Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap - LARVOL DELTA

Efficacy and Safety of Polyacrylamide Hydrogel for Stress Urinary Incontinence: A Retrospective Longitudinal US Study with and without OnabotulinumtoxinA. (PubMed, J Womens Health (Larchmt)) - "In this study, PAHG was associated with clinically meaningful improvement in SUI symptoms and few complications. Concomitant onabotulinumtoxinA appeared feasible in selected patients with MUI, although superiority over PAHG alone was not demonstrated. Extended follow-up findings should be interpreted cautiously because of attrition at later time points."

Journal • Retrospective data • Cough • Respiratory Diseases • Urinary Incontinence • Urology

Clinical and preclinical investigation of the mechanism promoting aura in post-traumatic headache and inhibition of pain-related behavior in mice by onabotulinumtoxinA. (PubMed, Pain) - "These findings suggest that mTBI elicits sensitization to CSD induction and promotes the emergence of aura in humans, likely contributing to PTH. It is important that, even after mTBI-induced sensitization, onabotulinumtoxinA decoupled CSD from pain behaviors, suggesting efficacy in treating PTH associated with aura."

Journal • Preclinical • CNS Disorders • Depression • Migraine • Pain • Psychiatry • Vascular Neurology

Comparison of the Effectiveness of Greater Occipital Nerve and Supratrochlear Nerve Pulsed Radiofrequency Versus Botulinum Toxin Type A Injection in Chronic Migraine (clinicaltrials.gov) - P4 | N=70 | Not yet recruiting | Sponsor: Assiut University

New P4 trial • CNS Disorders • Migraine

BTXDE: A Randomized Double-Blind Clinical Study of Intracavernosal OnabotulinumtoxinA Injection in Patients With Erectile Dysfunction Refractory to Phosphodiesterase-5 Inhibitors (clinicaltrials.gov) - P2 | N=114 | Completed | Sponsor: Clinica Universidad de Navarra, Universidad de Navarra

New P2 trial • Erectile Dysfunction

Complex Esophageal Dysphagia With Aperistalsis, Recurrent Hiatal Hernia, Gastroparesis, and Eosinophilic Esophagitis in a Pediatric Patient (ACG 2026) - "EoE, previously uncontrolled with 40â100 eosinophils/hpf and microabscesses, has been stable on dupilumab since 2023...Current planned workup includes EGD with pyloric Botox, pH probe, and esophagram...Figure: Fluoroscopic upper GI showed esophageal strictures within the mid and distal esophagus. Figure: Fluoroscopic upper GI showing gastroesophageal reflux up to the level of the mid-esophagus, extending proximal to the mid-esophageal stricture."

Clinical • Eosinophilic Esophagitis • Fibrosis • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Immunology • Infectious Disease • Pediatrics • Rare Diseases

Clinical and economic value of onabotulinumtoxinA vs oral pharmacotherapies in overactive bladder in the United States. (PubMed, J Med Econ) - "Comparators included onabotA and oral therapies (vibegron [brand], mirabegron 25/50 mg [brand and generic], and anticholinergics [generic]), using inputs for efficacy, costs, and healthcare resource use. About 1 in 4 patients treated with onabotA could achieve a 100% response over 1 year compared to 1 in at least 8 with oral pharmacotherapies. These findings support onabotA as a treatment option with demonstrated clinical and economic value for patients who do not achieve adequate symptom relief with oral OAB therapies."

Journal • Overactive Bladder • Urinary Incontinence • Urology

Antibiotic Prophylaxis for Bladder Botox (clinicaltrials.gov) - P4 | N=202 | Recruiting | Sponsor: University of Alberta | Trial completion date: Jun 2026 ➔ Jun 2028 | Trial primary completion date: Jun 2026 ➔ Jun 2028

Trial completion date • Trial primary completion date • Infectious Disease • Nephrology • Overactive Bladder

PS236. Putting It All Together: Techniques, Materials, and Multidisciplinary Care in Abdominal Wall Reconstruction (ACS-CLINCON 2026) - "Topics will include component separation (both minimally invasive anterior and posterior), chemical component separation (botox), choice of mesh and mesh inset plane, patient selection criteria and prehabilitation, soft tissue repairs (flaps), and more...Articulate the importance of multidisciplinary collaboration in the care of the complex abdominal wall reconstruction patient. Understand the differences in mesh materials currently available and whether there are different indications for their respective use."

