rezetamig (JNJ-8780)
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November 11, 2025
A Study of JNJ-80948543 in Combination With Other CD3 T-Cell Engagers in Participants With Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma (R/R B-Cell NHL)
(clinicaltrials.gov)
- P1 | N=19 | Active, not recruiting | Sponsor: Janssen Research & Development, LLC | Recruiting ➔ Active, not recruiting | N=40 ➔ 19
Enrollment change • Enrollment closed • B Cell Lymphoma • B Cell Non-Hodgkin Lymphoma • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology
October 16, 2025
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
(clinicaltrials.gov)
- P1 | N=147 | Completed | Sponsor: Janssen Research & Development, LLC | Active, not recruiting ➔ Completed
First-in-human • Trial completion • B Cell Lymphoma • Chronic Lymphocytic Leukemia • Follicular Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • BCL2
June 27, 2025
A Study of JNJ-87801493 in Combination With T-Cell Engagers in Participants With B-cell Non-Hodgkin Lymphoid (NHLs) Cancer
(clinicaltrials.gov)
- P1 | N=235 | Recruiting | Sponsor: Janssen Research & Development, LLC | Trial primary completion date: Jul 2026 ➔ Nov 2027
Trial primary completion date • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology
June 27, 2025
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
(clinicaltrials.gov)
- P1 | N=147 | Active, not recruiting | Sponsor: Janssen Research & Development, LLC | Trial completion date: May 2025 ➔ Oct 2025 | Trial primary completion date: Apr 2025 ➔ Sep 2025
Trial completion date • Trial primary completion date • B Cell Lymphoma • Chronic Lymphocytic Leukemia • Follicular Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • BCL2
May 27, 2025
A Study of JNJ-87801493 in Combination With T-Cell Engagers in Participants With B-cell Non-Hodgkin Lymphoid (NHLs) Cancer
(clinicaltrials.gov)
- P1 | N=235 | Recruiting | Sponsor: Janssen Research & Development, LLC | N=70 ➔ 235 | Trial completion date: Jul 2026 ➔ Nov 2027
Enrollment change • Trial completion date • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology
January 24, 2025
A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring
(clinicaltrials.gov)
- P1 | N=80 | Enrolling by invitation | Sponsor: Janssen Research & Development, LLC
New P1 trial • Acute Myelogenous Leukemia • B Cell Lymphoma • B Cell Non-Hodgkin Lymphoma • Castration-Resistant Prostate Cancer • Chronic Lymphocytic Leukemia • Genito-urinary Cancer • Hematological Malignancies • Leukemia • Lymphoma • Myelodysplastic Syndrome • Non-Hodgkin’s Lymphoma • Oncology • Prostate Cancer • Solid Tumor
October 28, 2024
A Study of JNJ-80948543 in Combination With Other CD3 T-Cell Engagers in Participants With Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma (R/R B-Cell NHL)
(clinicaltrials.gov)
- P1 | N=40 | Recruiting | Sponsor: Janssen Research & Development, LLC
Combination therapy • New P1 trial • B Cell Lymphoma • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology
January 03, 2024
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
(clinicaltrials.gov)
- P1 | N=148 | Active, not recruiting | Sponsor: Janssen Research & Development, LLC | Trial completion date: Sep 2026 ➔ May 2025
Trial completion date • Chronic Lymphocytic Leukemia • Follicular Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • BCL2
December 18, 2023
A Study of JNJ-87801493 in Combination With T-Cell Engagers in Participants With B-cell Non-Hodgkin Lymphoid (NHLs) Cancer
(clinicaltrials.gov)
- P1 | N=70 | Recruiting | Sponsor: Janssen Research & Development, LLC | Not yet recruiting ➔ Recruiting | Trial completion date: Jul 2028 ➔ Jul 2026
Combination therapy • Enrollment open • Trial completion date • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology
December 06, 2023
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
(clinicaltrials.gov)
- P1 | N=148 | Active, not recruiting | Sponsor: Janssen Research & Development, LLC | Trial primary completion date: Oct 2023 ➔ Apr 2025
Trial primary completion date • Chronic Lymphocytic Leukemia • Follicular Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • BCL2
November 18, 2023
A Study of JNJ-87801493 in Combination With T-Cell Engagers in Participants With B-cell Non-Hodgkin Lymphoid (NHLs) Cancer
(clinicaltrials.gov)
- P1 | N=70 | Not yet recruiting | Sponsor: Janssen Research & Development, LLC
Combination therapy • New P1 trial • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology
October 11, 2023
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
(clinicaltrials.gov)
