Litx (talaporfin) / Light Sciences Oncology - LARVOL DELTA

Postoperative Diffusion-Weighted Imaging Hyperintensity Following Combined Photodynamic Diagnosis and Therapy Using 5-Aminolevulinic Acid and Talaporfin Sodium in Malignant Brain Tumors. (PubMed, Cancers (Basel)) - "Furthermore, there were no significant differences in the incidence of photosensitivity and liver enzyme elevation. Concomitant use of 5-ALA-PDD and TS-PDT can be used without worsening DWI findings at the PD laser irradiation site."

Journal • Brain Cancer • Oncology • Solid Tumor

Photodynamic therapy for central type early-stage lung cancer: Long-term outcomes, repeatability, and the impact of metachronous malignancies. (PubMed, Photodiagnosis Photodyn Ther) - "PDT is a robust, repeatable, lung-sparing modality for local airway control with favorable long-term survival. Morphology-informed selection of irradiation strategy and timely integration of multimodal therapy may optimize outcomes, while lifelong surveillance remains necessary due to the high incidence of metachronous malignancies."

Journal • Lung Cancer • Oncology • Solid Tumor

Rationale and design of a prospective cohort study and biobank of the offspring born to mothers with a solid organ transplant: protocol for the TransplantLines Next Generation study. (PubMed, BMJ Open) - P | "This study will be the first with detailed data on overall health status at later age in offspring born to mothers after kidney, liver, pancreas (including pancreas islet), heart and lung transplantation (KTx, LiTx, PTx, HTx and LuTx, respectively)...The results of this study are planned to be submitted for publication in relevant peer-reviewed journals and will be presented at national and international conferences. NCT07291258."

Journal • Cardiovascular • Solid Organ Transplantation • Transplantation

Integrin α6-targeted photodynamic therapy potentiates PD-1 blockade in MSS colorectal cancer. (PubMed, J Nanobiotechnology) - "In vivo fluorescence imaging demonstrated enhanced tumor accumulation and prolonged retention of Ce6-RWYD compared with the talaporfin sodium (NPe6)...Combination with anti-PD-1 further enhanced antitumor efficacy, accompanied by increased intratumoral CD8⁺ T-cell infiltration and reduced Gr-1⁺ myeloid cells. Collectively, these findings demonstrate that Ce6-RWYD-mediated PDT sensitizes MSS colorectal cancer to PD-1 blockade."

Journal • Colorectal Cancer • Metabolic Disorders • Oncology • Solid Tumor • CD8

Outcomes of a Dedicated Weight Management Clinic for Pre- and Post-Transplant Patients (ATC 2026) - "English-speaking patients who agreed to participate are enrolled in a prospective cohort study.* Over 22 months, 151/194 pre-/post-transplant/donation patients seen in the POWER Clinic consented to enrollment: 76 potential transplant candidates (48-kidney [KT], 5-liver [LiTx], 9-heart [HT],11-lung [LuTx], 1 simultaneous heart kidney [sHK], 1 simultaneous liver kidney, 1 simultaneous liver lung [sLiLu]); 12 potential kidney donors; and 1 potential liver donor... While longer follow-up is needed, the POWER Clinic is a potential model for transplant programs to increase transplant and donor eligibility through comprehensive weight management and increase access to transplantation."

Clinical • Post-transplantation • Genetic Disorders • Obesity • Transplantation

Efficacy and safety of photodynamic therapy using an ultra-thin endoscope for local failure with esophageal stenosis after chemoradiotherapy for esophageal cancer. (PubMed, Esophagus) - "UTE-PDT for local failure after chemoradiotherapy for ESCC showed short-term outcomes that did not differ substantially from those of CE-PDT and may represent a potential therapeutic option for patients with no alternative treatment options."

Journal • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Gastrointestinal Disorder • Oncology • Pain • Squamous Cell Carcinoma

Recommendation-adherent systematic lymph node sampling is not associated with increased complication rates in non-small cell lung cancer surgery-combined cardiothoracic center experience. (PubMed, J Thorac Dis) - "The number of severe complications did not differ at a statistically significant level between the groups, NS 12.4%, LS 11.2% vs. RA 17.6%, P=0.20. Main conclusion was that more extensive lymph node harvesting was not associated with increased complication rates in NSCLC patients who underwent lobectomy."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

Quantitative spectroscopic analysis of talaporfin sodium fluorescence: Utility in fluorescence-guided surgery and detection of invasive tumor cells in glioblastoma. (PubMed, Surg Neurol Int) - "They correlated with tumor density assessed by Ki-67 SI. Aggressive surgical resection, including regions with TS fluorescence intensity >1000 a.u., should be considered for maximum resection of GBs."

Journal • Brain Cancer • Glioblastoma • Glioma • Oncology • Solid Tumor

Photodynamic therapy using talaporfin sodium for grade 2/3 meningiomas: a preliminary study of safety, feasibility, and clinical outcomes. (PubMed, J Neurooncol) - "PDT combined with resection is a safe adjunctive strategy for grade 2/3 meningiomas. Our preliminary data suggest that its efficacy is limited in post-radiation recurrences, but it may delay disease progression when applied before RT. PDT should hence be considered as a therapeutic option for grade 2/3 meningiomas."

