tazarotene topical / Generic mfg. - LARVOL DELTA

Tazarotene-Induced Gene 2 Promotes Melanoma Cell Death via the Activation of Endoplasmic Reticulum Stress. (PubMed, Front Biosci (Landmark Ed)) - "These findings suggest that TIG2 suppresses melanoma cell growth by activating ER stress and modulating immune-related chemokines, highlighting its potential therapeutic relevance."

Journal • Genetic Disorders • Melanoma • Oncology • Skin Cancer • Solid Tumor • CCL2 • CXCL10 • CXCL11 • DDIT3 • RARRES2

Purvalanol A identified by in silico screening as treatment option for Multiple Sulfatase Deficiency (SSIEM 2026) - "Results from a high-throughput drug screen identified the third-generation retinoids tazarotene and bexarotene as compounds capable of correcting MSD pathology in vitro... The in-silico drug repurposing approach identified three candidate compounds for the treatment of MSD: bosutinib, purvalanol A, and purvalanol B. Subsequent in vitro testing revealed that only purvalanol A (PubChem ID 456214) increased multiple sulfatase activities in a concentration-and time-dependent manner across different genetic backgrounds and reduced elevated glycosaminoglycan subspecies in MSD fibroblasts... We demonstrate the effectiveness of an in silico drug repurposing approach in identifying a compound that reversed key features of MSD pathology in vitro. Despite these beneficial effects, early signs of toxicity may limit the potential of purvalanol A for repurposing in MSD. Further elucidating its mode of action may help identify alternative treatment strategies with a more favorable..."

Metabolic Disorders

Addition of silver nanoparticle solutions to alginate: microbiological and mechanical analysis. (PubMed, Braz Dent J) - "AW and JCHX exhibited antimicrobial potential, as evidenced by bacterial inhibition. Jeltrate or Avagel, regardless of AgNP concentration, did not demonstrate antimicrobial activity."

Journal

Improving the efficacy of tazarotene in psoriasis via bilosomal gel delivery: in vitro characterization, ex vivo evaluation, and preclinical assessment in an imiquimod induced psoriasis in a rat model. (PubMed, Int J Pharm) - "Histopathological evaluation confirmed the restoration of skin architecture with minimal inflammatory infiltration. These findings indicate that the Opt-BLs gel represents a stable and deformable vesicular system that enhances dermal delivery and therapeutic performance of tazarotene in psoriasis."

Journal • Preclinical • Dermatology • Immunology • Psoriasis

Improving dimensional stability of irreversible hydrocolloid by condensation silicone incorporation. (PubMed, J Clin Exp Dent) - "Three groups (n = 10) were evaluated: Group I (conventional alginate, Avagel), Group II (extended-pour alginate, Hydrogum 5), and Group III (alginate modified with condensation silicone)...The incorporation of condensation silicone resulted in improved stability, as evidenced by more controlled dimensional variation. The addition of condensation silicone to an irreversible hydrocolloid significantly improved its dimensional stability, suggesting a promising approach to enhance clinical performance, especially when immediate pouring is not feasible."

Journal • Review

New Agents for Acne Treatment and Updates to Isotretinoin Guidelines. (PubMed, Pediatr Clin North Am) - "New topical treatments include tazarotene lotion, trifarotene, combined microencapsulated benzoyl peroxide and tretinoin, minocycline foam, topical dapsone, and clascoterone cream. More recent systemic options include subantimicrobial doxycycline, sarecycline, combined oral contraceptives, spironolactone, and isotretinoin-lidose."

Journal • Review • Acne Vulgaris

Topicals for Psoriasis: Classical Drugs, New Concepts, and New Medications. (PubMed, J Rheumatol) - "Other legacy options (tazarotene, salicylic acid, coal tar, and calcineurin inhibitors) serve as adjuvants with variable efficacy. Recent advances have led to new targeted nonsteroidal topicals such as tapinarof (aryl hydrocarbon receptor agonist) and roflumilast (phosphodiesterase 4 inhibitor)...A persistent challenge is affordability, in which high acquisition costs for novel topicals may restrict real-world access unless supported by pricing and reimbursement policies. This work was presented at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2025 annual meeting in Bogotá as a concurrent session."

