NexoBrid (bromelain) / MediWound, Kaken Pharma, Teva - LARVOL DELTA

Comparison of the Efficiency of the Carie-Care and Bromelain Gel, as Chemomechanical Caries Removal Techniques in Primary Teeth: Randomized Controlled Clinical Trial. (PubMed, Int J Clin Pediatr Dent) - "Comparison of the Efficiency of the Carie-Care and Bromelain Gel, as Chemomechanical Caries Removal Techniques in Primary Teeth: Randomized Controlled Clinical Trial. Int J Clin Pediatr Dent 2026;19(8):999-1005."

Clinical • Journal • Pain

Synergistic Effects of Dual-Enzyme Hydrolysis on Flavor Enhancement and Umami Improvement in Tilapia Bone Byproducts. (PubMed, J Food Sci) - "Five commercial endopeptidases-bromelain, neutral protease, alkaline protease, papain, and trypsin-were evaluated in combination with flavorzyme to improve the physicochemical properties and flavor characteristics of tilapia bone hydrolysates...GC-IMS and HS-GC-IMS analyses demonstrated that the TF system generated the highest concentrations of total aldehydes and alcohols and significantly increased the levels of key volatile compounds, including aldehydes (nonanal, octanal, hexanal), alcohols (1-octen-3-ol), ketones (1-hepten-3-one), and esters. These results indicate that this innovative dual-enzyme hydrolysis strategy enables the deep and efficient hydrolysis of proteins, transforming fish processing byproducts into high-value flavor enhancers; this approach not only significantly improves flavor quality and added value but also expands avenues for efficient utilization, thereby enhancing the fishery supply value chain."

Journal

Oral Bromelain Reduces Postoperative Edema Following Upper Blepharoplasty: A Randomized Triple-Blind Placebo-Controlled Trial. (PubMed, Aesthet Surg J) - "Oral bromelain markedly reduces swelling after blepharoplasty and has a notable effect on ecchymosis during the early recovery period. It may represent a safe and effective postoperative adjunct following upper blepharoplasty, although larger multicenter trials are required."

Clinical • Journal • Aesthetic Medicine • Mood Disorders • Psychiatry

Anacaulase-Bcdb for Enzymatic Eschar Removal in Adult and Paediatric Thermal Burns: Clinical Evidence, Safety, and Therapeutic Positioning. (PubMed, Wound Repair Regen) - "Its greatest value is likely in eligible deep partial-thickness and selected full-thickness thermal burns treated within protocolized burn-center pathways. Future adoption will depend on comparative effectiveness, cost-effectiveness, real-world safety, optimal patient selection and evidence that reduced operative burden translates into improved clinical and health-system outcomes."

Journal • Review • Immunology • Pain • Pediatrics • Thermal Injury

Development of biodegradable bioplastics from pineapple bromelain processing waste: Utilization of decanter and fiber flours. (PubMed, Food Chem ) - "The resulting bioplastic exhibited a water content of 6.21%, density of 1.405 g/cm3, tensile strength of 2.065 MPa, elongation at break of 38.423%, Young's modulus of 25.912 MPa, swelling capacity of 10.196%, WVTR of 1815.48 g/m2·24 h, and a fungal colonization score of 95.75% after 10 days, indicating a high biodegradation potential under the tested conditions. These findings demonstrate the potential of pineapple bromelain processing waste as a renewable feedstock for biodegradable packaging materials, supporting a promising approach for sustainable waste valorization and circular bioeconomy initiatives."

Journal

Biomimetic HDL nanoparticles functionalized with bromelain and chondroitin sulfate for enhanced penetration and targeted therapy of liver fibrosis. (PubMed, Int J Biol Macromol) - "Then RNA seq was further performed to explore the potential molecular mechanisms underlying the therapeutic effects of the nanoparticles, revealing alterations in multiple signaling pathways and biological processes related to liver fibrosis. In conclusion, these results suggest that BCSH represents a promising therapeutic strategy for liver fibrosis."

