Litx (talaporfin) / Light Sciences Oncology - LARVOL DELTA

A Multicenter Phase II Study on Photodynamic Therapy Using Talaporfin Sodium (ME2906) and a Semiconductor Laser (PNL6405CIN) for Intraepithelial Tumors of the Cervix. (PubMed, Reprod Med Biol) - "Talaporfin-PDT showed excellent efficacy, safety, and fertility preservation in CIN2-3, supporting its potential as a non-excisional alternative. This study was registered in the Japan Registry of Clinical Trials (jRCT) under the identifier jRCT2041190087."

Journal • P2 data • Cervical Cancer • Gynecology • Obstetrics • Oncology • Solid Tumor

Prognostic Factors and Talaporfin Sodium Concentration in Photodynamic Therapy for Recurrent Grade 4 Glioma (SNO 2025) - "TS concentration is a critical determinant of PDT efficacy, especially in recurrent glioma, highlighting its prognostic significance. Alb may affect treatment outcomes by mediating TS binding. RNA-seq findings imply that low TS concentrations may suppress immune and stress response-related genes, potentially diminishing PDT sensitivity."

Biomarker • Brain Cancer • Glioblastoma • Glioma • Solid Tumor

Antitumor effects of a novel glucose-conjugated bacteriochlorin for photodynamic therapy. (PubMed, Sci Rep) - "Talaporfin sodium (TS), widely used in Japan, has shown limited efficacy in advanced tumors, highlighting the need for novel PSs...PDT with Glc-TFPB significantly suppressed tumor growth in xenografted mice, with greater efficacy at 24 h than at 2 h after administration. These findings indicate that Glc-TFPB is a promising next-generation PS with improved tumor selectivity, deeper tissue penetration, and superior photodynamic efficacy, supporting its potential for clinical translation."

Journal • Oncology

Prognostic Factors and Talaporfin Sodium Concentration in Photodynamic Therapy for Recurrent Grade 4 Glioma (WFNOS 2025) - "TS concentration is a critical determinant of PDT efficacy, especially in recurrent glioma, highlighting its prognostic significance. Alb may affect treatment outcomes by mediating TS binding. RNA-seq findings imply that low TS concentrations may suppress immune and stress response-related genes, potentially diminishing PDT sensitivity."

Biomarker • Brain Cancer • Glioblastoma • Glioma • Oncology • Solid Tumor

Long-term outcome of PDT for local failure after CRT or RT for oesophageal cancer. (PubMed, J Gastroenterol) - P | "Talaporfin PDT for patients with oesophageal cancer with local failure after CRT can achieve long-term local complete response and long-term survival as a minimally invasive salvage treatment."

Journal • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Oncology • Squamous Cell Carcinoma

TALAPORFIN SODIUM PHOTODYNAMIC THERAPY AS A SALVAGE TREATMENT FOR LOCALLY RECURRENT ESOPHAGEAL SQUAMOUS CELL CARCINOMA: EFFICACY AND SAFETY EVALUATION (UEGW 2025) - "TS-PDT demonstrated high local control rates and favorable survival outcomes, making it a promising salvage therapy for ESCC recurrence post-CRT/RT (4). Despite some adverse events, its minimal invasiveness and reduced phototoxicity enhance its applicability, particularly in elderly or high-risk patients. The effectiveness of multiple PDT sessions supports its role as a flexible treatment strategy."

Clinical • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Gastrointestinal Disorder • Oncology • Squamous Cell Carcinoma

Talaporfin-Mediated Photodynamic Therapy Enhances Antitumor Immunity via the ROS/HIF-1α/PD-L1 Pathway in Non-Small Cell Lung Cancer (ERS 2025) - "Notably, the upregulation of PD-L1 and HIF-1α induced by PDT was reversed by N-acetylcysteine (NAC), an ROS inhibitor, and the knockdown of the HIF1A gene also reversed PDT-induced PD- L1 expression. Talaporfin-mediated PDT exhibits potent anti- tumor effects in NSCLC, potentially through activation of the ROS/HIF-1α/PD-L1 signaling pathway. The combination of PDT with PD-L1 blockade represents a promising strategy for enhancing the efficacy of PDT by modulating the tumor immune microenvironment."

IO biomarker • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • CD8 • HIF1A

Metachronous esophageal squamous cell carcinoma suspected as a second malignancy arising at the site of post-radiotherapy for esophageal adenocarcinoma. (PubMed, Clin J Gastroenterol) - "Complete remission was achieved through chemotherapy with docetaxel, cisplatin, and S-1, followed by intensity-modulated radiation therapy...Photodynamic therapy (PDT) with talaporfin sodium was administered, resulting in complete response without complications...This report underscores the importance of vigilant post-treatment surveillance and the need for tailored management strategies. Future research should focus on understanding the mechanisms of radiation-induced carcinogenesis, evaluating the long-term outcomes of PDT, and developing preventive strategies to enhance patient care and outcomes."

