fluoxetine / Generic mfg. - LARVOL DELTA

Age- and Sex-Specific Incidence Trends of Eating Disorders in South Korea: Insights From a Decade of National Health Insurance Data (2012-2021). (PubMed, Int J Eat Disord) - "The findings show distinct age- and sex-specific patterns in eating disorder incidence, underscoring the need for a tailored approach. Worldwide differences may offer etiological insights. A limitation is the aggregation of eating disorder subtypes."

Journal • Reimbursement • US reimbursement • CNS Disorders • Mood Disorders • Psychiatry

Association between selective serotonin reuptake inhibitors and 28-day in-hospital mortality in critically ill patients with depression: A cohort study stratified by exposure timing. (PubMed, J Affect Disord) - "In ICU patients with comorbid depression, overall SSRI exposure was not clearly associated with 28-day mortality after time-aligned analyses. A lower mortality signal was observed for post-ICU initiation, whereas pre-ICU maintenance use showed no survival advantage. These findings are hypothesis-generating and warrant prospective confirmation."

Journal • CNS Disorders • Critical care • Depression • Mood Disorders • Psychiatry

Phosphated maltodextrin as an anionic chiral selector for capillary electrophoresis: Application to the enantiomeric separation of basic drugs. (PubMed, J Chromatogr A) - "Its chiral recognition capability in CE was systematically assessed using five model drugs: tramadol, citalopram, hydroxyzine, amlodipine, and fluoxetine. PMD is a new anionic chiral selector combining affordability, solubility, and enhanced selectivity. Major resolution gains without longer analysis times demonstrate PMD's promising potential for routine pharmaceutical applications, with broader chiral separations to be explored in future studies."

Journal

Temporal Patterns of Adverse Events Associated With Selective Serotonin Reuptake Inhibitors: A Global Pharmacovigilance Analysis of Early-Onset Versus Late-Onset Toxicity. (PubMed, Cureus) - "Objective This study aims to explore the timing of AEs associated with six commonly used SSRIs: sertraline, fluoxetine, fluvoxamine, paroxetine, citalopram, and escitalopram using global pharmacovigilance data, with a focus on early- versus late-onset profiles. Early-onset symptoms require timely management to improve tolerability, while late-onset effects highlight the need for ongoing monitoring. These findings can inform personalized monitoring strategies and guide patient counseling to support safer long-term SSRI use."

Adverse events • Journal • CNS Disorders • Dermatology • Diabetes • Insomnia • Metabolic Disorders • Osteoporosis • Rheumatology • Sexual Disorders • Sleep Disorder

Effects of electroconvulsive shock on the function, circuitry, and transcriptome of dentate gyrus granule neurons. (PubMed, Neuropsychopharmacology) - "We also find global differences in ECS- vs fluoxetine-induced transcriptomic shifts. Together, these findings highlight a critical role for immature granule cells in the antidepressant action of ECS."

Journal • CNS Disorders • Depression • Psychiatry

The effects of Kai-Xin-San in alleviating chronic social defeat stress-induced depression-like behaviors are associated with CD4+ T cells. (PubMed, J Ethnopharmacol) - "KXS may ameliorate CSDS-induced depression-like behaviors through the regulation of CD4+ T cells. The underlying mechanisms involve immune-related protein expression and cellular signaling pathways, regulation of the tryptophan-kynurenine metabolic pathway, and restoration of central immune homeostasis."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry • CD4 • CD8

Prucalopride, a serotonin type 4 receptor agonist, induces fast anxiolytic/antidepressant effects and concomitant changes in the gut microbiota. (PubMed, NPJ Biofilms Microbiomes) - "Behavioral effects of prucalopride (0.5 and 1.5 mg/kg/day) were compared to fluoxetine, a common SSRI, over 7 (subchronic) and 28 (chronic) days. Notably, prucalopride restored levels of the genus Ruminococcus, which were depleted by CORT. Our findings highlight prucalopride's rapid anxiolytic and antidepressant-like effects and its impact on gut microbiota, supporting the potential of 5-HT4R-targeting molecules as therapeutic options for psychiatric disorders."

Journal • CNS Disorders • Constipation • Depression • Gastroenterology • Gastrointestinal Disorder • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry

Translational reprogramming of dentate gyrus peptidergic circuitry gates antidepressant efficacy. (PubMed, Mol Psychiatry) - "Chronic, but not acute, treatment with an SSRI fluoxetine (FLX) selectively enhances translational activity in hilar mossy cells (MCs), with no detectable changes in neighboring granule cells (GCs)...This PACAP induction mediates neuroadaptive plasticity in PAC1 receptor-expressing GCs and drives behavioral responses prominently in female mice during prolonged FLX administration. Our findings establish cell type-specific translational reprogramming as a novel mechanistic framework for antidepressant action."

