences the Elimination of Protein-Bound Uremic Toxins (ERA 2025) - "This study aimed to evaluate the effectiveness of ibuprofen (800mg) in enhancing PBUT removal compared to other commonly used analgesics, including lysine acetylsalicylic acid (900mg), acetaminophen (1g), and dexketoprofen (50mg), during post- dilution hemodiafiltration (HDF) since its competitive capability demonstrated currently. This dual benefit—effective pain relief and improved toxin clearance—highlights the potential of ibuprofen as a preferred analgesic for hemodialysis patients. However, further long- term studies are necessary to assess the safety, optimal dosing, and clinical significance of this approach. The development of additional PBUT-displacing agents and adsorptive membranes also warrants exploration to enhance toxin removal further."

Cardiovascular • Pain • Renal Disease

Application of bilateral recto-intercostal fascial plane block as rescue analgesia after laparoscopic cholecystectomy: a case report (Euroanaesthesia 2025) - "described a new interfascial plane block technique called the "Recto-Intercostal Fascial Plane Block"(RIFPB).RIFPB is performed between the rectus abdominis muscle and the sixth and seventh costal cartilages just inferior lateral to the xiphoid.RIFPB targets the anterior and lateral cutaneous branches of the T6-T9 thoracoabdominal nerves.This case report, consisting of two cases, aims to share the analgesic effects of RIFPB when applied as rescue analgesia in patients whose pain could not be controlled with IV analgesics following laparoscopic cholecystectomy.Case Report: Informed consent was obtained, and standard ASA monitoring was performed for laparoscopic cholecystectomy surgery on a 51-year-old female patient with ASA II due to smoking and a 49-year-old female patient with ASA II due to hypertension.Anesthesia induction was performed with 1 mcg/kg fentanyl IV 1 mg/kg lidocaine IV and 2 mg/kg propofol IV.Maintenance anesthesia included sevoflurane..."

Case report • Clinical • Anesthesia • Cardiovascular • Hypertension • Pain

Impact of robotic-assisted colorectal surgery on intraoperative and postoperative pain: a retrospective comparison with conventional laparoscopic surgery (Euroanaesthesia 2025) - "In terms of intraoperative analgesia, all patients were managed with multimodal anesthesia, incluiding lidocaine (2 mg/kg bolus + infusion at 1.5 mg/kg/h), ketamine (0.5 mg/kg after induction), magnesium sulfate (10 mg/kg/h), dexmedetomidine (0.3 µg/kg/h) and fentanyl (on demand according to hemodynamics). Postoperatively, they received paracetamol 1 g/6h and dexketoprofen 50 mg/8h... Although robotic surgery has a longer duration, it requires fewer opioids to maintain adequate intraoperative analgesia. Robotic surgery provides better pain control during the first 48 hours postoperatively."

Retrospective data • Surgery • Anesthesia • Pain

Postoperative pain management with opioid free intravenous pump infusion after sleeve gastrectomy - a case series (Euroanaesthesia 2025) - "Magnesium sulphate (2,5gr), dexamethasone (8mg), dexketoprofen (50mg), fentanyl (100μg) and oxycodone (8mg) were given before skin incision. Propofol and rocuronium were used for induction of anaesthesia and desflurane for maintenance. Intraoperative pain management included lidocaine (1mg/kg IBW/h) and esmolol infusion -according to sympathetic stimulation, along with remifentanil (50μg/ml) in low dose...At the end of operation 1gr of paracetamol and 2mg of oxycodone was given in addition to wound infiltration with levobupivacaine 0.25%.Postextubation an infusion pump of nonopioids was initiated (0,5ml/10kg IBW/h). It was a mixture of dexmedetomidine (100μg), lidocaine (1gr) and ketamine (100mg) in N/S (total volume 100ml) according to Mulier's protocol (Mulimix). Additionally paracetamol (1gr) quid and ondansetron (4mg) bid were prescribed...No side effects were recorded. A larger sample of patients should be recruited to solidify these results."

Clinical • Anesthesia • Gastrointestinal Disorder • Obesity • Pain

Peng block as part of multimodal analgesia for pain management in hip arthroplasty (Euroanaesthesia 2025) - "The following data was evaluated during the first 48 postoperative hours: ENA scale, analgesic medication used, milligrams of dexamethasone administered, opioid consumption, side effects, recovery time from the anesthetic block, time to the onset of sitting and ambulation, and length of hospital stay.Results and • 76.6% received a complete multimodal analgesic treatment, which consisted of the administration of an analgesic (paracetamol), a NSAID (dexketoprofen or ibuprofen), and intraoperative dexamethasone, along with the performance of a PENG block (levobupivacaine 0.25%, 20 ml).• 60% of the patients received a dose of dexamethasone ≥ 10 mg. In patients with complete treatment who received a dose of dexamethasone ≥ 10 mg, the average morphine consumption was 2.31 mg.Conclusion(s): We observed that the PENG block is a safe and effective block. However, further studies are still needed to determine the optimal timing and dosage for its administration."

