Dyloject (diclofenac) / Pfizer - LARVOL DELTA

Evaluating clinically relevant pharmacological agents in a rat ambulation model to ameliorate PEGylated recombinant hyaluronidase PH20 (PEGPH20)-mediated musculoskeletal adverse events (AACR 2017) - P3; "...The most advanced clinical trial (Phase 3) is evaluating PEGPH20 plus Abraxane® (nab-paclitaxel)/gemcitabine (AG) in patients with stage IV untreated pancreatic ductal adenocarcinoma (PDA)(NCT02715804)...The steroid dexamethasone, currently being used in the Phase 2 and Phase 3 PDA clinical trials to manage MSEs, was the positive control. As a class, nonsteroidal anti-inflammatory drugs (NSAIDs), including ketorolac, ketoprofen, diclofenac, and piroxicam, increased rat ambulation by ~40% on the first night following PEGPH20 treatment compared to PEGPH20 alone...No other drug classes increased rodent ambulation. These data suggest that NSAIDs may be useful in partially alleviating the MSEs experienced by patients receiving PEGPH20."

Adverse events • Biosimilar • Demo Pain • Gastrointestinal Cancer • Oncology • Pain • Pancreatic Cancer • Venous Thromboembolism

An Open-Label Safety Study Of DIC075V (Intravenous Diclofenac Sodium) In Patients With Acute Post-Operative Pain (clinicaltrials.gov) - P3; N=1050; Completed; Sponsor: Pfizer; Active, not recruiting ➔ Completed

Clinical • Trial completion • Pain

Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis with a Combination of Pharmacological Agents Based on Rectal Non-Steroidal Anti-Inflammatory Drugs: A Systematic Review and Network Meta-Analysis. (PubMed, J Gastroenterol Hepatol) - "Rectal indomethacin with intravenous hydration and rectal diclofenac with sublingual nitrate are the most efficacious combination regimens for the overall prevention of PEP."

Journal • Retrospective data • Review • Pancreatitis

Rapid determination of pharmaceuticals in wastewater by direct infusion HRMS using target and suspect screening analysis. (PubMed, Sci Total Environ) - "The highest detection frequencies in treated wastewater effluents were observed for diclofenac, metoprolol and telmisartan, while hydroxydiclofenac, dextrorphan, and carbamazepine metabolites were the most frequently detected TPs. The obtained API profiles were in accordance with the national consumption statistics and the origin of wastewater samples. The developed method is suitable for rapid screening of APIs in wastewater and can be used as a complementary tool to characterize API emissions from wastewater treatment facilities and to identify problematic compounds that require more rigorous monitoring."

Journal

Reinforced Supramolecular Hydrogels from Attapulgite and Cyclodextrin Pseudopolyrotaxane for Sustained Intra-Articular Drug Delivery. (PubMed, Macromol Biosci) - "The hybrid hydrogels demonstrate good shear-thinning and thixotropic properties, excellent biocompability, and sustained release behavior both in vitro and in vivo. Furthermore, preliminary in vivo treatment in an acute inflammatory rat model reveals that the ATP hybrid hydrogels present sustained anti-inflammatory effect."

Journal • Immunology • Osteoarthritis • Pain • Rheumatology

[VIRTUAL] INCIDENCE OF POST-ENDOSCOPIC RETROGRADE CHOLANGIOGRAPHY PANCREATITIS (PEP) ACCORDING TO THE PROTOCOL OF PROPHYLAXIS USED. A RETROSPECTIVE, CROSS-SECTIONAL OBSERVATIONAL STUDY (UEGW 2020) - "This study showed that any combination of either rectal indomethacin or diclofenac with hydration with LR in high-risk patients or in every patient undergoing ERCP are equally effective in preventing PEP. Smoking and cannulation of the pancreatic duct are risk factors of PEP in the era of routine prophylaxis."

Observational data • Retrospective data • Gastrointestinal Cancer • Gastrointestinal Disorder • Hepatology • Oncology • Pain • Pancreatic Cancer • Pancreatitis • Solid Tumor

[VIRTUAL] INCIDENCE OF POST-ENDOSCOPIC RETROGRADE CHOLANGIOGRAPHY PANCREATITIS (PEP) ACCORDING TO THE PROTOCOL OF PROPHYLAXIS USED. A RETROSPECTIVE, CROSS-SECTIONAL OBSERVATIONAL STUDY (UEGW 2020) - "This study showed that any combination of either rectal indomethacin or diclofenac with hydration with LR in high-risk patients or in every patient undergoing ERCP are equally effective in preventing PEP. Smoking and cannulation of the pancreatic duct are risk factors of PEP in the era of routine prophylaxis."

