piperacillin / Generic mfg. - LARVOL DELTA

Antibiotic resistance, pathogenicity and genomic characteristics of a novel sequence type 6839 Klebsiella pneumoniae strain isolated from cultured bullfrogs (Rana catesbeiana). (PubMed, Front Cell Infect Microbiol) - "It displayed multidrug resistance against penicillins (carbenicillin, piperacillin, ampicillin, penicillin), chloramphenicol, trimethoprim and tetracycline. ZYRC75 possessed a single circular chromosome of 5,454,922 bp, carrying 179 virulence‑related genes and 157 antimicrobial‑resistance genes. This investigation presents a detailed phenotypic and genomic profile of ZYRC75, revealing its antimicrobial resistance and virulence, and establishing a basis for future studies on the pathogenicity of K. pneumoniae."

Journal • Infectious Disease • Pneumonia

Beta-Lactam Dose Optimization Using Therapeutic Drug Monitoring in Pediatric Patients. (PubMed, Hosp Pediatr) - "Over half of all patients failed to achieve 100%fT ≥ 4 × MIC with standard BL regimens. Furthermore, dosing adjustments made in nearly one-third of cases further emphasizes BL-TDM's role in individualizing pediatric dosing."

Journal • Critical care • Pediatrics

Antimicrobial and probiotic potential of Lactobacillus from traditional dairy products against uropathogenic gram-negative bacteria. (PubMed, Antonie Van Leeuwenhoek) - "Most isolates showed susceptibility or intermediate responses to several clinically relevant antibiotics, while resistance was mainly observed to vancomycin, penicillin G, piperacillin, and nalidixic acid. This repeated regimen also significantly controlled the inflammatory host response, with leukocyte counts decreasing from greater than 104 cells/mL to approximately 4 × 103 cells/mL by day 11, while successfully preventing kidney dissemination and minimizing bladder tissue damage. These findings highlight their potential as complementary strategies to prevent or mitigate UTIs."

Journal • Infectious Disease • Inflammation • Nephrology • Pneumonia • Renal Disease

Practical use of piperacillin MICs to distinguish β-lactamase-producing isolates from non-producing isolates in Haemophilus influenzae. (PubMed, Future Microbiol) - "When a threshold of 4 µg/mL was used to distinguish β-lactamase-producing isolates from non-producing isolates, the sensitivity and specificity were 100%. PIPC MICs may be useful supplementary indicator to distinguish β-lactamase producing H. influenzae from non-producing isolates, particularly when chromogenic cephalosporin-based testing is unavailable because of supply interruptions."

Journal • Infectious Disease • Influenza • Respiratory Diseases

Antimicrobial-associated adverse events in neonates: an integrated literature review and FAERS pharmacovigilance analysis. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "In parallel, FAERS reports from Q1 2004 to Q2 2024 were retrieved through OpenVigil 2.1 for 12 commonly used antimicrobial agents: gentamicin, vancomycin, fluconazole, ampicillin, amphotericin B, metronidazole, piperacillin, meropenem, amikacin, amoxicillin, voriconazole, and cefotaxime. Clinically, our results support conservative antimicrobial stewardship, individualized dosing, and organ-specific monitoring in routine neonatal intensive care unit (NICU) care. Future research should prioritize gestational age-stratified analyses and prospective registries linking antimicrobial exposure to long-term outcomes to define drug-specific safety profiles."

Adverse events • Journal • Review • Candidiasis • Critical care • Gastroenterology • Gastrointestinal Disorder • Hepatology • Infectious Disease • Nephrology • Respiratory Diseases • Septic Shock

Phenotypic and molecular detection of efflux pump and expression profiling genes in Klebsiella pneumoniae exposed to ciprofloxacin and amoxicillin/clavulanic acid. (PubMed, Braz J Microbiol) - "The efficacy of synergistic antibiotic and efflux pump inhibitor combinations in eradicating MDR bacterial resistance is an encouraging discovery."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of piperacillin in human serum and plasma. (PubMed, Clin Chem Lab Med) - "This candidate RMP enables accurate determination of piperacillin in human serum and plasma, providing a standardized platform to facilitate reliable clinical TDM and routine assay harmonization."