Intraprocedural Pain During Intradetrusor Onabotulinum Toxin-A Injections: A Clinical Evaluation of Pain Distribution. (PubMed, Neurourol Urodyn) - "Intravesical onabotulinumtoxinA injections are generally well tolerated under local anesthesia, though para-trigonal injections may cause greater discomfort, particularly in patients with OAB-wet. While pain perception did not differ significantly by gender or diagnosis overall, region-specific sensitivity should be considered when planning injection techniques. These findings may help inform strategies to improve procedural comfort and support individualized treatment approaches."

Journal • Anesthesia • Overactive Bladder • Pain

Efficacy and Safety of OnabotulinumtoxinA for the Masseter Muscle: A Meta-analysis of Aesthetic and Functional Studies (EADV 2026) - No abstract available

Retrospective data • Aesthetic Medicine • Dermatology

Herpes Zoster Ophthalmicus Post-Botox Injection: A Case Report (EADV 2026) - No abstract available

Case report • Clinical • Herpes Zoster • Ophthalmology • Varicella Zoster

Glabellar chemodenervation with onabotulinumtoxinA in major depressive disorder: a systematic review and meta-analysis of 8 randomized controlled trials defining the therapeutic dose-response window (EADV 2026) - No abstract available

Retrospective data • Review • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Hyperhidrosis, botox vs surgery (EADV 2026) - No abstract available

Surgery • Dermatology

Botulinum toxin for depression (EADV 2026) - "More recent studies, including the 2024 OnaDEP randomized trial in treatment-resistant depression, have shown statistically significant efficacy of glabellar BoNT-A injections using an active-comparator design (glabellar vs. crow's feet injections, with all participants receiving active onabotulinumtoxinA), with response rates of 44.8% vs. 17.9%...3. Identify current limitations, including optimal injection sites, dosing strategies, and patient selection, and discuss BoNT-A as a potential adjunctive or alternative treatment in depression management."

CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Chemical Decompensation for Frontalis-Driven Multiple Eyelid Folds After Revision Double-Eyelid Surgery. (PubMed, Aesthetic Plast Surg) - "Chemical decompensation may provide temporary improvement during recovery while scar maturation and later reassessment proceed. The post-injection response offers supportive, case-specific information rather than a validated diagnostic test. This approach does not replace definitive revision when indicated. Prospective validation in larger cohorts is warranted."

Journal • Aesthetic Medicine

Long-term dose-effect patterns with incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA in cervical dystonia: multicenter real-world analysis (MDS Congress 2026) - No abstract available

Clinical • Real-world • Real-world evidence • CNS Disorders • Dystonia • Movement Disorders

Long-term utilization of onabotulinumtoxinA for the treatment of cervical dystonia (MDS Congress 2026) - No abstract available

CNS Disorders • Dystonia • Movement Disorders

Trends in the utilization of minimally invasive therapies for overactive bladder among older adults: a national Medicare study. (PubMed, Urology) - "Use of MITs for OAB increased from 2015-2019, mainly driven by increases in BTX. For all three types of MITs, greater levels of frailty were associated with increased utilization among beneficiaries <85 years, regardless of age, while rates for all 3 procedures were low regardless of frailty for beneficiaries ≥85, indicating that utilization of these procedures is driven more by age than frailty in the oldest age group. Further research is needed to determine the factors which influence MIT utilization rates."