Journal • ADCYAP1

Large Hiatal Hernia in a Patient With Bulimia Nervosa and Obesity: An Interdisciplinary Case Report. (PubMed, Am J Case Rep) - "The patient underwent laparoscopic cruroplasty with Toupet fundoplication and cholecystectomy, combined with psychiatric management including cognitive-behavioral therapy and fluoxetine...CONCLUSIONS This case highlights the importance of thorough history-taking in patients with atypical gastrointestinal symptoms and demonstrates that bulimia nervosa can contribute to HH development through repeated increases in intra-abdominal pressure. A multidisciplinary approach integrating surgical and psychiatric interventions is essential for successful management of HH when associated with eating disorders and other complex comorbidities."

Journal • Bulimia • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Hematological Disorders • Obesity • Pain • Psychiatry • Pulmonary Disease

Fluoxetine minimally affects hearing loss but induces gene expression changes in the cochlear nuclei after noise exposure. (PubMed, PLoS One) - "Fluoxetine exerted only modest, 4 kHz‑restricted improvements in ABR thresholds and did not restore cochlear structure or normal hearing following noise‑induced hearing loss. However, it induced distinct transcriptional alterations in the VCN and modulated the extracellular environment, suggesting a potential role in neural remodeling rather than direct auditory restoration."

Journal • Otorhinolaryngology • ACAN • NR4A1 • PDE5A

Stereoselective, sex-dependent 5-HT2A receptor modulation of cortical plasticity by MDMA in mice. (PubMed, Neuropsychopharmacology) - "Pharmacological blockade of the serotonin transporter (SERT) with fluoxetine fully prevented S(+)-MDMA-induced HTR and IP1 signaling, without affecting responses to the direct 5-HT2AR agonist DOI. These findings indicate that MDMA engages 5-HT2AR signaling indirectly via serotonin efflux and that this effect is both stereoselective and sex-dependent in mice, uncovering a previously unrecognized interaction between sex, MDMA stereochemistry, and 5-HT2AR-mediated cortical plasticity, with important implications for the rational design of MDMA-based therapeutics."

Journal • Preclinical • CNS Disorders • Mental Retardation • Psychiatry

STAMD: Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD) (clinicaltrials.gov) - P1/2 | N=520 | Recruiting | Sponsor: First Affiliated Hospital of Chongqing Medical University | Trial primary completion date: Dec 2025 ➔ Dec 2026

Trial primary completion date • CNS Disorders • Depression • Mood Disorders • Psychiatry

New fluoxetine analogues as anti-enterovirus agents targeting 2C protein. (PubMed, Eur J Med Chem) - "In this study, we describe the optimization of (S)-fluoxetine, a promising hit identified through drug repurposing that binds to an allosteric site on the CV-B3 2C ATPase domain. Our optimization process was guided by rational design, X-ray crystallographic structures, computational docking, and validation by enzyme and cell-based assays, leading to several new inhibitors, among which compound 53 (CV-B3 EC50 = 0.5 μM and EV-D68 EC50 = 0.4 μM), a novel anti-enterovirus with higher selectivity indexes than (S)-fluoxetine."

Journal • Infectious Disease

A randomized controlled study on the combination of fasudil hydrochloride and PD1 inhibitors with androgen deprivation therapy in neoadjuvant treatment of prostate cancer (ChiCTR) - P=N/A | N=83 | Not yet recruiting | Sponsor: The Affiliated Zhongda Hospital of Southeast University; The Affiliated Zhongda Hospital of Southeast University

New trial • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Study on the Efficacy and Safety of Esketamine Hydrochloride Nasal Spray Combined with Antidepressants in Rapidly Improving Symptoms in Patients with Depression (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Xi'an Jiaotong University; The First Affiliated Hospital of Xi'an Jiaotong University

New trial • CNS Disorders • Depression • Mood Disorders • Psychiatry • Suicidal Ideation

Drug-related suicidal events in children and teenagers: Age-stratified insights from FAERS. (PubMed, Leg Med (Tokyo)) - "Across FAERS youth suicide reports, drug-associated fatality risk varies markedly by drug, surges in mid- to late adolescence, diverges by sex and shifts at both age extremes. These heterogeneities underscore the need for age-appropriate pharmacovigilance and trial strategies rather than direct extrapolation from adult data, particularly regarding the safety of drugs associated with suicide."

Journal • Pediatrics

Living with an imagined odor: first case report of olfactory reference syndrome in East Africa treated using a multimodal approach. (PubMed, J Med Case Rep) - "Olfactory reference syndrome is an underrecognized condition with significant psychosocial consequences. Reporting this case from Ethiopia aims to raise awareness among clinicians in low-resource settings, encourage timely diagnosis, and promote multidisciplinary management."

