terbinafine HCL / Generic mfg. - LARVOL DELTA

A zebrafish model of parn deficiency identifies altered lipid metabolism as a novel therapeutic target for restoring hematopoiesis in dyskeratosis congenita (ASH 2025) - "Larvae were treated with 10 nMfatostatin and 100 μM terbinafine hydrochloride from 24 hpf to 4 days post-fertilization. Excitingly,cholesterol inhibition with either drug significantly improved erythrocyte levels in the mutants.In sum, leveraging novel mechanistic insights and preclinical testing in the zebrafish, we present themodulation of lipid metabolism as a promising therapy to restore hematopoiesis and prevent malignancyin DC."

Aplastic Anemia • Bone Marrow Transplantation • Cardiovascular • Hematological Malignancies • Metabolic Disorders • Myelodysplastic Syndrome

P017 A multifaceted case of pyoderma gangrenosum: insights into diagnosis and management in the presence of comorbid conditions. (PubMed, Br J Dermatol) - "She initially presented with a large ulcerative lesion that was misdiagnosed as a fungal infection and treated unsuccessfully with terbinafine...The patient's treatment journey involved multiple immunosuppressive therapies, such as prednisolone and ciclosporin, although ciclosporin was later discontinued due to kidney complications. She was also treated with mycophenolate mofetil, which was halted after it aggravated her diverticular disease, and with dapsone, which was eventually stopped due to liver-related concerns...She is currently under close, multidisciplinary monitoring and is awaiting approval for biologic therapy with risankizumab, which her gastroenterology team favours over infliximab because of liver concerns...Biologic therapies, although currently restricted, represent a promising option for refractory PG. Continuous collaboration among specialists, careful monitoring of treatment impacts on comorbidities, and further research into biologic efficacy..."

Journal • Autoimmune Hepatitis • Dermatology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Nephrology • Pain • Pyoderma Gangrenosum • Renal Disease • Septic Shock • Thrombocytopenia

P097 Atypical pemphigoid and an acneiform eruption in a patient with inflammatory bowel disease. (PubMed, Br J Dermatol) - "The differential diagnosis included fungal and bacterial infections, and his scalp responded to terbinafine and ciprofloxacin, with partial improvement of his face and trunk...He responded rapidly to high-dose oral prednisolone, which was tapered over 3 months...His working diagnosis is two concurrent conditions: an atypical pemphigoid and a separate acneiform/pustular eruption possibly on the pyoderma gangrenosum-hidradenitis suppurativa spectrum in the context of irritable bowel disease. He is now well controlled on dapsone and doxycycline, with isotretinoin added recently, given an overarching clinical feature of an acneiform eruption at present."

Journal • Acne Vulgaris • Dermatology • Gastroenterology • Gastrointestinal Disorder • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Pyoderma Gangrenosum • Ulcerative Colitis

Chromoblastomycosis in an Immunocompetent Child: A Case Report. (PubMed, Cureus) - "Histopathology confirmed the presence of a brownish, dematiaceous, fungal organism with internal septations. The patient was treated with oral itraconazole and terbinafine for six months."

Journal • Infectious Disease

Trichophyton indotineae: a new diagnostic and therapeutic challenge. (PubMed, Actas Dermosifiliogr) - No abstract available

Journal • Dermatology

Unsuspected Adverse Drug Reactions to Dermatologic Medications: An Epidemiological Hypothesis-Free Screening Study of Real-World Data in Denmark. (PubMed, Drug Saf) - "Systematic hypothesis-free screening using SSA on nationwide real-world data can effectively identify potential unknown ADRs for dermatological drugs. The specific signals found in this study potentially have clinical implications and warrant further targeted investigations to support causality. This approach supports the implementation of routine real-world data screening to supplement traditional pharmacovigilance."

Adverse drug reaction • Journal • Real-world evidence • Atrial Fibrillation • Cardiovascular • Dermatology • Gastroenterology

A Case of Signal Transducer and Activator of Transcription 1 Gain of Function Mutation (ACAAI 2025) - "Discussion Despite increased in CXCL9 in response to Ruxolitinib; fungal infection has been difficult to control while on isavuconazole and ruxolitinib for approximately 12 and 9 months respectively. Antifungals was changed to high dose Posaconazole with Terbinafine. Patient is currently under medical preparation for hematopoietic stem cell transplant."