Journal • Fibrosis • Immunology • Inflammation • Liver Cirrhosis

Comparative evaluation of a bromelain-based endodontic irrigant versus sodium hypochlorite, chlorhexidine gluconate, and chitosan against Enterococcus faecalis - An in vitro study. (PubMed, J Conserv Dent Endod) - "BCC irrigant did not show statistically significant difference than NaOCl and chlorhexidine for antibacterial action. The novel BCC irrigant is effective in preparing dentinal surfaces for root canal without adverse effects and promising longevity."

Journal • Preclinical

Effects of bromelain-induced protein hydrolysis of mealworm (Tenebrio molitor larva) flour on protein characteristics, proximate composition, and glycemic response of crackers. (PubMed, Food Res Int) - "Consequently, the 35% substitution crackers exhibited the lowest glycemic index (GI) at 22.54 and a favorable glycemic load (GL) compared to the control. Substituting wheat flour with mealworm hydrolysate yields protein-rich crackers with potentially enhanced nutritional value, lowered total sugar, and optimal glycemic properties, demonstrating their strong potential as a functional snack for diabetes management."

Journal • Diabetes • Metabolic Disorders

A Photothermally Amplified Enzyme-Nitric Oxide Co-Regulatory System Reprograms Pathological ECM-Fibroblast Crosstalk to Alleviate Hypertrophic Scarring. (PubMed, Adv Sci (Weinh)) - "Specifically, a microneedle platform is developed for localized co-delivery of the thermosensitive protease bromelain (Bro) and NO-donor-functionalized polydopamine nanoparticles (PDA-NO)...In vivo studies demonstrate that this system alleviates HS and restores balanced fibrotic remodeling, as evidenced by coordinated suppression of YAP signaling and the TGF-β1/α-SMA/Collagen I axis, supporting effective interruption of the fibrotic feedback loop. Distinct from existing fibroblast-centric approaches, this study establishes pathological ECM-fibroblast crosstalk as a key mechanistic entry point for HS, advancing a mechanism-driven, materials-enabled framework for antifibrotic strategy design."

Journal • Fibrosis • TGFB1

Sustainable extraction and in situ separation of bromelain from pineapple peel using deep eutectic solvent/salt system: molecular mechanism, hydrolytic activity and stability. (PubMed, Food Res Int) - "More importantly, ChCl:Gly exhibited the capacity for multiple recycling and reuse cycles with stable extraction efficiency, activity recovery and purification fold. The proposed platform integrates extraction, purification and enrichment in one step, achieving green and sustainable extraction of high-yield and high-purity bromelain from pineapple peel."

Journal

Bromelain-digested casein peptide pool ameliorates chronic stress-induced impairments in hippocampal long-term potentiation and synaptic plasticity in rats. (PubMed, Brain Res) - "The results demonstrated that chronic stress significantly reduced population spike (PS) amplitudes across multiple stimulation intensities (I/O) after LTP. Treatment with BDCPP effectively mitigated these deficits, enhancing PS responses across stimulation intensities after LTP induction and improving the means of both PS and fEPSP measures at 120 minutes post-LTP. The findings of this study indicate that BDCPP enhances LTP induction, increases both PS and fEPSP responses, and ultimately attenuates synaptic plasticity impaired by chronic stress."

Journal • Preclinical

Prevention of lymphedema after extended pelvic lymphadenectomy using diosmin, bromelain, melilotus, and hesperidin: results from a prospective randomized study (PRELYNE trial). (PubMed, J Robot Surg) - "In conclusion, Meliven Top® did not significantly reduce postoperative lower-limb volume changes after RARP with ePLND, but it was associated with improved genital symptom recovery. Larger studies with longer follow-up are warranted.Clinical trial registration This study was not registered in a public clinical trial registry."

Clinical • Journal • Genito-urinary Cancer • Oncology • Pain • Prostate Cancer • Solid Tumor

Bromelain and N-acetylcysteine (BromAc) as novel adjunctive therapy for prosthetic joint infection: a narrative review. (PubMed, J Bone Jt Infect) - "Important translational gaps remain in peer-reviewed staphylococcal validation on prosthetic materials, formulation stability (particularly the susceptibility of N-acetylcysteine to oxidation in aqueous solution), intra-articular safety with respect to cartilage and osseointegration, and the absence of an in vivo orthopaedic implant model. These limitations must be resolved before clinical translation can be responsibly considered."

