domperidone / Generic mfg. - LARVOL DELTA

An Intriguing Case of Hypermobile Ehlers-Danlos Syndrome Presenting With Severe Gut Dysmotility and Refractory Gastroparesis (ACG 2025) - "Full-thickness biopsy via laparoscopic gastric pacemaker placement revealed fibrosis of the myenteric plexus with sparse ganglion cells. Despite trials of metoclopramide, erythromycin, domperidone, and prucalopride, the patient exhibited minimal clinical improvement. Early recognition, combined with integrative care, is critical. As awareness of hEDS-related GI dysfunction grows, more systematic investigation is needed to inform targeted therapies and long-term outcomes."

Clinical • Fibrosis • Gastrointestinal Disorder • Genetic Disorders • Immunology • Rheumatology

The Nausea Atlas: Identifying and Characterizing Nausea Subtypes Using Patient-Reported Information (ACG 2025) - "Ondansetron was the most effective anti-nausea medication, followed by promethazine, lorazepam, prochlorperazine, and domperidone. Marijuana was the most effective non-medication treatment, outperforming dronabinol... 745 participants (77% Female; 19% Male), reporting 1200 distinct nausea types/experiences were evaluated. The most represented age range was 31–40 years. 22% of respondents reported their nausea as severely or completely debilitating."

Clinical • Gastrointestinal Disorder • Mood Disorders • Psychiatry

Comparative Efficacy of Pharmacologic Therapies for Gastroparesis: A Systematic Review and Network Meta-Analysis (ACG 2025) - "Interventions included prucalopride, cisapride, revexepride, metoclopramide, relamorelin, TZP-102, aprepitant, tradipitant, cannabidiol (CBD), and domperidone. A total of 21 trials comprising 2,452 patients were included in the study. For symptom improvement, 19 studies that compared 10 treatments contributed to the network. Cisapride (SMD, 1.88; 95% CI –2.71 to –1.06; SUCRA=0.98), relamorelin (SMD, 1.15; 95% CI –2.15 to –0.16; SUCRA=0.86), and aprepitant (SMD: 0.60; 95% CI –0.88 –0.32; SUCRA=0.76) significantly outperformed the placebo."

Retrospective data • Review • Gastrointestinal Disorder

Eco-Friendly Simultaneous Quantification of Domperidone and Safinamide by Spectral Resolution using deconvoluted Synchronous Fluorescence: Application to Spiked Human Plasma. (PubMed, Luminescence) - "Sustainability of the current method was assessed using spider chart measure, green solvent selection tool, Analytical GREEnness Metric, Modified Green Analytical Procedure index, and Blue Applicability Grade Index. The proposed technique represents a simple, sensitive, and sustainable tool for routine analysis of this therapeutically significant drug pair."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease

Repurposing terfenadine and domperidone for inhibition of apoptotic gene association in colorectal cancer: A system pharmacology approach integrated with molecular docking, MD simulations, and post-MD simulation analysis. (PubMed, Bioinform Biol Insights) - "In conclusion, this integrative computational analysis highlights terfenadine and domperidone as promising candidates capable of modulating key apoptotic pathways in CRC. The findings provide a strong rationale for subsequent in vitro and in vivo studies to validate their therapeutic potential and facilitate clinical translation in CRC management."

Journal • Colorectal Cancer • Oncology • Solid Tumor • DRD2 • EGFR • HTR2A • SLC6A4

A Study to Evaluate the Efficacy and Safety of CIN-102 (Deudomperidone) in Adults With Diabetic Gastroparesis (clinicaltrials.gov) - P2 | N=380 | Active, not recruiting | Sponsor: CinDome Pharma, Inc. | Recruiting ➔ Active, not recruiting

Enrollment closed • Gastrointestinal Disorder

Domperidone and the Risk of Serious Adverse Events (clinicaltrials.gov) - P=N/A | N=15000 | Completed | Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Adverse events • New trial • Serious adverse event • Chronic Kidney Disease • Nephrology • Renal Disease

A Study to Evaluate the Efficacy and Safety of CIN-102 (Deudomperidone) in Adult Subjects With Idiopathic Gastroparesis. (clinicaltrials.gov) - P2 | N=400 | Recruiting | Sponsor: CinDome Pharma, Inc. | Not yet recruiting ➔ Recruiting

Enrollment open • Gastrointestinal Disorder

The evaluation of body surface gastric mapping for the assessment of patients with gastrointestinal symptoms in New Zealand (ANZCTR) - P=N/A | N=200 | Active, not recruiting | Sponsor: Alimetry Ltd. | Not yet recruiting ➔ Active, not recruiting

Enrollment closed • Dyspepsia • Gastroenterology • Gastrointestinal Disorder

Contributions of pharmaceutical interventions to the multidisciplinary dysphagia team: A retrospective observational study. (PubMed, J Pharm Health Care Sci) - "Pharmaceutical interventions may offer clinically meaningful contributions when utilized for patients with dysphagia, supporting the relevance of pharmacovigilance regarding the risks of dopamine antagonists. The findings of this study suggest the importance of reinstating pharmaceutical expertise to multidisciplinary dysphagia teams, as pharmacists provide clinically significant medication optimization, including identifying additional optimization opportunities through systematic medication reviews among vulnerable populations."

