mefenamic acid / Generic mfg. - LARVOL DELTA

AKR1C inhibitors medroxyprogesterone acetate and mefenamic acid exhibit antitumor activity alone and combined with carboplatin in platinum-resistant high-grade serous ovarian cancer models. (PubMed, Biomed Pharmacother) - "In 3D spheroids, both agents disrupted tumor architecture and reduced viability, alone or in combination with carboplatin. Our findings highlight that platinum resistance in HGSOC can be tackled by repurposing MEF and MPA that act also as AKR1C inhibitors."

Journal • Platinum resistant • Preclinical • High Grade Serous Ovarian Cancer • Oncology • Ovarian Cancer • Ovarian Serous Adenocarcinoma • Solid Tumor • AKR1C1 • NFE2L2

The Effect of Uridine Diphosphate-Glucuronosyltransferase Inhibition on the Pharmacokinetics of Ecopipam and Its Metabolites. (PubMed, Clin Transl Sci) - "This open-label, fixed-sequence study evaluated the effect of mefenamic acid (UGT1A9 inhibitor) and divalproex sodium extended release (ER; general UGT inhibitor) on the pharmacokinetics (PK) of ecopipam and its metabolites. Divalproex sodium ER increased the Cmax (66%) and AUCinf (2.1×) of ecopipam, increased the Cmax (40%) and AUCinf (86%) of EBS-101-40853, and decreased the Cmax of ecopipam glucuronide and EBS-101-40853 glucuronide (23% and 32%, respectively). Inhibition of ecopipam metabolism indicated that ecopipam dose adjustments may be needed when administered with UGT inhibitors."

Journal • PK/PD data • Movement Disorders • Tourette Syndrome

Efficacy of Herbaceous Apiaceae Plants in Primary Dysmenorrhea: A Systematic Review and Meta-analysis of RCTs. (PubMed, Ann Pharm Fr) - "Apiaceae plants are potentially effective adjunct therapies for dysmenorrhea, though further high-quality trials are warranted to confirm these findings. PROSPERO Registration number: CRD42024538888."

Journal • Retrospective data • Review • Women's Health

Transcutaneous tibial nerve stimulation to treat primary dysmenorrhea in adolescents. A Double-blind randomized placebo controlled trial. (PubMed, J Pediatr Adolesc Gynecol) - "TC-TNS produces a reduction of primary dysmenorrhea in adolescents that is comparable to the effect achieved by mefenamic acid and could be considered as a therapeutic alterative as it free of adverse effects and self-applicable."

Clinical • Journal • Developmental Disorders • Long-acting Reversible Contraceptives • Mental Retardation • Pain • Women's Health

Effectiveness and Safety of Mefenamic Acid Oral Suspension in Pediatric Practice for Febrile Illness: An Observational Study (EASE-O-MAPP Study). (PubMed, Cureus) - "Conclusion Mefenamic acid oral suspension demonstrates a rapid and sustained antipyretic effect in pediatric patients, producing significant temperature reduction without affecting hematological or biochemical parameters. These findings confirm its efficacy, safety, and good GI tolerability in the management of febrile illnesses among children."

Journal • Observational data • Hematological Disorders • Infectious Disease • Mood Disorders • Pain • Pediatrics • Psychiatry • Respiratory Diseases

Seasonal and spatial dynamics of organic micropollutants in a Mediterranean river: implications for environmental risk assessment. (PubMed, Environ Geochem Health) - "Among the 27 tested pharmaceuticals, ibuprofen (4.7 µg/L), caffeine (23.6 µg/L), telmisartan (833.5 ng/L), carbamazepine (658.5 ng/L), gemfibrozil (71.0 ng/L), mefenamic acid (64.7 ng/L), and diphenhydramine (65.9 ng/L) were the most frequently detected, with some reaching notably high concentrations in the µg/L range in surface water. Sediments revealed ubiquitous contamination by ibuprofen, telmisartan, climbazole, diphenhydramine, and azithromycin...The findings from this study contribute to the state of knowledge of pollution levels of emerging contaminants in a major Mediterranean river and permit to inform and guide future mitigation and management strategies. The environmental risk assessment applied in this study enabled the translation of measured concentrations into ecologically meaningful indicators allowing the identification of priority contaminants and high-risk locations."

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Exploring the in vitro urease inhibitory potential, molecular docking and dynamics simulations investigation of mefenamic acid derivatives. (PubMed, Future Med Chem) - "This work identifies 2a as a potent, and competitive urease inhibitor. The integrated experimental, ADMET and computational strategy provides a robust molecular blueprint for its activity, positioning it as a promising lead candidate for developing new therapeutic agents against urease-related pathologies."

