mefenamic acid / Generic mfg. - LARVOL DELTA

Drug-induced enterocolitis syndrome triggered by mefenamic acid in a child: TARC and DLST as diagnostic aids. (PubMed, Pediatr Allergy Immunol) - No abstract available

Journal • Gastrointestinal Disorder • Infectious Disease

Mesoporous silica encapsulated wheat straw derived carbon dots functionalized with Schiff base silane pockets: a sensing probe for aspirin. (PubMed, RSC Adv) - "The m-SiO2_ws-CDs@SBs showed pronounced fluorescence quenching towards ASP and excellent selectivity for ASP in the presence of other pharmaceutical drugs, i.e., diclofenac, ibuprofen, naproxen, and mefenamic acid. Moreover, it displayed negligible interference from common excipients and metal ions at 1 : 1 and 1 : 10 molar ratios of ASP and interferent, respectively. The fluorescent probe has been used to analyze ASP in an aspirin drug product available at a local pharmacy, as well as in tap water and river water with an excellent recovery of 95.00-99.44%."

Journal

Mapping therapeutic alternatives: a systematic review of preclinical drug repurposing for schistosomiasis. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Praziquantel is the primary drug used in international schistosomiasis treatment...The best results observed were celecoxib (over 90% for egg burden and parasite load), mefenamic acid (92% for parasite load and 82% for egg burden), and chlorambucil (75% parasite load and 85% egg burden). This review highlights the data supporting this strategy as a viable alternative for developing new therapies for schistosomiasis. As these compounds have been used clinically for a long time, substantial preclinical, biosafety, and pharmacovigilance data are already available. Their adverse effects and toxicities are well characterized, which may contribute to a reduction in overall costs and development timelines, although robust clinical validation remains a prerequisite for their use."

Journal • Preclinical • Review • Infectious Disease

Mefenamic acid attenuates NLRP3-associated neuroinflammation and mitochondrial dysfunction and is associated with prevention of long-term cognitive impairment after sepsis. (PubMed, J Neuroimmunol) - "MFA also reduced amyloid-β accumulation and increased transthyretin levels, suggesting modulation of neurodegeneration-related pathways after sepsis. These findings are consistent with a protective effect of MFA against sepsis-associated long-term brain dysfunction and identify NLRP3-associated neuroinflammation and mitochondrial damage as interconnected pathways for further therapeutic investigation."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Infectious Disease • Inflammation • Metabolic Disorders • Septic Shock • IL18 • IL1B • NLRP3

BET Bromodomain Targeting by NSAIDs: Structural, Biophysical, and Computational Insights. (PubMed, Proteins) - "Herein, we present the crystal structures of the second bromodomain (BD2) of hBRD2 in complex with the FDA-approved drugs, mefenamic acid (ID8) and nimesulide (NIM), and that of the first bromodomain (BD1) of hBRD4 in complex with nimesulide (NIM). Moreover, molecular dynamics simulations were performed on the selected derivatives of ID8 and NIM against these bromodomains and confirmed the stability of these derivatives' binding throughout the simulations. We propose that the derivatives of the aforementioned parent molecules may be potential inhibitors of the function of hBRD2 and hBRD4."

Journal • Oncology

How painful is Implanon NXT® insertion?: A multicenter randomized trial on the use of Acetaminophen, Mefenamic Acid and Diclofenac Sodium for pain management post Implanon NXT® insertion. (PubMed, BMC Womens Health) - "All oral analgesics demonstrated a reduction in pain score. Based on this limited study, the most suitable analgesic for pain management post Implanon NXT® insertion is tablet Mefenamic Acid 250 mg twice daily for up to 2 days. More robust double-blinded studies using placebos as a control are needed to confirm this finding."

Journal • Pain

Spectral, Electrochemical and Molecular Docking Studies Over Effects of Interaction Between Two Different NSAIDs With BSA and DNA Base. (PubMed, Luminescence) - "The role of two different non-steroidal anti-inflammatory drugs, namely, mefenamic acid (MA) (2-[(2,3-dimethylphenyl)amino]benzoic acid) and aceclofenac (ACF) (2-[(2,6-dichlorophenyl)amino]phenyl acetoxyacetic acid), and their electrostatic interactions with bovine serum albumin (BSA) and adenine model systems have been studied. The free energy, van der Waals and hydrogen-bonding interaction values of BSA with the drugs are determined. In order to assess the electrochemical process, the scan rate is another important parameter, which has been determined by using cyclic voltammograms."