Clinical • Anemia • Atopic Dermatitis • Bone Marrow Transplantation • Dermatitis • Dermatology • Endocrine Disorders • Hematological Disorders • Immunology • Infectious Disease • Seborrheic Dermatitis • CD4 • CXCL9 • IL17A • STAT1

Efficacy Comparison of Itraconazole Pulse Therapy and Terbinafine Therapy in Treatment of Tinea Capitis in Children. (clinicaltrials.gov) - P=N/A | N=164 | Completed | Sponsor: Muhammad Aamir Latif | Recruiting ➔ Completed

Trial completion • Dermatology • Pediatrics

Breaking the mold: a case of invasive Medicopsis romeroi pulmonary infection with innovative granulocyte treatment strategy. (PubMed, ASM Case Rep) - "The nodules progressed despite a combination of posaconazole, isavuconazole, terbinafine, and liposomal amphotericin B. A course of HLA-compatible granulocytes was initiated, resulting in stabilization of the infection. This is a rare case of M. romeroi causing an invasive fungal infection of a visceral organ, the second documented M. romeroi infection in a CGD patient, and a report of a novel treatment regimen for this pathogen."

Journal • CNS Disorders • Immunology • Infectious Disease • Primary Immunodeficiency • Respiratory Diseases • Ventriculomegaly

Efficacy of Ultraviolet B Phototherapy in the Management of Resistant and Relapsing Tinea Corporis and Tinea Cruris (clinicaltrials.gov) - P=N/A | N=36 | Not yet recruiting | Sponsor: Cairo University

New trial • Dermatology

A Cross-sectional Study Comparing the in vitro Biofilm Optical Density of Dermatophytic Isolates with Clinical Profile, Risk Factors, and Antifungal Susceptibility. (PubMed, Indian J Dermatol) - "mentagrophytes ITS genotype VII" exhibits widespread resistance to terbinafine due to mutations in the squalene epoxidase gene...Biofilm density was also significantly associated with antifungal resistance, particularly against fluconazole and griseofulvin (P < 0.001)...Biofilm density correlates significantly with antifungal resistance, which may hinder clinical outcomes. These results highlight the need for tailored treatment strategies targeting biofilm-associated resistance to improve the management of chronic dermatophytosis."

Journal • Observational data • Preclinical • Dermatology

SQLE drives bladder cancer progression by boosting mitochondrial oxidative phosphorylation. (PubMed, Oncogene) - "Treatment with the SQLE inhibitor terbinafine effectively blocks this process, providing a potential therapeutic strategy to inhibit tumor progression. The Graphical Abstract was created using Smart.Servie ( https://smart.servier.com/citation-sharing/ )."

Journal • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • LONP1 • SQLE • TFAM

The First Isolation of Multiple Antifungal-Drug-Resistant Trichophyton Rubrum in China and the Novel Resistance Mechanism. (PubMed, Mycoses) - "Drug-resistant T. rubrum has emerged in China, indicating the possibly increasing severity of antifungal resistance. The complex mechanism of multidrug-resistant dermophytes poses challenges to clinical treatment, needing more attention."

Journal • Dermatology • Infectious Disease

Invasive fusariosis after CD19 chimeric antigen receptor T-cell therapy. (PubMed, ASM Case Rep) - "She developed grade 1 cytokine release syndrome (CRS) and grade 3 immune effector cell-associated neurotoxicity syndrome (ICANS), requiring dexamethasone and anakinra. Treatment with liposomal amphotericin B, voriconazole, and terbinafine followed by voriconazole and terbinafine led to clinical improvement. Though rare, healthcare providers should maintain an index of suspicion for Fusarium infections in recipients of cellular therapies with risk factors."

Journal • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Hemophagocytic lymphohistiocytosis • Immunology • Infectious Disease • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • Rare Diseases

Evaluation of Clinical Studies of Patients With Dermatophyte Infections Caused by Trichophyton indotineae: Treatment Response and Resistance to Antifungal Medications. (PubMed, Dermatol Pract Concept) - "Treatment guidelines should be established to select the appropriate alternative antifungal medication and determine the adequate drug dose and duration in treatment-resistant fungal skin infections caused by T. indotineae. Nevertheless, the data required to develop standard treatment regimens are insufficient."

Journal • Review • Dermatology • Infectious Disease

Investigating inhibitory effect of sterol targeting compounds against B. anthracis: Membrane Microdomain a probable target. (PubMed, Res Microbiol) - "These findings highlight membrane microdomains as crucial regulators of virulence in B. anthracis and identify RALBIs as promising adjunctive agents. By targeting MMd, sterol inhibitors disrupt multiple pathogenic pathways and enhance antibiotic efficacy, underscoring their potential as novel antibacterial strategies."

Journal

Targeting Metabolism to Restore Hematopoiesis in Inherited Bone Marrow Failure Syndromes: Preclinical Insights from Zebrafish Models (ASH 2024) - "We are currently investigating the effects of altered cholesterol metabolism on hematopoietic differentiation, and the potential for SQLE inhibitors such as terbinafine for rescuing cytopenia in parn-mutant DC. In summary, our zebrafish models of SDS and DC serve as promising in vivo platforms for revealing disease mechanisms and preclinical screening of targeted therapies."

