fluoxetine / Generic mfg. - LARVOL DELTA

Antibacterial Synergism of Fluoxetine and Paroxetine with Ceftriaxone, Plasmid DNA Cleavage and Repositioning. (PubMed, Curr Microbiol) - "Antidepressants cleaved plasmid DNA by hydrolytic mechanism, demonstrating greater cleavage efficiency at pH 7.4 and temperature of 37 °C, that is, under physiological conditions. This is a demonstrative study of the promising action of FX/PX in combination with CTX in strains registered in 2019 and 2021, confirming it to be a promising alternative in antibacterial treatments."

Journal

Optimizing treatment for depression in primary care using psychotherapy versus antidepressant medication in a low-resource setting: protocol for the OptimizeD randomized controlled trial. (PubMed, BMC Psychiatry) - P3 | "The OptimizeD trial will evaluate whether baseline information collected in routine care can inform optimal depression treatment selection and identify predictors of nonresponse to facilitate timely specialist referrals. Findings have the potential to enhance personalized depression care in primary health systems, particularly in low-resource settings, with broader implications for global public health."

Clinical protocol • Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Urinary metabolic ratio of pain management and substance abuse treatment drugs: Drug-drug interactions. (PubMed, J Opioid Manag) - "The 18 drugs include dextromethorphan, oxycodone, hydrocodone, tramadol, morphine, buprenorphine, fentanyl, clonazepam, alprazolam, quetiapine, carisoprodol, tapentadol, ketamine, methadone, impramine, and amitriptyline. The 14 interfering drugs include fluoxetine, paroxetine, bupropion, citalopram, sertraline, venlafaxine, duloxetine, risperidone, trazodone, aripiprazole, cyclobenzaprine, amphetamine, and tetrahydrocannabinol...Using the MR reference intervals of the 18 drug pairs established in an earlier study, and the current DDI system, we can alert providers of unusual metabolism caused by DDIs. This will help providers do better prescribing or review more closely all medications and supplements patients are taking, thus avoiding underdosing or potential medication adverse reactions."

Journal • Pain • Substance Abuse • CYP2C19 • CYP3A4

Fluoxetine in functional constipation with somatic symptom disorder - Efficacy and safety from a propensity score-matched cohort study. (PubMed, Rev Esp Enferm Dig) - "Fluoxetine appears to be a safe and effective therapeutic option over a 6-month period for patients with FC and SSD, exerting dual benefits in alleviating both constipation and associated psychological symptoms."

Journal • Constipation • Gastroenterology • Gastrointestinal Disorder • Inflammatory Bowel Disease • Psychosomatic Disorders

Immunomodulatory Effects of Cucurbita pepo L. Extract in Chronic Stress-Induced Dysregulation of Lymphoid Organs in Rats. (PubMed, Pharmaceuticals (Basel)) - "The aim of the present work was to assess the impact of Cucurbita pepo L. (CP) on chronic unpredictable mild stress (CUMS)-induced changes in lymphoid organs through evaluating its effect on the histological structure of spleen, thymus gland, and lymph nodes compared to the antidepressant fluoxetine (FLU)...It significantly reduced the number of CD4, CD8, CD68, CD20, and caspase-3 immunopositive cells in the studied organs. This study proved the potential efficacy of CP in alleviating depression-associated immunodysregulation either alone or in combination with antidepressant therapy."

Journal • Preclinical • CNS Disorders • Depression • Psychiatry • CASP3 • CD20 • CD4 • CD68 • CD8 • IL6 • NR3C1 • TNFA

Selection of an Optimal Metabolic Model for Accurately Predicting the Hepatic Clearance of Albumin-Binding-Sensitive Drugs. (PubMed, Pharmaceuticals (Basel)) - "Building on previous studies that employed multinomial logistic regression analysis for model selection, a three-phase classification method was implemented to identify five representative drugs: diazepam, diclofenac, rosuvastatin, fluoxetine, and tolbutamide. These findings demonstrate the accuracy of an in silico-based model selection approach for predicting liver metabolism and highlight its potential for guiding dosage adjustments. Furthermore, the IPRL system serves as a practical tool for validating the accuracy of the results derived from this approach."

