timolol maleate ophthalmic solution / Generic mfg. - LARVOL DELTA

Glaucoma in disguise: the role of hormones in intraocular pressure (SOE 2025) - "A diagnosis of advanced JOAG was suspected, and the patient continued treatment with topical timolol...However, even when IOP values remain within the normal range, a significant proportion of pregnant patients experience progression during both the gestation and post-partum periods. Ophthalmologists should be aware of the pregnancy-related changes occurring in the eye, since the phenomenon of IOP reduction during gestation may delay a straightforward diagnosis of glaucomatous neuropathy."

Glaucoma • Ophthalmology

Selective laser trabeculoplasty as an effective method of reducing intraocular pressure in myopic patient after LASIK with primary open-angle glaucoma in a 3-month follow-up period – a case report (SOE 2025) - "The real IOP values reached 21.57 mmHg in the right eye (the measured IOP was 19 mmHg) and 20.22 mmHg in the left eye (the measured IOP was 18 mmHg) despite antiglaucoma therapy including timolol twice daily and dorzolamide three times daily in both eyes. Myopia and a history of previous LASIK procedures complicate the diagnosis of glaucoma, including assessment of intraocular pressure, visual field, and optic disc morphology, and also pose challenges in glaucoma therapy. SLT may be an effective treatment option for these patients."

Case report • Clinical • Glaucoma • Ophthalmology

Topical timolol reduces the number of electrocauterization treatments required for treatment of pyogenic granulation after bromhidrosis surgery. (PubMed, Wounds) - "Application of topical timolol twice daily is effective in decreasing the number of electrocauterization treatments required to treat pyogenic granulation after bromhidrosis surgery. Topical timolol can enhance wound healing and improve electrocauterization treatment outcomes."

Journal • Retrospective data

Drug Utilization, Adherence and Predictors of Drug-Changes and Discontinuation of Glaucoma Drug Therapies. (PubMed, Adv Ther) - "Older age and chronic polypharmacy were key predictors of therapy changes and discontinuation. Prostaglandin analogues and beta-blocker agents demonstrated greater therapy stability. These findings emphasize further need for targeted interventions to improve adherence and persistence, particularly among older patients and those with complex medication regimens."

Journal • Glaucoma • Ophthalmology

Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy (clinicaltrials.gov) - P=N/A | N=60 | Not yet recruiting | Sponsor: University of Maryland, Baltimore

Biomarker • New trial • Glaucoma • Ophthalmology

Effect of Topical Timolol on Healing of Immature Breast Scars After Mammoplasty: A Randomized Controlled Trial With Blinded Assessors and Patients. (PubMed, J Cosmet Dermatol) - "Topical application of 0.5% timolol significantly improved the aesthetic appearance and reduced erythema of post-mammoplasty breast scars over a 1-month period. The results demonstrate a measurable clinical benefit, with statistically significant differences favoring timolol over placebo. These findings suggest that early intervention with topical timolol may offer a safe, effective, and non-invasive option for optimizing scar outcomes in surgical patients."

Clinical • Journal • Dermatology • Inflammation

Late ulcerating infantile hemangioma responsive to propranolol (SID 2025) - "The patient had been previously treated with topical timolol solution (0.5%) for eight months and metronidazole cream (0.75%) and mupirocin ointment (2%) for one month, all without resolution...The patient's topical regimen was changed to gentamicin ointment (0.1%) with Duoderm dressings, but the ulceration and drainage persisted for another two weeks...Ulceration of IHs most commonly occurs while they are proliferating in the first 3-6 months of life, when propranolol therapy is thought to be most beneficial. This case highlights the rare occurrence of late ulceration and demonstrates that propranolol remains effective even when initiated later in the disease course."

Pain

Efficacy of 0.5% Timolol Maleate versus 0.05% Clobetasol Propionate in Treating Superficial Infantile Hemangioma: A Pilot Randomized Controlled Trial. (PubMed, J Indian Assoc Pediatr Surg) - "To compare the efficacy of two topical agents in superficial infantile hemangioma (SIH)...In arm I, two patients were transitioned from TTM to oral propranolol due to rapid progression deep into the dermis...0.5%-TTM solution can be a first-line therapy for SIH due to its rapid onset of action and overall comparable efficacy in reducing SIH size. While clobetasol remains effective, its slower response may limit its utility."

Journal • Oncology

Efficacy of Topical Timolol in Chronic Unhealed Ulcers: A Systematic Review and Meta-Analysis. (PubMed, Int J Low Extrem Wounds) - "This meta-analysis, focusing on chronic venous ulcers, consistently showed favorable results across different time points. However, the small sample sizes, lack of blinding, and inclusion of only four studies limit the generalizability of the findings."

Journal • Retrospective data • Review • Venous Ulcer

Comparative Evaluation of Laser Therapy for Infantile Hemangiomas: A Systematic Review of Clinical Outcomes and Treatment Considerations. (PubMed, Photodiagnosis Photodyn Ther) - "Laser therapy is effective and well-tolerated for IHs. PDL is preferred for superficial lesions and Nd:YAG for deeper or mixed types. Standardized protocols are needed, and further research should refine therapeutic parameters and clinical guidelines."

Clinical data • Journal • Review • Oncology

Efficacy and Tolerability of Single-Dose Timolol Eye Drops in the Sequential Treatment of Acute Angle-Closure Crisis: A Double-Blind, Randomized, Placebo-Controlled Trial. (PubMed, Clin Ther) - "In the sequential treatment of AACC, timolol is not helpful to improve the success rate of treatment."