Journal • Infectious Disease

H2S-Responsive Carbon Dot-Poly(α-Lipoic Acid) Nanodrug Delivery Platform for Multimodal Antibacterial Therapy. (PubMed, Small) - "To address these challenges, we developed an H2S-responsive nanodrug delivery platform (PIP@CDs-PαLA) based on multifunctional carbon dots (CDs) and poly(α-lipoic acid) (PαLA), enabling efficient encapsulation of the broad-spectrum antibiotic piperacillin (PIP) via a self-assembly strategy...Both in vitro and in vivo evaluations demonstrate that the platform exhibits potent antibacterial activity and effective biofilm eradication, while also promoting infection resolution and tissue regeneration in a mouse abscess model. This study provides a robust strategy to overcome the limitations of conventional antibiotic therapies and offers a promising approach for intelligent antibacterial nanoplatforms."

Journal • Infectious Disease

A Rare Case of Amyand's Hernia Accompanied by Complicated Appendicitis in a Neonate (ACG 2026) - "The neonate received intravenous piperacillin-tazobactum for 72 hours postoperatively and was discharged on 3rd postoperative day. Preventing life-threatening consequences requires early surgical exploration guided by clinical observations and imaging. Figure: Perforation near base of appendix"

Clinical • Cough • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Respiratory Diseases • Septic Shock

Isolation, Identification, Drug Sensitivity, Pathogenicity and Genomic Analysis of Vibrio mimicus from Pelteobagrus fulvidraco. (PubMed, Microorganisms) - "Antimicrobial susceptibility testing demonstrated that the isolate was highly susceptible to piperacillin, norfloxacin, roxithromycin, azithromycin, furazolidone, ceftriaxone and tetracycline, whereas it displayed high-level resistance to compound sulfamethoxazole and clindamycin. Collectively, this work lays a scientific foundation for the isolation, identification and comprehensive research of Vibrio mimicus-induced ulcerative disease in yellow catfish."

Journal • Gastroenterology • Immunology • Infectious Disease • Inflammatory Bowel Disease • Ulcerative Colitis

A Retrospective Cohort Study to Optimize Piperacillin/Tazobactam Dosing in Routine Intensive-Care Patients via a Newly Designed Clinical Pharmacy Service Including TDM- and Algorithm-Based Recommendations. (PubMed, Pharmacy (Basel)) - " Inappropriate piperacillin plasma concentrations were common. A TDM- and algorithm-based clinical-pharmacy-service especially decreased the number of overdosed patients in routine practice."

Journal • Retrospective data • Critical care • Infectious Disease • Septic Shock

Piperacillin-Induced Immune Hemolytic Anemia Masked by Intestinal Failure-Associated Liver Disease: A Case Report with Three Serial Exposures. (PubMed, J Community Hosp Intern Med Perspect) - "A 27-year-old woman with traumatic short bowel syndrome requiring total parenteral nutrition for 6 months, IFALD (baseline total bilirubin 2.5 mg/dL), and chronic kidney disease experienced three piperacillin-tazobactam exposures over two months. When baseline cholestasis masks unconjugated bilirubin elevation, diagnosis requires non-bilirubin hemolytic markers, peripheral smear, and positive IgG DAT. Immediate drug discontinuation is essential, with favorable prognosis in most cases."

Journal • Anemia • Cholestasis • Chronic Kidney Disease • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Nephrology • Renal Disease • Short Bowel Syndrome • HP

Quinolone resistance of Pseudomonas aeruginosa isolated from hospital infections and MexAB-OprM efflux pumps. (PubMed, Int Microbiol) - "The findings demonstrate a strong association between the presence of the mexAB-oprM determinant and elevated quinolone resistance in clinical P. aeruginosa isolates. The significant reduction in MIC values following PAβN exposure supports the contribution of RND-type efflux mechanisms to resistance. However, given the intrinsic nature of MexAB-OprM and the broad inhibitory spectrum of PAβN, these results should be interpreted as correlative rather than causative. These data underscore efflux activity as a key resistance factor and highlight the need for expression-based profiling in future mechanistic studies."