Preclinical • Anemia • Aplastic Anemia • Bone Marrow Transplantation • Genetic Disorders • Hematological Disorders • Hematological Malignancies • Leukemia • Neutropenia • Oncology • Pediatrics

Tinea Blepharociliaris: A Case Report. (PubMed, Cureus) - "The condition was resolved through the administration of oral terbinafine for two weeks. This case emphasizes that tracing the source of contact and identifying subtle signs (e.g., sesame scab) in the medical history are key to the early diagnosis of fungal eyelid infection and to avoid the chronicity caused by misdiagnosis. When determining the cause of blepharitis, particular attention should be paid to a history of recalcitrance to conventional therapy and the presence of atypical lesions, such as brownish crusts."

Journal • Atopic Dermatitis • Dermatology • Dry Eye Disease • Immunology • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Impact of Antifungal Therapy on Allergic Sensitization (ACAAI 2025) - "All patients were treated with terbinafine with or without another antifungal such as itraconazole. Conclusion This pilot study suggests that airway mycosis in part drives atopy and indicates the potential of prolonged antifungal treatment to reduce allergy severity and improve quality of life in patients suffering from chronic food and environmental allergies. Prospective studies are required to confirm these findings."

Allergic Rhinitis • Asthma • Dermatology • Food Hypersensitivity • Immunology • Inflammation • Otorhinolaryngology • Respiratory Diseases • Sinusitis

A Case Of STAT3 Hyper-IgE Syndrome Complicated By Scedosporium Pneumonia And ABPA (ACAAI 2025) - "Case Description The patient had multiple bacterial and fungal pneumonias and was started on immunoglobulin replacement and prophylaxis with posaconazole and trimethoprim/sulfamethoxazole...She was subsequently diagnosed with Scedosporium apiospermum pneumonia and was started on voriconazole and terbinafine. On this therapy, she experienced worsening productive cough with continued positive sputum cultures for Scedosporium apiospermum , requiring hospitalization for intravenous micafungin...Her other atopic conditions also improved. Discussion This case highlights the first reported successful use of Dupilumab for ABPA in a patient with HIES."

Clinical • Allergic Bronchopulmonary Aspergillosis • Asthma • Atopic Dermatitis • Cough • Dermatology • Eosinophilia • Eosinophilic Esophagitis • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Musculoskeletal Diseases • Orthopedics • Pneumonia • Primary Immunodeficiency • Respiratory Diseases • STAT3

Trichophyton indotineae isolated in 2 migrant workers: An emerging fungal pathogen of global importance. (PubMed, Ann Acad Med Singap) - No abstract available

Journal • Dermatology

The first case of subcutaneous Fusariosis in an immunocompetent host in China: A case report. (PubMed, Diagn Microbiol Infect Dis) - "The patient received combined oral therapy with itraconazole and terbinafine for 2 years, with a favorable outcome. This report alerts clinicians to the possibility of F. falciforme infections in healthy individuals and emphasizes the early diagnosis and timely treatment."

Journal • Infectious Disease

A RARE CASE OF TRICHOPHYTON LUNG ABSCESS COMPLICATED BY BRAIN ABSCESS IN A PATIENT WITH NEPHRO-PLEURAL FISTULA (CHEST 2025) - "She was being treated with terbinafine and recommended to continue for 1 year, but she was lost to follow-up...She was started on IV Dexamethasone and Levetiracetam, and neurosurgery performed a craniectomy, finding a glial neoplasm and brain abscess...She was treated with IV Meropenem and transferred for rehabilitation... In this rare case, the Trichophyton lung infection was likely triggered by a nephro-pleural fistula with underlying onychomycosis and diabetes. The chronic right lower lobe lung abscess likely contributed to the development of bacteremia and a brain abscess."

Clinical • Bone Marrow Transplantation • Brain Cancer • Cardiomyopathy • CNS Disorders • Dermatology • Diabetes • Fibrosis • Hematological Malignancies • Hepatology • Hypertension • Immunology • Infectious Disease • Leukemia • Metabolic Disorders • Nephrology • Neutropenia • Pneumonia • Pulmonary Disease • Respiratory Diseases • Type 2 Diabetes Mellitus

Emerging Antifungal Resistance in Dermatophytosis: A Clinicomycological Study From North India. (PubMed, Cureus) - "Resistance was seen to fluconazole (77; 85.6%) and terbinafine (54; 60%), while itraconazole, ketoconazole, and griseofulvin were sensitive. Conclusion Dermatophytosis continues to be a significant public health concern due to its chronicity and recurrence. Irrational use of medications and emerging resistance to commonly used antifungals highlight the need for better treatment compliance and periodic monitoring of resistance patterns."

Journal • Dermatology • Infectious Disease

Efficacy and Safety of Voriconazole for Difficult-to-Treat Distal Lateral Subungual Onychomycosis (DLSO). (PubMed, Pathogens) - "Voriconazole was well tolerated and may be considered for DLSO refractory to terbinafine ± itraconazole. Antifungal stewardship remains essential."

Journal • Retrospective data • Infectious Disease