Observational data • Retrospective data • Gastrointestinal Cancer • Gastrointestinal Disorder • Hepatology • Oncology • Pain • Pancreatic Cancer • Pancreatitis • Solid Tumor

[VIRTUAL] INCIDENCE OF POST-ENDOSCOPIC RETROGRADE CHOLANGIOGRAPHY PANCREATITIS (PEP) ACCORDING TO THE PROTOCOL OF PROPHYLAXIS USED. A RETROSPECTIVE, CROSS-SECTIONAL OBSERVATIONAL STUDY (UEGW 2020) - "This study showed that any combination of either rectal indomethacin or diclofenac with hydration with LR in high-risk patients or in every patient undergoing ERCP are equally effective in preventing PEP. Smoking and cannulation of the pancreatic duct are risk factors of PEP in the era of routine prophylaxis."

Observational data • Retrospective data • Gastrointestinal Cancer • Gastrointestinal Disorder • Hepatology • Oncology • Pain • Pancreatic Cancer • Pancreatitis • Solid Tumor

Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials. (PubMed, Pain Physician) - "Considering the availability of other effective analgesics with potentially fewer side effects, the use of meperidine for acute postoperative or labor pain should not be recommended."

Adverse events • Clinical • Journal • Anesthesia • CNS Disorders • Depression • Gynecology • Orthopedics • Pain

β-Glycerol phosphate/genipin chitosan hydrogels: A comparative study of their properties and diclofenac delivery. (PubMed, Carbohydr Polym) - "A wide range of β-GP concentrations have been selected in order to analyze its influence on a variety of properties, including gelation time, pore size, water uptake ability, in vitro hydrolytic and enzymatic degradation, mucoadhesion and mechanical and rheological properties. Furthermore, the potential application of the developed systems for the administration and controlled release of an anti-inflammatory anionic drug, such as diclofenac, has been successfully demonstrated."

Journal

Severe neck pain and odynophagia secondary to acute calcific longus colli tendinitis: a case report. (PubMed, J Med Case Rep) - "This case report details the presentation, characteristic radiographic findings, and management of a patient with an extremely rare condition of neck pain and odynophagia that could be treated with nonsteroidal anti-inflammatory drugs."

Clinical • Journal • Immunology • Musculoskeletal Pain • Otorhinolaryngology • Pain • CRP

[VIRTUAL] Participation COX and NOS in effect of IL-1ß on lung ventilation and hypoxic chemoreception (ERS 2020) - "Pretreatment with both inhibitors diclofenac and L-NAME significantly reduced respiratory effects of IL-1β.We suggested that the effect of pro-inflammatory cytokines on the respiratory system is due to the interaction of СОХ and NOS mechanisms. The study was supported by Program for Basic Research of the RAS Presidium№19"

Anesthesia • Chronic Obstructive Pulmonary Disease • Immunology • IL1B

Osteogenic and Anti-Inflammatory Behavior of Injectable Calcium Phosphate Loaded with Therapeutic Drugs. (PubMed, Nanomaterials (Basel)) - "The results exhibited that the three systems exerted an osteoinductive effect during later phases of osteogenesis. Simultaneously, all compositions showed an anti-inflammatory activity on inflammation in vitro models."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Osteoarthritis • Osteoporosis • Pain • Rheumatology

Cyclodextrin Cationic Polymer-Based Nanoassemblies to Manage Inflammation by Intra-Articular Delivery Strategies. (PubMed, Nanomaterials (Basel)) - "Finally, polyCD@Ada-Rhod/DCF significantly suppressed IL-1 production in hMSCs, revealing the anti-inflammatory properties of these nanoassemblies. With these premises, this study might open novel routes to exploit original CD-based nanobiomaterials for the treatment of osteoarticular diseases."

Journal • Immunology

Antinociceptive Potential of Zinnia grandiflora. (PubMed, J Nat Prod) - "The structure of compound 2 was established unequivocally by an X-ray crystallographic analysis. This compound exerted a significant antinociceptive effect in the formalin assay, better than that of diclofenac used as a positive control."