Journal • Review • Gastroenterology • Infectious Disease • Orthopedics

Is There a Role for Arnica or Bromelain in the Perioperative Care of Facial Plastic Surgery? (PubMed, Laryngoscope) - No abstract available

Journal • Aesthetic Medicine

The Preparation of Hypoallergenic Goat Milk Protein Hydrolysates via Targeted Hydrolysis of Cross-Reactive Linear Epitopes Between Cow and Goat Milk. (PubMed, Int J Mol Sci) - "Mass spectrometry revealed the peptide composition and epitope coverage of the hydrolysates: bromelain yielded two overlapping peptides (FAWPQY, LKDLKDY), protamex one (LAMAAS), Alcalase three (PPQSVLS, IPIQYVLS, LPYPYY), trypsin two (YLGYLEQL, AMAASDISLL), papain three (NEINQFYQK, FQSEEQQQTEDELQDK, AMAASDISL); and no matching peptide was detected for pepsin. These results confirmed at the molecular level that enzymatic hydrolysis can effectively disrupt cross-reactive epitopes."

Journal • Allergy • Food Hypersensitivity • Immunology

Dietary pineapple peel powder supplementation enhances resistance against Aeromonas veronii in Labeo rohita fingerlings. (PubMed, Dis Aquat Organ) - "Processing 1 kg of pineapple fruit generates approximately 30-35% waste, primarily peels, containing bioactive compounds including bromelain enzyme...Growth performance also improved significantly, with specific growth rate (2.84 ± 0.12% vs. 2.15 ± 0.09% d-1) and feed conversion ratio (1.42 ± 0.06 vs. 1.85 ± 0.08) both enhanced in T3 compared to control. These results demonstrate that 6% PPP supplementation optimally enhances immunophysiological parameters, disease resistance, and growth performance in L. rohita, highlighting its potential as a natural immunostimulant in sustainable aquaculture health management."

Journal • Hematological Disorders • Infectious Disease • CAT

Platelet-Rich Plasma Fibrin Glue Dressing Combined with a Novel Repairing Gel for Healing Recalcitrant Diabetic Foot Ulcers: Findings from an Exploratory Randomized Pilot Trial. (PubMed, Clin Cosmet Investig Dermatol) - "The repairing gel contained multiple active components, including vitamins A, B3, and C, collagen, glycine, organic acids, sodium alginate, carboxymethyl cellulose, benzoic acid, gentian violet, methylene blue, triethanolamine, bromelain, allantoin, and dimethyl sulfoxide...This exploratory pilot trial suggests that combined PRP‑FG and repairing gel therapy may promote superior healing of recalcitrant DFUs compared with standard care or single‑agent treatments. Larger, multicenter clinical trials are warranted to validate these preliminary findings."

Journal

Investigating the in vivo effects of the human adipose tissue-derived stem cell transplantation and bromelain in myelin regeneration. (PubMed, Res Pharm Sci) - "It can be said that hADSCs transplantation, along with bromelain administration, is able to increase myelination and improve balance function. Therefore, the use of these agents could be a fundamental step towards finding a suitable method for the treatment of neurodegenerative diseases."

Journal • Preclinical • CNS Disorders • Multiple Sclerosis • Solid Tumor • Transplantation • IFNG • IL10 • IL17A • OLIG2 • TGFB1

Effectiveness of Arnica and Bromelain for Improving Ecchymosis Following Facial Plastic Surgery: A Systematic Review. (PubMed, Plast Surg (Oakv)) - "Arnica may help reduce postoperative ecchymosis and edema after facial plastic surgery; however, the evidence for Bromelain is limited. Marked heterogeneity in dosing and assessment tools limits the generalizability of findings and the ability to perform meta-analysis."

