piperacillin / Generic mfg. - LARVOL DELTA

Intravenous Fosfomycin in hospitalized patients with complicated urinary tract infections due to Third-generation cephalosporinresistant Enterobacterales (clinicaltrialsregister.eu) - P4 | N=548 | Recruiting | Sponsor: Azienda Ospedaliero Universitaria Di Modena | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease • Nephrology

Population pharmacokinetic analysis of piperacillin in critically ill women based on multi-centre data (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data

Population pharmacokinetic analysis of piperacillin in critically ill women based on multi-centre data (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data

Individualisation of piperacillin therapy: a multi-centre evaluation of a dosing software tool's predictive performance in intensive care patients (ESCMID Global 2026) - No abstract available

Clinical • Critical care

Immune phenotype and tissue oedema predict piperacillin pharmacokinetics in critical illness (ESCMID Global 2026) - No abstract available

PK/PD data

Impact of tazobactam concentration and inoculum on the antibacterial effect of piperacillin (ESCMID Global 2026) - No abstract available

Comparative evaluation of fingerpick microsampling methods for therapeutic drug monitoring of meropenem and piperacillin in clinical patients (ESCMID Global 2026) - No abstract available

Clinical

Rethinking piperacillin dosing: a machine learning-assisted post-hoc analysis of sex-related differences in exposure and target attainment in critically ill patients (ESCMID Global 2026) - No abstract available

Clinical • Machine learning • Retrospective data

Surgical treatment of the patient with locally advanced esophageal cancer and concurrent thymoma after neoadjuvant therapy: a case report. (PubMed, Front Immunol) - "The patient received chemotherapy (paclitaxel + cisplatin) combined with toripalimab at the local hospital but developed elevated thyroid hormone levels during treatment...Postoperative management included oxygen support, nebulization, analgesia, gastrointestinal decompression, antibiotics (piperacillin/cefradine), expectorants, antispasmodics, acid suppression, intravenous and enteral nutrition, and albumin supplementation...During the 10-month follow-up, the patient remained recurrence-free and reported no dysphagia. This case provides valuable insights and therapeutic strategies for managing similar cases."

Journal • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Gastrointestinal Disorder • Oncology • Pulmonary Disease • Respiratory Diseases • Solid Tumor • Squamous Cell Carcinoma • Thrombosis • Thymoma • Thymus Cancer

Enzymatic assay in a lab-on-a-disk format to measure free piperacillin concentration in serum. (PubMed, Biomed Microdevices) - "This paper describes the design and characterization of the chemical kinetics and the microfluidic strategy underlying this assay. The data are compared to measurements made in well-plates with a conventional method."

Journal

A study of clinical profile, sputum microbiology, and laboratory parameters of patients admitted with acute exacerbation of chronic obstructive pulmonary diseases in rural-based hospital. (PubMed, J Family Med Prim Care) - "Aminoglycosides (amikacin) were sensitive in 91%, followed by carbapenem (meropenem) in 87%, fluoroquinolones (levofloxacin), and penicillin with beta-lactamase inhibitor (piperacillin-tazobactum) were sensitive in 78%, and cephalosporins with beta-lactamase inhibitor (cefoperazone-sulbactam) were sensitive in 69% of patients. Clinical parameters can be good predictors to start the treatment without waiting for culture and investigations. Data on sputum culture and antibiogram of such loco regional study will help to select and start antibiotics as early as possible in AECOPD."

Journal • Chronic Obstructive Pulmonary Disease • Cough • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • CRP

OmpK35/36 absence does not confer carbapenem-resistance alone nor ceftazidime-avibactam resistance with one bla KPC-2. (PubMed, Front Cell Infect Microbiol) - "As to ΔompK36, the minimum inhibitory concentrations (MICs) of piperacillin, cefoxitin, cefazolin, cefuroxime, and imipenem increased to 4, 4, 4, 8, and 4 times respectively compared with those against NTUH-K2044; the MICs of piperacillin, cefoxitin, cefazolin, cefuroxime, imipenem, and meropenem increased to 8, 32, 32, 16, 8, and 8 times in ΔompK35/36 respectively. The loss of OmpK35/36 confers increased resistance to certain β-lactams, with OmpK36 being dominant. Moreover, OmpK35/36 loss is a contributor but not a determinant in the formation of carbapenem-resistance under the absence of bla KPC-2, as well as in the formation of CZA-resistance with one bla KPC-2."

