CFX-1 / Akari Therap - LARVOL DELTA

Coagulation Pediatric Reference Interval Study: Procoagulant Proteins Preliminary Findings (ASH 2024) - "Assay mean and range were calculated.ResultsInsufficient numbers of patients <1yr were collected.Type of assay, age range in yr and number of samples (n), assay mean in % and range results respectively were as follows : PCAG1-5 (n=15) 87(46-146); 5-10 (n=82) 81 (45-158); 10-15 (n=169) 84 (44-157); 15-18 (n=107) 91 (57-149).PCFX1-5 (n=20) 97 (56-140); 5-10 (n=84) 89 (62-135); 10-15 (n=188) 91 (55-140); 15-18 (n=124) 96 (54-138).PST (males) : 1-5 (n=10) 120 (96-145); 5-10 (n=46) 108 (75-150); 10-15 (n=91) 111 (80-168); 15-18 (n=63) 113 (72-184).PST (females) : 1-5 (n=9) 104 (67-146); 5-10 (n=37) 111 (81-159); Ages 10-15 (n=94) 107 (78-153); 15-18 (n=63) 101 (65-148).PSF (males) : 1-5 (n=10) 94 (74-109); 5-10 (n=47) 101 (66-141); 10-15 (n=93) 101 (69-151); 15-18 (n=62) 111 (74-187).PSF (females) : 1-5 (n=9) 78 (9-124); 5-10 (n=37) 107 (79-137); 10-15 (n=95) 99 (63-138); 15-18 (n=63) 97 (60-132).SFX (males) : 1-5 (n=9) 100 (85-128); 5-10 (n=48) 104 (66-144); 10-15 (n=93)..."

Clinical • Pediatrics • PROS1

Effects of heavy metals on variation in bacterial communities in farmland soil of tailing dam collapse area. (PubMed, Sci Rep) - "The genera of UTCFX1 (Chloroflxi) and norank_TRA3-20 had strong tolerance to the heavy metal Hg...Therefore these can be used as indicators for monitoring potential heavy metal contamination. The results can be used to predict the changes in the ecosystem of the mining area to maintain its ecological balance and health."

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A Comparative Analysis of Bacterial and Fungal Communities in Coastal and Inland Pecan Plantations. (PubMed, Microorganisms) - "Bacillus, Nitrospira and UTCFX1 were significantly more abundant bacterial genera in DF soil, whereas Candidatus Udaeobacter, HSB_OF53-F07 and ADurbBin063-1 were more prevalent in GM soil...Significantly positive correlations were detected between certain bacterial and fungal genera and pH and total soluble salt content, suggesting their role in pecan adaptation to coastal environments and saline-alkali stress mitigation. These findings enhance our understanding of soil microbiomes in coastal pecan plantations, and are anticipated to foster ecologically sustainable agroforestry practices and contribute to coastal marshland ecosystem management."

Journal • Immunology • Scleroderma • Systemic Sclerosis

Effects of Different Farming Modes on Salmo trutta fario Growth and Intestinal Microbial Community. (PubMed, Microorganisms) - "Notably, the dominant genera of Salmo trutta fario gut microbiota varied across farming modes: for instance, in the FTA model, the most prevalent genera were SC-I-84 (7.34%), Subgroup_6 (9.93%), and UTCFX1 (6.71%), while, under RA farming, they were Bacteroidetes_vadinHA17 (10.61%), MBNT15 (7.09%), and Anaeromyxoactor (6.62%)...Transparency, pH, dissolved oxygen, conductivity, total dissolved solids, and temperature emerged as pivotal factors influencing Salmo trutta fario gut microbiota under diverse farming conditions. These research findings offer valuable scientific insights for fostering healthy aquaculture practices and disease prevention and control measures for Salmo trutta fario, holding substantial significance for the sustainable development of the cold-water fish industry in the Qinghai-Tibet Plateau."