- P1 | N=148 | Active, not recruiting | Sponsor: Janssen Research & Development, LLC | Recruiting ➔ Active, not recruiting
Enrollment closed • Chronic Lymphocytic Leukemia • Follicular Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • BCL2
August 21, 2023
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
(clinicaltrials.gov)
- P1 | N=200 | Recruiting | Sponsor: Janssen Research & Development, LLC | Trial primary completion date: May 2023 ➔ Oct 2023
Trial primary completion date • Chronic Lymphocytic Leukemia • Follicular Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Mantle Cell Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • BCL2
April 13, 2023
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
(clinicaltrials.gov)
- P1 | N=200 | Recruiting | Sponsor: Janssen Research & Development, LLC | Trial completion date: May 2025 ➔ Sep 2026
Trial completion date • Chronic Lymphocytic Leukemia • Follicular Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Mantle Cell Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • BCL2
January 10, 2023
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
(clinicaltrials.gov)
- P1 | N=200 | Recruiting | Sponsor: Janssen Research & Development, LLC | N=120 ➔ 200
Enrollment change • Chronic Lymphocytic Leukemia • Follicular Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Mantle Cell Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • BCL2
December 02, 2022
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
(clinicaltrials.gov)
- P1 | N=120 | Recruiting | Sponsor: Janssen Research & Development, LLC | Trial completion date: Mar 2024 ➔ May 2025
Trial completion date • Chronic Lymphocytic Leukemia • Follicular Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Mantle Cell Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • BCL2
February 01, 2022
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
(clinicaltrials.gov)
- P1 | N=120 | Recruiting | Sponsor: Janssen Research & Development, LLC | Trial completion date: May 2023 ➔ Sep 2023
Trial completion date • Chronic Lymphocytic Leukemia • Follicular Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Mantle Cell Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • BCL2
April 05, 2021
Teneobio Announces Achievement of Milestone Payment as Janssen Advances Phase I Study of Bispecific JNJ-75348780 for the Treatment of NHL and CLL
(GlobeNewswire)
- “Teneobio…reported the Phase I clinical entry and the dosing of patients with the bispecific JNJ-75348780 in a Phase I study…with B-cell lymphoid malignancies, including non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL)….Teneobio entered a research collaboration and license agreement with Janssen in July of 2018. Janssen subsequently exercised a commercial license to Teneobio’s bispecific lead candidate in September of 2019. Teneobio will receive a payment for the Phase I clinical milestone and is eligible for future clinical development and commercial milestone payments per potential candidate. Teneobio would also receive royalties on world–wide net sales of each multi-specific product.”
Licensing / partnership • Trial status • Chronic Lymphocytic Leukemia • Hematological Malignancies • Leukemia • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology
January 28, 2021
Korea Yaxen double antibody approved for phase 1 clinical trial by the Ministry of Food and Drug Safety… What are the domestic double antibody companies? [Google translation]
(The Value News)
- "...the Ministry of Food and Drug Safety announced that it had approved a phase 1 clinical trial of Janssen's dual antibody 'JNJ-75348780', which targets lymphocytic disease proteins...with non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL)."
Trial status • Chronic Lymphocytic Leukemia • Non-Hodgkin’s Lymphoma • Oncology
December 07, 2020
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
(clinicaltrials.gov)
- P1; N=120; Recruiting; Sponsor: Janssen Research & Development, LLC; Not yet recruiting ➔ Recruiting
Enrollment open • Chronic Lymphocytic Leukemia • Follicular Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Mantle Cell Lymphoma • Non-Hodgkin’s Lymphoma • Oncology
September 08, 2020
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
(clinicaltrials.gov)
- P1; N=120; Not yet recruiting; Sponsor: Janssen Research & Development, LLC
New P1 trial • Chronic Lymphocytic Leukemia • Follicular Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Mantle Cell Lymphoma • Marginal Zone Lymphoma • Non-Hodgkin’s Lymphoma • Oncology
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