tazarotene topical / Generic mfg. - LARVOL DELTA

A Novel Role for Tazarotene-induced Gene 1 in Suppressing Melanoma Growth - Schlafen 11. (PubMed, Front Biosci (Landmark Ed)) - No abstract available

Journal • Melanoma • Oncology • Solid Tumor

Clinical research of Tazarotene Betasone Cream in the Treatment of Chronic Eczema (ChiCTR) - P4 | N=150 | Recruiting | Sponsor: Shenzhen University General Hospital; Shenzhen University General Hospital

New P4 trial • Atopic Dermatitis • Dermatology • Immunology

Efficacy and safety of tazarotene betasone cream in the treatment of inflammatory lichen/keratotic dermatosis: a randomized, controlled study (ChiCTR) - P4 | N=420 | Not yet recruiting | Sponsor: Xi'an Jiaotong University Second Affiliated Hospital; Xi'an Jiaotong University Second Affiliated Hospital

New P4 trial • Amyloidosis • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Single Cell Fixed RNA Profiling reveals Hepatocytes (Cyp2e1+Cyp1a2+Tnx1+) drives liver fibrosis regression via retinoic acid receptor responder 2 (APASL 2025) - "Pharmacological induction of RARRES1/2 expression in human hepatic stellate cells (HHSteCs) using all-trans retinoic acid, adapalene, bexarotene, or tazarotene dose-dependently suppressed HSC activation by downregulating COL1A1 and α-SMA expression. This study uncovered previously unrecognized molecular and cellular mechanisms of hepatocytes in liver fibrosis regression, identifying RARRES2 as a potential biomarker and therapeutic target for antifibrotic treatment. Table and Figure:Figure 1. Figure 2."

Fibrosis • Hepatology • Immunology • Liver Cirrhosis • COL1A1 • CYP1A2 • CYP2E1 • RARRES1 • RARRES2 • TGFB1

Combined cryotherapy and topical imiquimod, 5-fluorouracil, and tazarotene effectively treats locally advanced basal cell carcinoma and is associated with nearby nodular basal carcinoma regression. (PubMed, JAAD Case Rep) - No abstract available

Journal • Basal Cell Carcinoma • Non-melanoma Skin Cancer • Oncology

A Retrospective Analysis of Adherence to Acne Treatment Guidelines (AAD 2025) - "Topical treatments (adapalene, benzoyl peroxide, tazarotene, tretinoin, trifarotene) tried within 12 months prior to antibiotics were included. This study provides an automated approach to assess adherence to acne treatment guidelines. Next steps involve educating providers on these guidelines and assessing changes in adherence."

Adherence • Retrospective data • Acne Vulgaris • Dermatology • Dermatopathology • Hidradenitis Suppurativa • Immunology • Infectious Disease • Malaria • Pneumonia • Respiratory Diseases • Rosacea

Rural-urban disparities in the use of FDA-approved steroid-sparing topical medications for inflammatory dermatologic conditions: A DataDerm study (AAD 2025) - " Compared to rural patients, urban patients were more likely to be prescribed 3 of 6 topicals queried: crisaborole (OR 1.46, p<0.001), roflumilast (OR 11603130, p<0.001), and tacrolimus (OR 1.57, p<0.001). While odds ratios for pimecrolimus, tapinarof, and tazarotene also exceeded 1.0, no statistically significant differences were observed for these medications. There is an evident disparity in prescribing patterns for steroid-sparing topical medications between urban and rural populations, with the former being less likely to incur steroid-related adverse effects such as dermal atrophy. This could be attributable to differences in the concentration of dermatologists between these areas (4), with rural patients encountering significantly more obstacles in accessing dermatologic care."

Atopic Dermatitis • Dermatitis • Dermatology • Hidradenitis Suppurativa • Immunology • Inflammation • Psoriasis

Linear Darier Disease Treated with Ruxolitinib: A Case Report and Review of the Literature (AAD 2025) - "A treatment trial of topical ruxolitinib, ammonium lactate, and tazarotene was initiated. This case report presents the first documented use of ruxolitinib for linear Darier disease, demonstrating its potential as an effective treatment option for managing this rare genodermatosis. Further research is needed to establish ruxolitinib's role in the treatment of Darier disease."