Journal • Metabolic Disorders

Soil microorganisms play an important role in the detrimental impact of biodegradable microplastics on plants. (PubMed, Sci Total Environ) - "The abundance of Methyloversatilis, IS-44, and UTCFX1 in the rhizosphere bacterial community increased significantly in the presence of PBAT-MPs...Furthermore, a higher percentage of strains with PBAT-MPs-degrading ability was found in PBAT-MPs-soil. Our results confirm that PBAT-MPs significantly inhibit the growth of vegetable crops and that soil bacterial communities affected by PBAT-MPs are instrumental in degrading them."

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A new quantitative insight: Interaction of polyethylene microplastics with soil - microbiome - crop. (PubMed, J Hazard Mater) - "Age-PE MPs significantly affected soil microbial diversity, mainly caused by bacterial genera such as UTCFX1, Sphingomonas, Subgroup-6 and Gemmatimonas. Age-PE MPs also affected some metabolism related to microbial community composition and maize growth, including Glycerolipid, Citrate cycle (TCA cycle), C5-Branched dibasic acid, Arginine and proline, Tyrosine metabolism, pentose phosphate pathway, Valine, leucine and isoleucine biosynthesis. These research results indicated that the PE MPs, which are widely present in farmland soils, can affect crop growth, soil microbial community and metabolic function after aging, thus affecting agroecosystems and terrestrial biodiversity."

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The synergistic mechanism of β-lactam antibiotic removal between ammonia-oxidizing microorganisms and heterotrophs. (PubMed, Environ Res) - "In this study, the mechanism of β-lactam antibiotic (cefalexin, CFX) removal was studied in a nitrifying sludge system. Results showed that CFX was synergistically removed by AOB (Nitrosomonas, played a major role) and AOA (Candidatus_Nitrososphaera) through ammonia monooxygenase-mediated co-metabolism, and by heterotrophs (Pseudofulvimonas, Hydrogenophaga, RB41, Thauera, UTCFX1, Plasticicumulans, Phaeodactylibacter) through antibiotic resistance genes (ARGs)-encoded β-lactamases-mediated hydrolysis. Regardless of increased archaeal and heterotrophic CFX removal with the upregulation of amoA in AOA and ARGs, the system exhibited poorer CFX removal performance at 10 mg/L, mainly due to the inhibition of AOB. This study provides new reference for the important roles of heterotrophs and ARGs, opening the possibilities for the application of ARGs in antibiotic biodegradation."

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"$CIEN C&W Networks Upgrades CFX-1 and EWC Submarine Cables with Ciena https://t.co/l6MeJVMI1L" (@stock_titan)

Research on removal of fluoroquinolones in rural domestic wastewater by vertical flow constructed wetlands under different hydraulic loads. (PubMed, Chemosphere) - "Devosia, Pseudorhodoferax, Cellvibrio, Bosea, Caulobacter, Acinetobacter, Zoogloea, Arcobacter, Dechloromonas, Flavobacterium, Nakamurella, Chloroplast, Clostridium_sensu_stricto_1, Pelosinus, UTCFX1 and Hypnocyclicus became the new dominated genera and were essential to remove pollutants. In summary, VFCW was an effective system to remove fluoroquinolones in rural domestic wastewater."

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Dioecious hemp (Cannabis sativa L.) plants do not express significant sexually dimorphic morphology in the seedling stage. (PubMed, Sci Rep) - "To answer these questions, we collected data on phenotypic traits of 112 C. sativa plants (50 female, 52 male, 10 co-sexuals) from two hemp cultivars (CFX-1, CFX-2) during the second week of vegetative growth and used ANOVAs to compare morphology among sexes...Our preliminary data suggests that short hypocotyl length may be an indicator of co-sexuality. These results are the first steps towards developing diagnostic tools for predicting sex using vegetative morphology in dioecious species and understanding how sexual dimorphism influences phenotype preceding sexual maturity."

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"https://t.co/b5nIy4cFX1" (@ProfDFrancis)

Antinociceptive effects of ceftriaxone in formalin-induced nociception. (PubMed, Drug Dev Res) - "We also tested the effect of CFX 1 day after its administration and in two schedules of repeated administration. Repeated administration (daily during 3 or 7 days) with CFX (50-400 mg/kg, ip) diminished formalin-induced nociception. Results suggest that local or systemic as well as single or repeated administration of CFX reduces formalin-induced nociception."

Journal • Pain