Journal • Dermatology • Immunology • Inflammatory Arthritis • Psoriasis • Psoriatic Arthritis • Rheumatology • Seronegative Spondyloarthropathies

Paradoxical Immune Reactions under IL-17 Blockade: Insights from a Clinical Case Series (EADV-Sp 2026) - "Topical treatment with mometasone furoate ointment and keratolytic agents was initiated...Case 2: A 50-year-old female patient with a history of psoriatic arthritis (PsA) since 2021 and PV since 2022 was switched to ixekizumab in December 2022 after methotrexate (MTX) and apremilast proved ineffective...Topical treatment with calcipotriol and betamethasone dipropionate foam was prescribed, leading to a favorable clinical response...However, worsening of PV prompted a switch to adalimumab in August 2023, followed by a further switch to risankizumab in October 2024 due to fluctuating disease activity. Case 4: A 56-year-old woman with palmoplantar PV and autoimmune thyroiditis was started on ixekizumab in November 2025 after failure of MTX and topical therapies (betamethasone+calcipotriol and tazarotene)...Ixekizumab was discontinued, and treatment with topical steroids and systemic colchicine was initiated, resulting in marked improvement within two months...Conclusions..."

Clinical • Endocrine Disorders • Immunology • Inflammatory Arthritis • Plaque Psoriasis • Psoriasis • Psoriatic Arthritis • Pustular Psoriasis • Seronegative Spondyloarthropathies

Post-inflammatory hyperpigmentation in third- vs. fourth-generation retinoids: A faers pharmacovigilance study (SID 2026) - "This mixed-methods study integrates published clinical evidence with post-market surveillance data to assess the relative safety and efficacy of third-generation (adapalene, tazarotene) and fourth-generation (trifarotene) retinoids for PIH in skin of color. These findings demonstrate that FAERS reporting patterns diverge substantially from randomized trial efficacy evidence, suggesting market-age bias obscures comparative safety assessment. This mixed-methods approach identifies an evidence gap and underscores the necessity for prospective, adequately powered randomized controlled trials evaluating fourth-generation retinoids for the management of PIH in darker phototypes, to guide evidence-based dermatologic practice in skin of color populations."

Adverse events

Tazarotene ameliorates steroid-induced osteonecrosis of the femoral head by activating autophagy. (PubMed, Int Immunopharmacol) - "Tazarotene ameliorates SIONFH by activating autophagy in BMSCs. These findings highlight tazarotene's potential as a novel therapeutic strategy for SIONFH."

Journal • Metabolic Disorders

Topical Pimecrolimus for Treatment-Refractory Tazarotene-Induced Photosensitive Facial Erosions. (PubMed, Cureus) - "Subsequent treatment with pimecrolimus 1% cream resulted in progressive clinical improvement, with complete healing of erosions within three months. This case highlights topical calcineurin inhibition as an effective steroid-sparing strategy for persistent retinoid-associated inflammatory dermatoses and underscores the role of cumulative ultraviolet exposure as a potentiating factor."

Journal • Acne Vulgaris • Dermatitis • Dermatology • Immunology • Inflammation • Psoriasis • CRP

Potential Antifungal Activity of Retinoids Against Non-albicans Candida Species. (PubMed, Microorganisms) - "This study aimed to assess the antifungal potential of three retinoids, all-trans retinoic acid (ATRA), trifarotene, and tazarotene, against NAC clinical isolates. Trifarotene at 0.5 mM was also the most effective retinoid in inhibiting C. glabrata and C. tropicalis adherence and biofilm formation, with inhibitory activity maintained even at sub-0.5 mM concentrations (0.25-0.12 mM). Overall, the results suggest that all three retinoids exhibited dose-dependent and species-specific antifungal activity against NAC species, supporting their potential as novel, tailored antifungal agents against drug-resistant Candida strains."

Journal • Candidiasis

Topical Retinoids in Acne Vulgaris and Acne Scars-From Monotherapy to Combining Regimens. (PubMed, Pharmaceuticals (Basel)) - "A review of published clinical and experimental studies evaluating tretinoin, adapalene, tazarotene, and trifarotene was performed, including their use as monotherapy and in combination with other topical agents or procedural interventions. In conclusion, topical retinoids represent a relevant therapeutic option in acne vulgaris and acne scarring, from monotherapy in mild cases to components of multimodal treatment protocols in more severe disease. Further large-scale, comparative studies are needed to better define the optimal clinical use of advanced drug delivery systems for topical retinoids."

