mefenamic acid / Generic mfg. - LARVOL DELTA

Primary Genital HSV-2 Infection in a Resource-Limited Setting: Diagnostic Challenges and Clinical Implications. (PubMed, Cureus) - "Treatment with oral acyclovir, cefadroxil, and mefenamic acid, supplemented by topical gentamicin and counselling on recurrence risk and safe sexual practices, led to complete lesion resolution within 14 days and no recurrence at six-week follow-up. These limitations hinder accurate case identification and contribute to the underrecognition of HSV-2 prevalence. Early clinical recognition, prompt antiviral initiation, and strengthened patient education remain essential for mitigating morbidity, preventing recurrence, and reducing transmission in low-resource environments."

Journal • Herpes Simplex • Human Immunodeficiency Virus • Infectious Disease • Pain

Mefenamic Acid Poisoning Revisited: Central Nervous System Toxicity and Acute Kidney Injury. (PubMed, Cureus) - "Given its common use in dysmenorrhea and overlapping demographic with at-risk populations for overdose, clinicians should maintain a high index of suspicion and monitor closely when mefenamic acid ingestion is suspected. Further reports are needed to clarify relationships between serum concentrations, ingested dose, and clinical severity."

Journal • Acute Kidney Injury • CNS Disorders • Epilepsy • Nephrology • Pain • Renal Disease • Women's Health

Duality of Simplicity and Accuracy in QSPR: A Machine Learning Framework for Predicting Solubility of Selected Pharmaceutical Acids in Deep Eutectic Solvents. (PubMed, Molecules) - "This three-step procedure enables extensive exploration of the model's hyperspace and effective selection of models fulfilling notable accuracy, simplicity, and also persistency of the descriptors selected during model development. The dual-solution landscape clarifies the trade-off between complexity and cost in QSPR for DES systems and shows that physically meaningful energetic descriptors can replace or enhance explicit COSMO-RS predictions depending on the application."

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Management of Bleeding Irregularities during Contraceptive Implant Use: A Systematic Review. (PubMed, Contraception) - "Implications: Patients experiencing bothersome bleeding irregularities during contraceptive implant use may be offered different options to manage bleeding and improve their satisfaction. More data are needed on the effectiveness of specific interventions (drugs, regimens, and repeat dosing) and patient satisfaction outcomes."

Clinical • Journal • Review • Long-acting Reversible Contraceptives

Fluorescent Carbon Dots Decorated with ONN Donor Sites by Using Schiff Base Silatrane for Selective Recognition of Mefenamic Acid in Environmental Samples. (PubMed, Langmuir) - "The ONN donor sites in CDs@SBONN interact with the mefenamic acid (MA) selectively out of different drugs (such as ibuprofen, acetylsalicylic acid, naproxen, diclofenac, and ketoprofen), amino acids (like glycine, valine, and alanine), excipients (like glucose and urea), cations (like Cd2+, Cu2+, Fe3+, and Cr3+), and anions (like Cl-, AcO-, NO3-, and SO42-), and display a quenching signal at λems = 460 nm (λexc = 360 nm). The standardization of the analytical method offers applicability of CDs@SBONN for the evaluation of MA with high accuracy and recovery range in pharmaceutical samples (89.42-102.55) and river water (98.05-100.79) with a relative standard deviation of <5%. Thus, CDs@SBONN can have a promising potential application in environmental and biological analysis."

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Marksans Pharma has announced that its wholly owned UK subsidiary, Relonchem Limited, has received marketing authorization from the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) for two new formulations of Mefenamic Acid. (Business Upturn) - "The approvals cover the 250 mg and 500 mg film-coated tablet variants, expanding the company’s footprint in the UK pharmaceutical market."

ANDA • Pain

Optimization of pharmaceutical effluent treatment by oxidation using laccase-enriched enzymatic extracts from Xylaria sp. (PubMed, Environ Technol) - "for treating pharmaceutical effluents containing paracetamol, diclofenac, mefenamic acid, ibuprofen, and sulfamethoxazole, each at concentrations of 50 ppm. Importantly, this work represents the first demonstration of using Xylaria sp. as a laccase source for pharmaceutical degradation, underlining its novelty and potential."

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Anaphylactic shock due to mefenamic acid. (PubMed, Indian J Pharmacol) - No abstract available

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Monitoring Apoptotic Activity of Silver(I) Metallodrugs Containing Mefenamic Acid and Mitochondriotropic Agents in Artificial Breast Tumor Tissues. (PubMed, ChemMedChem) - "The compounds, previously evaluated in 2D cultures, demonstrated potent antiproliferative activity with IC50 values ranging from 1.01 to 5.20 μM, significantly outperforming cisplatin. This study underscores the potential of 3D spheroid models for preclinical evaluation and highlights silver(I) metallodrugs as promising candidates for breast cancer therapy. Future research should focus on in vivo validation to further explore their therapeutic applications."