Journal • Esophageal Adenocarcinoma • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Fibrosis • Gastrointestinal Disorder • Oncology • Solid Tumor • Squamous Cell Carcinoma

Clinical Outcomes and Prognostic Factors in Patients Undergoing Salvage Endoscopic Therapy for cT1N0M0 Local Failure After Chemoradiotherapy for Esophageal Cancer: A Multicenter Retrospective Study. (PubMed, Dig Endosc) - "We clarified the clinical outcomes and prognosis of salvage endoscopic therapy for cT1 local failure. The Charlson Comorbidity Index may serve as a useful prognostic factor to aid in clinical decision-making."

Biomarker • Clinical data • Journal • Retrospective data • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Oncology • Squamous Cell Carcinoma

Photodynamic therapy for glioblastoma: a narrative review. (PubMed, J Neurooncol) - "PDT offers a novel targeted approach for improving local control of GBM. With continued innovation in photosensitizer design, delivery technologies, and combinatorial strategies, PDT holds promise as a viable therapeutic adjunct in GBM treatment. Further clinical validation through randomized controlled trials is warranted to establish its efficacy and gain regulatory approval with the eventual goal of integration into standard neuro-oncology practice."

Journal • Review • Brain Cancer • Glioblastoma • Glioma • Oncology • Solid Tumor

Photodynamic therapy using talaporfin sodium and semiconductor laser induces dose and time dependent cytocidal effect for human glioma derived stem cells. (PubMed, Photodiagnosis Photodyn Ther) - "Given that GSC resistance is partly attributed to hypoxic microenvironments that diminish treatment-induced oxidative damage, these findings suggest that strategies to enhance tissue oxygenation could improve the therapeutic efficacy of NPe6-PDT against GSCs. To our knowledge, this is the first study to investigate NPe6-PDT in patient-derived GSCs and provides a foundation for future translational research."

Journal • Brain Cancer • Glioblastoma • Glioma • Oncology • Solid Tumor

Efficacy and safety of talaporfin sodium photodynamic therapy as a salvage treatment for locally recurrent esophageal squamous cell carcinoma. (PubMed, Int J Clin Oncol) - "TS-PDT is a potentially effective salvage treatment for ESCC, offering efficient local control and favorable survival outcomes. Despite some adverse events, its reduced phototoxicity and versatility make it a viable option, particularly for elderly patients. Further multicenter trials are warranted to validate its role in esophageal cancer management."

Journal • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Oncology • Squamous Cell Carcinoma

cGAS-STING Pathway Activation Enhances Antitumor Effect of Talaporfin Photodynamic Therapy Through ROS Production. (PubMed, Cancer Sci) - "Furthermore, the efficacy of STING agonist (2'-3'-cyclic GMP-AMP sodium and ADU-S100) and TS-PDT combination was assessed in a xenograft tumor model. STING is an important regulator of cellular ROS homeostasis and tumor cell susceptibility to ROS in PDT. Combining a STING agonist with PDT could enhance its therapeutic efficacy and may have potential for future clinical applications."

Journal • Colorectal Cancer • Oncology • Solid Tumor

Non-Cytotoxic Photodynamic Therapy with Talaporfin Sodium Reduces the Expression of CXCR4 and Enhances Chemotherapeutic Efficacy in Undifferentiated Gastric Cancer Cell Line HGC27. (PubMed, Acta Histochem Cytochem) - "These findings highlight the potential of non-cytotoxic TS-PDT as a synergistic treatment approach. We conclude that non-cytotoxic TS-PDT could enhance drug sensitivity and offers a promising therapeutic strategy for GC."

Journal • Preclinical • Gastric Cancer • Oncology • Solid Tumor • CXCR4

Evaluation of the efficacy and safety of salvage photodynamic therapy with talaporfin sodium for lesions beyond those indicated for investigator-initiated clinical trials. (PubMed, Esophagus) - "Salvage PDT might be effective for local recurrence after CRT for lesions exceeding the indications in the investigator-initiated clinical trial."

Journal • Esophageal Cancer • Oncology

NOVEL PHOTOSENSITIZER METAL-CONJUGATED MALTOTRIOS CHLORINS WITH ENHANCED WATER SOLUBILITY FOR PHOTODYNAMIC THERAPY AND IMPROVED THERAPEUTIC EFFICACY THROUGH THE HEAVY ATOM EFFECT (DDW 2025) - "The IC 50 of M (Mal 3 -chlorin)-PDT is approximately 10 times lower than that of drugs currently used (Talaporfin sodium), suggesting that a stronger therapeutic effect could be achieved with smaller amount of the agent. Our findings suggest that M (Mal 3 -Chlorin) could serve as a promising photosensitizer due to its notable anti-tumor PDT effect."

Clinical • Gastric Cancer • Oncology • Solid Tumor

Optimizing Photodynamic Therapy for Cervical Esophageal Cancer: A Novel Technique for Precise Lesion Targeting by Transnasal Thin Endoscopy and Upward-Facing Attachment. (PubMed, Cureus) - "Photodynamic therapy (PDT) with talaporfin sodium shows promise as a salvage treatment for locoregional recurrence of esophageal cancer after chemoradiotherapy (CRT)...We report two cases with complete local control and no recurrence over one to four years. While promising, further studies are required to assess its long-term efficacy and broader applicability."