Journal • Monotherapy • Review • Acne Vulgaris • Dermatology • Inflammation

Risks of epistaxis and chronic rhinosinusitis in oral isotretinoin vs topical retinoid users (COSM 2026) - "Two groups were identified: new users of oral isotretinoin and new users of topical retinoids (tretinoin, adapalene, tazarotene) without oral exposure. This highlights the importance of preventive nasal care during treatment. Improved patient counseling and early ENT evaluation may reduce morbidity associated with these sinonasal adverse effects."

Hematological Disorders • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Mechanistic Insights Into the Photosensitizing Properties of the Topical Retinoid Tazarotene. (PubMed, ChemMedChem) - "These results correlate with reduced cell viability in fibroblasts exposed to light after treatment with TZE or TZA, indicating potential phototoxic effects. Such light-induced reactivity may also be related to the enhanced therapeutic results observed when TZE is used alongside narrow-band UVB phototherapy."

Journal • Acne Vulgaris • Dermatopathology

Comparison of Systemic and Topical Retinoids and the Association of Inflammatory Bowel Disease in Ichthyosis Patients: A Population-Based Cohort Study (AAD 2026) - "Patients with acquired ichthyosis, congenital ichthyosis , or ichthyosis vulgaris treated with systemic retinoids such as alitretinoin, isotretinoin, etretinate, and acitretin (n=449) were identified using validated ICD-10 codes. A comparator cohort treated with topical retinoids such as adapalene, tazarotene, bexarotene, alitretinoin, and tretinoin (n=449) was established... These findings indicate that the protective association is specific to systemic retinoid therapy and highlights the importance of treatment selection in patients with ichthyosis who have comorbid or potential IBD. Future studies should further explore the role of systemic retinoids as potential disease-modifying agents for IBD and other inflammatory conditions in ichthyosis patients."

Clinical • Atopic Dermatitis • Crohn's disease • Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • Vitiligo

A Comparison of the Protective effects of Systemic vs Oral Retinoids on Non Melanoma Skin Cancers in Acne Patients: A Retrospective Cohort Study (AAD 2026) - "Two matched cohorts were created: systemic retinoids (alitretinoin, isotretinoin, etretinate, acitretin; n=34,851) and topical retinoids (adapalene, tazarotene, bexarotene, tretinoin; n=34,851). Patients with known NMSC risk factors (chemical exposures, HPV, or use of BRAF inhibitors, cyclosporine, voriconazole, hydrochlorothiazide) were excluded... The enhanced protective effect of systemic retinoids may reflect their deeper influence on keratinocyte turnover and skin cell regeneration compared to topical formulations. Further studies are warranted to clarify the relative efficacy of individual agents and optimize retinoid prophylaxis in high-risk patients."

Retrospective data • Acne Vulgaris • Basal Cell Carcinoma • Genetic Disorders • Kaposi Sarcoma • Non-melanoma Skin Cancer • Sarcoma • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma

Vitamins and the Skin: Vitamin A and Retinoids in Dermatology. (PubMed, Clin Dermatol) - "Retinoids used as therapeutic agents include oral retinoids, e.g. isotretinoin, acitretin, alitretinoin, and bexarotene, and topical retinoids, e.g. isotretinoin, tretinoin, adapalene, tazarotene, and trifarotene. In addition, other retinoids, with distinct routes of administration (oral or topical), and distinct dosing or safety profiles, are recommended for different skin disorders. We discuss the mode of action and indications of retinoids used as pharmacologic agents in dermatology and provide an update on their use, effectiveness and tolerability."

Journal • Acne Vulgaris • Atopic Dermatitis • Cutaneous T-cell Lymphoma • Dermatology • Dermatopathology • Hematological Malignancies • Immunology • Lymphoma • Oncology • Psoriasis • Skin Cancer • Squamous Cell Carcinoma • T Cell Non-Hodgkin Lymphoma • Vitiligo

Divergent System Organ Class Safety Profiles of Isotretinoin Versus Topical Retinoids: An EudraVigilance Disproportionality Analysis. (PubMed, Pharmaceuticals (Basel)) - " Aggregated ADR data for isotretinoin and four topical retinoids (tretinoin, adapalene, tazarotene, trifarotene) were retrieved from the EMA ADRreports portal (April 2025). Isotretinoin presents a distinct safety profile characterized by consistently elevated reporting of psychiatric, gastrointestinal, and musculoskeletal adverse events, independent of age and sex. These results refine the comparative safety landscape of systemic versus topical retinoids and support focused pharmacovigilance monitoring."

