S-38844 / Servier, Amgen - LARVOL DELTA

Transient heart rate reduction improves acute decompensated heart failure-induced left ventricular and coronary dysfunction. (PubMed, ESC Heart Fail) - "In a model mimicking human ADHF, early, but not delayed, transient HRR induced by the I current inhibitor S38844 opposes acute decompensation by preventing the decompensated-related aggravation of cardiovascular dysfunction as well as the development of pulmonary congestion, and these protective effects persist beyond the transient treatment. Whether early transient HRR induced by I current inhibitors or other bradycardic agents, i.e. beta-blockers, exerts beneficial effects in human ADHF warrants further investigation."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • MRI