Journal • Preclinical

In-silico evaluation of Hedychium spicatum phytochemicals as potential COX-2 inhibitors: molecular docking, dynamics simulation, and ADMET analysis. (PubMed, In Silico Pharmacol) - "Mefenamic acid, a well-known nonsteroidal anti-inflammatory drug (NSAID), was used as the standard for comparative analysis...This work will later serve as a foundation for experimental investigations conducted both in vitro and in vivo to confirm the anti-inflammatory capabilities of the same. The online version of this article (10.1007/s40203-025-00537-9) contains supplementary material, which is available to authorized users."

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Synthesis, structural characterization, and biological evaluation of a bioactive strontium (II)-mefenamic acid complex: In-vivo and in-silico insights. (PubMed, J Inorg Biochem) - "In-silico ADMET study showed safe drug profiling for Sr-complex than only ligand and biological prediction of biological activities by PASS online webserver further confirmed the better bioactivities ((Pa > Pi) of pharmacological relevance. With further molecular insight, the synthesized complex may serve as promising lead compound for anti-inflammatory drug development."

Journal • Preclinical • Inflammation • Pain

Cooperative Split DNA Activation of CRISPR-Cas12a for Sensitive and Selective Detection of Flunixin. (PubMed, ACS Meas Sci Au) - "Furthermore, our sensor was highly selective: other commonly used veterinary drugs such as ciprofloxacin, neomycin, sulfanilamide, sulfamethoxazole, ketoprofen, meloxicam, and mefenamic acid would not interfere with the detection of flunixin. In addition, the simulated water samples were successfully analyzed. The cooperative split DNA activation of the CRISPR-Cas12a sensing strategy developed in this work should find useful application in the development of CRISPR sensors for various non-nucleic acid species, including large biomolecules such as proteins and small molecules and ionic species like metals."

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Primary Genital HSV-2 Infection in a Resource-Limited Setting: Diagnostic Challenges and Clinical Implications. (PubMed, Cureus) - "Treatment with oral acyclovir, cefadroxil, and mefenamic acid, supplemented by topical gentamicin and counselling on recurrence risk and safe sexual practices, led to complete lesion resolution within 14 days and no recurrence at six-week follow-up. These limitations hinder accurate case identification and contribute to the underrecognition of HSV-2 prevalence. Early clinical recognition, prompt antiviral initiation, and strengthened patient education remain essential for mitigating morbidity, preventing recurrence, and reducing transmission in low-resource environments."

Journal • Herpes Simplex • Human Immunodeficiency Virus • Infectious Disease • Pain

Mefenamic Acid Poisoning Revisited: Central Nervous System Toxicity and Acute Kidney Injury. (PubMed, Cureus) - "Given its common use in dysmenorrhea and overlapping demographic with at-risk populations for overdose, clinicians should maintain a high index of suspicion and monitor closely when mefenamic acid ingestion is suspected. Further reports are needed to clarify relationships between serum concentrations, ingested dose, and clinical severity."

Journal • Acute Kidney Injury • CNS Disorders • Epilepsy • Nephrology • Pain • Renal Disease • Women's Health

Duality of Simplicity and Accuracy in QSPR: A Machine Learning Framework for Predicting Solubility of Selected Pharmaceutical Acids in Deep Eutectic Solvents. (PubMed, Molecules) - "This three-step procedure enables extensive exploration of the model's hyperspace and effective selection of models fulfilling notable accuracy, simplicity, and also persistency of the descriptors selected during model development. The dual-solution landscape clarifies the trade-off between complexity and cost in QSPR for DES systems and shows that physically meaningful energetic descriptors can replace or enhance explicit COSMO-RS predictions depending on the application."

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Management of Bleeding Irregularities during Contraceptive Implant Use: A Systematic Review. (PubMed, Contraception) - "Implications: Patients experiencing bothersome bleeding irregularities during contraceptive implant use may be offered different options to manage bleeding and improve their satisfaction. More data are needed on the effectiveness of specific interventions (drugs, regimens, and repeat dosing) and patient satisfaction outcomes."

Clinical • Journal • Review • Long-acting Reversible Contraceptives

Fluorescent Carbon Dots Decorated with ONN Donor Sites by Using Schiff Base Silatrane for Selective Recognition of Mefenamic Acid in Environmental Samples. (PubMed, Langmuir) - "The ONN donor sites in CDs@SBONN interact with the mefenamic acid (MA) selectively out of different drugs (such as ibuprofen, acetylsalicylic acid, naproxen, diclofenac, and ketoprofen), amino acids (like glycine, valine, and alanine), excipients (like glucose and urea), cations (like Cd2+, Cu2+, Fe3+, and Cr3+), and anions (like Cl-, AcO-, NO3-, and SO42-), and display a quenching signal at λems = 460 nm (λexc = 360 nm). The standardization of the analytical method offers applicability of CDs@SBONN for the evaluation of MA with high accuracy and recovery range in pharmaceutical samples (89.42-102.55) and river water (98.05-100.79) with a relative standard deviation of <5%. Thus, CDs@SBONN can have a promising potential application in environmental and biological analysis."