Journal

Environmental Antidepressants Disrupt Metabolic Pathways in Spirostomum ambiguum and Daphnia magna: Insights from LC-MS-Based Metabolomics. (PubMed, Molecules) - "Pharmaceuticals such as fluoxetine, paroxetine, sertraline, and mianserin occur in aquatic environments at low yet persistent concentrations due to their incomplete removal in wastewater treatment plants. They also underscore the considerable potential of metabolomics as a powerful and sensitive tool for ecotoxicological risk assessments, particularly when applied across multiple model organisms to capture interspecies variations. However, further research is essential to identify which specific pathway disruptions are most predictive of adverse effects on organismal health."

Journal • Metabolic Disorders

Possible Association Between Concomitant Use of SSRIs with NSAIDs and an Increased Risk of Adverse Events Among People with Depressive Disorders: Data Mining of FDA Adverse Event Reporting System. (PubMed, Pharmaceuticals (Basel)) - "Objectives: This study analyzed FDA Adverse Event Reporting System (FAERS) data (2004-2024) to assess gastrointestinal bleeding, thrombocytopenia, and acute kidney injury (AKI) potential risks linked to SSRIs (citalopram, escitalopram, fluoxetine, paroxetine, fluvoxamine, and sertraline) and NSAIDs (propionic/acetic/enolic acid derivatives, COX-2 inhibitors) in depression patients, alone and combined. Certain combinations of SSRIs and NSAIDs might further elevate these risks of gastrointestinal bleeding, thrombocytopenia, and acute kidney injury in patients with depression. Given the potential drug-drug interactions, heightened clinical vigilance is advised when prescribing SSRIs and NSAIDs in combination to patients with depression."

Adverse events • Journal • Acute Kidney Injury • CNS Disorders • Depression • Gastroenterology • Hematological Disorders • Inflammation • Nephrology • Pain • Psychiatry • Renal Disease • Thrombocytopenia

Psilocybin in the treatment of eating disorders: a systematic review of the literature and registered clinical trials. (PubMed, Eat Weight Disord) - "The initial evidence shows that psilocybin might be safe and well-tolerated in AN. The promising results and the need for tests in enlarged samples encourage further research on psilocybin in EDs."

Clinical • Journal • Review • Anorexia • Bulimia

Rheumatologists' Adherence to EULAR Recommendations for Systemic Sclerosis Treatment: Experience of a Single Center in Serbia. (PubMed, J Clin Med) - "Medications such as iloprost, phosphodiesterase type 5 (PDE-5) inhibitors, fluoxetine, and bosentan, recommended for the treatment of RP and digital ulcers, were not approved for SSc by the Republic Health Insurance Fund. Treatment for pulmonary arterial hypertension (PAH) was administered to only 16 patients (4.2%), including 2 who received bosentan, 10 who received PDE-5 inhibitors, and 4 who were treated with riociguat...Cyclophosphamide was consistently prescribed for interstitial lung disease (ILD), with an increased frequency observed after the guideline update. No significant differences were observed in the use of methotrexate for skin involvement, ACE inhibitors for scleroderma renal crisis, or antibiotics for gastrointestinal symptoms... Rheumatologists' adherence to the EULAR/EUSTAR guidelines varied considerably, with 25% to 100% of eligible patients receiving the recommended treatments. Concordance improved in the management of PAH, ILD, and..."

Journal • Cardiovascular • Hypertension • Immunology • Interstitial Lung Disease • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Rheumatology • Scleroderma • Systemic Sclerosis

Identifying and Treating Depression in the Orthopaedic Trauma Population (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: Wake Forest University Health Sciences | Not yet recruiting ➔ Recruiting

Enrollment open • CNS Disorders • Depression • Mood Disorders • Orthopedics • Psychiatry

Paeonol facilitates the repair of neuronal damage in the mPFC caused by chronic stress via the Rho GTPases-cofilin1 signalling pathway. (PubMed, Neurosci Lett) - "Paeonol alleviates CUMS-induced behavioural impairments, potentially through modulating the Rho GTPases-cofilin1 signaling axis."

Journal • CDC42 • RAC1 • RHOA

The role of mitochondria-related genes in hepatocellular carcinoma prognosis: construction of prognostic models based on machine learning. (PubMed, Discov Oncol) - "This study highlights the prognostic significance of mitochondrial function-related genes in HCC and establishes a framework for developing innovative diagnostic and therapeutic interventions. Future research should prioritize clinical validation of these findings and evaluate the translational potential of the identified drug candidates in HCC."