Case report • Clinical • Review • Dermatology • Oncology • Pruritus

Cleanse, Treat, Moisturize, Protect (CTMP®) regimen: Enhancing skin quality and treatment outcomes in acne and sensitive skin (AAD 2025) - "Retinoids, such as adapalene, tretinoin, tazarotene, and trifarotene, are considered fundamental topical acne treatments as they target multiple disease aspects (5), and are frequently studied with regimens of cleansers, moisturizers, and protection (6-11). The review also found that combined drug treatments (e.g., topical trifarotene or other retinoids) and corrective procedures (e.g., fillers) may provide optimal treatment outcomes and satisfaction for some patients (21). Overall, the narrative review found that CTMP® may improve adherence, treatment outcomes, patient satisfaction, and overall skin quality in patients with acne and/or sensitive skin."

Clinical • Acne Vulgaris

Comparison of Efficacy of the Combination of Topical Tazarotene Gel and Oral Fluconazole Versus Oral Fluconazole Monotherapy in the Treatment of Onychomycosis. (PubMed, Cureus) - "The efficacy of oral weekly fluconazole combined with daily topical tazarotene 0.1% gel is significantly higher than that of weekly fluconazole monotherapy in the treatment of OM."

Journal • Monotherapy • Dermatology • Infectious Disease

Retinoids as Alternative Antifungal Agents Against Candida albicans: In Vitro and In Silico Evidence. (PubMed, Microorganisms) - "Here, we further investigated the possible anti-Candida potential of trifarotene and tazarotene, which are the other two molecules belonging to the retinoid family, compared to ATRA. In silico studies suggest that all three retinoids may exert antifungal activity through their molecular interactions with the heat shock protein (Hsp) 90 and 14α-demethylase of C. albicans. Moreover, interactions between retinoids and ergosterol have been observed, suggesting that those compounds have great potential against C. albicans infections."

Journal • Preclinical • Candidiasis • Dermatology • Infectious Disease

Recommendations to Improve Outcomes in Acne and Acne Sequelae: A Focus on Trifarotene and Other Retinoids. (PubMed, Dermatol Ther (Heidelb)) - "Adapalene, tretinoin and tazarotene have demonstrated efficacy in reducing acne and acne sequelae in several studies. Finally, management of acne and acne sequelae should include maintenance therapy with topical retinoids. This article supports the American Academy of Dermatology's call for acne sequelae treatment guidance and emphasizes the need for continued research to optimize patient care."

Journal • Acne Vulgaris • Dermatology

Optimization and Validation of an Ultra-Performance Liquid Chromatography with Quadrupole Detector Mass Spectrometry Quantification Method for the Simultaneous Detection of Tazarotene and Tazarotenic Acid in Porcine Skin: An In Vitro Study. (PubMed, Int J Mol Sci) - "Chromatographic analysis demonstrated acceptable accuracy and precision (<15%), and stability tests confirmed the analytes' stability under various conditions. This validated method offers a reliable and accurate approach for the simultaneous analysis of tazarotene and tazarotenic acid, facilitating further research into their therapeutic applications for hand osteoarthritis."

Journal • Preclinical • Immunology • Osteoarthritis • Pain • Rheumatology

Developing a method for the study of perfusion effects in topical product pharmacokinetics. (PubMed, Eur J Pharm Sci) - "The observed permeation differences in lipid-rich and lipid-poor regions in perfused and non-perfused skin reflects increased tazarotene permeation rate and removal in the presence of perfusion (in vivo) and decreased permeation rate and lack of elimination route in the absence of perfusion (ex vivo). Our method is demonstrated to be effective in assessing in vivo perfusion effects on topical drug uptake, promoting a better understanding of the influence of perfusion on topical drug delivery."

Journal • PK/PD data • Dermatology

Empagliflozin Attenuates Renal Tubular Ferroptosis in Preeclampsia via Tazarotene-Induced Gene 1. (PubMed, Eur J Pharmacol) - "Furthermore, we demonstrated that tazarotene-induced gene 1 is involved in AT1-AA-induced PTEC injury. These findings suggest that renal tubules are injured in PE and empagliflozin has therapeutic potential for PE-induced PTEC injury."

