BHB810 / BigHat Biosci - LARVOL DELTA

BigHat Biosciences Announces First Patient Dosed in Phase 1 Trial Evaluating BHB810, a Novel CDH17-Directed Antibody-Drug Conjugate, for the Treatment of Gastric Cancer and other Advanced Gastrointestinal Tumors (Businesswire) - "The first-in-human, Phase 1 dose escalation trial will evaluate the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of BHB810. The trial will initially enroll patients with advanced gastric and gastroesophageal (GEJ) tumors."

First-in-human • Trial status • Gastric Cancer • Gastroesophageal Junction Adenocarcinoma

ChefHat-001: Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma (clinicaltrials.gov) - P1/2 | N=164 | Recruiting | Sponsor: BigHat Biosciences, Inc. | Not yet recruiting ➔ Recruiting

Enrollment open • Colon Cancer • Colorectal Cancer • Esophageal Adenocarcinoma • Esophageal Cancer • Gastric Adenocarcinoma • Gastric Cancer • Gastroesophageal Cancer • Gastroesophageal Junction Adenocarcinoma • Gastrointestinal Cancer • Oncology • Pancreatic Cancer • Solid Tumor • CDH17

BHB810: A novel site-specific CDH17-directed VHH-Fc ADC for gastric cancer (AACR 2026) - "BHB810 is a novel, potentially best-in-class CDH17-directed ADC for the treatment of advanced gastric and other GI malignancies. The molecule was engineered on BigHat Biosciences's AI/ML-powered antibody design platform to maximise ADC internalization and potency against cells that express CDH17. First-in-human studies are planned for 2026, prioritizing patients with gastric cancer."

ADC • First-in-human • Gastric Cancer • Oncology • Solid Tumor • CDH17 • CLDN18 • HER-2

ChefHat-001: Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma (clinicaltrials.gov) - P1/2 | N=164 | Not yet recruiting | Sponsor: BigHat Biosciences, Inc.

New P1/2 trial • Colon Cancer • Colorectal Cancer • Esophageal Adenocarcinoma • Esophageal Cancer • Gastric Adenocarcinoma • Gastric Cancer • Gastroesophageal Cancer • Gastroesophageal Junction Adenocarcinoma • Gastrointestinal Cancer • Oncology • Pancreatic Cancer • Solid Tumor • CDH17