Journal

Comparative Evaluation of Glidants for Enhancing the Flowability of Poorly Flowing Powdered Materials with Varying Particle Sizes and Morphologies. (PubMed, Pharmaceutics) - " Binary mixtures were prepared using one of four model substances (ibuprofen, metamizole sodium, mefenamic acid, or sunflower lecithin) combined with a glidant (colloidal silica, precipitated silica, or tricalcium phosphate). Very fine or cohesive powders, such as mefenamic acid and sunflower lecithin, showed limited response to silica-based glidants, whereas tribasic calcium phosphate proved more effective and additionally increased bulk density. Overall, no universal glidant strategy was identified; effective flow enhancement requires a tailored approach based on specific powder characteristics."

Journal

The impact of ubrogepant on the use of other migraine acute treatments, opioid discontinuation, and healthcare utilization: Results from a pre-post opioid subcohort analysis (AHS 2026) - "Acute medications other than ubrogepant included acetaminophen, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan, dihydroergotamine, ergotamine, amobarbital, aprobarbital, butabarbital, butalbital, mephobarbital, metharbital, pentobarbital, phenobarbital, secobarbital, talbutal, barbital, codeine, hydrocodone, meperidine, morphine, oxycodone, propoxyphene, tramadol, aspirin, bromfenac, celecoxib, diclofenac, diflunisal, esomeprazole, etodolac, famotidine, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen, oxaprozin, piroxicam, sulindac, tolmetin, lasmiditan, Zavegepant, and Rimegepant (<15 pills). Opioid use included acetaminophen/tramadol, oxymorphone, levorphanol, buprenorphine/naloxone, meperidine, morphine, oxycodone, codeine, methadone, oxycodone, hydromorphone, butorphanol, and tapentadol... In patients with a history of opioid use,..."

HEOR • CNS Disorders • Migraine • Pain

A novel nail polish/graphite/nickel nanoparticles-based disposable screen-printed sensor for enhanced voltammetric detection of mefenamic acid in environmental water samples. (PubMed, Mikrochim Acta) - "The sensor exhibited good repeatability (RSD = 3.85%), satisfactory long-term stability (88% signal retention after 30 days), and excellent recovery (96-99%) in tap and river water samples. The proposed platform combines sensitivity, reliability, low cost, and operational simplicity, demonstrating strong potential for on-site environmental monitoring of mefenamic acid."

Journal

Micro- and nanoencapsulation strategies for mefenamic acid delivery: carrier design, release mechanisms, and preclinical performance. (PubMed, J Microencapsul) - "Mucoadhesive intranasal nanoemulsions are also discussed for potential nose-to-brain delivery in neuroinflammation. Overall, we appraise pharmacokinetic and therapeutic gains and outline key considerations for clinical translation."

Journal • Preclinical • Review • Gastroenterology • Inflammation • Pain • Peptic Ulcer

The impact of vaginal bromocriptine on reducing pain and menstrual bleeding in women with adenomyosis: a randomized controlled trial. (PubMed, Sci Rep) - "The control group received standard treatment comprising oral contraceptive pills (OCPs) and mefenamic acid. Vaginal bromocriptine appears to be an effective and well-tolerated therapeutic option for alleviating symptoms of adenomyosis, particularly pelvic pain, excessive menstrual bleeding, and irregular cycles. The beneficial effects may result from reduced prolactin levels, inhibition of angiogenesis, and modulation of the hypothalamic-pituitary-ovarian axis.Trail registration number IRCT20240806062668N3."

Journal • Endometriosis • Gynecology • Musculoskeletal Pain • Obstetrics • Pain • Women's Health

Structural modification of mefenamic acid to enhance medicinal efficacy and reduce toxicological effect: a DFT and in-silico study. (PubMed, In Silico Pharmacol) - "These results provide a conceptual framework for the optimization of MFC analogs in the therapy of pain and inflammation. The online version contains supplementary material available at 10.1007/s40203-026-00647-y."