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Marksans Pharma has announced that its wholly owned UK subsidiary, Relonchem Limited, has received marketing authorization from the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) for two new formulations of Mefenamic Acid. (Business Upturn) - "The approvals cover the 250 mg and 500 mg film-coated tablet variants, expanding the company’s footprint in the UK pharmaceutical market."

ANDA • Pain

Optimization of pharmaceutical effluent treatment by oxidation using laccase-enriched enzymatic extracts from Xylaria sp. (PubMed, Environ Technol) - "for treating pharmaceutical effluents containing paracetamol, diclofenac, mefenamic acid, ibuprofen, and sulfamethoxazole, each at concentrations of 50 ppm. Importantly, this work represents the first demonstration of using Xylaria sp. as a laccase source for pharmaceutical degradation, underlining its novelty and potential."

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Anaphylactic shock due to mefenamic acid. (PubMed, Indian J Pharmacol) - No abstract available

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Monitoring Apoptotic Activity of Silver(I) Metallodrugs Containing Mefenamic Acid and Mitochondriotropic Agents in Artificial Breast Tumor Tissues. (PubMed, ChemMedChem) - "The compounds, previously evaluated in 2D cultures, demonstrated potent antiproliferative activity with IC50 values ranging from 1.01 to 5.20 μM, significantly outperforming cisplatin. This study underscores the potential of 3D spheroid models for preclinical evaluation and highlights silver(I) metallodrugs as promising candidates for breast cancer therapy. Future research should focus on in vivo validation to further explore their therapeutic applications."

Journal • Breast Cancer • Oncology • Solid Tumor

Eco-friendly and efficient electro-membrane extraction coupled with HPLC for simultaneous determination of nonsteroidal anti-inflammatory drugs in biological samples. (PubMed, Anal Chim Acta) - "This work establishes for the first time a suitable and efficient analytical platform using a wholly fatty acid-based NADES-SUPRAS as a supported liquid membrane for EME of NSAIDs. The synergy of EME with this novel green solvent offers a highly sustainable solution, confirmed by an AGREE score of 0.72. It ensures high-throughput sample preparation with a rapid 20-min extraction time. The method's reliability in challenging clinical matrices makes it a significant advancement for therapeutic drug monitoring and environmental analysis."

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SIDE EFFECTS AND ACCEPTIBILITY OF IMPLANON A SINGLE ROD IMPLANTABLE CONTRACEPTIVE (FIGO 2025) - "Manageent of prolonged and irregular bleeding was done by Assurance, and Haematiniics (61.44%), NSAID like Mefenamic acid (16.86%), COC pills (7.22%)... In Bangladesh, population growth is one of the major problems. Here growth rate is high due to poverty, low literacy and lack of awareness. In this study it was found that, Implanon is popular and rational contraceptive more in lower socioeconomic class and young multiparous women (21–30 years)."

Adverse events • Otorhinolaryngology • Vertigo

Jasmonate-Mediated Mitigation of Salinity Stress During Germination and Early Vegetative Development in Hemp. (PubMed, Plants (Basel)) - "Given hemp's inherently low salt tolerance and limited data on JAs-mediated responses, we investigated salinity tolerance JAs modulation using methyl jasmonate (MeJA; 0.001-0.01 mM) and the JAs-biosynthesis inhibitor mefenamic acid (MEF; 0.01-0.1 mM) applied via seed priming or foliar treatment in factorial experiments with NaCl concentrations of 0.05-0.3 M. We demonstrate that MeJA and MEF differentially modulate responses of Henola hemp variety to salt stress during germination and seedling development...MEF co-treatment partially reversed these protective effects, reducing MeJA-mediated improvements, confirming that maintaining JAs homeostasis is critical for salt-stress adaptation. These findings establish MeJA as a promising tool for enhancing hemp cultivation under saline conditions and provide a framework for integrating JAs treatments into sustainable hemp cultivation protocols."

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Development of a green spectrofluorimetric method for mefenamic acid determination using Rhodamine 6G with mechanistic investigation and central composite design optimization. (PubMed, RSC Adv) - "Furthermore, sustainability assessment revealed the superior environmental performance (AGREE score: 0.76 vs. 0.66, whiteness: 88.1% vs. 72.7%) compared to conventional HPLC methods. This work establishes a practical green alternative for routine mefenamic acid analysis in pharmaceutical quality control and therapeutic monitoring."

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Synthesis, in vivo analgesic activity, molecular docking and density functional theory analysis of acyl hydrazide derivatives of mefenamic acid. (PubMed, Bioorg Chem) - "Chlorinated derivatives exhibited balanced lipophilicity and target specificity, while aliphatic chains reduced efficacy. This work establishes halogenated acyl hydrazides as promising candidates for inflammation pain management with reduced gastrointestinal toxicity."

Journal • Preclinical • Inflammation • Pain

Management of Abnormal Uterine Bleeding (clinicaltrials.gov) - P=N/A | N=130 | Completed | Sponsor: Egymedicalpedia | Recruiting ➔ Completed

Trial completion • Women's Health