Journal • CNS Disorders • Mental Retardation • Mood Disorders • Otorhinolaryngology • Psychiatry

Synergistic Efficacy of Lactobacillus plantarum Supernatant-Preconditioned BM-MSCs in Alleviating Depression, Anxiety-Like Behavior, and Memory Impairment in a Rat Stress Model by Suppressing the NF-κB Pathway. (PubMed, Mol Neurobiol) - "BM-MSCs were pretreated with 15 μM of fluoxetine (Flx) or 10 µl/ml of L.PS for 24 h...An in silico analysis also supported the importance of evaluating and targeting this pathway. In conclusion, we found that L.PS pretreated MSCs significantly improves CRS-induced depressive-like behavior, which can be partly attributed to the inhibition of NLRP3-mediated neuroinflammation."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Depression • Inflammation • Mood Disorders • Psychiatry • Transplantation • IL18 • IL1B • IL6 • NLRP3 • TNFA

Multi-Layered Antidepressant Mechanisms of Gami-Soyosan in a Corticosterone-Induced Mouse Model. (PubMed, J Microbiol Biotechnol) - "Behavioral assessments, including the forced swim test and tail suspension test, demonstrated that GSS significantly reduced immobility, indicating improved coping behaviors comparable to those of fluoxetine...In addition, in vitro experiments using neuronal cells demonstrated that GSS attenuated oxidative stress by reducing whole-cell ROS generation and enhancing lysosomal activity, highlighting a neuroprotective role. Together, these findings provide multi-layered evidence that GSS acts through behavioral, immune, metabolic, and oxidative pathways, supporting its potential as a complementary therapeutic approach for stress-related depression."

Journal • Preclinical • CNS Disorders • Depression • Metabolic Disorders • Psychiatry • IL1B • IL6 • TNFA

Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression model. (PubMed, Transl Psychiatry) - "DMT administered after UCMS reversed depressive-like behavior and restored cognitive performance, outperforming chronic fluoxetine across most domains...Exploratory assessments in anesthetized animals showed that DMT's behavioral and cellular benefits persisted under isoflurane, though the role of the psychedelic experience remains uncertain due to potential confounding effects of isoflurane not controlled for in our design. Histological analyses revealed that all DMT regimes significantly increased adult-born granule cell (abGC) integration and reduced the number of ectopically abnormally integrated abGCs. Together, our findings highlight the robust and multifaceted effects of DMT on behavior and neurogenesis, positioning it as a promising candidate for rapid-acting antidepressant strategies that target structural circuit repair."

Journal • Alzheimer's Disease • Anesthesia • CNS Disorders • Cognitive Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Serotonergic Signaling Rewired: A Lipid Raft-Controlled Model of Synaptic Transmission Grounded in the Fundamental Parameters of Biological Systems. (PubMed, Life (Basel)) - "This extended serotonergic persistence prompts a reconsideration of current pharmacological models and the action of antidepressants such as fluoxetine, which not only inhibits the serotonin transporter (SERT) but also accumulates in lipid rafts, perturbs raft organization, and alters serotonin-cholesterol equilibria, contributing to SERT-independent effects. Grounded in the recently established fundamental parameters of biological systems, this model invites a broader, quantum-informed rethinking of synaptic transmission."

Journal

Pharmacogenomics of CYP2D6, CYP2C19, CYP2C9, and Clinical Determinants of Fluoxetine-Norfluoxetine Pharmacokinetics in Real-World Clinical Conditions. (PubMed, Pharmaceutics) - " These findings highlight CYP2D6 genotype as a key determinant of fluoxetine metabolism during standard treatment. No associations were observed with CYP2C9 or CYP2C19 genotypes or clinical factors."

Biomarker • Journal • PK/PD data • Real-world evidence • CYP2C19 • CYP2C9

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint. (PubMed, J Vis Exp) - "For model establishment, rats in the stroke, PSD, fluoxetine hydrochloride (FXT), and YNJYP groups underwent MCAO: a monofilament suture was advanced from the internal carotid artery to the middle cerebral artery (MCA) for 2 h of ischemia, followed by reperfusion...YNJYP reversed these depressive-like behaviors (P < 0.01), with efficacy comparable to FXT. This protocol confirms the validity of the PSD model and YNJYP's therapeutic potential, supported by rigorous experiments and data analysis."

Journal • Preclinical • Cardiovascular • CNS Disorders • Depression • Mood Disorders • Psychiatry

Adjunctive individual meaning-centered psychotherapy plus protocolized fluoxetine for moderate-to-severe adolescent depression. (PubMed, Front Psychiatry) - "Neither group experienced SAEs, and AE frequencies were low and did not differ meaningfully between groups. Adjunctive IMCP with standardized fluoxetine produced greater 12-week improvements than TAU in symptoms, clinician ratings, functioning, self-esteem, and felt meaning, supporting IMCP as a feasible and effective adjunct."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Macaranga peltata Alleviates Neuropsychiatric Disorders in Mouse Model and Computational Study. (PubMed, Food Sci Nutr) - "Although MEMPL reduced immobility in both FST and TST, its effects were notably weaker than fluoxetine, indicating modest antidepressant-like activity...Computational screening identified 2-hydroxy-6-methylbenzaldehyde as a potential bioactive compound with strong binding to proteins involved in anxiety, depression, and nociception. Overall, these findings highlight MEMPL's broad neuropharmacological and analgesic potential, demanding further mechanistic and dose-response studies."

Journal • Preclinical • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Pain • Psychiatry