Journal • Observational data • Retrospective data • Alzheimer's Disease • CNS Disorders • Dementia • Gastrointestinal Disorder • Infectious Disease • Pneumonia • Respiratory Diseases

Effects of combining increased lysine (protein) supply in late gestation and domperidone in lactation on sow and piglet performances. (PubMed, J Anim Sci) - "In conclusion, feeding supplementary Lys (protein) in late gestation either with or without domperidone in lactation did not increase sow milk yield. Findings emphasize that a greater litter size was likely needed to see beneficial effects of supplementary Lys, and that the use of primiparous sows or inadequate lactational feed intake may have impeded effects of the domperidone."

Journal • IGF1

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence-Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis. (PubMed, Vet Dermatol) - "Recommended treatments include meglumine antimoniate-allopurinol (first-line treatment), miltefosine-allopurinol (first-line treatment) and aminosidine-allopurinol (second-line treatment); marbofloxacin may be considered in dogs with advanced chronic kidney disease. In endemic areas, recommended measures for prevention include deltamethrin 4% collar, flumethrin 4.5%-imidacloprid 10% collar or permethrin 50%-imidacloprid 10% spot-on, not using infected blood products for transfusion, not breeding seropositive bitches or dogs with CanL, administration of domperidone (seronegative dogs) and dietary nucleotides-active hexose correlated compound (subclinically infected, seropositive dogs). Vaccination with LiESP with MDP may be considered, whereas protein Q vaccine is recommended in areas with very high rates of seroconversion. In non-endemic areas, recommended measures include not using infected blood products for transfusion and removal of infected female dogs from..."

Clinical guideline • Journal • Review • Dermatology • Infectious Disease • Nephrology • Renal Disease

Repurposed Antipsychotics as Potential Anticancer Agents: Clozapine Efficacy and Dopaminergic Pathways in Neuroblastoma and Glioblastoma. (PubMed, Life (Basel)) - "This study aimed to evaluate the potential anticancer effects of repurposed antipsychotic dopamine-targeting drugs (Clozapine, CLZ; Pimozide, PIM; Olanzapine, OLZ; and Risperidone, RIS) and antiemetic drugs (Domperidone, DOM; Droperidol, DRO) on neuroblastoma (SH-SY5Y) and glioblastoma (A172) cell lines, and to assess whether their efficacy is modulated by oxidative stress and DA synthesis. In summary, several of the repurposed antipsychotics demonstrated cytotoxic effects on central nervous system tumor cells, with CLZ showing the most promising activity, even under oxidative stress conditions. These findings support further investigation into dopamine-targeting drugs as potential therapeutic agents in neuro-oncology."

Journal • Brain Cancer • CNS Disorders • CNS Tumor • Glioblastoma • Neuroblastoma • Oncology • Solid Tumor

Oral Administration of GnRH and Domperidone via Gel Feed and Their Effect on Reproductive Performance of Devario devario (Bengal Danio), an Ornamental Fish. (PubMed, Gels) - "Improvements in haematological parameters were observed across all treatments. These results suggest that an optimal dose of 50 µg GnRH + 25 mg domperidone can enhance reproductive performance in D. devario."

Journal • Hematological Disorders

Data mining-based analysis to explore the application of an animal model of diabetic gastroparesis. (PubMed, Front Endocrinol (Lausanne)) - "Blood glucose, general condition, and gastric emptying rate were commonly used as modeling criteria, and domperidone served as the positive control drug...On the basis of the results of data analysis, it is recommended to use a one-time injection of streptozotocin (60-65 mg/kg) to induce type 1 diabetic gastroparesis animal model or a one-time injection of streptozotocin (40-55 mg/kg) combined with irregular feeding of high-sugar and high-fat feed to induce type 2 diabetic gastroparesis animal model. Blood glucose, general condition, and gastric emptying rate were used to judge the models."

Journal • Preclinical • Review • Diabetes • Gastrointestinal Disorder • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus

Structure-based discovery of thiamine uptake inhibitors. (PubMed, Br J Pharmacol) - "These findings offer a basis for addressing drug-induced thiamine deficiencies and pre approach can be used to optimise pharmacological strategies involving SLC19A3-interacting compounds in the future."