Journal • Chronic Kidney Disease • Gynecology • Nephrology • Renal Disease • KIM1

One Acne™: a holistic management approach to improve overall skin quality and treatment outcomes in acne with or without sensitive skin. (PubMed, Int J Dermatol) - "Tretinoin, trifarotene, adapalene, and tazarotene have all been assessed in clinical studies for managing acne-associated scarring, with varying success, with the latter three reported to improve skin quality. This narrative review highlights that comprehensive skincare regimens should be used throughout acne patients' journeys to reduce treatment-related irritation, improve treatment outcomes, adherence, and satisfaction, and enhance overall skin quality. Patients with sensitive skin should choose tailored skincare products to maintain skin barrier integrity and restore skin function."

Journal • Review • Acne Vulgaris • Dermatology

The Goeckerman protocol- review of 100 years of experience (EADV 2024) - "Modification protocols: with additives such as anthralin, tazarotene and/or calcipotriene as well as with systemic treatments...Malignancy when using cyclosporine and UVB has not been documented... Time proven treatments should not be disposed of where they have been shown to be highly effective. They should be utilized for patients who are wary of newer treatments for a variety of reasons including suffering side effects and development of resistance. Recent experiences with the covid19 pandemic have created a need for safe, effective treatments that can be done at home."

Clinical • Review • Atopic Dermatitis • Dermatology • Immunology • Infectious Disease • Novel Coronavirus Disease • Oncology • Prurigo Nodularis • Pruritus • Psoriasis • Renal Disease

A rare case of erythrokeratodermia variabilis in a 7-year-old child. (EADV 2024) - "Hyperkeratotic lesions usually show a good response to topical keratolitics, topical retinoids, tazarotene, alpha-hydroxy acid, and topical corticosteroid... EKV is a very rare type of EK, determined by an autosomal dominant gene of variable expressivity, characterized by reddish-brown plaques, which are hyperkeratotic and fixed in location, particularly over the knees, elbows and ankles; associated with figurate patches of erythema which vary in size, shape and location. There are two major subtypes of EKV: EK variabilis (Mendes da Costa) , and EK progressiva symmetrica (Gottron) . The classical EKV initially described by Mendes da Costa is characterized by two types of skin lesions: Figurate hyperkeratotic plaques and transient erythematous areas."

Clinical • Dermatology • Oncology

Vellus hair cyst a diagnostic challenge (EADV 2024) - "Treatment options are limited and include topical tretinoin, tazarotene, calcipotriol, oral isotretinoin, exfoliation, dermabrasion, CO2 laser, curettage, and surgical incision. Eruptive vellus hair cyst can mimic other skin conditions. Physician awareness aids diagnosis, with histopathology and other tools helpful. Knowing the diagnosis reassures patients; treatment is challenging, but the condition is benign with potential for regression."

Acne Vulgaris • Infectious Disease • Oncology • Pruritus • KRT17

Addressing Melanin Dysregulation: Treatments for Post-Inflammatory Hyperpigmentation from Acne (EADV 2024) - "The studies demonstrated efficacy with first-generation retinoids such as tretinoin and third-generation retinoids like tazarotene and adapalene...Conversely, no studies supported the use of hydroquinone alone; it is more commonly used in combination therapies due to its side effects when used singly Other Topical Agents: One randomised controlled study identified the treatment of PIH with niacinamide, which recorded a notable reduction in hyperpigmentation by assessing image analysis, visual assessment, and self- assessment...Oral Agents: The use of oral isotretinoin in treating PIH was only documented in one case report. No studies were found on the use of oral tranexamic acid for PIH, though it has shown promise in several studies for treating melasma, a similar hyperpigmentation condition... This review highlights the effectiveness of various treatments for PIH following acne. Topical retinoids like tretinoin and tazarotene are affirmed as primary therapies, with..."

