piperacillin / Generic mfg. - LARVOL DELTA

Warm autoimmune hemolytic anemia following epstein-barr virus reactivation: An uncommon clinical association (ASH 2025) - "His only medications were atenolol and atorvastatin, and he denied use of herbal supplements or over-the-counter drugs... Warm AIHA is most commonly idiopathic but can also occur secondary to various conditions, including rheumatologic diseases (e.g., systemic lupus erythematosus), chronic lymphoblastic leukemia, non-Hodgkin's lymphoma, certain medications (e.g., cephalosporins, piperacillin), and infections...Initial corticosteroid therapy varies widely during the first 72 hours, ranging from 1–2 mg/kg of prednisone every 8–12 hours to high-dose intravenous methylprednisolone (250–1000 mg/day)...In cases refractory to steroids, additional therapies such as mycophenolate mofetil or sirolimus may be considered. This case highlights a rare presentation of warm AIHA likely triggered by EBV reactivation, an association that is infrequently reported in the literature."

Clinical • Anemia • Autoimmune Hemolytic Anemia • Chronic Lymphocytic Leukemia • Cytomegalovirus Infection • Dyslipidemia • Epstein-Barr Virus Infections • Hematological Malignancies • Hepatology • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Leukemia • Lupus • Lymphoma • Non-Hodgkin’s Lymphoma • Pulmonary Disease • Rheumatology • Systemic Lupus Erythematosus • HP

Prevalence and Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing Escherichia coli and Effects of Antimicrobial Use in Multiple Pig Industry Sectors in Korea. (PubMed, Ann Lab Med) - "Pig-derived E. coli isolates had antimicrobial resistance (AMR) rates of 80.4%, 47.2%, 32.6%, 36.7%, 43.4%, 62.4%, and 72.1% to ampicillin, piperacillin, cefazoline, ciprofloxacin, cotrimoxazole, chloramphenicol, and tetracycline, respectively. The findings highlight the significance of elucidating AMR networks among humans, animals, and the environment. Prudent antimicrobial usage and continuous AMR monitoring in the pig industry are crucial to safeguard food safety."

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Integrative Chinese-western therapy for Leukocytoclastic vasculitis-induced refractory leg ulcer: An 8-month healing journey with reduced corticosteroid dependency. (PubMed, Explore (NY)) - "This case demonstrates that a combination of oral Chinese herbal decoction and low-dose corticosteroids is a highly effective treatment for recalcitrant wounds caused by LCV, with a low recurrence rate. This approach may contribute to a reduction in corticosteroid or immunosuppressant dosage, promote skin ulcer healing, and reduce recurrence rates. The necessity for future randomized controlled trials is evident to ascertain the efficacy of this therapeutic strategy."

Journal • Cardiovascular • Dermatology • Immunology • Pruritus • Vasculitis

Design Optimization for Developing Population Pharmacokinetic Models in Critically Ill Children: Application to Teicoplanin, Piperacillin and Meropenem. (PubMed, Clin Pharmacokinet) - "This work emphasizes the importance of optimizing study designs to improve accuracy and precision in the model parameters while reducing the number of samples needed. This is a relevant advantage especially when dealing with critically ill pediatric patients."

Journal • PK/PD data • Pediatrics

Development of population pharmacokinetic models of total and free piperacillin in critically ill children and young adults for Monte Carlo simulations and model-informed precision dosing. (PubMed, J Antimicrob Chemother) - "Using a large sample of critically ill children, we developed total and free piperacillin population PK models and newly identified uNGAL and time as significant covariates on piperacillin clearance. These models may be used for model-informed precision dosing after external validation."

Journal • PK/PD data • Pediatrics • LCN2

Regulatory relationships among aldB, ampH, and acoR and their impact on β-lactam susceptibility in Phytobacter diazotrophicus. (PubMed, Front Microbiol) - "Compared with the wild-type strain, the ampH-knockout strain exhibited significantly increased MICs for carbenicillin, piperacillin, cefalotin, cefoxitin, cefuroxime, cefotaxime, ceftazidime, cefepime, aztreonam, and ertapenem by at least 2-, 4-, 8-, 4-, 4-, 4-, 4-, 4-, 4-, and 2-fold, respectively. Under ceftazidime stress, P. diazotrophicus reduced aldB expression to increase its tolerance to the antibiotic. The discovery of the mechanism by which AcoR regulates aldB expression provides preliminary evidence for subsequent research on drug resistance mechanisms."