Journal • Gastroenterology • Gastrointestinal Disorder • DRD2 • SLC19A2

Functional disorders of the upper digestive tract: epidemiological, clinical and therapeutic aspects. (PubMed, Recenti Prog Med) - "First-line drugs for the management of functional dyspepsia include prokinetics, such as domperidone and itopride, and proton pump inhibitors, the latter being indicated mainly in patients with symptoms associated with hyperacidity. However, current guidelines emphasize the need for further clinical evidence to consider such approaches as standard of care. In conclusion, although significant progress has been made in the understanding and treatment of these disorders, there remains much room for development with regard to targeted and personalized therapeutic strategies."

Journal • Review • Dyspepsia • Gastrointestinal Disorder • Immunology • Musculoskeletal Pain • Pain

Prescribing trends of fixed-dose combination of domperidone and proton-pump inhibitor across tertiary care centers in India, is the combination rational? (PubMed, Indian J Pharmacol) - "This study has shown a lack of rationality in the prescribing practices in FDC containing domperidone and PPI in terms of indications, dose, frequency, duration, and administration instructions."

Journal

Cyclical Vomiting Syndrome in Individuals With BPTF Haploinsufficiency. (PubMed, Pediatr Neurol) - "This study broadens the syndromic phenotype associated with BPTF haploinsufficiency, highlighting CVS as a core feature. The findings raise clinician awareness, guide management, and enhance understanding of this rare condition."

Journal • CNS Disorders • Developmental Disorders • Epilepsy • Migraine • Pain • Psychiatry • BPTF

Observation on the clinical efficacy on dyspepsia after ischemic stroke treated with elongated needle (PubMed, Zhen Ci Yan Jiu) - "Elongated needling therapy with deep insertion can significantly relieve the symptoms of dyspepsia after ischemic stroke and promote the recovery in the patients. The effect of this therapy is superior to the treatment with either filiform needle or medication."

Journal • Cardiovascular • Dyspepsia • Ischemic stroke

Provisional expert recommendations for the management of refractory gastroesophageal reflux disease in systemic sclerosis: a report from the World Scleroderma Foundation (WSF) Gastrointestinal "Ad hoc committee" (EULAR 2025) - "In patients with refractory GERD and dysphagia, treatment with a promotility agent, such as prucalopride, pyridostigmine, domperidone, or metoclopramide, should be strongly considered as a therapeutic trial (100%)...In the context of refractory GERD and associated nausea, when promotility agents are suboptimal in managing symptoms, consider adding medications with anti-emetic properties (e.g., ondansetron, promethazine, mirtazapine) (85.7%)...Baclofen might be useful for patients with significant reflux episodes, with mainly weakly acidic or non-acidic on pH-impedance studies, and who show positive symptom association (78.6%)... We present provisional recommendations for the management of refractory GERD in SSc. Only minimal refinement and voting is required to finalize these practical recommendations. Our final recommendations shall also include ‘special circumstances’: ILD, myositis and CTD-overlap, and peri-lung transplant."

Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Immunology • Infectious Disease • Myositis • Oncology • Osteoporosis • Pain • Rheumatology • Scleroderma • Systemic Sclerosis • Tobacco Cessation

Investigating the effect of domperidone on breast milk supply following preterm birth- the SUMMIT study (ANZCTR) - P3 | N=100 | Recruiting | Sponsor: South Australian Health and Medical Research Institute | N=170 ➔ 100

Enrollment change

CiPA-qualified human iPSC-derived cardiomyocytes: A new frontier in toxicity testing by evaluating drug-induced arrhythmias. (PubMed, Toxicol In Vitro) - "Notably, droperidol (173 %) and domperidone (182 %), originally classified as intermediate-risk compounds, were identified as high-risk in our model, consistent with previous findings by Nguyen et al...Additionally, YBLiCardio showed enhanced predictive accuracy for chlorpromazine. These findings highlight the potential of hiPSC-CMs for proarrhythmia risk assessment within the CiPA framework, complementing ion channel data and in silico modeling approaches. Overall, YBLiCardio provides a robust and physiologically relevant platform for predicting cardiotoxicity, supporting safer and more efficient pre-clinical drug discovery & development."

Journal • Cardiovascular

Efficacy of Fecal Microbiota Transplantation in Treating Gastrointestinal Dysfunction in Critically Ill Patients: A Single-Center Prospective Study (ChiCTR) - P=N/A | N=366 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Anhui Medical University; The First Affiliated Hospital of Anhui Medical University

New trial • Transplantation

Prevalence of nausea and vomiting and anti-emetic use in the tinding the optimal regimen for Mycobacterium abscessus treatment (Format) trial (ECFS 2025) - "Antibiotic prescribing frequency from 146 prescriptions was: ondansetron 43% metoclopramide 21%, cyclizine 12%, lorazepam 8%, aprepitant 6%, palonosetron 5% and other (domperidone, olanzapine, haloperidol) 5%. The high prevalence of nausea and vomiting and antiemetic use in the MABSC-PD cohort requires further evaluation. Optimised antiemetic protocols in patients receiving MABS-PD treatment are required to tolerate therapy"

Pulmonary Disease • Respiratory Diseases