terbinafine HCL / Generic mfg. - LARVOL DELTA

Dematiaceous fungal keratitis: prevalence, spectrum, clinical features, outcome, and antifungal susceptibility from a tertiary care centre in North India. (PubMed, Med Mycol) - "Antifungal susceptibility testing (AFST) was performed as per the CLSI (Clinical Laboratory and Standards Institute) broth microdilution method (M38-A2) for a panel of 9 drugs including voriconazole, itraconazole, posaconazole, luliconazole, miconazole, ketoconazole, amphotericin-B, natamycin and terbinafine. as the predominant causative agent. In vitro susceptibility of voriconazole demonstrated better performance against DFK isolates."

Journal • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology

Diaporthe fructicola as a Cause of Subcutaneous Hyalohyphomycosis. (PubMed, Mycopathologia) - No abstract available

Journal

Impact of filter selection on UPLC quantification of terbinafine hydrochloride: Optimization of sample preparation and method validation. (PubMed, J Pharmacol Toxicol Methods) - "Robustness testing confirmed that small variations in flow rate, column temperature, and mobile phase composition did not significantly affect quantification. These results demonstrate that syringe filter selection is a critical parameter in terbinafine hydrochloride analysis and highlight the importance of optimized sample preparation in pharmaceutical quality control."

Journal • Infectious Disease

Fulzerasib in Combination With Omeprazole Pretreatment and/or Terbinafine in KRAS G12C Mutant Lung Cancer Cell Lines (IASLC-WCLC 2026) - "Introduction : Fulzerasib plus cetuximab demonstrate significant clinical outcomes in KRAS G12C-mutant NSCLC patients (Gregorc et al. Western blot analysis confirms the broad shutdown effect of the triple combination on multiple receptors and critical downstream effectors that confer resistance to KRAS G12C inhibitors. Clinical translational relevance warrants being highlighted."

Combination therapy • Preclinical • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • AURKA • EGFR • HES1 • KEAP1 • KRAS • SOX2 • SQLE • STK11

Molecular correlates of elevated terbinafine and fluconazole MICs in Trichophyton mentagrophytes complex isolates. (PubMed, Med Mycol) - "The MDR2 V438I variant appears to be species associated and showed no evident relationship with reduced fluconazole susceptibility. These findings define molecular associations within this clinical collection but do not establish causality."

Journal • Dermatology • Infectious Disease • ABCB4 • SQLE

TOR kinase inhibition reverses azole resistance in Candida auris by targeting heme biosynthesis. (PubMed, Arch Microbiol) - "We show that Hemin confers stress-specific protection in C. auris, rescuing growth and biofilm defects caused by Fluconazole (Flc) and the TOR kinase inhibitor Torin2...Notably, scavenged heme from Sheep Blood increased MICs for azoles and terbinafine, demonstrating heme-mediated drug tolerance...This study highlights the crucial link between the TOR pathway and heme and ergosterol metabolism, which contributes to drug resistance. It proposes targeting heme dynamics as a promising avenue for combination antifungal therapies, potentially improving clinical outcomes against C. auris and other resistant fungal pathogens."

Journal • Infectious Disease

Diversity of ITS Genotypes in Trichophyton mentagrophytes Species Complex Isolates Causing Tinea Corporis and Tinea Capitis: A Multicenter Study in France. (PubMed, Med Mycol) - "Twelve of the 21 T. indotineae isolates grew on a terbinafine screening medium and harbored the F397L or L393S substitution in the SQLE sequence. The emerging pathogens T. indotineae and T. mentagrophytes ITS genotype VII together account for 39.1% of T. mentagrophytes species-complex isolates identified in three private laboratories In France and infecting glabrous skin or scalp."

Clinical • Journal • Dermatology • Infectious Disease

Exploring a Persistent Terbinafine - CYP2D6 Interaction Using Physiologically - Based Pharmacokinetic Modeling. (PubMed, AAPS J) - "Experimentally determined Kiu,CYP2D6 for TBNF and DMT enabled to predict the interaction with CYP2D6 substrates Desipramine, Amitriptyline and Nortriptyline. This PBPK framework can be applied in different clinical pharmacology settings for drugs characterized by extensive distribution, formation rate limited metabolism and enzyme inhibition. The framework provides applicability in informing the rational design of clinical trials where sustained plasma drug levels warrant patient monitoring long after termination of dosing."