Journal • Medicare • Reimbursement • US reimbursement • Overactive Bladder

Ice Water Test Unmasks Detrusor Overactivity in Apparently Normal Conventional Cystometry. (PubMed, Eur Urol Open Sci) - "Detection was more frequent in patients with an underlying neurological disorder (53% vs 34%, p = 0.004), males (57% vs 42%, p = 0.007), and those using antimuscarinics (67% vs 43%, p < 0.001) or being treated with intradetrusor onabotulinumtoxinA injections in the past year (66% vs 46%, p = 0.002)...In patients with LUTS but no DO on conventional filling cystometry, the IWT might reveal DO in approximately half of the cases. This underscores the diagnostic value of the IWT in both patients with neurological and nonneurological conditions and leads to a better understanding of LUTS-causing pathophysiology."

Journal • CNS Disorders

Beyond Botox: The Role of Burping Therapy in Retrograde Cricopharyngeal Dysfunction (AAO-HNSF 2026) - "Behavioral retraining is a feasible and effective adjuvant therapy for patients with R-CPD. Given the simplicity of the protocol and the favorable response rates observed in this cohort, "burping therapy" should be implemented broadly as a post-operative standard of care to maximize surgical success. Future investigation is warranted to determine its viability as a standalone conservative treatment for select patients."

Otorhinolaryngology

Postmarket Safety Profile of Daxxify: A Review of the FDA Adverse Event Reporting System Database (AAO-HNSF 2026) - "Daxxify demonstrates an early post-marketing safety profile dominated by expected, localized adverse events, with frequent reports of ineffectiveness and procedural complications. Comparative studies with Botox are needed to further define its real-world safety profile."

Adverse events • Clinical • P4 data • Review

Exploring the Clinical Application of High-resolution Esophageal Manometry in Dysphagia Evaluation (AAO-HNSF 2026) - "Finally, 4 CP bar patients underwent myotomy, with 3 reporting significant improvement and 4 of 9 who were newly diagnosed with EGJOO and underwent LES botox endorsed significant improvement. Our findings indicate HREM has considerable utility in dysphagia evaluation. Our findings indicate HREM has considerable utility in dysphagia evaluation. In patients with dysphagia unexplained by qualitative studies, HREM may identify underlying esophageal pathology in more than half of cases. We show that it may not be elevated absolute UES pressure that leads to CP bar formation but rather relative impaired relaxation evidenced by a smaller difference between basal and residual UES pressures."

Clinical • Gastrointestinal Disorder

Procedures for Pain: Nerve Blocks and Botox for the Otolaryngologist (AAO-HNSF 2026) - "Techniques for occipital nerve and sphenopalatine ganglion blocks, as well as onabotulinumtoxinA injection sites for headache disorders, are reviewed.Learning Objectives: • Explain the sensory and autonomic physiology of the trigeminal, parasympathetic, and occipital nerves • Understand the effect of single branch anesthesia on a multi branch neural system. • Know the technique for sphenopalatine ganglion and occipital nerve blocks and Botox injections"

CNS Disorders • Migraine • Musculoskeletal Pain • Neuralgia • Otorhinolaryngology • Pain

Management of the Partial Facial Palsy Patient: Dynamic Machine Learning Analysis of the Overlay Gracilis (AAO-HNSF 2026) - "Patient demographics and facial nerve history including alternate interventions including number of Botox sessions, physical therapy sessions prior to facial reanimation surgery as well as surgical details (choice of donor nerve, static or other interventions performed) were recorded... Facial reanimation surgery with an overlay gracilis can substantially improve smile symmetry and strength and may be performed safely with proper technique. This case series is the first dynamic analysis of smile outcomes in this patient population using a recently described video-based ML-tool."

Clinical • Machine learning • CNS Disorders • Infectious Disease

OnabotulinumtoxinA for Painful Foot Dystonia in Parkinson Disease: A Randomized, Double-Blind, Placebo-Controlled Trial. (PubMed, Neurol Clin Pract) - P2/3 | "BTXA reduced pain associated with foot dystonia in PD without adversely affecting motor outcomes and was well tolerated, supporting its use as a targeted treatment for this disabling symptom."

Clinical • Journal • CNS Disorders • Dystonia • Movement Disorders • Pain • Parkinson's Disease