Journal • Breast Cancer • Oncology • Solid Tumor

Eco-friendly and efficient electro-membrane extraction coupled with HPLC for simultaneous determination of nonsteroidal anti-inflammatory drugs in biological samples. (PubMed, Anal Chim Acta) - "This work establishes for the first time a suitable and efficient analytical platform using a wholly fatty acid-based NADES-SUPRAS as a supported liquid membrane for EME of NSAIDs. The synergy of EME with this novel green solvent offers a highly sustainable solution, confirmed by an AGREE score of 0.72. It ensures high-throughput sample preparation with a rapid 20-min extraction time. The method's reliability in challenging clinical matrices makes it a significant advancement for therapeutic drug monitoring and environmental analysis."

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SIDE EFFECTS AND ACCEPTIBILITY OF IMPLANON A SINGLE ROD IMPLANTABLE CONTRACEPTIVE (FIGO 2025) - "Manageent of prolonged and irregular bleeding was done by Assurance, and Haematiniics (61.44%), NSAID like Mefenamic acid (16.86%), COC pills (7.22%)... In Bangladesh, population growth is one of the major problems. Here growth rate is high due to poverty, low literacy and lack of awareness. In this study it was found that, Implanon is popular and rational contraceptive more in lower socioeconomic class and young multiparous women (21–30 years)."

Adverse events • Otorhinolaryngology • Vertigo

Jasmonate-Mediated Mitigation of Salinity Stress During Germination and Early Vegetative Development in Hemp. (PubMed, Plants (Basel)) - "Given hemp's inherently low salt tolerance and limited data on JAs-mediated responses, we investigated salinity tolerance JAs modulation using methyl jasmonate (MeJA; 0.001-0.01 mM) and the JAs-biosynthesis inhibitor mefenamic acid (MEF; 0.01-0.1 mM) applied via seed priming or foliar treatment in factorial experiments with NaCl concentrations of 0.05-0.3 M. We demonstrate that MeJA and MEF differentially modulate responses of Henola hemp variety to salt stress during germination and seedling development...MEF co-treatment partially reversed these protective effects, reducing MeJA-mediated improvements, confirming that maintaining JAs homeostasis is critical for salt-stress adaptation. These findings establish MeJA as a promising tool for enhancing hemp cultivation under saline conditions and provide a framework for integrating JAs treatments into sustainable hemp cultivation protocols."

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Development of a green spectrofluorimetric method for mefenamic acid determination using Rhodamine 6G with mechanistic investigation and central composite design optimization. (PubMed, RSC Adv) - "Furthermore, sustainability assessment revealed the superior environmental performance (AGREE score: 0.76 vs. 0.66, whiteness: 88.1% vs. 72.7%) compared to conventional HPLC methods. This work establishes a practical green alternative for routine mefenamic acid analysis in pharmaceutical quality control and therapeutic monitoring."

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Synthesis, in vivo analgesic activity, molecular docking and density functional theory analysis of acyl hydrazide derivatives of mefenamic acid. (PubMed, Bioorg Chem) - "Chlorinated derivatives exhibited balanced lipophilicity and target specificity, while aliphatic chains reduced efficacy. This work establishes halogenated acyl hydrazides as promising candidates for inflammation pain management with reduced gastrointestinal toxicity."

Journal • Preclinical • Inflammation • Pain

Management of Abnormal Uterine Bleeding (clinicaltrials.gov) - P=N/A | N=130 | Completed | Sponsor: Egymedicalpedia | Recruiting ➔ Completed

Trial completion • Women's Health

Molecularly Imprinted Magnetic Fluorescent Carbon Dots Using Polydopamine with Dual Functionality as a Monomer and Cross-Linking Agent for Selective Mefenamic Acid Detection. (PubMed, Langmuir) - "Moreover, the current approach exhibits a BAGI score of 75. These results underscore the potential of MCDs@PI as a robust, selective, and sustainable platform for trace-level detection of pharmaceutical pollutants in complex matrices."

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Stimulation of Transient Receptor Potential Channels TRPM3 and TRPM8 Increases Human Prostaglandin Endoperoxide Synthase-2 Promoter Activity. (PubMed, Molecules) - "Mutational analysis of the prostaglandin endoperoxide synthase-2 promoter showed the importance of a cAMP response element within the proximal promoter region of the prostaglandin endoperoxide synthase-2 gene. In summary, our results establish a link between the stimulation of TRPM3 and TRPM8 and the biosynthesis of proinflammatory mediators via the regulation of prostaglandin endoperoxide synthase-2 expression."

Journal • Pain • PTGS2 • TRPM3 • TRPM8

Consensus on the Use of Mefenamic Acid in Pediatric Practice (MAPP): Perspectives From Indian Pediatricians. (PubMed, Cureus) - "Highlights include its superior antipyretic efficacy compared to paracetamol and ibuprofen, with preclinical and limited clinical data suggesting potential antiviral activity, and a possible role in the management of febrile seizures and inflammatory conditions. Future research should prioritize well-powered clinical trials, particularly in children aged six months to five years, using standardized outcome measures and long-term follow-up protocols. Addressing these evidence gaps is important to inform safe and effective use in pediatric practice."