Journal • Hepatocellular Cancer • Liver Cancer • Metabolic Disorders • Oncology • Solid Tumor • CKS1B • PSMD4

The shallow water test (SWT) as a novel behavioral paradigm to measure anxiety- and despair-like states in zebrafish. (PubMed, Neurosci Lett) - "While DZP increased distance traveled, maximum speed, and average velocity, FLU had no significant effects. These findings suggest the SWT as a sensitive and reliable tool for evaluating affective-like states in zebrafish, with implications for translational neurobehavioral research on affective disorders and therapeutic interventions."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Screening of the FDA-approved drug library identifies CCL17 inhibitors that block arthritic pain. (PubMed, Sci Rep) - "In this study, we screened a panel of 1508 FDA-approved drugs and identified five drugs, namely fluoxetine, ractopamine, ponesimod, terbutaline and etravirine, which potently inhibited CCL17 production without adverse effects on cell viability and CCL22 formation in human monocytes and mouse macrophages. Significantly, therapeutic administration of these five drugs in an inflammatory arthritis model revealed that fluoxetine, ractopamine, ponesimod and terbutaline could inhibit arthritic pain, correlating with decreased CCL17 expression. Given the need for new and safe anti-inflammatory therapeutics to treat RA and the benefits of repurposing existing drugs for new indications, our findings reported here offer four new promising analgesics for treating inflammatory pain."

FDA event • IO biomarker • Journal • Preclinical • Immunology • Inflammation • Inflammatory Arthritis • Pain • Rheumatoid Arthritis • Rheumatology • CCL2 • CCL22 • CCR4 • CSF2 • IRF4 • STAT5 • STAT5AWqe

Selective Serotonin Reuptake Inhibitor-Associated Intracranial Hemorrhage: Drug-Specific Risk Patterns and Patient-Level Modifiers. (PubMed, Neurol Int) - "This study highlights significant differences in ICH reporting patterns across SSRIs, modified by patient age, gender, and co-medication. These findings underscore the need for individualized SSRI prescribing, particularly in patients receiving anticoagulant therapy particularly in elderly patients and those receiving anticoagulant therapy, where sertraline and fluoxetine may pose increased risk."

Journal • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Subarachnoid Hemorrhage

EFFECTS OF SEROTONIN REUPTAKE INHIBITION ON ANXIETY-LIKE BEHAVIOR AND ADIPOCYTES MORPHOMETRY IN OFFSPRING SUBMITTED TO MATERNAL HIGH-FAT/HYPERCALORIC DIET. (PubMed, Behav Brain Res) - "IRS attenuated the effects of maternal HHD consumption on BW and RWAT and on the area and perimeter of adipocytes in the offspring of rats. However, in the long term, the effects of SRI on behavioral phenotypic expression were less obvious."

Journal • Mood Disorders • Obesity • Psychiatry

Overdose Toxicological Effect of Methanol Extract of Popular Edible Colocasia esculenta Linn. Flowers: Biochemical, Hematological, and Behavioral Study on Swiss Albino Mice. (PubMed, Food Sci Nutr) - "Behavioral evaluations revealed the extract's anxiolytic, sedative, and antidepressant properties, with effects comparable to diazepam and fluoxetine. The therapeutic potential of CEF-ME was evident; however, its administration at high doses triggered toxicity concerns, particularly impacting the hepatic and renal systems. These observations highlight a pressing need for further studies to investigate its prolonged safety, pharmacological mechanisms, and optimal therapeutic range."

Journal • Preclinical • Hematological Disorders • Thrombocytopenia

Repositioning Fluoxetine as a TRPV3 Channel Inhibitor to Alleviate Skin Inflammation and Pruritus. (PubMed, Curr Issues Mol Biol) - "It lessens the severity of dorsal lesions and ear edema in mice. Our study not only identified TRPV3 as a novel target of fluoxetine and provides new ideas for the treatment of TRPV3-mediated skin diseases with fluoxetine, but also provides a valuable tool molecule for further understanding TRPV3 channel pharmacology."