Journal • Infectious Disease

Anaphylactic Shock Probably due to a Cross-Reaction Between Cefuroxime and Piperacillin-Presentation of a Fatal Case, Diagnostic Considerations, and Literature Review. (PubMed, Case Rep Crit Care) - "During the postoperative period, the patient received ampicillin/sulbactam without any signs of hypersensitivity. Following a switch to piperacillin/tazobactam prior to a procedure, the patient suddenly developed cardiovascular arrest and died...This case report highlights the potential risks of cross-reactivity between beta-lactam antibiotics and the importance of autopsy in ambiguous cases. Clinicians should be aware of cross-reactivity or cosensitization to multiple beta-lactams in patients with a beta-lactam allergy and consider non-beta-lactam alternatives in high-risk cases."

Journal • Allergy • Cardiovascular • Critical care • Immunology

LC-MS/MS method for simultaneous quantification of antibiotics in dialysis effluent and human serum for routine therapeutic drug monitoring. (PubMed, Scand J Clin Lab Invest) - "Therefore, this study aimed to develop and validate a multiplex LC-MS/MS method for the routine quantification of 4 antibiotics (cefepime, levofloxacin, meropenem, and piperacillin) and a β-lactamase inhibitor (tazobactam) in human serum and CRRT effluent. The developed method confirms its suitability for routine clinical application, providing a reliable tool for antibiotics TDM in critically ill patients. Additionally, measuring drug concentrations in CRRT effluent offers valuable insights into drug clearance and pharmacokinetics, which could ultimately lead to better patient management and more tailored, effective treatments in the future."

Journal

Piperacillin Population Pharmacokinetics in Children Supported With Extracorporeal Membrane Oxygenation. (PubMed, Pediatr Crit Care Med) - P | "Continuous infusion of 300 mg/kg/d piperacillin reliably achieves PK target across all renal-function ranges in children undergoing support with ECMO. Dose escalation to 400 mg/kg/d is required for augmented renal clearance (eGFR > 200 mL/min/1.73 m2)."

Journal • PK/PD data • Critical care • Infectious Disease • Pediatrics

Impact of augmented renal clearance on piperacillin and meropenem exposure in critically ill adult burn patients: A prospective observational study. (PubMed, Burns) - "ARC was frequent in critically ill burn patients and was associated with significantly reduced β-lactam target attainment. Although isolate-specific MIC targets were usually achieved, breakpoint-based thresholds were frequently subtherapeutic. Further research is needed to clarify the role of therapeutic drug monitoring and ARC in this high-risk population."

Journal • Observational data • Critical care

Antimicrobial resistance in post-cataract endophthalmitis: a systematic review on resistance pattern and treatment outcomes. (PubMed, Int Ophthalmol) - "AMR in Post-Cataract Endophthalmitis is an escalating concern with marked geographic variation. Prompt intravitreal therapy remains the key determinant of prognosis, but empiric regimens must reflect local resistance trends, particularly for Gram-negative coverage. Current evidence is limited by retrospective design and regional variability; multicentre prospective studies are needed to refine prophylaxis and treatment protocols, reducing visual and economic burden."

Journal • Review • Cataract • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Predictive performance of an antibiotic precision dosing software program in critically ill adults with infection. (PubMed, J Antimicrob Chemother) - "In a heterogenous adult ICU population, the a priori predictive performance of vancomycin was shown to be acceptable. Conversely, the a priori predictive performance for the beta-lactams was not acceptable. Although predictive performance improved with the a posteriori approach for beta-lactams, only cefepime met acceptance criteria."

