piperacillin / Generic mfg. - LARVOL DELTA

Pathogen Distribution and Antimicrobial Resistance Patterns in Pediatric Lower Respiratory Tract Mycoplasma pneumoniae Pneumonia. (PubMed, APMIS) - "Among Gram-negative isolates, Klebsiella pneumoniae had the highest resistance to cefotaxime (40%), Escherichia coli to piperacillin (50%), and Pseudomonas aeruginosa to aztreonam (54%)...Staphylococcus epidermidis showed elevated resistance to clindamycin, levofloxacin, and penicillin (43% each)...Co-isolated bacterial pathogens from children with lower respiratory tract MPP show notable antimicrobial resistance. Routine pathogen testing and susceptibility profiling are crucial for guiding targeted therapy and curbing multidrug resistance."

Journal • Retrospective data • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Real-World Data on Severe Cutaneous Adverse Reactions to Drugs. (PubMed, Pharmaceuticals (Basel)) - "The top five drugs involved in SCARs were dupilumab (2.14%, n = 244), piperacillin and beta-lactamase inhibitor (2.0%, n = 227), pembrolizumab (1.98%, n = 225), levofloxacin (1.95%, n = 222), and linagliptin (1.93%, n = 220). The strongest signals were detected for linagliptin (PRR = 15.37, 95% CI: 13.54-17.44; ROR = 17.24, 95% CI: 14.95-19.88), followed by clindamycin (PRR = 12.44, 95% CI: 10.89-14.21; ROR = 13.62, 95% CI: 11.77-15.77) and by piperacillin and beta-lactamase inhibitor (PRR = 10.02, 95% CI: 8.86-11.43; ROR = 10.81, 95% CI: 9.42-12.40). Pharmacovigilance databases facilitate the identification of diverse phenotypes of SCARs and the list of culprit drugs. The accumulated data serve as a valuable tool to enhance clinical practice outcomes and strengthen overall healthcare monitoring."

Journal • Real-world evidence • Allergy • Eosinophilia • Immunology • Oncology • Steven-Johnson Syndrome

Current drug hypersensitivity challenges facing patients with cystic fibrosis. (PubMed, J Cyst Fibros) - "The CFTR correctors (vanzacaftor, elexacaftor, tezacaftor, lumacaftor) and potentiators (ivacaftor, deuterated ivacaftor) target the underlying CFTR defect to improve protein function...Piperacillin has been defined as a leading drug culprit within non-immediate drug allergy in patients with CF, with a growing body of evidence alluding to the central role of T-lymphocytes...This phenomenon has led us to hypothesise that increased levels of inflammation and dysregulation of regulatory T-cells in CF patients could propagate adverse reactions to CFTR modulators that resolve alongside underlying infection. The introduction of CFTR modulator therapies has been highly transformative for patients with CF, therefore, adverse reactions to these compounds that lead to cessation of treatment are serious and important to understand."

Journal • Review • Allergy • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Inflammation • Pulmonary Disease • Respiratory Diseases • CFTR

Influence of environmental parameters on total and pathogenic Vibrio parahaemolyticus isolated from mussels and clams. (PubMed, Microb Pathog) - "All strains exhibited multidrug-resistance (MDR), showing resistance to at least four antimicrobial classes; notably, all were resistant to piperacillin and tetracycline. Moderate biofilm production was observed only in clam-derived strains (7.1%). These findings demonstrate the influence of environmental and host-related factors on V. parahaemolyticus ecology and stress the need for species-specific monitoring strategies to safeguard seafood safety."

Journal • Gastroenterology • Gastrointestinal Disorder

Individualisation of piperacillin therapy: a multi-centre evaluation of a dosing software tool's predictive performance in intensive care patients (ESCMID Global 2026) - No abstract available

Clinical • Critical care

Immune phenotype and tissue oedema predict piperacillin pharmacokinetics in critical illness (ESCMID Global 2026) - No abstract available

PK/PD data

Population pharmacokinetic analysis of piperacillin in critically ill women based on multi-centre data (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data

Rethinking piperacillin dosing: a machine learning-assisted post-hoc analysis of sex-related differences in exposure and target attainment in critically ill patients (ESCMID Global 2026) - No abstract available

Clinical • Machine learning • Retrospective data

Impact of tazobactam concentration and inoculum on the antibacterial effect of piperacillin (ESCMID Global 2026) - No abstract available

Comparative evaluation of fingerpick microsampling methods for therapeutic drug monitoring of meropenem and piperacillin in clinical patients (ESCMID Global 2026) - No abstract available

Clinical

Pharmacokinetics of Piperacillin in an Experimental Porcine Liver Model During Normothermic Machine Perfusion. (PubMed, Transpl Int) - No abstract available

Journal • PK/PD data • Preclinical • Transplantation

Population pharmacokinetic modeling of piperacillin in critically ill adult patients: consideration of sex-based differences during model development. (PubMed, Expert Rev Clin Pharmacol) - "This study is the first to consider sex-specific covariates during the modeling process for piperacillin in critically ill patients. This approach may help reduce differences in model predictions between males and females in model-informed precision dosing strategies."