Journal • Cardiovascular • Inflammation • Pain

Pharmaceuticals, personal care-products and current-use pesticides: a review of the available data from European seas. (PubMed, Environ Res) - "The highest TOIs were found for the pharmaceuticals salicylic acid, hydrochlorothiazide, gemfibrozil, mefenamic acid, paracetamol and diclofenac; the PCPs 2-ethylhexyl-4-methoxycinnamate, 4-methylbenzylidene camphor, octocrylene, galaxolide, benzophenone-3 and tonalide; and the CUPs chlorpyrifos, chlorthal-dimethyl, simazine and irgarol. It is noted that additional data are required, particularly in the sediment and the biota matrices, to more fully understand the distribution and impact of these CECs in the marine environment, when considering the wide geographical distribution areas covered in this review. Further assessment is also required, to prioritise those CECs, based on which of them are expected to cause the most adverse toxic effects to marine ecosystems."

Journal

Polymorphism engineering of mefenamic acid for enhanced pharmacokinetic performance. (PubMed, EXCLI J) - "However, the contemporary research limited only to the proof-of-concept studies fails to provide a clinical evidence or translational insights, which necessitates the rational design of synthons and engineering of the solid-state landscape of the drug for developing the co-crystallization formulation of mefenamic acid. This commentary provides critical insights into the polymorphism-driven co-crystal design of mefenamic acid aimed at filling the critical gaps in scalability and clinical translation."

Journal • PK/PD data

Response of microbial interactions in hybrid biofilm system with low organic loading to micropollutant removal. (PubMed, Environ Technol) - "For this purpose, laboratory-scale control hybrid and micropollutant-amended (1 μg/L of diclofenac, ketoprofen, indomethacin, and mefenamic acid, 10 μg/L of ibuprofen, and naproxen) hybrid reactors were operated at organic loading rate of 0.3 kg COD/m3.day and ammonium concentration of 60 mg/L N with a sludge retention time of 10 days and hydraulic retention time of 24 hrs. Dominant genera detected in hybrid micropollutant reactor were Chitinophagaceae (10.1%), Ferruginibacter (7.8%), and Comamonas (6.8%) for suspended biomass, and Fimbriimonadaceae (8.7%), Parafilimonas (6.5%), and Rickettsia (5.6%) for attached biomass, which might contribute to the removal of NSAIDs. Moreover, the genera Chitinophagaceae and Comamonas which are reported as heterotrophic ammonia-oxidizing bacteria, might contribute to nitrification in hybrid biofilm reactors."

Journal

Efficacy and safety of extended-release dinalbuphine sebacate in a multimodal analgesic regimen following cesarean section: A prospective observational study. (PubMed, Taiwan J Obstet Gynecol) - P | "Dinalbuphine sebacate is safe and effective for post-cesarean pain management when integrated into multimodal analgesic regimens."

Journal • Observational data • Pain

Acute pharmaceutical poisoning as a cause of seizure events: a database analysis (2011-2023). (PubMed, Clin Toxicol (Phila)) - "Seizures occurred at low relative overdoses for clozapine, chlorprothixene, and trimipramine (1.3×, 2.0×, 2.8×, respectively)...Overdoses of mefenamic acid, quetiapine, bupropion, venlafaxine and tramadol, respectively, were most commonly associated with seizures. Cefepime exhibited the highest seizure potential, in patients with impaired renal function. Tricyclic antidepressants (trimipramine, amitriptyline), tolperisone, mefenamic acid and bupropion were associated with seizures at relatively small overdoses compared to respective non-seizure cases."

Journal • CNS Disorders • Epilepsy

Efficacy of Plant-Derived Therapies for Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (PubMed, Phytother Res) - "The findings indicate that herbal medicine can be as effective as conventional pharmacological treatments (n = 1133, MD: 0.12, 95% CI: -0.29 to 0.53, p = 0.58, I2 = 95%), such as mefenamic acid or ibuprofen, in managing primary dysmenorrhea. Plant-based treatments may reduce pain associated with primary dysmenorrhea and are probably comparable to conventional drug therapies. However, further studies employing more rigorous methodologies are required to establish stronger evidence regarding the efficacy and safety of herbal medicine in addressing this health condition."