Clinical • Journal • Glaucoma • Ophthalmology

Timolol: A Low-Cost Adjunctive Treatment for Erythematotelangiectatic Rosacea. (PubMed, Am Fam Physician) - No abstract available

Journal • Dermatology • Rosacea

Topical timolol for calciphylaxis: a case report. (PubMed, Wounds) - "This case highlights the potential of topical timolol in promoting wound healing in calciphylaxis ulcers, a novel therapeutic approach not previously reported. Further studies are warranted to validate the efficacy of topical timolol and explore its role in managing calciphylaxis. Despite the challenges in diagnosis and management of calciphylaxis, topical timolol appears promising for improving outcomes in affected patients."

Journal • Calciphylaxis • Cardiovascular • Chronic Kidney Disease • Dermatology • Hematological Disorders • Nephrology • Pain • Rare Diseases • Renal Disease • Thrombosis

Retraction: Development of Timolol Maleate-Loaded Poloxamer-co-Poly (acrylic acid) based hydrogel for controlled drug delivery. (PubMed, PLoS One) - No abstract available

Journal

Beta-Adrenergic Blockers for Acute Myocardial Infarction: 50 years of Expert Opinions in Cecil Textbook of Medicine. (PubMed, Am J Ther) - "The decades long delay in the change in the experts' opinion regarding the utility of beta-adrenergic blockers in acute myocardial infarction in the United States is an instance of prudence and well-tempered clinical judgment."

Journal • Cardiovascular • Myocardial Infarction

ONLY A MATTER OF TIMOLOL: A CASE REPORT OF A FALSE NEGATIVE EPIDURAL TEST DOSE (ASRA-SPRING 2025) - "While institutional practices may determine which methods are utilized, one common safety check includes injecting lidocaine with epinephrine to assess for intravascular or intrathecal placement. This case and supporting literature suggest more frequent blood pressure monitoring may enhance safety during epidural placement in patients on beta blockers, whether systemic or topical. Additionally, this case reinforces the need for multiple safety measures during epidural placement, as no single technique is infallible."

Case report • Clinical • Anesthesia • Cardiovascular • Gastrointestinal Disorder • Glaucoma • Hypertension • Oncology • Ophthalmology • Pain • Small Intestinal Carcinoma

Corneal Complications: Drug-Induced Deposits and Food and Drug Administration Adverse Event Reporting System Data Insights-A Retrospective Study. (PubMed, J Ocul Pharmacol Ther) - "Cyclopentolate and chloramphenicol demonstrated robust statistical relevance in association with corneal deposits. Positive signals for drug-induced corneal deposits included both well-known medications such as amiodarone and lesser-studied medications such as prednisolone and timolol. Clinician awareness of these findings alongside further investigation is needed."

Adverse events • Journal • Retrospective data

Topical Timolol in the Treatment of Hemodialysis Tunneled Catheter Exit-Site Pyogenic Granuloma. (PubMed, Kidney Int Rep) - No abstract available

Journal

Transdermal delivery of timolol maleate using hydrogel microneedles for the treatment of infantile haemangiomas. (PubMed, Mater Today Bio) - "Our TIM-delivering MNs exhibited high therapeutic efficacy, minimal cytotoxicity, and reduced dosing frequency. In conclusion, BSAMA-TIM MNs provide a promising strategy for treating IH."

Journal • Oncology

Fractional CO2 laser alone versus combined with topical timolol or insulin for acne Scar treatment: a randomized controlled clinical trial. (PubMed, Lasers Med Sci) - "Fractional CO2 laser alone or its combination with topical Timolol or insulin mitigated acne scar severity and enhanced patients' quality of life, despite the absence of significant differences."

Clinical • Journal • Acne Vulgaris • Dermatology

BAART-DFU: Beta Adrenergic Antagonist for the Healing of Chronic DFU (clinicaltrials.gov) - P3 | N=48 | Completed | Sponsor: VA Office of Research and Development | N=35 ➔ 48

Enrollment change • Diabetic Neuropathy

Topical 0.5% Timolol Solution for Healing Lower Extremity Wounds (clinicaltrials.gov) - P1 | N=102 | Recruiting | Sponsor: Icahn School of Medicine at Mount Sinai

New P1 trial

Salt as a Simple, Cost-Effective Treatment for Drug-Induced periungual pyogenic granulomas. (EADO-WCM 2025) - "Background Pyogenic Granuloma (PG) is a benign, vascular lesion seen as a side effect of systemic therapies for melanoma like dabrafenib and trametinib...Both patients were initially treated with once daily application of clobetasol propionate, timolol, an iodine-based dressing along with vinegar soaks...We highlight that our patients presented with complete nail loss shortly after the resolution of the pyogenic granuloma. This potential complication needs to be discussed with the patient in advance, even if nail regrowth is expected"

Cost effectiveness • HEOR • Melanoma • Oncology • Solid Tumor

Pyogenic granuloma resolved with timolol and table salt. (PubMed, An Pediatr (Engl Ed)) - No abstract available

Journal

Formulation and Characterization of Ophthalmic in Situ Gel Forming Solution of Timolol Maleate for Glaucoma. (PubMed, Int J Pharm Compd) - "Rabbit eye irritation studies confirmed safety. Stability assessments over three months validated consistent attributes, supporting their potential as effective ophthalmic formulations."

Journal • Glaucoma • Ophthalmology