C-122 / Corridor Pharma - LARVOL DELTA

The C553-C581 Disulfide of Human Factor XI Is Crucial for Its Activation and Is Targeted By Thiol Isomerase Pdir (ASH 2024) - "When FXI carrying single cysteine with the disruption of disulfide bonds were expressed in 293T cells, we found that the C122-C128 disulfide bond was critical for FXI synthesis process; the C2-C85, C28-C58 and C32-C38 of the A1 domain, the C92-C175 and C118-C147 of the A2 domain, the C182-C265, C208-C237 and C212-C218 of the A3 domain, the C273-C356, C299-C328 and C303-C309 of the A4 domain, as well as the C398-C414, C496-C563 and C527-C542 of the catalytic domain were necessary for the secretion of FXI...In a laser-induced cremaster arteriole injury model, PDIr deficiency enhanced fibrin formation at the site of injury suggesting that PDIr inhibits coagulation in vivo, consistent with its inhibition and reduction of FXI. Taken together, this study identified the role of every single FXI disulfide in protein synthesis, secretion and enzymatic activity, and provides the new evidence showing that the C553-C581 of human factor XI is a novel crucial disulfide for its..."

Cardiovascular • Hematological Disorders • Thrombosis

Early experience of inclisiran: real-world analysis of utilization and lipid-lowering effects (ESC-WCC 2025) - " Among 16,531 inclisiran recipients (mean age 71.4 years, 54.4% women, 88.8% White, baseline LDL-C 122.2 mg/dL), 30.2% (n=4,997) only received a single dose, and 86.7% (n=10,004) patients received ≥2 doses on-schedule. In the largest reported analysis to-date of LDL-C changes in patients given inclisiran, those with an LDL-C level ≥155 mg/dL who received three doses on-schedule in the first year experienced LDL-C lowering similar to what was observed in clinical trials after accounting for baseline LDL-C. Those with lower starting LDL-C and on PCSK9i mAb therapy had attenuated LDL-C lowering likely due to changes in background therapy."

Clinical • Real-world • Real-world evidence • Cardiovascular • Dyslipidemia

A complete circular genome of ΦX174 host Escherichia coli C122. (PubMed, Microbiol Resour Announc) - "Escherichia coli C122 and the bacteriophage that uses it as the standard laboratory host (ΦX174) make up a dream team of model microorganisms. This ΦX174 host is the second complete, published genome of E. coli C122, and is ~1% different from the other, justifying that it is another strain."

Journal

C122 - Diagnosis and Management of Concussions (AAN 2025) - "Learning Objectives Participants should gain an understanding of the diagnosis and management of common post-traumatic diagnoses; learn what options exist for treatment of acute and chronic post-traumatic autonomic dysfunction; understand how sleep challenges can affect concussion recovery and best approaches to diagnosis and treatment; and understand the evidence on repetitive head impact and resulting long-term consequences. Recommended Audience Fellow, Resident, General Neurologist, Specialist Neurologist, Non-neurologist, Advanced Practice Provider, Medical Student Teaching Styles Case-based, Didactic"

Microhardness, Young's and Shear Modulus in Tetrahedrally Bonded Novel II-Oxides and III-Nitrides. (PubMed, Materials (Basel)) - "By incorporating a bond-orbital and a valance force field model, we have reported comparative results of our systematic calculations for the bond length d, bond polarity αP, covalency αC, bulk modulus B, elastic stiffness C(=c11-c122), bond-stretching α and bond-bending β force constants, Kleinmann's internal displacement ζ, and Born's transverse effective charge eT*...Calculations of microhardness H, shear modulus G, and Young's modulus Y have predicted BN (BeO) satisfying a criterion of super hardness. III-Ns (II-Os) could be vital in electronics, aerospace, defense, nuclear reactors, and automotive industries, providing integrity and performance at high temperature in high-power applications, ranging from heat sinks to electronic substrates to insulators in high-power devices."

Journal

Functionalizable bacterial cellulose composite membrane for guided tissue regeneration. (PubMed, Int J Biol Macromol) - "Mineralization assay indicated that the p-rhOPN-C122 immobilized CMC/PEO-BC membrane promoted hPDLs osteogenic differentiation. These results suggested that the developed membrane could serve as a promising GTR membrane for application in bone tissue regeneration."

Journal • SPP1

C122 - Theater for Health Care Equity (AAN 2024) - "Through interactive theater techniques, participants can consider difficult encounters through activities that engage all of their sense. The playfulness of theater opens the door for participants to move beyond endless conversation to act out problematic scenarios and creatively explore solutions."

Comparing Hypothermic and Thermal Neutral Conditions to Induce Metabolic Suppression. (PubMed, Ther Hypothermia Temp Manag) - "We hypothesized that hypothermia would have an additive effect with dexmedetomidine on suppressing metabolism...DANA Go/No-Go time increased between baseline and start of recovery in both conditions (20°C 222.1 CE and 31°C 122.3 CE)...Subjects experienced decrements in cognitive performance in both conditions. A significant recovery period may be required after metabolic suppression before completing mission critical tasks."

Journal • Anesthesia

Assessing Public Dialogue About Living Donation from Anonymous Reddit Users: Who’s in the Room and What Do They Share? [Board No. C122] (ATC 2023) - "Within Reddit, many threads are created to share personal experiences about KD and LKD, often in preparation for transplantation. These communities can help researchers understand attributes of people at different stages of learning, before presenting to the transplant center, and target potential living donors in the public domain. Future work will utilize machine learning techniques to explore the digital behavior of users."