Journal • Acne Vulgaris • Cardiovascular • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Mental Retardation • Musculoskeletal Diseases • Oncology • Otorhinolaryngology • Psychiatry • Rheumatology

Retinoids enhance NK effector function against HIV-infected CD4 T cells. (PubMed, J Virol) - "From the retinoids tested, alitretinoin, tazarotene acid, and AM80 significantly enhanced NK natural cytotoxicity in the presence of IL-15. This makes the infected cells more vulnerable to being eliminated. Since some of these retinoids are already approved for medical use, they could offer a promising way to reduce persistent HIV reservoirs in the body and improve efforts to cure the infection."

Journal • Human Immunodeficiency Virus • Infectious Disease • CD4 • IL15

A portable bilayer microneedle patch for rapid and patient-friendly administration of rabies immunoglobulin and enhanced wound healing. (PubMed, J Mater Chem B) - "We developed a bilayer MN patch composed of a hyaluronic acid (HA) tip containing HRIG and a polyvinylpyrrolidone (PVP) base incorporating tazarotene (TA)...The patch's portability, stability, and efficacy make it ideal for emergency scenarios, offering reduced discomfort compared to traditional methods. This approach also broadens the potential applications of microneedles in emergency care and vaccination."

Journal • Infectious Disease • Pain

Chronic Ulcerative Complications in the Management of Advanced Mycosis Fungoides with Large Cell Transformation (ISDS 2025) - "Though initially treated with localized radiation, methotrexate, bexarotene, and narrowband UVB phototherapy, funding limitations disrupted therapy continuity...Management included total skin electron beam therapy, reintroduction of oral bexarotene (750 mg daily), and topical Triamcinolone, later switched to tazarotene cream...At follow-up, the patient reported significant improvement in skin lesions leg ulcers with partial disease response and no lymphadenopathy or hepatosplenomegaly despite persistent ulceration. This case highlights the challenges of advanced mycosis fungoides with large cell transformation and ulcerations, where the relapsing course of cutaneous T-cell lymphoma necessitates multidisciplinary care, and the leading infectious complication is Staphylococcus aureus-driven cellulitis and bacteremia due to skin barrier disruption."

Metastases • Cutaneous T-cell Lymphoma • Dermatology • Hematological Malignancies • Infectious Disease • Lymphoma • Mycosis Fungoides • Oncology • T Cell Non-Hodgkin Lymphoma • Ulcerative Colitis

Coating Janus Nanoparticles with Immunoregulatory Protein Embedded Membrane for Enhanced Anti-Inflammatory and Sonodynamic Therapy of Psoriasis. (PubMed, Adv Healthc Mater) - "The encapsulated core is designed as Janus nanoparticles (mSiO2&rPMO) for co-delivery of hydrophilic 5-aminolevulinic acid (5-ALA) and hydrophobic tazarotene, facilitating synergistic sonodynamic therapy (SDT) and anti-inflammatory effects...Notably, CNPs outperformed non-membrane counterparts in both cellular and animal models, highlighting the anti-psoriatic amplification conferred by the engineered membrane. Overall, this research presents a novel therapeutic strategy for psoriasis management using engineered membrane-coated mesoporous Janus nanoparticles to target keratinocyte proliferation and T cell activation."

Journal • Dermatology • Immunology • Inflammation • Psoriasis • RARG

A Rare Dermatologic Condition: Insights from Three Cases of Circumscribed Acral Hypokeratosis. (PubMed, Clin Dermatol) - "Therapeutic responses were varied to topical calcipotriene, tazarotene, antifungal agents, and fractional laser therapy, highlighting the absence of standardized treatment guidelines...Due to its benign yet chronic and refractory nature, accurate histopathologic diagnosis is crucial to facilitate appropriate management and surveillance for such rare potential complications as squamous dysplasia. This series underscores the importance of recognizing CAH's distinct clinicopathologic entity to guide effective clinical management."

Journal • Aesthetic Medicine • Dermatitis • Dermatology • Human Papillomavirus Infection • Immunology • Infectious Disease • Inflammation • Mood Disorders • Psoriasis

Effects of AI-Powered Embodied Avatars on Communication Quality and Social Connection in Asynchronous Virtual Meetings. (PubMed, IEEE Trans Vis Comput Graph) - "Results showed that Avagents enhance the asynchronous communication experience by increasing social presence, sense of belonging, emotional intimacy, and other user perceptions. We discuss the findings and their implications for designing effective AI-driven asynchronous communication tools in VR/AR environments."

Journal • Cognitive Disorders