Journal • Dermatitis • Dermatology • Inflammation • Pain • Pruritus

Prescription and Nonprescription Drug Use Among People With Eating Disorders. (PubMed, JAMA Netw Open) - "Substances evaluated included caffeine, alcohol, nicotine, cannabis, prescription psychotropics, psychedelics, ketamine, 3,4-methylenedioxymethamphetamine (or ecstasy), stimulants, opioids, and other drugs...Prescription antidepressants were rated highly for overall mental health but not for ED symptoms, with the exception of fluoxetine for bulimia nervosa and lisdexamfetamine for binge-eating disorder...The findings of this survey study of prescription and nonprescription drug use suggest that cannabis and psychedelics were perceived by survey respondents as efficacious in alleviating their ED symptoms, which supports further research in this area. Prescription psychotropics were perceived as being relatively ineffective for ED symptoms but beneficial to general mental health."

Journal • Anorexia • Binge Eating Disorder • Bulimia • CNS Disorders • Depression • Psychiatry

Duloxetine inhibits breast cancer progression by suppressing AKT signaling and inducing Bax/Bcl-2-mediated apoptosis. (PubMed, Med Oncol) - "This study systematically evaluated the anti-tumor efficacy of six clinically used antidepressants (escitalopram, amitriptyline, fluoxetine, paroxetine, desvenlafaxine, and duloxetine) in 4T1 (murine triple negative) and MCF-7 (human ER+/HER2-) breast cancer cells...Although less potent than docetaxel, duloxetine still exhibited significant anti-proliferative, anti-migratory, and pro-apoptotic effects...Additionally, duloxetine promotes apoptosis by upregulating Bax and downregulating Bcl-2 expression both in vitro and in vivo. These findings reveal that duloxetine exerts anti-breast cancer effects through inhibiting AKT/mTOR signaling and promoting Bax/Bcl-2-mediated apoptosis, highlighting its potential for therapeutic repurposing as an adjunct treatment-particularly, in breast cancer patients with coexisting depression."

IO biomarker • Journal • Breast Cancer • CNS Disorders • Depression • HER2 Breast Cancer • HER2 Positive Breast Cancer • Oncology • Psychiatry • Solid Tumor • Triple Negative Breast Cancer • BCL2 • CDH1 • ER • HER-2

Depression and physical comorbidities: an integrated review of challenges and treatment approaches. (PubMed, Riv Psichiatr) - "While SSRIs such as sertraline are generally preferred due to their relatively favorable safety profiles, medications like paroxetine and fluoxetine require caution due to potential teratogenic risks and higher infant exposure through breast milk. A comprehensive, multidisciplinary approach integrating psychiatric and medical care is essential to improve outcomes and ensure the safe and effective treatment of depression in individuals with chronic physical diseases and special populations."

Journal • Review • Cardiovascular • CNS Disorders • Depression • Gastroenterology • Gastrointestinal Disorder • Genito-urinary Cancer • Inflammation • Metabolic Disorders • Mood Disorders • Psychiatry • Renal Disease

Chronic stress and cytogenesis ablation disrupt hippocampal neuron connectivity, with fluoxetine restoring function with sex-specific effects. (PubMed, Neurobiol Stress) - "Using a virus-mediated retrograde tracing approach, we quantified synaptic inputs to mature neurons and hABNs. Our findings reveal significant impairments in both intra- and extra-hippocampal connectivity following disruptions in cytogenesis, providing new insights into hippocampal network dynamics in the context of cytogenetic impairment, depression, and therapeutic interventions."

Journal • CNS Disorders • Depression • Psychiatry • GFAP

Viral Load to Overload: A Multisystem Meltdown in Motion (ASA 2025) - "Required several weeks of ECMO before transition to Trach placement for long term ventilation and discharge to LTAC. Course also complicated by bronchopleural fistula treated with Endobronchial valve placement & serotonin syndrome from Linezolid/Fluoxetine/Trazadone, requiring transition to Tedizolid/Doxycycline with cessation of Fluoxetine/Trazadone."

Infectious Disease • Influenza • Pneumonia • Respiratory Diseases • Septic Shock

Neural basis of GAD improvement following a mindfulness-based intervention and antidepressant treatment: an analysis from a randomized controlled trial. (PubMed, Psychiatry Res) - "Symptom improvement in GAD may involve enhanced functional coupling between brain regions and circuits critical for emotional regulation, self-referential processing, and stimulus selection, particularly between the left amygdala and right OFC. Larger sample studies are needed to elucidate treatment-specific neural mechanisms and refine personalized therapeutic strategies."

Clinical • Journal • CNS Disorders • General Anxiety Disorder • Mood Disorders • Psychiatry