Journal • PK/PD data

Cross-reactivity between Amoxicillin and Piperacillin-Tazobactam in Patients with Amoxicillin Allergy: A Prospective Study. (PubMed, Ann Allergy Asthma Immunol) - "In this cohort of confirmed AX-allergic patients, cross-reactivity to PPZ-TZB occurred in approximately one-fifth of cases, most frequently identified by skin testing. These results emphasize that systematic allergy work-up - particularly skin testing followed by DPT when negative - is essential before prescribing PPZ-TZB in patients with AX hypersensitivity."

Journal • Allergy • Immunology

Polypharmacy and nephrotoxicity (PubMed, Inn Med (Heidelb)) - "In patients receiving calcineurin inhibitors, any additional prescriptions should be carefully reviewed for potential interactions and accompanied by dose adjustment and close therapeutic drug monitoring where appropriate. The concurrent use of several agents with structural tubular toxicity generally increases risk, whereas functional mechanisms, such as those seen with combined ACE inhibitor and sodium-glucose cotransporter 2 inhibitor (SGLT2) inhibitor therapy, are usually well tolerated. The concept of nephrotoxic burden shows promise but requires further refinement and prospective validation before it can serve as a practical tool for risk stratification in polypharmacy."

Journal • Review • Acute Kidney Injury • Nephrology • Renal Disease • CYP3A4

Dose Optimization of Piperacillin for Pseudomonas aeruginosa Infection in Febrile Neutropenic Pediatric Patients. (PubMed, Eur J Drug Metab Pharmacokinet) - "Conventional piperacillin dosing is insufficient in pediatric patients with febrile neutropenia. Loading dose with accelerated maintenance dosing achieves 50% fT > 4 × MIC, while continuous infusion is essential for 100% fT > MIC target attainment."

Journal • Febrile Neutropenia • Hematological Disorders • Infectious Disease • Neutropenia • Oncology • Pediatrics

Characterization and Antimicrobial Resistance of Bacteria Causing Subclinical Mastitis in Dairy Cows in the Upper Cheliff Region, Northern Algeria. (PubMed, Antibiotics (Basel)) - "Coagulase-negative staphylococci (CoNS) showed remarkable rates of methicillin-resistance (22.2%), as well as resistance towards fosfomycin (37.8%) and tetracycline (31.1%). A substantial proportion of E. coli isolates exhibited resistance to piperacillin (40%) and ciprofloxacin (15%)... The results of this study demonstrated that subclinical mastitis is prevalent in the Upper Cheliff region and is associated with reduced milk production and reproductive performance. The detection of pathogenic and resistant microorganisms in milk is alarming and requires effective management strategies to control subclinical mastitis and improve dairy farm productivity."

Journal • Infectious Disease

Critical threshold target attainment rates for tazobactam combined with piperacillin among patients admitted to the ICU with hospital-acquired pneumonia. (PubMed, Antimicrob Agents Chemother) - "High-dose CI improved PTA at this higher threshold but may increase the risk of piperacillin overexposure. TAZ exposures sufficient for enzymatic beta-lactamase inhibition are generally achieved with standard dosing for lower thresholds but not for more aggressive targets (e.g., high extended-spectrum β-lactamase expression), particularly in patients with preserved or augmented renal function, who may require therapeutic drug monitoring or alternative therapy."

Journal • Infectious Disease • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases

Pharmacokinetic-pharmacodynamic target attainment with continuous infusion piperacillin in patients admitted to the ICU with hospital-acquired pneumonia. (PubMed, Antimicrob Agents Chemother) - "Continuous infusion (CI) of piperacillin/tazobactam aims to improve pharmacodynamic target attainment, though both subtherapeutic and potentially toxic concentrations have been reported in practice. CI PIP dosing based on CrCL results in variable exposures among ICU patients. Individualized dosing of PIP may be required to optimize efficacy and minimize toxicity in ICU patients treated with CI dosing."

Journal • PK/PD data • Critical care • Infectious Disease • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases

Thyroid storm complicated by metabolic encephalopathy in a young patient: A case report and literature review. (PubMed, Medicine (Baltimore)) - "Thyroid storm complicated by metabolic encephalopathy requires early diagnosis and treatment, and the neurological function damage caused by it is usually reversible."