IO biomarker • Journal • Infectious Disease • ACACA • PD-1

Population pharmacokinetics and dose optimization of piperacillin-tazobactam in premature and term neonates with severe infections. (PubMed, Antimicrob Agents Chemother) - "Additional simulations supported individualized initial regimens based on renal maturation and suggested that extended infusions (1-4 h) may improve target attainment for stricter targets and less-susceptible pathogens. This study provides a validated pharmacokinetic model for piperacillin in neonates with severe infections, offering a framework to optimize empiric dosing based on renal function and developmental stage."

Journal • PK/PD data • Critical care • Infectious Disease

A Middle-Aged Lady Presenting with Multiple Cavitatory and Necrotic Pneumonia Due to PVL Producing Staphylococcus Infection (APSR 2025) - "She was treated with Piperacillin and Vancomycin but despite this, continued to have fever spikes with raised CRP. She was suspected to have PVL producing Staph pneumonia and antibiotics were changed to Linezolid and Doxycycline to which she responded...Discussion : PVL producing pneumonia can cause cavitatory pneumonia and has a higher mortality. Routine antibiotics to cover Staphylococcus will not cover PVL producing pneumonia and escalation of antibiotics needs to be done accordingly."

Cough • Hematological Disorders • Hematological Malignancies • Hodgkin Lymphoma • Infectious Disease • Lymphoma • Neutropenia • Pneumonia • Respiratory Diseases

Lemierre Syndrome Complicated with Parapharyngeal Collection and Empyema—A Challenging Case with Airway Compromise (APSR 2025) - "He was initially treated with Ceftriaxone which was changed to Piperacillin and Clindamycin. There is no consensus for antibiotic duration and most experts recommend 4-6 weeks antibiotics. Anticoagulation in Lemmiere syndrome is a debatable area and no consensus made and need to be decided on individual basis."

Clinical • Cardiovascular • Hematological Disorders • Infectious Disease • Inflammation • Otorhinolaryngology • Pneumonia • Respiratory Diseases • Thrombosis

Limitations of antimicrobial agent choice based on MIC value against Pseudomonas aeruginosa. (PubMed, J Med Microbiol) - "The antibiotics used in this study were piperacillin (PIPC), imipenem (IPM), meropenem, ciprofloxacin and amikacin (AMK). Choosing an appropriate antibiotic based on exceeding the MIC may be insufficient. While the PK/PD theory focuses on MIC, measuring MPC alongside MIC is urgent in clinical practice for optimal antibiotic selection."

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In Vitro Nephrotoxicity of Combined Piperacillin and Vancomycin (KIDNEY WEEK 2025) - "Funding Private Foundation Support Background Piperacillin-tazobactam and vancomycin are widely used parenteral antibiotics...Using culture conditions with improved organic anion transporter expression, we examined the nephrotoxicity of these antibiotics by supplementing culture media with piperacillin and vancomycin Methods Primary human renal proximal tubule cells (Lonza, Basel) were seeded at 10^5 cells per cm^2 on permeable supports and grown in 50:50 DMEM/F12 with ITS, hydrocortisone, T3, and ascorbic acid in humidified 5% CO2/Air...1 week after confluence, media was supplemented with metformin and SB431542...The concentration of vancomycin in media to cause injury is similar to concentrations that would be expected to cause nephrotoxicity in vivo. More research is needed to determine whether synergistic toxicity is present and if so whether specific prophylaxis will reduce toxicity."

Preclinical • Infectious Disease • Nephrology • Septic Shock • TGFBR1

An Antibiotic-Based Scoring Model for Predicting Early and Late Hematologic Toxicity Following CD19 CAR-T Therapy in B-ALL Patients (ASH 2024) - "High-risk antibiotics (HR ABX) were identified as the most used ones, including meropenem, teicoplanin, piperacillin, and ceftazidime. A high score represents a greater risk of severe cytopenia, either occurring early (before day 28) or prolonged (6-months follow-up). Finally, patients with high scores in the model exhibited notably poorer clinical outcomes."