Nephrology • Renal Disease • Transplantation

C122 - Normal Pressure Hydrocephalus (AAN 2023) - "Participants should become familiar with the differential diagnoses and work-up of NPH with an emphasis on case selection for CSF diversion procedures. This will include an in-depth review of brain MRI findings related to CSF dynamics, and an update on emerging concepts in the field."

CNS Disorders • Ventriculomegaly

Reoperations and Long-term Survival of Kock's Continent Ileostomy in Inflammatory Bowel Disease Patients: A Population Based National Cohort Study from Sweden. (PubMed, Dis Colon Rectum) - "Continent ileostomy is associated with substantial need for revisional surgery, but most patients get to keep their reconstruction for a long time. See Video Abstract at http://links.lww.com/DCR/C122."

Journal • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

"Day 5 CAS #ILC2022 #Fiji C105 - penal sanctions involving forced labour for trade unionists exercising rights to free assembly & speech #Djibouti C122 - lack of national employment policy to combat unemployment #Ecuador C87 - need for wholesale labour law reform ref FoA" (@RuwanSubasinghe)

C122 - Infections of Nervous System 1 (AAN 2022) - "During this course participants will recognize the clinical presentation and diagnostic tools availabel for acute meningoencephalitis; recognize neuroimaging patterns in common neuroinfectious diseases; provide a differential of acute meningoencephalitis and develop a framework for evaluation and management of common neuroinfectious diseases (i.e. HSV-1 encephalitis and neuroinvasive West Nile Virus). This program complements Infections of the Nervous System 2 and Infections of the Nervous System 3 but covers independent topics."

CNS Disorders • Infectious Disease

Osteopontin induces osteogenic differentiation by human periodontal ligament cells via calcium binding domain-ALK-1 interaction. (PubMed, J Periodontol) - "The results suggest that next to full length OPN, the CaBD of OPN, if coated to a surface, induces osteogenic differentiation via interaction with ALK-1 receptor."

Journal • ALK • SPP1

"Day 13 #ILC2021 CAS: We just adopted the outcome doc on the CEACR's General Survey, which covered selected ILO employment instruments, notably C122, C159, C177, R169, R168, R184, R198, and R204. Link: https://t.co/8JLnIBTxDi" (@RuwanSubasinghe)

Distribution of Lipids and Prevalence of Dyslipidemia among Indian Expatriates in Qatar. (PubMed, J Lipids) - "Among the total 4483 Indian expatriates (3891 men and 592 women), the mean (SD) mg/dL levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) were higher in men TC 196.9 (40.6), TG 168.9 (114.6), and LDL-C 122.9 (37.2) mg/dL compared to women TC 185 (38.1), TG 117.7 (78.2), and LDL-C 114.1 (31.1) mg/dL, p value < 0.0001...The screening programs and awareness campaigns must be initiated to prevent the early onset of dyslipidemia induced atherosclerosis leading to CVD. Future controlled studies are needed to estimate the prevalence of dyslipidemias among Indian migrants in Qatar."

Journal • Atherosclerosis • Cardiovascular • Dyslipidemia • Metabolic Disorders

[VIRTUAL] Personalizing Cholesterol Management Therapy Using Electronic Medical Records and Machine Learning (AHA 2020) - "Results Our study cohort consisted of 50,911 patients (age 54.6 ± 9.84 years, baseline LDL-C 122 ± 34.2 mg/dL, follow-up LDL-C 121 ± 35.9 mg/dL) including 54% female, 47% Non-Hispanic White, 32% Asian, and 7.5% Hispanic patients...Conclusions EMR-trained wKNN models are able to determine patient LDL-C trajectories under different lines of statin therapy. Machine learning models leveraging real-world datasets may provide useful statin therapy treatment recommendations for primary ASCVD prevention."

Atherosclerosis • Cardiovascular • Dyslipidemia

Impact of the disulfide bond on hydrolytic characteristics of a xylanase from Talaromyces thermophiles F1208. (PubMed, Int J Biol Macromol) - "The T-Xyn-C122S-C166S mutant does not have the C122-C166 disulfide bond present in wild-type T-Xyn, whereas T-Xyn-T38C-S50C and T-Xyn-T38C-S50C-C122S-C166S mutants have an introduced disulfide bond, C38-C50, to T-Xyn and T-Xyn-C122S-C166S, respectively...When birchwood xylan was used as the substrate, the introduction of a disulfide bond increased the content of xylose, decreased the content of xylotriose and a high degree of polymerization (DP ≥ 5) was observed. The hydrolysis of oat-spelt xylan is more complex with the introduction of the disulfide bond causing an increase in the degradation rate of xylotriose."

Journal

Tuning the Schottky barrier height in graphene/monolayer-GeI2 van der Waals heterostructure. (PubMed, J Phys Condens Matter) - "C122, 22137 (2018)]...In particular, positive values resulted in an increase of then-type Schottky barrier height, while negative electric field values induced a transition fromn-type top-type Schottky contact. From our results, we show that m-GeIis an interesting material to design new electronic Schottky devices based on graphene vdW heterostructures."

Journal

Effect of Hypertonic Saline Solution on different models of respiratory ephitelium inflammation (ERS 2019) - "treatment with HSS has no effect on cell viability and reduce IL-6 liberation to medium in poly I:C model (2129.2±269.3 vs C 122.2±71.3 p0.05 en pg/ml). Conclussions: Our results confirm that antiinflamatory actions of HSS on models related to clinical conditions in therapy with HSS seems to have effect, but also shaws that these effect is not extended to other inflammatory ways"