Journal • Infectious Disease • Pneumonia

Identification of Novel Trypanosoma cruzi Cysteine Protease Inhibitors via Ligand-Based Virtual Screening of FDA-Approved Drugs with Trypanocidal Activity. (PubMed, Diseases) - "These results encourage the development of new and more potent anti-Trypanosoma cruzi agents using FDA-approved drugs as scaffolds."

FDA event • Journal

PIVOT: Pivmecillinam as oral step-down treatment for Escherichia coli febrile urinary tract infection versus standard of care; a randomized controlled non-inferiority multicenter trial (clinicaltrialsregister.eu) - P1/2 | N=560 | Recruiting | Sponsor: Uppsala Universitet

Head-to-Head • New P1/2 trial • Infectious Disease • Nephrology

Whole-Genome Sequence Analysis of Colistin-Resistant, mcr-Harboring Escherichia coli Isolated from a Swine Slaughterhouse in Thailand. (PubMed, Antibiotics (Basel)) - "Overall, the 82 mcr E. coli isolates showed the highest level of resistance to ampicillin (97.56%), followed by tetracycline (95.12%), piperacillin (73.17%), and chloramphenicol (65.85%). In conclusion, this study reveals a high prevalence of MDR E. coli harboring colistin resistance genes (mcr-1 to mcr-9) in a swine slaughterhouse in southern Thailand. The findings highlight the potential risk of zoonotic transmission of antimicrobial resistant E. coli through the food production chain and emphasize the importance of continuous genomic surveillance and prudent antimicrobial use in livestock production systems."

Journal

ContraIndicator: A Natural Language Processing-Based Approach to Potential Drug-Drug Interaction Detection in Pediatric Intensive Care. (PubMed, Clin Drug Investig) - "The study suggests that potential drug-drug interactions are frequent in pediatric intensive care units. The majority of these interactions were moderate, followed by major severity. There is a statistically significant association between the quantity of drugs provided and the prevalence of potential drug-drug interactions. The findings of this study could aid in planning and executing future studies, as well as in monitoring and preventing potential drug-drug interactions in patients receiving intensive care. This study introduces ContraIndicator, a graphical user interface that presents empirical findings and promotes awareness regarding potential drug-drug interactions."

Journal • Critical care • Pediatrics

Differences in International Recommendations for Piperacillin Dosing: A Japanese Perspective. (PubMed, JMA J) - "Clinicians should tailor dosing to the clinical context, reserving aggressive regimens for patients who are critically ill or at high risk while maintaining safety-oriented dosing in routine ward practice. By recognizing the underlying philosophies and their intended applications, physicians can avoid inappropriate extrapolation, optimize patient outcomes, and reduce the ecological burden of antibiotic use."

Journal • Allergy • Critical care • Gastrointestinal Disorder • Immunology • Infectious Disease • Renal Disease

Pathogen Distribution and Antimicrobial Resistance Patterns in Pediatric Lower Respiratory Tract Mycoplasma pneumoniae Pneumonia. (PubMed, APMIS) - "Among Gram-negative isolates, Klebsiella pneumoniae had the highest resistance to cefotaxime (40%), Escherichia coli to piperacillin (50%), and Pseudomonas aeruginosa to aztreonam (54%)...Staphylococcus epidermidis showed elevated resistance to clindamycin, levofloxacin, and penicillin (43% each)...Co-isolated bacterial pathogens from children with lower respiratory tract MPP show notable antimicrobial resistance. Routine pathogen testing and susceptibility profiling are crucial for guiding targeted therapy and curbing multidrug resistance."