Clinical • Anemia • B Acute Lymphoblastic Leukemia • Hematological Disorders • Hematological Malignancies • Neutropenia • Oncology • Thrombocytopenia

A Case of Piperacillin-Induced Immune Thrombocytopenia: Diagnostic Challenges and Management. (PubMed, Cureus) - "She was started on intravenous fluids and broad-spectrum antibiotics, including piperacillin-tazobactam and vancomycin. The patient's platelet count normalized within a week after stopping piperacillin and receiving IV immunoglobulin (1 g/kg). Hence, DITP needs to be considered among other causes in patients with acute severe thrombocytopenia, as early recognition and prompt cessation of the offending agent are important for preventing life-threatening hemorrhagic sequelae."

Journal • Cardiovascular • Cognitive Disorders • Dyslipidemia • Gastroenterology • Hematological Disorders • Hypertension • Immune Thrombocytopenic Purpura • Immunology • Infectious Disease • Pancreatitis • Septic Shock • Thrombocytopenia • Thrombocytopenic Purpura • Thrombosis

Antimicrobial resistance in bacterial pathogens from postoperative surgical site infections in a tertiary care centre in India. (PubMed, BMC Microbiol) - "Linezolid and ofloxacin emerged as the most effective agents against S. aureus and P. aeruginosa respectively. These findings highlight the importance of continuous antimicrobial resistance surveillance to guide appropriate empirical therapy for SSIs."

Journal • Gastroenterology • Infectious Disease • Oncology

Piperacillin/tazobactam versus ceftriaxone/metronidazole for children with perforated appendicitis: a systematic review and meta-analysis. (PubMed, Pediatr Surg Int) - "This systematic review suggests that there is ongoing uncertainty regarding the optimal post-operative antibiotics for children with perforated appendicitis."

Clinical • Journal • Retrospective data • Review • Gastroenterology • Gastrointestinal Disorder • Infectious Disease

First Report of New Delhi Metallo-β-Lactamase-6 (blaNDM-6) gene in Africa identified in a Carbapenem-Resistant Acinetobacter baumannii Clinical Isolate. (PubMed, Int J Infect Dis) - "This study presents the first report of blaNDM-6 in Africa. The detection in a rare lineage suggests an independent acquisition via plasmids. Further, it highlights an ongoing evolution of historically susceptible A. baumannii lineages into multidrug-resistant threats. This emphasizes the need for enhanced genomic surveillance in LMICs to monitor the emergence and dissemination of resistance determinants."

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Fungating Colon Mass, Not Always Cancer: A Case Report of Fistulizing Infected Necrotizing Pancreatitis (ACG 2025) - "Case Description/ A 60-year-old man with an initial hospitalization for gallstone pancreatitis treated with ERCP and cholecystectomy and subsequent admission for an infected necrotizing pancreatic abscess growing Enterobacter cloacae complex and Enterococcus faecium treated with IV vancomycin and piperacillin-sulbactam with transition to levofloxacin and linezolid, presented as an outside hospital transfer for worsening abdominal pain, bloody bowel movements, and hemorrhagic shock. Fungating mass seen within the transverse colon on colonoscopy.Figure: Figure 2. Severe necrotizing pancreatitis with walled off necrotic collections and involvement of the transverse colon seen on CT imaging."

Case report • Clinical • Cardiovascular • Gastroenterology • Infectious Disease • Oncology • Pancreatitis

Piperacillin dosing in pediatric patients and augmented renal clearance: are current guidelines sufficient to achieve therapeutic concentration coverage? (PubMed, J Antimicrob Chemother) - "This study highlights the critical impact of renal function on piperacillin pharmacokinetics in pediatric patients. Continuous infusion regimens are necessary to ensure optimal drug exposure and efficacy, particularly in patients with augmented creatinine clearance. These results emphasize the need to revise pediatric dosing strategies considering a broader range of renal function."

Journal • Pediatrics

Distribution and antibiotic resistance of pathogens in post-earthquake traumatic infections: a systematic review and meta-analysis. (PubMed, BMC Infect Dis) - "This study shows that there is limited research on the pathogens and their drug resistance after the earthquake disaster, and the data is concentrated in one region. The distribution of pathogens in earthquake-affected patients shows specific patterns, with a higher incidence and common resistance observed in Gram-negative rods. These pathogens exhibited the lowest resistance to Imipenem/Cilastatin and were less likely to develop resistance to quinolone antibiotics such as Netilmicin and Amikacin."