Clinical data • Journal • Retrospective data • Brain Cancer • Meningioma • Oncology • Solid Tumor

Enhanced Antitumor Efficacy of a Combination of Immunotoxin and Photosensitizer Under Illumination in Xenograft Mice. (PubMed, Biomedicines) - "In the present study, we investigated the in vivo therapeutic efficacy of iTAP using an EGFR-targeted IT composed of cetuximab conjugated to saporin (IT-Cmab), administered in combination with the clinically used photodynamic therapy (PDT) photosensitizer NPe6, in a xenograft mouse model. Overall, iTAP demonstrated the strongest and most durable therapeutic efficacy in vivo. These findings indicate that iTAP represents a promising therapeutic strategy for HNSCC."

Journal • Preclinical • Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Phase I/II Clinical Study of Next-Generation Photodynamic Therapy (L-PDT) Using Talaporfin Sodium (Laserphyrin®) for Cervical Intraepithelial Neoplasia: Efficacy, Safety, and Fertility Preservation. (PubMed, Photodiagnosis Photodyn Ther) - "These results suggest that L-PDT is a safe and highly effective non-excisional treatment for CIN that may contribute to fertility preservation; however, potential advantages over conventional conization and laser vaporization need to be confirmed in comparative studies."

Journal • P1/2 data • Cervical Cancer • Gynecologic Cancers • Gynecology • Oncology • Pain • Solid Tumor

Clinical benefits of photodynamic therapy in glioblastoma: systematic review and meta-analysis. (PubMed, J Neurosurg) - "PDT significantly improved tumor control and extended survival for patients with GBM without increasing major complications. These findings support PDT as a promising adjunctive treatment during surgery. However, further randomized clinical trials are needed to validate its long-term efficacy and to optimize treatment protocols."

Clinical • Journal • Retrospective data • Brain Cancer • Glioblastoma • Oncology • Solid Tumor

Treatment resistance factors associated with Talaporfin sodium photodynamic therapy for local control after chemoradiotherapy for esophageal cancer. (PubMed, Esophagus) - "Esophageal stenosis before Talaporfin-PDT was associated with resistance to local control and poor survival. The indications for the use of Talaporfin-PDT in patients with stenosis should be considered carefully."

Journal • Esophageal Cancer • Gastrointestinal Disorder • Oncology

Talaporfin Sodium as a Clinically Translatable Radiosensitizer in Radiodynamic Therapy. (PubMed, Biomolecules) - "Furthermore, an exploratory RNA-seq analysis of xenografts revealed transcriptional signatures of stress and immune activation, suggesting that talaporfin-mediated RDT enhances oxidative and immunogenic responses within the tumor microenvironment. These findings highlight the potential of talaporfin sodium as a clinically translatable radiosensitizer for RDT, offering a promising strategy for the treatment of deep-seated cancers such as pancreatic carcinoma."

Journal • Oncology • Pancreatic Cancer • Solid Tumor

A Multicenter Phase II Study on Photodynamic Therapy Using Talaporfin Sodium (ME2906) and a Semiconductor Laser (PNL6405CIN) for Intraepithelial Tumors of the Cervix. (PubMed, Reprod Med Biol) - "Talaporfin-PDT showed excellent efficacy, safety, and fertility preservation in CIN2-3, supporting its potential as a non-excisional alternative. This study was registered in the Japan Registry of Clinical Trials (jRCT) under the identifier jRCT2041190087."

Journal • P2 data • Cervical Cancer • Gynecology • Obstetrics • Oncology • Solid Tumor

Prognostic Factors and Talaporfin Sodium Concentration in Photodynamic Therapy for Recurrent Grade 4 Glioma (SNO 2025) - "TS concentration is a critical determinant of PDT efficacy, especially in recurrent glioma, highlighting its prognostic significance. Alb may affect treatment outcomes by mediating TS binding. RNA-seq findings imply that low TS concentrations may suppress immune and stress response-related genes, potentially diminishing PDT sensitivity."

Biomarker • Brain Cancer • Glioblastoma • Glioma • Solid Tumor

Antitumor effects of a novel glucose-conjugated bacteriochlorin for photodynamic therapy. (PubMed, Sci Rep) - "Talaporfin sodium (TS), widely used in Japan, has shown limited efficacy in advanced tumors, highlighting the need for novel PSs...PDT with Glc-TFPB significantly suppressed tumor growth in xenografted mice, with greater efficacy at 24 h than at 2 h after administration. These findings indicate that Glc-TFPB is a promising next-generation PS with improved tumor selectivity, deeper tissue penetration, and superior photodynamic efficacy, supporting its potential for clinical translation."