Anesthesia • Orthopedics • Pain

Low opioid anesthesia combined with loco-regional anesthesia: A successful alternative in patients undergoing oncological surgery and allergic to muscle relaxants (Euroanaesthesia 2025) - "We administered as in a LOA protocol: Midazolam, Magnesium Sulfate, Dexketoprofen, Dexamethasone, and IV Lidocaine...General anesthesia was maintained with Sevoflurane, Magnesium Sulfate infusion, and Remifentanil TCI...We used an epidural pump of Ropivacaine 48h...Amongst the drugs at our reach, we chose those which would provide a greater muscle relaxation whilst keeping in sight our goal of an enhanced recovery. Induction without NMBAs was successful under videolaryngoscopy (3)."

Clinical • Surgery • Anesthesia • Gastroenterology • Pain

Determination of postoperative pain intensity in difficult laparoscopic cholecystectomy surgeries (Euroanaesthesia 2025) - "After anesthesia induction, all patients received 8 mg dexamethasone. Thirty minutes before the end of surgery, 1 g paracetamol and 50 mg dexketoprofen were administered as postoperative analgesics...NRS 24-hour follow-up values were 2.1 (1.7-2.6) for the easy LC group and 1.95 (1.3-2.32) for the difficult LC group (p=0.08). There was no significant difference observed in pain levels between the two groups.Conclusion(s): Our study concluded that difficult LC surgery is not directly associated with higher pain intensity."

Surgery • Anesthesia • Gastroenterology • Pain

Diclofenac sodium vs. dexketoprofen trometamol: selecting NSAIDs for managing postoperative inflammatory complications after third molar surgery-a randomized clinical trial. (PubMed, Head Face Med) - "Following impacted tooth extraction, administering DT during the initial days-when pain is more intense and the inflammatory response is developing-followed by DS in the later recovery phase may enhance postoperative comfort."

Clinical • Journal • Inflammation • Pain

The effect of hot application with cherry seed belt on dysmenorrhoea: A randomized controlled trial. (PubMed, Eur J Obstet Gynecol Reprod Biol) - "As a result, although there was no significant difference in terms of VAS scores between the intervention and control groups, except for one measurement, the intervention group was satisfied with the heated cherry seed belt for treatment of dysmenorrhoea."

Journal • Gynecology • Pain

Comparison of Superior Hypogastric Plexus Block and Peritoneal Bupivacaine in Pain Management (clinicaltrials.gov) - P=N/A | N=94 | Completed | Sponsor: Enes Celik

New trial • Gynecology • Pain

Enhanced Drug Loading Capacity Using the Dual Metformine-Dexketoprofren Salt on Nanoapatite Materials. (PubMed, Mol Pharm) - "To this purpose, the full synthesis and comprehensive characterization of apatite nanoparticles and the molecular pharmaceutical salt metformin-dexketoprofen are reported, paying special attention to the improvements regarding solubility and stability of the novel materials compared to the parent active pharmaceutical ingredients, as well as the drug loading capacity enhancement achieved in nanoapatites. Our results evidence the potential of the presented novel strategy, enhancing the dexketoprofen-loading a remarkable 50-fold when compared to native drug, thanks to the improvement of solubility achieved via salt-formation (567 and 168 mg/mL at pH 6.8 and 1.2, respectively), thus expecting improved therapeutic outcomes."

Journal

Dexketoprofen-Loaded Alginate-Grafted Poly(N-vinylcaprolactam)-Based Hydrogel for Wound Healing. (PubMed, Int J Mol Sci) - "DEXHY exhibited a very good in vitro wound closure rate, given its ability to modify DEX release kinetics. The hydrogel developed in this study has shown considerable potential to facilitate and even accelerate wound healing, including surgical wounds, by inhibiting the overexpressed inflammation process."

Journal • Infectious Disease • Inflammation • Pain

The Efficacy of Dexketoprofen And Methylprednisolone in the Acute Low Back Pain (clinicaltrials.gov) - P4 | N=150 | Completed | Sponsor: Ali Gur

New P4 trial • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (clinicaltrials.gov) - P4 | N=120 | Not yet recruiting | Sponsor: Medical University of Silesia

New P4 trial • Anesthesia • Orthopedics • Pain