Journal • Retrospective data • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Real-World Data on Severe Cutaneous Adverse Reactions to Drugs. (PubMed, Pharmaceuticals (Basel)) - "The top five drugs involved in SCARs were dupilumab (2.14%, n = 244), piperacillin and beta-lactamase inhibitor (2.0%, n = 227), pembrolizumab (1.98%, n = 225), levofloxacin (1.95%, n = 222), and linagliptin (1.93%, n = 220). The strongest signals were detected for linagliptin (PRR = 15.37, 95% CI: 13.54-17.44; ROR = 17.24, 95% CI: 14.95-19.88), followed by clindamycin (PRR = 12.44, 95% CI: 10.89-14.21; ROR = 13.62, 95% CI: 11.77-15.77) and by piperacillin and beta-lactamase inhibitor (PRR = 10.02, 95% CI: 8.86-11.43; ROR = 10.81, 95% CI: 9.42-12.40). Pharmacovigilance databases facilitate the identification of diverse phenotypes of SCARs and the list of culprit drugs. The accumulated data serve as a valuable tool to enhance clinical practice outcomes and strengthen overall healthcare monitoring."

Journal • Real-world evidence • Allergy • Eosinophilia • Immunology • Oncology • Steven-Johnson Syndrome

Current drug hypersensitivity challenges facing patients with cystic fibrosis. (PubMed, J Cyst Fibros) - "The CFTR correctors (vanzacaftor, elexacaftor, tezacaftor, lumacaftor) and potentiators (ivacaftor, deuterated ivacaftor) target the underlying CFTR defect to improve protein function...Piperacillin has been defined as a leading drug culprit within non-immediate drug allergy in patients with CF, with a growing body of evidence alluding to the central role of T-lymphocytes...This phenomenon has led us to hypothesise that increased levels of inflammation and dysregulation of regulatory T-cells in CF patients could propagate adverse reactions to CFTR modulators that resolve alongside underlying infection. The introduction of CFTR modulator therapies has been highly transformative for patients with CF, therefore, adverse reactions to these compounds that lead to cessation of treatment are serious and important to understand."

Journal • Review • Allergy • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Inflammation • Pulmonary Disease • Respiratory Diseases • CFTR

Influence of environmental parameters on total and pathogenic Vibrio parahaemolyticus isolated from mussels and clams. (PubMed, Microb Pathog) - "All strains exhibited multidrug-resistance (MDR), showing resistance to at least four antimicrobial classes; notably, all were resistant to piperacillin and tetracycline. Moderate biofilm production was observed only in clam-derived strains (7.1%). These findings demonstrate the influence of environmental and host-related factors on V. parahaemolyticus ecology and stress the need for species-specific monitoring strategies to safeguard seafood safety."

Journal • Gastroenterology • Gastrointestinal Disorder

Pharmacokinetics of Piperacillin in an Experimental Porcine Liver Model During Normothermic Machine Perfusion. (PubMed, Transpl Int) - No abstract available

Journal • PK/PD data • Preclinical • Transplantation

Population pharmacokinetic modeling of piperacillin in critically ill adult patients: consideration of sex-based differences during model development. (PubMed, Expert Rev Clin Pharmacol) - "This study is the first to consider sex-specific covariates during the modeling process for piperacillin in critically ill patients. This approach may help reduce differences in model predictions between males and females in model-informed precision dosing strategies."

Journal • PK/PD data

Cross-reactivity between Amoxicillin and Piperacillin-Tazobactam in Patients with Amoxicillin Allergy: A Prospective Study. (PubMed, Ann Allergy Asthma Immunol) - "In this cohort of confirmed AX-allergic patients, cross-reactivity to PPZ-TZB occurred in approximately one-fifth of cases, most frequently identified by skin testing. These results emphasize that systematic allergy work-up - particularly skin testing followed by DPT when negative - is essential before prescribing PPZ-TZB in patients with AX hypersensitivity."

Journal • Allergy • Immunology

Polypharmacy and nephrotoxicity (PubMed, Inn Med (Heidelb)) - "In patients receiving calcineurin inhibitors, any additional prescriptions should be carefully reviewed for potential interactions and accompanied by dose adjustment and close therapeutic drug monitoring where appropriate. The concurrent use of several agents with structural tubular toxicity generally increases risk, whereas functional mechanisms, such as those seen with combined ACE inhibitor and sodium-glucose cotransporter 2 inhibitor (SGLT2) inhibitor therapy, are usually well tolerated. The concept of nephrotoxic burden shows promise but requires further refinement and prospective validation before it can serve as a practical tool for risk stratification in polypharmacy."

Journal • Review • Acute Kidney Injury • Nephrology • Renal Disease • CYP3A4