Journal • PK/PD data • Infectious Disease

Microbial community structure in tinea corporis and antifungal activity of Lactiplantibacillus plantarum YM-4-3 strain. (PubMed, Front Cell Infect Microbiol) - "Ketoconazole (MIC < 1 μg/mL) and terbinafine (MIC 1-2 μg/mL) were highly active against T. rubrum, while amphotericin B (MIC < 1 μg/mL) was most effective against C. albicans. These findings reveal distinct microbial signatures associated with tinea corporis and demonstrate the salt-dependent antifungal potential of L. plantarum YM-4-3. This study provides a theoretical basis for novel antifungal probiotic formulations and offers a new strategy to circumvent adverse effects and resistance associated with conventional antifungal therapies."

Journal • Dermatology • Infectious Disease • GDF15

A Case of Kerion Celsi due to Trichophyton rubrum Successfully Treated with Fosravuconazole. (PubMed, Med Mycol J) - "The oral antifungal medicines approved for treatment of tinea capitis in Japan are limited to itraconazole and terbinafine hydrochloride. However, itraconazole has many contraindicated drugs, and antifungal resistance has recently become a major concern.As the challenge of drug-resistant fungi is expected to become more significant in the future, the clinical benefits of using fosravuconazole L-lysine ethanolate (F-RVCZ) for treating kerion celsi may increase. Our experience suggests that F-RVCZ could be a valuable therapeutic option."

Journal • Dermatology

Microsporum canis Complex Infections in the United Arab Emirates: Clinical, Molecular, and Antifungal Susceptibility Profiles. (PubMed, Med Mycol) - "All isolates showed low MICs (terbinafine MIC₅₀/₉₀ 0.015/0.03; itraconazole ≤0.03/0.06; voriconazole ≤0.03/≤0.03; griseofulvin 0.125/0.25; fluconazole 4/8 µg/mL). This first molecular and antifungal characterization of M. canis complex infections in the UAE over three decades showed that ITS sequencing corrected phenotypic identification in nearly 10% of cases. High recurrence despite low MICs suggests limited predictive value of in vitro susceptibility, supporting species directed management, molecular confirmation, species-directed management, and One Health strategies."

Journal • Dermatology • Infectious Disease • Pediatrics

Use of Terbinafine in pulse therapy for Onychomycosis: a multicenter study of 29 patients (EADV 2026) - No abstract available

Clinical • Infectious Disease

Terbinafine susceptibility with dual squalene epoxidase alterations in Trichophyton mentagrophytes: a case of Majocchi's granuloma (EADV 2026) - No abstract available

Clinical • Infectious Disease

Pooled Effectiveness of Terbinafine Versus Griseofulvin in the Management of Tinea Capitis: A Systematic Review and Meta-Analysis. (EADV 2026) - No abstract available

Retrospective data • Review • Dermatology

Emergence of difficult-to-treat lymphocutaneous sporotrichosis? Analysis based on two cases with Sporothrix brasiliensis isolates with high itraconazole and terbinafine MICs (EADV 2026) - No abstract available

Clinical • Infectious Disease

Comparative efficacy of Voriconazole versus High-Dose Terbinafine in Recalcitrant Tinea Corporis and Cruris. (EADV 2026) - No abstract available

Clinical • Dermatology

KID Syndrome Associated with Inflammatory Tinea Capitis Misdiagnosed as Scalp Involvement of the Disease: Successful Treatment with Terbinafine (EADV 2026) - No abstract available

Dermatology

Squalene Epoxidase in Cancer: Mechanistic Insights, Therapeutic Potential, and Future Perspectives. (PubMed, Exp Cell Res) - "We objectively dissect the pharmacokinetic bottlenecks limiting terbinafine's single-agent anti-tumor efficacy and discuss the developmental advantages and toxic challenges of human-specific SQLE inhibitors. Finally, we highlight unresolved research gaps, prioritize translational directions including SQLE expression as a potential biomarker for immunotherapy responsiveness requiring independent cohort validation, the development of low-toxicity selective SQLE degraders, and synergistic regimens combining SQLE blockade with immune checkpoint inhibitors or ferroptosis inducers, offering a comprehensive and critical update for lipid metabolism and tumor immunology researchers."