Clinical • Journal • Retrospective data • Review • Infectious Disease

The Impact of Ser165Glu Substitution Within the Ω-Loop on the Hydrolytic Activity of a Novel Ambler Class A β-Lactamase Variant LAP-3. (PubMed, Infect Drug Resist) - "The cloned bla LAP-3 gene resulted in elevated MIC levels for Amoxicillin (64-fold), Piperacillin (64-fold), cefuroxime (16-fold), and Cephalothin (32-fold) and while conferring resistance to clavulanic acid and tazobactam by increasing their MICs 8- and 4-fold, respectively, thereby indicating an expanded resistance spectrum. The findings reveal that the novel Ambler class A β-lactamase LAP-3 demonstrates an expanded hydrolysis spectrum against Penicillins, certain cephalosporins, and β-lactamase inhibitors. The Ser165Glu substitution within the Ω-loop may influence the resistance characteristics associated with LAP β-lactamases."

Journal • Infectious Disease • Pneumonia • HSP90AA1

SELENIUM SULFIDE STRICTURES: TOXIC INGESTION OF DANDRUFF SHAMPOO (CHEST 2025) - "Empiric antibiotics – ampicillin sulbactam were started to cover for aspiration pneumonia...Antibiotic regimen was broadened to piperacillin tazobatem... There have been no documented case of substantial amounts of toxic SSe ingestion in humans. Our case illustrates acute bronchial mucosal injury secondary to caustic ingestion of anti-dandruff shampoo with regurgitant aspiration."

CNS Disorders • Fibrosis • Immunology • Infectious Disease • Liver Cancer • Pneumonia • Respiratory Diseases • Seborrheic Dermatitis • Septic Shock • Solid Tumor • Vascular Neurology

Molecular Epidemiology and Resistant Gene Mapping of Bacterial Isolates from Houbara bustards. (PubMed, Curr Microbiol) - "Antibiogram of E. coli revealed 80% resistance against oxytetracycline and 60% against streptomycin, ciprofloxacin, erythromycin and piperacillin, while in case of S. aureus highest sensitivity against ciprofloxacin (80%) and lowest against ampicillin (10%) was observed. The overlap of AMR emergence with the Houbara's existing risk factors underscores the complex challenges at the human-animal-environment interface. These findings support the urgent need for a One Health approach to control AMR, particularly in ecologically sensitive species that traverse international boundaries and diverse ecosystems."

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Development and application of a wipe sampling method for detection of antibiotic surface contamination in hospital wards. (PubMed, Ann Work Expo Health) - "A widespread environmental contamination of antibiotics was observed in hospital wards that potentially can contribute to the development of antibiotic-resistant bacteria as well as health impacts of exposed personnel. Probable sources include compounding, handling and administration of drug tablets, antibiotic contaminated waste as well as other sources such as excretions from patients and contaminated drug vials. Current surface cleaning routines do not sufficiently reduce spills and leakage regardless of source."

Journal • Immunology • Infectious Disease

Piperacillin Pharmacokinetics in a Pediatric Patient With Primary Hyperoxaluria Receiving High-Dose Continuous Dialysis Post Liver-Kidney Transplant. (PubMed, J Pediatr Pharmacol Ther) - "CKRT CL was 40% of total CL on CKRT and 51% of the CKRT dialysis dose, suggesting PIP elimination was mostly renal despite high-intensity dialysis. Monitoring of free PIP concentrations may help ensure proper TA in non-oligoanuric patients receiving high-dose CKRT."

Journal • PK/PD data • Nephrology • Pediatrics • Transplantation

Resistance Patterns and Optimization of Empirical Therapy for Urinary Tract Infections in Patients on Trimethoprim-Sulfamethoxazole Prophylaxis Against Pneumocystis jirovecii. (PubMed, Microb Drug Resist) - "Susceptibility to other antibiotics also declined, including ampicillin (31.2% vs. 71.6%), piperacillin (32.5% vs. 74.8%), levofloxacin (57.5% vs. 74.7%), and ciprofloxacin (56.2% vs. 74.1%). Resistance correlates with prophylaxis duration. For empirical UTI therapy, intravenous expanded-spectrum cephalosporins may be preferable."

Journal • Infectious Disease • Nephrology • Pneumonia • Respiratory Diseases