RCY-1305 / Regenacy - LARVOL DELTA

A novel HDAC1/2 inhibitor alleviates physical and emotional symptoms associated with spontaneous oxycodone withdrawal in neuropathic pain mice. (PubMed, FASEB J) - "Since RCY1305 displays antiallodynic actions with no rewarding effects in models of neuropathic pain, inhibition of HDAC1/2 may provide an avenue for chronic pain patients dependent on opioids to transition to non-opioid analgesics. Overall, our study highlights transcriptomic events in components of the reward circuitry associated with oxycodone withdrawal under pain-naïve and prolonged neuropathic pain states, thereby providing information on possible new targets for the treatment of physical dependence to opioids and transitioning individuals to non-opioid medications for chronic pain management."

Journal • Preclinical • Addiction (Opioid and Alcohol) • CNS Disorders • Neuralgia • Pain • Psychiatry

Oxycodone Physical Dependence Promotes Gene Adaptations in the Brain Reward Pathway Under Neuropathic and Pain-Free States (ACNP 2021) - "Using a novel inhibitor for HDAC1/2, RCY1305, we treated mice with RCY1305 (3mg/kg i.p daily) during oxycodone administration and drug withdrawal for 5- weeks. Our findings suggest that chronic pain states exacerbate the behavioral and transcriptomic signatures of oxycodone withdrawal. Overall, our studies highlight intracellular pathways, thereby providing novel possibilities for treating oxycodone dependence under neuropathic and pain-free states."

Addiction (Opioid and Alcohol) • Alzheimer's Disease • CNS Disorders • Depression • Neuralgia • Pain • Psychiatry • Sleep Disorder • Substance Abuse

Oxycodone Physical Dependence Promotes Gene Adaptations in the Brain Reward Pathway Under Neuropathic and Pain-Free States (ACNP 2021) - "Using a novel inhibitor for HDAC1/2, RCY1305, we treated mice with RCY1305 (3mg/kg i.p daily) during oxycodone administration and drug withdrawal for 5- weeks. Our findings suggest that chronic pain states exacerbate the behavioral and transcriptomic signatures of oxycodone withdrawal. Overall, our studies highlight intracellular pathways, thereby providing novel possibilities for treating oxycodone dependence under neuropathic and pain-free states."

Addiction (Opioid and Alcohol) • Alzheimer's Disease • CNS Disorders • Depression • Neuralgia • Pain • Psychiatry • Sleep Disorder • Substance Abuse