Journal • Aesthetic Medicine

The Effects of Bromelain Supplementation on Clinical Outcomes, Inflammatory and Oxidative Stress Biomarkers in Patients With Traumatic Brain Injury: A Randomized, Double-Blind Placebo-Controlled Clinical Trial. (PubMed, Food Sci Nutr) - "These findings suggest that bromelain may serve as a promising adjunctive therapy to reduce inflammation and improve clinical outcomes in critically ill TBI patients. Further studies with larger sample sizes and longer follow-up periods are needed to confirm these results."

Biomarker • Clinical • Clinical data • Journal • CNS Disorders • Inflammation • Vascular Neurology • IL6

Bromelain-based enzymatic debridement versus standard of care in deep partial- and full-thickness burns: A systematic review and meta-analysis of randomized controlled trials. (PubMed, Burns) - "Randomized evidence demonstrates that, in early-treated debridement-eligible burns with limited total body surface area burned (TBSA), BBD reduces operative and graft burden without compromising wound closure or long-term remodeling. Future trials incorporating blinded operative endpoint adjudication, objective assessment of dermal preservation and broader clinical outcomes will further clarify treatment effect and optimize patient selection."

Journal • Retrospective data • Thermal Injury

DSD-Guided Ultrasound-Assisted Protein Recovery From Chlamydomonas reinhardtii: Modeling, Optimization, and Enzyme Inhibitory Activity Assessment. (PubMed, J Food Sci) - "Enzymatic hydrolysis with seven proteases improved inhibitory potency; proteinase K and bromelain hydrolysates performed best...PRACTICAL APPLICATIONS: An efficient and flexible microalgae protein extraction method was developed using design space optimization, defining a range of conditions rather than a single point for greater practicality. The extracted proteins produce bioactive peptides with potential blood sugar-regulating effects, offering a sustainable, high-value ingredient for functional foods or nutraceuticals."

Journal

Assessment of Drug Utilization Pattern of Antimicrobials Prescribed in the Orthopedic Department of a Tertiary Care Hospital. (PubMed, Cureus) - "Antimicrobial use was dominated by broad-spectrum agents, particularly ceftriaxone (43.4%), ciprofloxacin (47.5%), and metronidazole (54.5%), with moderate use of aminoglycosides (35.4%). Fixed-dose combinations were led by Cefuroxime + Sulbactam (25.2%). Supportive therapy was extensive, including ranitidine (62.6%), tramadol (59.6%), antihypertensives, insulin, and nutraceuticals. Combination therapies such as Bromelain + Trypsin + Rutoside (37.4%) were frequently used. Conclusion This study reflects a pattern of polypharmacy characterized by extensive use of broad-spectrum antimicrobials and adjunctive therapies, emphasizing the need for rational prescribing practices and antimicrobial stewardship to optimize clinical outcomes and minimize resistance."

Journal • Musculoskeletal Diseases • Orthopedics

The Effect of Premedication With Trypsin, Bromelain and Rutoside Combination on Anaesthetic Success and Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial. (PubMed, Int Endod J) - P=N/A | "Systemic enzyme therapy may offer a viable, natural, and potentially safer alternative to corticosteroids or NSAIDs for enhancing pulpal anaesthesia and managing postoperative pain in symptomatic irreversible pulpitis."

Journal • Anesthesia • Dental Disorders • Inflammation • Pain • PRSS1

Programmable-bacteria-macrophage backpacks for enhanced solid tumor therapy via mechanobiological interplay. (PubMed, Cell Rep Med) - "These bacteria are surface-modified for bromelain conjugation and bacterial "backpack" formation on macrophages...Moreover, treatment reduces collagen I deposition, weakens the mechanobiological properties of tumor cells, and mitigates tumor-mediated immune evasion. Collectively, this system remodels the immunosuppressive TME through macrophage-mediated bacterial delivery and US-triggered CCL21 release, facilitating dendritic cell and CD4+/CD8+ T cell infiltration and improving antitumor immunotherapy."

Journal • Oncology • Solid Tumor • CCL21 • CD4 • CD8 • CD86