Journal • Cervical Cancer • Esophageal Cancer • Oncology

Prognostic Factors and Talaporfin Sodium Concentration in Photodynamic Therapy for Recurrent Grade 4 Glioma. (PubMed, Pharmaceuticals (Basel)) - "Alb may affect treatment outcomes by mediating TS binding. RNA-seq findings imply that low TS concentrations may suppress immune and stress response-related genes, potentially diminishing PDT sensitivity."

Biomarker • Journal • Brain Cancer • CNS Tumor • Glioblastoma • Glioma • Oncology • Solid Tumor

Photodynamic therapy and tumor-treating fields therapy for newly diagnosed glioblastoma. (PubMed, Front Oncol) - "More patients who underwent PDT + TTF relapsed with distant and/or disseminated recurrence than local recurrence, suggesting that this treatment strategy targets local recurrence. Our results demonstrate that combination therapy for newly diagnosed glioblastoma with PDT + TTF may prolong the time to recurrence and improve survival outcomes of patients, although the data in this study are preliminary."

Journal • Brain Cancer • CNS Tumor • Glioblastoma • Oncology • Solid Tumor

Mono-HOPE Versus Dual-HOPE in Liver Transplantation: A Propensity Score-Matched Evaluation of Early Graft Outcome. (PubMed, Transpl Int) - "Hypothermic oxygenated machine perfusion (HOPE) has become an integral technique to enhance donor graft function in liver transplantation (LiTx)...Results suggest that dual-HOPE did not significantly improve patient or graft survival, nor did it reduce NAS or HLS compared to mono-HOPE. Assuming that larger cohorts and long-term follow-up data confirm this, additional cannulation of the hepatic artery during machine perfusion in hypothermic conditions may not be beneficial."

Clinical • Journal • Retrospective data • Hepatology • Transplantation

Beneficial effects on T cells by photodynamic therapy with talaporfin enhance cancer immunotherapy. (PubMed, Int Immunol) - "These beneficial effects of Tal-PDT on anti-tumor immunity collectively enhance ICB cancer immunotherapy. Our study demonstrates the potential of combining Tal-PDT with ICB therapy for clinical applications."

Journal • Oncology • CD8

Clinical Benefits of Photodynamic Therapy Using Talaporfin Sodium in Patients With Isocitrate Dehydrogenase-Wildtype Diagnosed Glioblastoma: A Retrospective Study of 100 Cases. (PubMed, Neurosurgery) - "PDT with talaporfin sodium provided effective local control with minimal adverse effects. The survival time of the patients treated with PDT was significantly longer than that of the patients who did not receive PDT. Therefore, a randomized controlled clinical trial on PDT is warranted."

Clinical • Journal • Retrospective data • Brain Cancer • CNS Tumor • Glioblastoma • Glioma • Oncology • Solid Tumor

ANTITUMOR[A1] EFFECT[A2] OF TALAPORFIN PHOTO DYNAMIC THERAPY (PDT) COMBINED WITH DUAL IMMUNE CHECKPOINT INHIBITON (UEGW 2024) - "Our results demonstrate that TS-PDT not only induces a direct cytotoxic effect on tumor cells but also enhances anti-tumor immunity and exhibits synergism with dual ICIs. Therefore, these findings suggest that a combination of TS-PDT and dual ICI antibodies may be a promising approach for the development of anti-tumor therapeutics."

Checkpoint inhibition • IO biomarker • Oncology • ANXA5 • CASP3 • CD4 • CD8 • GZMB • HMGB1 • IFNG • PRF1

CGAS-STING PATHWAY ACTIVATION ENHANCES ANTI-TUMOR EFFECT OF TALAPORFIN PHOTODYNAMIC THERAPY THROUGH REACTIVE OYGEN SPECIES PRODUCTION AND DNA DAMAGE (UEGW 2024) - "We have established STING knockout cell using CRISPER-Cas9 and identified novel regulators of DNA damage in Photodynamic therapy. Our results point to a role for STING in DNA damage sensing and cyclic dinucleotide detection that goes beyond its conventional function. According to these results, talaporfin PDT is more effective when a STING agonist is used to control the degree of DNA damage."

Colon Cancer • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor • CGAS • STING

Screening of photosensitizers-ATP binding cassette (ABC) transporter interactions in vitro. (PubMed, Cancer Drug Resist) - " The ABCG2 inhibitor (fumitremorgin C) and P-gp inhibitor (valspodar) effectively blocked the transport mediated by ABCG2 and P-gp of rose bengal and BPD... In summary, our study provided new knowledge that temoporfin, talaporfin sodium, methylene blue, and indocyanine green are not substrates of ABCG2, P-gp, or MRP1...Rose bengal is a substrate of ABCG2, P-gp, and MRP1. The results presented here indicate ABC transporter substrate status as a possible cause for cellular resistance to photodynamic therapy with rose bengal, redaporfin, and BPD."

Journal • Preclinical • Breast Cancer • Oncology • Solid Tumor • ABCB1 • ABCC1 • ABCG2