Journal • Review • CNS Disorders • Endocrine Disorders • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia • Rare Diseases • Respiratory Diseases • Septic Shock

Warm autoimmune hemolytic anemia following epstein-barr virus reactivation: An uncommon clinical association (ASH 2025) - "His only medications were atenolol and atorvastatin, and he denied use of herbal supplements or over-the-counter drugs... Warm AIHA is most commonly idiopathic but can also occur secondary to various conditions, including rheumatologic diseases (e.g., systemic lupus erythematosus), chronic lymphoblastic leukemia, non-Hodgkin's lymphoma, certain medications (e.g., cephalosporins, piperacillin), and infections...Initial corticosteroid therapy varies widely during the first 72 hours, ranging from 1–2 mg/kg of prednisone every 8–12 hours to high-dose intravenous methylprednisolone (250–1000 mg/day)...In cases refractory to steroids, additional therapies such as mycophenolate mofetil or sirolimus may be considered. This case highlights a rare presentation of warm AIHA likely triggered by EBV reactivation, an association that is infrequently reported in the literature."

Clinical • Anemia • Autoimmune Hemolytic Anemia • Chronic Lymphocytic Leukemia • Cytomegalovirus Infection • Dyslipidemia • Epstein-Barr Virus Infections • Hematological Malignancies • Hepatology • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Leukemia • Lupus • Lymphoma • Non-Hodgkin’s Lymphoma • Pulmonary Disease • Rheumatology • Systemic Lupus Erythematosus • HP

Prevalence and Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing Escherichia coli and Effects of Antimicrobial Use in Multiple Pig Industry Sectors in Korea. (PubMed, Ann Lab Med) - "Pig-derived E. coli isolates had antimicrobial resistance (AMR) rates of 80.4%, 47.2%, 32.6%, 36.7%, 43.4%, 62.4%, and 72.1% to ampicillin, piperacillin, cefazoline, ciprofloxacin, cotrimoxazole, chloramphenicol, and tetracycline, respectively. The findings highlight the significance of elucidating AMR networks among humans, animals, and the environment. Prudent antimicrobial usage and continuous AMR monitoring in the pig industry are crucial to safeguard food safety."

Journal

Integrative Chinese-western therapy for Leukocytoclastic vasculitis-induced refractory leg ulcer: An 8-month healing journey with reduced corticosteroid dependency. (PubMed, Explore (NY)) - "This case demonstrates that a combination of oral Chinese herbal decoction and low-dose corticosteroids is a highly effective treatment for recalcitrant wounds caused by LCV, with a low recurrence rate. This approach may contribute to a reduction in corticosteroid or immunosuppressant dosage, promote skin ulcer healing, and reduce recurrence rates. The necessity for future randomized controlled trials is evident to ascertain the efficacy of this therapeutic strategy."

Journal • Cardiovascular • Dermatology • Immunology • Pruritus • Vasculitis

Design Optimization for Developing Population Pharmacokinetic Models in Critically Ill Children: Application to Teicoplanin, Piperacillin and Meropenem. (PubMed, Clin Pharmacokinet) - "This work emphasizes the importance of optimizing study designs to improve accuracy and precision in the model parameters while reducing the number of samples needed. This is a relevant advantage especially when dealing with critically ill pediatric patients."

Journal • PK/PD data • Pediatrics

Development of population pharmacokinetic models of total and free piperacillin in critically ill children and young adults for Monte Carlo simulations and model-informed precision dosing. (PubMed, J Antimicrob Chemother) - "Using a large sample of critically ill children, we developed total and free piperacillin population PK models and newly identified uNGAL and time as significant covariates on piperacillin clearance. These models may be used for model-informed precision dosing after external validation."

Journal • PK/PD data • Pediatrics • LCN2

Regulatory relationships among aldB, ampH, and acoR and their impact on β-lactam susceptibility in Phytobacter diazotrophicus. (PubMed, Front Microbiol) - "Compared with the wild-type strain, the ampH-knockout strain exhibited significantly increased MICs for carbenicillin, piperacillin, cefalotin, cefoxitin, cefuroxime, cefotaxime, ceftazidime, cefepime, aztreonam, and ertapenem by at least 2-, 4-, 8-, 4-, 4-, 4-, 4-, 4-, 4-, and 2-fold, respectively. Under ceftazidime stress, P. diazotrophicus reduced aldB expression to increase its tolerance to the antibiotic. The discovery of the mechanism by which AcoR regulates aldB expression provides preliminary evidence for subsequent research on drug resistance mechanisms."

IO biomarker • Journal • Infectious Disease • ACACA • PD-1