Journal • Retrospective data • Review • Pain • Women's Health

Wound-Healing Efficacy of Garcinia pedunculata Fruit Extract: In Vivo and In Silico Validation of Regenerative Mechanisms With Histological Analysis. (PubMed, Food Sci Nutr) - "Molecular docking showed that quercetin and ellagic acid exhibited strong binding affinities for TGF-βR1 (-9.3 kcal/mol) and IL-1β (-6.3 kcal/mol), comparable to mefenamic acid. The synergistic antioxidant, anti-inflammatory, and collagen-promoting activities of GP-EE accelerate wound contraction and tissue regeneration. These findings validate the traditional use of G. pedunculata and suggest that GP-EE is a promising natural candidate for the development of phytotherapeutic wound-healing formulations."

Journal • Preclinical • Infectious Disease • Inflammation • IL1B • TGFB1

Leverage of Eichhornia crassipes in modulating pharmaceuticals and personal care products in Delhi-NCR hotspots. (PubMed, Int J Phytoremediation) - "Paracetamol (up to 2866.9 ± 41.60 ng/L) and mefenamic acid (up to 829.5 ± 5.48 ng/L) were the most abundant analytes found in post-monsoon with frequencies of detection (FoD) > 90%...Notably, seasonal analysis revealed that pre-monsoon concentrations of carbendazim were significantly higher than post-monsoon levels (p < 0.05). These findings emphasize the regulation of PPCP dynamics in urban rivers by the phytoremediation potential of E. crassipes and highlight the need for integrating natural wetland vegetation into water quality management strategies."

Journal

CARDIORENAL SAFETY OF NSAIDS IN PATIENTS WITH ARTHRITIS: A NETWORK METANALYSIS (ACC 2026) - " We included 23 studies (19 RCTs, 4 cohort) with 1245,108 patients,NSAIDs evaluated were Naproxen (n=69,209),Ibuprofen(n=535,651), Celecoxib(n=107,493),oral Diclofenac (n=335,154),Rofecoxib (n=105,102), Nabumetone (n=507),Valdecoxib (n=5,075), Meloxicam (n=27,713),Piroxicam (n=14,585),Mefenamic acid (n=13,856),Indomethacin (n=26,254),placebo (n=4192), Acetaminophen (n=287),and Amtolmetin guacil (n=30).Compared to placebo, Valdecoxib had highest odds of MACE [OR: 2.96 (95%CI:1.80-4.85)] and Rofecoxib highest odds of renal AEs [OR: 5.11 (95%CI: 2.58-10.10)].League tables showed no differences between different NSAIDs, SUCRA rankings identified Celecoxib with highest MACE and Rofecoxib with highest renal risk (Figure). Valdecoxib and Rofecoxib confer the highest cardiorenal risks. SUCRA rankings ranked Celecoxib as highest for MACE risk and Rofecoxib for renal risk, underscoring the importance of NSAID-specific safety profiles to guide arthritis treatment decisions."

Clinical • Cardiovascular • Immunology • Rheumatology

Vitamin E Plus Mefenamic Acid Versus Mefenamic Acid Alone for Treating Primary Dysmenorrhea in Women (clinicaltrials.gov) - P4 | N=60 | Completed | Sponsor: Nishtar Medical University

New P4 trial • Women's Health

Advancing drug allergy diagnosis in Tunisia using flow cytometry: a promising first step. (PubMed, Allergol Immunopathol (Madr)) - "By applying BAT in the Immunology Department of the Military Hospital of Tunisia, this study seeks to enhance diagnostic accuracy and contribute to personalized patient care."

Journal • Allergy • Immunology • PTGDR2

Medroxyprogesterone acetate and mefenamic acid as potential strategies to overcome platinum resistance in serous ovarian carcinoma (ISGE 2026) - "Second, AKR1C1–3 and NFE2L2 expression, as well as AKR1C1–3 protein levels, across six HGSOC cell lines with different carboplatin sensitivities was determined by qPCR. Funding: ARIS grant to T.L.R. J3-60065, P3-0449, CELSA grant to TL.R., F.A., and D.A., and a Young Researcher grant to N.M."

High Grade Serous Ovarian Cancer • Oncology • Ovarian Cancer • Ovarian Serous Adenocarcinoma • Solid Tumor • AKR1C1 • NFE2L2