Journal • Oncology

Prognostic Factors and Talaporfin Sodium Concentration in Photodynamic Therapy for Recurrent Grade 4 Glioma (WFNOS 2025) - "TS concentration is a critical determinant of PDT efficacy, especially in recurrent glioma, highlighting its prognostic significance. Alb may affect treatment outcomes by mediating TS binding. RNA-seq findings imply that low TS concentrations may suppress immune and stress response-related genes, potentially diminishing PDT sensitivity."

Biomarker • Brain Cancer • Glioblastoma • Glioma • Oncology • Solid Tumor

Long-term outcome of PDT for local failure after CRT or RT for oesophageal cancer. (PubMed, J Gastroenterol) - P | "Talaporfin PDT for patients with oesophageal cancer with local failure after CRT can achieve long-term local complete response and long-term survival as a minimally invasive salvage treatment."

Journal • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Oncology • Squamous Cell Carcinoma

TALAPORFIN SODIUM PHOTODYNAMIC THERAPY AS A SALVAGE TREATMENT FOR LOCALLY RECURRENT ESOPHAGEAL SQUAMOUS CELL CARCINOMA: EFFICACY AND SAFETY EVALUATION (UEGW 2025) - "TS-PDT demonstrated high local control rates and favorable survival outcomes, making it a promising salvage therapy for ESCC recurrence post-CRT/RT (4). Despite some adverse events, its minimal invasiveness and reduced phototoxicity enhance its applicability, particularly in elderly or high-risk patients. The effectiveness of multiple PDT sessions supports its role as a flexible treatment strategy."

Clinical • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Gastrointestinal Disorder • Oncology • Squamous Cell Carcinoma

Talaporfin-Mediated Photodynamic Therapy Enhances Antitumor Immunity via the ROS/HIF-1α/PD-L1 Pathway in Non-Small Cell Lung Cancer (ERS 2025) - "Notably, the upregulation of PD-L1 and HIF-1α induced by PDT was reversed by N-acetylcysteine (NAC), an ROS inhibitor, and the knockdown of the HIF1A gene also reversed PDT-induced PD- L1 expression. Talaporfin-mediated PDT exhibits potent anti- tumor effects in NSCLC, potentially through activation of the ROS/HIF-1α/PD-L1 signaling pathway. The combination of PDT with PD-L1 blockade represents a promising strategy for enhancing the efficacy of PDT by modulating the tumor immune microenvironment."

IO biomarker • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • CD8 • HIF1A

Metachronous esophageal squamous cell carcinoma suspected as a second malignancy arising at the site of post-radiotherapy for esophageal adenocarcinoma. (PubMed, Clin J Gastroenterol) - "Complete remission was achieved through chemotherapy with docetaxel, cisplatin, and S-1, followed by intensity-modulated radiation therapy...Photodynamic therapy (PDT) with talaporfin sodium was administered, resulting in complete response without complications...This report underscores the importance of vigilant post-treatment surveillance and the need for tailored management strategies. Future research should focus on understanding the mechanisms of radiation-induced carcinogenesis, evaluating the long-term outcomes of PDT, and developing preventive strategies to enhance patient care and outcomes."

Journal • Esophageal Adenocarcinoma • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Fibrosis • Gastrointestinal Disorder • Oncology • Solid Tumor • Squamous Cell Carcinoma

Clinical Outcomes and Prognostic Factors in Patients Undergoing Salvage Endoscopic Therapy for cT1N0M0 Local Failure After Chemoradiotherapy for Esophageal Cancer: A Multicenter Retrospective Study. (PubMed, Dig Endosc) - "We clarified the clinical outcomes and prognosis of salvage endoscopic therapy for cT1 local failure. The Charlson Comorbidity Index may serve as a useful prognostic factor to aid in clinical decision-making."

Biomarker • Clinical data • Journal • Retrospective data • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Oncology • Squamous Cell Carcinoma

Photodynamic therapy for glioblastoma: a narrative review. (PubMed, J Neurooncol) - "PDT offers a novel targeted approach for improving local control of GBM. With continued innovation in photosensitizer design, delivery technologies, and combinatorial strategies, PDT holds promise as a viable therapeutic adjunct in GBM treatment. Further clinical validation through randomized controlled trials is warranted to establish its efficacy and gain regulatory approval with the eventual goal of integration into standard neuro-oncology practice."

Journal • Review • Brain Cancer • Glioblastoma • Glioma • Oncology • Solid Tumor

Photodynamic therapy using talaporfin sodium and semiconductor laser induces dose and time dependent cytocidal effect for human glioma derived stem cells. (PubMed, Photodiagnosis Photodyn Ther) - "Given that GSC resistance is partly attributed to hypoxic microenvironments that diminish treatment-induced oxidative damage, these findings suggest that strategies to enhance tissue oxygenation could improve the therapeutic efficacy of NPe6-PDT against GSCs. To our knowledge, this is the first study to investigate NPe6-PDT in patient-derived GSCs and provides a foundation for future translational research."

Journal • Brain Cancer • Glioblastoma • Glioma • Oncology • Solid Tumor