Journal • Infectious Disease

Population pharmacokinetics of piperacillin in non-critically Ill hospitalized patients: A study from Pakistan. (PubMed, Pak J Pharm Sci) - "Piperacillin pharmacokinetics in non-critically ill patients are primarily influenced by renal function, with the CKD-EPI 2021 equation providing the most reliable estimates of clearance. Despite the limited sample size, these findings provide a foundation for future individualized and model-informed precision dosing approaches, particularly in Pakistan."

Journal • PK/PD data • Infectious Disease

Correlation of type 3 secretion system genes with antimicrobial resistance in Pseudomonas aeruginosa: A unique clinical signature. (PubMed, J Taibah Univ Med Sci) - "The highest sensitivity was recorded for meropenem with 84%, followed by piperacillin with 66% and ertapenem with 64%. The maximum resistance was to colistin with 100% antimicrobial susceptibility testing (AST) where the resistance was characterized by a minimum inhibitory concentration value ≥ 4 μg/mL, and tigecycline and aztreonam with 82%...Statistically significant correlations were found between exo genes and MARi resistotype groups, with a p-value <0.05 and Carmer's value of 1.00. In this study, significant correlations were detected between drug resistance and T3SS exo genes, which are a severe threat to the healthcare sector, and systemic surveillance is necessary to ensure good health and well-being."

Journal • Infectious Disease

Genomic Characterization, Antimicrobial Resistance Profiles, and tetA Nucleotide Substitutions of Escherichia coli Isolated from Healthy Dogs in Thailand. (PubMed, Animals (Basel)) - "High resistance rates were observed for ampicillin (100%), piperacillin (84.85%), ceftriaxone (60.61%), tetracycline (56.06%), and aztreonam (46.97%). These findings demonstrate that healthy dogs in Thailand can act as reservoirs of MDR and potentially virulent E. coli. The observed geographic variation in resistance and virulence gene distributions highlights the importance of antimicrobial stewardship and continuous molecular surveillance in companion animals within a One Health framework."

Journal

Development, Validation, and Application of an HPLC Method Combined with an In Vitro Model for the Determination of Antibiotic Binding to the Haemoadsorber CytoSorb®. (PubMed, Molecules) - "Imipenem (IMI), amoxicillin (AMO), cefepime (CEF), meropenem (MERO), vancomycin (VAN) and piperacillin (PIP) were measured in bovine plasma via precipitation with acetonitrile and liquid-liquid extraction with dichloromethane. Using the in vitro model, we showed that CytoSorb® significantly removed VAN and PIP, but not MERO. Further clinical studies are needed to establish the clinical significance of these findings and their impact on antibiotic exposure."

Journal • Preclinical • Infectious Disease • Inflammation • Septic Shock

TNF-alpha is a master regulator of drug-specific T-cell activation. (PubMed, J Allergy Clin Immunol) - "We challenge the central dogma that tolerant individuals do not express the correct immunological receptors to mount a drug-specific T-cell response and that the cellular machinery for response elicitation is not limited to hypersensitive patients."

Journal • Immunology • CD8 • TNFA

Epidemiology, Antimicrobial Resistance, and Genetic Determinants of Methicillin-Resistant Staphylococcus aureus (MRSA) in Broiler Chickens with Arthritis. (PubMed, Avian Dis) - "All isolates were resistant to multiple β-lactam antibiotics, including oxacillin, cefoxitin, penicillin G, and piperacillin. High resistance was also observed to clindamycin, cephradine, and cephalexin. The most effective agents were ampicillin-sulbactam and vancomycin...MRSA is an emerging pathogen in broiler flocks with a marked capacity for antimicrobial resistance and zoonotic transmission. The detection of multidrug-resistant strains carrying key resistance genes highlights the urgent need for enhanced biosecurity, prudent antimicrobial use, and routine monitoring programs to mitigate its impact on poultry and public health."

Journal • Immunology • Infectious Disease • Rheumatology