Journal

Pain relief of arthroscopic rotator cuff repair by nerve block. (PubMed, J Nippon Med Sch) - "Interscalene nerve blocks yielded good pain relief for ARCR. Although continuous interscalene nerve block produced continuous pain relief, complications are a concern."

Journal • Anesthesia • Orthopedics • Pain

Delivery and biodistribution of traceable polymeric micellar diclofenac in the rat. (PubMed, J Pharm Sci) - "Developed nano-formulations of diclofenac prolonged diclofenac circulation and reduced its presence in heart and kidney; strongly suggesting a cardiac-safe delivery vehicle for diclofenac."

Journal • Preclinical • Cardiovascular

Comparison of preemptive paracetamol, paracetamol-diclofenac & paracetamol-tramadol combination on postoperative pain after elective abdominal surgery under general anesthesia, Ethiopia: a randomized control trial study, 2018. (PubMed, BMC Anesthesiol) - "Preemptive combination of paracetamol-tramadol and paracetamol-diclofenac reduce total tramadol consumption and prolongs time to first analgesic request compared to paracetamol alone in patients undergoing laparotomy surgery."

Clinical • Journal • Anesthesia • Pain

The epidemiology and prehospital care of motorcycle crashes in a sub-Saharan African urban center. (PubMed, Traffic Inj Prev) - "Motorcycle-related RTCs represent a large burden of disease for patients treated by SAMU in Kigali, Rwanda. Young men are most at risk of injury, which imposes a financial strain on society. Though injuries occurred frequently, critical trauma cases from motorcycle crashes were uncommon. This may be a result of several initiatives in Rwanda to improve road safety."

Clinical • Journal • Hematological Disorders • Mood Disorders • Musculoskeletal Diseases • Orthopedics

Low Eosinophil Percentages as a New Predictive Marker for Infusion Reactions Due to Trastuzumab. (PubMed, Anticancer Res) - "A low eosinophil percentage can be a useful new predictive marker for trastuzumab-induced IRs in patients with breast cancer."

Biomarker • Journal • Breast Cancer • Oncology • Solid Tumor

"Not using much Cangrelor. If IV antiplt is needed, I go with bolus 2b3a or bolus + short infusion." - SVRaoMD

Biosimilar

Topical diclofenac-loaded liposomes ameliorate laser-induced choroidal neovascularization in mice and non-human primates. (PubMed) - "In conclusion, diclofenac-loaded liposome eye drops enhance penetration to the RPE-choroid, and reduce the CNV formation. These results suggest that a drug-loaded liposome is a useful tool for drug delivery into the posterior segment of the eye."

Journal • Age-related Macular Degeneration • Biosimilar • Complement-mediated Rare Disorders • Gene Therapies

Perioperative use of metamizole and other nonopioid analgesics in children : Results of a survey (PubMed, Anaesthesist) - "The survey confirmed that metamizole is frequently used in children in the perioperative setting. Intravenous metamizole is the preferred nonopioid analgesic administered intraoperatively for pain prophylaxis. Clinical symptoms of agranulocytosis should be monitored and patients should be better informed about metamizole-related side effects."

Clinical • Journal • Agranulocytosis • Allergy • Anesthesia • Granulocytopenia • Hypotension • Pain • Pediatrics

The effect of pre-emptive gabapentin on anaesthetic and analgesic requirements in patients undergoing rhinoplasty: A prospective randomised study. (PubMed, Indian J Anaesth) - "Time to the intended MAP was significantly less in G I than G II (59.1 ± 12.3 vs. 73.6 ± 16.4, respectively, with = 0.001). Pre-operative oral gabapentin significantly reduced intra-operative remifentanil and sevoflurane requirements during hypotensive anaesthesia along with decreased post-operative analgesic requirement."

Clinical • Journal • Biosimilar • Pain

AUDIT OF ANALGESIC EFFICACY OF CONTINUOUS ADDUCTOR CANAL BLOCK (ACB) IN TOTAL KNEE REPLACEMENT (TKR) AND ARTHROSCOPIC ANTERIOR CRUCIATE LIGAMENT (ACL) RECONSTRUCTION SURGERY (ESRA 2017) - "...Analgesia was achieved in 99.01% patients with regular paracetamol and diclofenac, tramadol as rescue analgesics...In our audit Continuous ACB provided effective opioid sparing analgesia for TKR and ACL reconstruction surgeries. It was also motor sparing nerve block that did not prevent early mobilization in TKR surgeries. To test statistical significance of this conclusion a prospective study needs to be done."

Clinical • Pain