LMT503
/ Lmito Therap, Samyang Group
- LARVOL DELTA
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March 03, 2025
NAD+ modulation of intestinal macrophages renders anti-inflammatory functionality and ameliorates gut inflammation.
(PubMed, Biomed Pharmacother)
- "Depletion of CX3CR1 expressing gut resident macrophages abrogated the immune regulatory effect of LMT503 in the colon. These data suggest that LMT503 is a therapeutic candidate that can target macrophages to drive polarization with an immunosuppressive character and ameliorate IBD."
Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • CX3CR1 • IL10 • IL6 • MRC1 • NQO1 • SIRT1 • SIRT3 • SIRT6 • TNFA
October 23, 2024
LMT503 First-in-human SAD, MAD, and FE Study
(clinicaltrials.gov)
- P1 | N=72 | Not yet recruiting | Sponsor: Lmito Therapeutics Inc. | Trial completion date: Mar 2025 ➔ Mar 2026 | Trial primary completion date: Oct 2024 ➔ Oct 2025
Trial completion date • Trial primary completion date • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis
May 10, 2024
Anti -Inflammatory Effect of LMT503, a Modulator of Immune Cell Metabolism, on Murine Adoptive T Cell Transfer -Induced Colitis Model
(IMKASID 2024)
- "Conclusion : Our data suggest that the anti-inflammatory effect of LMT503 ameliorates murine adoptive T cell transfer-induced colitis by modulating cellular metabolism and immune cell modulation. Therefore, LMT503 may represent a novel therapeutic drug that opens new avenues for the treatment of IBD."
Immune cell • Preclinical • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • IL2RA • ISG20 • RAG1
March 18, 2024
LMT503 First-in-human SAD, MAD, and FE Study
(clinicaltrials.gov)
- P1 | N=72 | Not yet recruiting | Sponsor: Lmito Therapeutics Inc. | Trial completion date: Dec 2024 ➔ Mar 2025 | Trial primary completion date: Jul 2024 ➔ Oct 2024
Trial completion date • Trial primary completion date • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis
December 15, 2023
LMT503 First-in-human SAD, MAD, and FE Study
(clinicaltrials.gov)
- P1 | N=72 | Not yet recruiting | Sponsor: Lmito Therapeutics Inc. | Trial completion date: Mar 2024 ➔ Dec 2024 | Trial primary completion date: Dec 2023 ➔ Jul 2024
Trial completion date • Trial primary completion date • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis
July 09, 2023
ANTI-INFLAMMATORY EFFECT OF LMT503, A MODULATOR OF CELL METABOLISM, AMELIORATES MURINE ADOPTIVE T CELL TRANSFER-INDUCED COLITIS
(UEGW 2023)
- "Our data suggest that the anti-inflammatory effect of LMT503 ameliorates murine adoptive T cell transfer-induced colitis by modulating cellular metabolism and immune cell modulation. Therefore, LMT503 may be a novel therapeutic drug that opens new avenues for the treatment of IBD."
Preclinical • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • IFNG • IL1B • IL2 • IL2RA • IL6 • ISG20 • MPO • PPARGC1A • RAG1 • TNFA
December 23, 2022
LMT503, A NOVEL THERAPY FOR INFLAMMATORY BOWEL DISEASE THROUGH MACROPHAGE POLARIZATIONS BY METABOLIC REPROGRAMMING OF ACTIVATED MACROPHAGE
(CCCongress 2023)
- "In summary, LMT503 was very efficacious in various IBD in vivo models with showing the resolution of intestinal inflammation and mucosal healing through improved epithelial restitution via macrophage polarizations, and this approach can be a very effective and safe therapy for multifaceted IBD. The first in human study with LMT503 will be initiating in 4Q 2022."
Fibrosis • Gastroenterology • Gastrointestinal Disorder • Immune Modulation • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • CD68 • CD80 • CD86 • IL10 • IL18 • IL1B • IL22 • IL6 • MRC1 • TNFA
December 21, 2022
LMT503 First-in-human SAD, MAD, and FE Study
(clinicaltrials.gov)
- P1 | N=72 | Not yet recruiting | Sponsor: Lmito Therapeutics Inc.
New P1 trial • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis
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