Acne Vulgaris • Aesthetic Medicine • Dermatopathology • Pain • Tyrosinase

Updates on Topical Dyad and Triple Combination Therapies Approved for Acne Vulgaris. (PubMed, Cureus) - "It was found that various topical dyad and triad combinations exist for acne vulgaris, including adapalene/BPO, tazarotene/clindamycin, clindamycin/BPO, adapalene/clindamycin, topical tretinoin/azelaic acid, topical tretinoin/BPO, and clindamycin phosphate/benzoyl peroxide/adapalene. Clindamycin phosphate/benzoyl peroxide/adapalene exhibited significantly high efficacy in treating both inflammatory and noninflammatory lesions, a minimal side effect profile, although no significant changes in quality-of-life measures. Further research is indicated to assess its long-term efficacy and impact on other acne metrics such as cost, scarring, psychosocial implications, and impact on diverse patient populations."

Combination therapy • Journal • Review • Acne Vulgaris • Dermatology

Efficacy of topical treatments for mild-to-moderate acne: A systematic review and meta-analysis of randomized control trials. (PubMed, J Eur Acad Dermatol Venereol) - "Adapalene-benzoyl peroxide (BPO), clindamycin-BPO and clindamycin-tretinoin demonstrated the greatest reduction in non-inflammatory (ratio of means [RoM] 1.76; 95% CI [1.46; 2.12], RoM 1.70; 95% CI [1.44; 2.02] and RoM 1.87; 95% CI [1.53; 2.30], respectively), inflammatory (RoM 1.56; 95% CI [1.44; 1.70], RoM 1.49; 95% CI [1.39; 1.60] and RoM 1.48; 95% CI [1.36; 1.61], respectively) and total lesion count (ROM 1.67; 95% CI [1.47; 1.90], RoM 1.59; 95% CI [1.42; 1.79] and RoM 1.64; 95% CI [1.42; 1.89], respectively) compared to placebo. All single agents outperformed placebo except tazarotene, which did not significantly outperform placebo for inflammatory and non-inflammatory lesion count reduction...There was no significant difference amongst most single agents when evaluating lesion count reduction. Combination agents are generally most effective for mild-to-moderate acne; however for non-inflammatory acne, the addition of clindamycin in topical regimens is unnecessary..."

Clinical • Journal • Retrospective data • Review • Acne Vulgaris • Dermatology

Tazarotene-induced Gene 1 Induces Melanoma Cell Death by Triggering Endoplasmic Reticulum Stress Response. (PubMed, Front Biosci (Landmark Ed)) - "TIG1 expression effectively hinders the growth of melanoma cells. TIG1 induces the upregulation of ER stress response-related genes, leading to an increase in caspase-3 activity and subsequent cell death. These findings suggest that the ability of retinoic acid to prevent melanoma formation may be associated with the anticancer effect of TIG1."

Journal • Melanoma • Oncology • Solid Tumor • Targeted Protein Degradation • CASP3 • DDIT3 • HSPA5

Canadian Expert Consensus on the Use of Halobetasol Propionate/Tazarotene Lotion for Plaque Psoriasis. (PubMed, Dermatol Ther (Heidelb)) - "Expert panel members agreed, based on the existing body of literature, that there is a place in therapy for HP/TAZ to address several current unmet treatment needs of patients with plaque psoriasis. Studies have shown that HP/TAZ is an effective and safe first-line treatment for moderate-to-severe plaque psoriasis. Due to its cosmetically pleasing vehicle and once-daily administration, HP/TAZ may improve patient acceptance and treatment adherence."

Journal • Dermatology • Immunology • Psoriasis

A Comparative Study of the Effectiveness and Safety of Topical Calcipotriol and Topical Methotrexate in Chronic Plaque Psoriasis. (PubMed, Cureus) - "Present available preparations for mild to moderate chronic plaque psoriasis for topical use are local corticosteroids, coal tar, dithranol, tazarotene, calcipotriol, tapinarof, and calcineurin inhibitors. Conclusion Topical calcipotriol and methotrexate were effective in reducing lesions in patients with chronic mild to moderate plaque psoriasis. Both drugs were well tolerated with mild and transient adverse effects and did not alter hematological and biochemical parameters."

Journal • Dermatology • Hematological Disorders • Immunology • Psoriasis