MT-3534
/ Mitsubishi Tanabe
- LARVOL DELTA
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September 15, 2025
Profiling of MT-3534, a Humanized Monoclonal Antibody Targeting Peptidylarginine Deiminase 4, as a Candidate Drug for the Treatment of RA
(ACR Convergence 2025)
- "The objectives of this study were to provide evidence that PAD4-related pathophysiology is the cause of non-response to existing bDMARDs and to profile the anti-arthritic effects of MT-3534 in mouse arthritis models. Human plasma PAD4 levels were measured in samples obtained from 29 RA patients treated with TNF inhibitors, IL-6 receptor inhibitors, or abatacept, and 25 healthy controls. MT-3534 inhibited arthritis in mice through a mechanism distinct. The unique mechanism of action of MT-3534 has the potential to fill an unmet medical need in the treatment of RA.AcknowledgementsMT-3534 was produced in collaboration with Pharma Foods International Co., Ltd."
Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • IL6
August 06, 2025
SAD Study: Clinical Pharmacology Study of MT-3534 in Healthy Adult Male Volunteers
(clinicaltrials.gov)
- P1 | N=56 | Completed | Sponsor: Mitsubishi Tanabe Pharma Corporation | Active, not recruiting ➔ Completed
Trial completion
May 29, 2025
PROFILING OF MT-3534, A HUMANIZED MONOCLONAL ANTIBODY TARGETING PAD4, AS A CANDIDATE DRUG FOR THE TREATMENT OF RA
(EULAR 2025)
- " Human plasma PAD4 levels were measured in samples obtained from 29 RA patients treated with TNF inhibitors, IL-6 receptor inhibitors, or abatacept, and 25 healthy controls...Furthermore, it was confirmed that the administration of MT-3534 to mice in which arthritis progressed despite etanercept treatment inhibited the progression of arthritis compared to mice that continued etanercept treatment alone. MT-3534 inhibited arthritis in mice through a mechanism distinct. The unique mechanism of action of MT-3534 has the potential to fill an unmet medical need in the treatment of RA."
Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • IL6
May 20, 2025
SAD Study: Clinical Pharmacology Study of MT-3534 in Healthy Adult Male Volunteers
(clinicaltrials.gov)
- P1 | N=56 | Active, not recruiting | Sponsor: Mitsubishi Tanabe Pharma Corporation | Recruiting ➔ Active, not recruiting
Enrollment closed
September 20, 2024
SAD Study: MT-3534 Clinical Pharmacology Study in Healthy Adult Male Volunteers
(clinicaltrials.gov)
- P1 | N=56 | Recruiting | Sponsor: Mitsubishi Tanabe Pharma Corporation | Not yet recruiting ➔ Recruiting
Enrollment open
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