IO biomarker • Journal • Review • Metabolic Disorders • Oncology • PD-L1 • SQLE

Global Spread of Trichophyton indotineae Tracked by Mass Spectrometry Identification Network, 2022-2025. (PubMed, Emerg Infect Dis) - "Trichophyton indotineae is an emerging dermatophyte that is often resistant to terbinafine. We analyzed data produced by the Mass Spectrometry Identification global network. Those data revealed a 3-fold increase in T. indotineae identification during 2022-2025, demonstrating that this application is an effective tool for monitoring global spread of this pathogen."

Journal • Dermatology • Dermatopathology • Infectious Disease

In vivo and in silico evaluation of terbinafine on oxidative stress and detoxification enzymes in the adult endoparasitic wasp, Pimpla turionellae L. (Hymenoptera: Ichneumonidae), reared on a natural host, Galleria mellonella L. (Lepidoptera: Pyralidae). (PubMed, Comp Biochem Physiol C Toxicol Pharmacol) - "In conclusion, TRB exposure via the host affects the oxidative status and detoxification enzymes of P. turionellae. However, the overall in vivo and in silico findings have strengthened the possibility of TRB being a suitable candidate for use in pest control."

Journal • Preclinical

Paediatric Tinea Capitis in New Zealand: A Case Series. (PubMed, Australas J Dermatol) - "The species was never established in 16 children. Most were treated with an oral antifungal (31 of 41), itraconazole most often."

Journal • Alopecia • Dermatology • Immunology • Pediatrics

Prolonged survival of 3 dogs with Prototheca bovis infection treated with posaconazole. (PubMed, J Vet Intern Med) - "The third dog survived 21 months before death because of central nervous system dissemination; additional treatments included itraconazole, AMB, terbinafine, and immunotherapy using an autologous vaccine. Posaconazole was well tolerated in all dogs and can be considered a therapeutic option for dogs with enteric protothecosis."

Journal • Infectious Disease

Establishment of epidemiological cutoff values against Purpureocillium lilacinum. (PubMed, J Clin Microbiol) - "AFST was performed by broth microdilution (CLSI M38 standard) for itraconazole, voriconazole, posaconazole, isavuconazole, terbinafine, flucytosine, amphotericin B, natamycin, and manogepix. Caution is needed in interpreting itraconazole AFST results due to high interlaboratory variability. These antifungal in vitro susceptibility data suggest limited options to treat P. lilacinum infections."

Journal • Infectious Disease • Ocular Infections • Ophthalmology

In vitro susceptibility and provisional epidemiological cutoff values for eight antifungal agents against Trichophyton mentagrophytes and Trichophyton interdigitale: a multicenter study from China. (PubMed, J Clin Microbiol) - "The remaining seven agents yielded ECVs of 1 µg/mL for ciclopirox olamine and griseofulvin, 0.5 µg/mL for itraconazole, 0.06 µg/mL for voriconazole, 0.25 µg/mL for posaconazole and amorolfine, and 0.016 µg/mL for terbinafine. For T. interdigitale, fluconazole showed a complex non-unimodal distribution, whereas itraconazole and posaconazole showed unstable low-MIC shoulders precluding ECV estimation...In this multicenter study, we established provisional epidemiological cutoff values for most tested species-agent combinations and showed that these two closely related species differ in MIC distribution profiles and in the detection of non-wild-type isolates. These data provide practical laboratory thresholds for recognizing isolates with reduced susceptibility, highlight the limitations of complex-level interpretation, establish a contemporary baseline for dermatophyte susceptibility surveillance in China, and may help support laboratory-informed..."

Clinical • Journal • Preclinical • Dermatology • Infectious Disease

Dermkielia cavawata sp. nov. gen. nov., Isolated From Plantar Eczema. (PubMed, Mycoses) - "Dermkielia gen. nov. (IF 905143) is introduced with Dermkielia cavawata sp. nov. (IF 905164) as the type species. Related ITS sequences in NCBI GenBank suggest that additional species of Dermkielia may be discovered. Dermkielia cavawata is presumably geophilic and possibly linked to forest ecosystems, but it possesses traits that may facilitate opportunistic colonization of human keratinized tissue."

Journal • Atopic Dermatitis • Dermatology • Immunology • Infectious Disease