Journal • Review • CNS Disorders • Epilepsy • Pain • Pediatrics • NLRP3

Treatment of Epidermal Pathology in a Pediatric Patient With Keratitis-Ichthyosis-Deafness (KID) Syndrome With Topical Mefenamic Acid. (PubMed, Pediatr Dermatol) - "While no targeted treatment currently exists, a previously published in vivo study demonstrated that flufenamic acid (FFA), a nonspecific connexin inhibitor, reduces epidermal pathology in transgenic mouse models expressing the lethal GJB2 mutation. Herein, we report the case of a 5-year-old boy with KID syndrome presenting with painful, persistent scalp lesions, which responded remarkably well to topical mefenamic acid, offering a potential novel therapy for managing this challenging condition."

Journal • Atopic Dermatitis • Dermatology • Dermatopathology • Immunology • Keratitis • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Pain • Pediatrics • Vitiligo • GJB2

Polymer-free β-cyclodextrins and mefenamic acid inclusion complex nanofibers for enhanced drug solubility and biomedical applications. (PubMed, Sci Rep) - "Additionally, fluorescence microscopy (DAPI and PI staining) confirmed enhanced cellular uptake and apoptosis induction in cancer cells after 24 h of incubation with the NFs. These findings highlight their potential as fast-dissolving drug delivery systems, effective antimicrobial agents, and promising candidates for targeted cancer therapy."

Journal • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor

Graded activation of mutant K41C-KCNE1:KCNQ1 channel complexes by mefenamic acid. (PubMed, Channels (Austin)) - "Our results show that the potency of mefenamic acid action is reduced by the presence of K41C-KCNE1 subunits in a graded and stoichiometric, but non-linear manner. Modeling results are consistent with the idea that WT IKs subunits, in the presence of mefenamic acid, precede activation of K41C-IKs subunits due to their augmented voltage sensor kinetics."

Journal • Cardiovascular • KCNQ1OT1

Evaluation of Nutrient and Anti-Inflammatory Drugs Removal Using a Pilot-Scale Novel Hybrid Biofilm Process. (PubMed, Environ Manage) - "Except diclofenac (32%), naproxen, ibuprofen, ketoprofen, and mefenamic acid (70%, 96%, 70% and 75%) were efficiently removed. Acinetobacter sp. (35%) and uncultured Arcobacteraceae sp (22%) were found to be the dominant species in the hybrid system."

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Concurrent analysis of six NSAIDs in human plasma using polyurethane/B-N-S-co-doped rGO nanofiber-modified glassy carbon electrode followed by EA-SPME. (PubMed, J Mater Chem B) - "Herein, a novel voltammetric biosensor was designed and constructed for the simultaneous measurement of six nonsteroidal anti-inflammatory drugs (NSAIDs), including celecoxib, mefenamic acid, acetaminophen, naproxen, ibuprofen, and caffeine. The intra-day and inter-day RSDs% were obtained within 4.17-4.90% and 4.92-5.49%, respectively. Finally, the efficiency of the electrochemical biosensor was evaluated to determine these six NSAIDs in human plasma samples with good recoveries (91.0-102.8%)."

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Pleiotropic Effects of the NSAID Fenamates on Chloride Channels: Opportunity for Ion Channelopathies? (PubMed, Pharmacol Res Perspect) - P=N/A, P1/2 | "This narrative review resumes the effects of niflumic acid (NFA), flufenamic acid (FFA), mefenamic acid (MFA), meclofenamic acid (MCFA), and tolfenamic acid (TFA) on different types of chloride channel. Therefore, thanks to their variegated modulatory activity on chloride channels, fenamates might be considered promising lead compounds for the development of new drug candidates that can target these altered channels involved in channelopathies. Trial Registration: EudraCT number: 2021-000708-39; ClinicalTrials.gov identifier: NCT029930005 and NCT02429570."

Journal • Review • CNS Disorders • Cystic Fibrosis • Epilepsy • Genetic Disorders • Immunology • Lysosomal Storage Diseases • Metabolic Disorders • Ophthalmology • Otorhinolaryngology • Pulmonary Disease • Rare Diseases • Respiratory Diseases

A dual magnetic fluorescent molecularly imprinted polymer sensing probe for simultaneous determination of mefenamic acid and diclofenac in milk. (PubMed, Mikrochim Acta) - "The fabricated nanocomposite MIP sensing probes are highly selective to the target analytes in the presence of other interferences in real samples. The dual sensing probes produced results that were consistent with high-performance liquid chromatography, yet the proposed method is more cost-effective, simpler, and faster."

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