domperidone / Generic mfg. - LARVOL DELTA

Domperidone Use in Lactation and Risk of Severe Postpartum Mental Health Outcomes. (PubMed, Obstet Gynecol) - "Initiation of domperidone postpartum was not associated with an increased risk of new-onset psychosis or ED visits or hospital admissions with mental health diagnoses."

HEOR • Journal • CNS Disorders • Psychiatry

Integrated Analysis of Transcriptomics and Proteomics Reveals the Ameliorative Effect of Processed Aucklandiae Radix on Functional Dyspepsia. (PubMed, J Ethnopharmacol) - "WMX ameliorates FD by regulating brain-gut peptide levels and suppressing the excessive inflammatory response mediated by the NOD1/RIPK2/ERK signaling pathway."

Journal • Dyspepsia • Inflammation • Pain • GAST • IL18 • IL6 • RIPK2 • TNFA

Antiemetic use during pregnancy and child neurodevelopment: population-based birth cohort study. (PubMed, BMC Med) - "This large-scale study found no association between antiemetic exposure during pregnancy and the risk of neurodevelopmental disorders or delays in children, providing reassurance for the use of antiemetics in pregnancy to treat nausea and vomiting. However, the slightly elevated risks observed in certain subgroups warrant further investigation. Meanwhile, these findings may assist in guiding decisions when considering antiemetic treatment during pregnancy."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • Cerebral Palsy • CNS Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Movement Disorders • Pediatrics • Psychiatry

Unveiling prognostic indicators in canine leishmaniosis: two decades of evidence. (PubMed, Parasit Vectors) - "Our study highlights important risk factors for poor prognosis in CanL that should be carefully considered by clinicians and researchers when managing sick dogs, particularly regarding therapy decision-making."

Biomarker • Journal • Retrospective data

Chitosan-based nanoconjugated hormone delivery boosts reproductive efficiency in male Labeo rohita. (PubMed, Anim Reprod Sci) - "Notably, T4 (half-dose) was comparable to Cp, suggesting efficacy at reduced hormone dosage. Overall, the findings demonstrate that full-dose ChN-sGnRH-a coadministered with domperidone is superior to commercial GnRH-a, and half-dose nanoconjugates provide equal efficacy, justifying a dose-reduction regime for sustainable, low-stress broodstock management of L. rohita."

Journal • FSHB

Choline chloride-malic acid Natural Deep Eutectic Solvent containing hydrophobic drugs: Insights into solubility and permeability behavior in digestive tract models. (PubMed, Int J Pharm) - "The selected APIs included weak bases (domperidone, cinnarizine, olanzapine), weak acids (nimesulide, flurbiprofen), and a pH-independent compound (carbamazepine). Nevertheless, its ability to improve bioavailability is highly dependent on the molecular characteristics of each API + NaDES system. Upon dilution in biorelevant media, performance is governed by a delicate interplay of hydrogen bonding, hydrophobic interactions and competition with solubilizing agents present in gastrointestinal fluids."

Journal

Mitochondrial aminoacyl- tRNA synthetase deficiency as a new cause of primary Pediatric Intestinal Pseudo-Obstruction (SSIEM 2023) - "Proton pump inhibitors, laxatives and/or enema were prescribed in all patients, while Pt 1 and 4 also started medical propulsive therapy with erythromycin, amoxicillin, domperidone and pyridostigmine with transient effect. Discussion Clinical and imaging studies with response to prokinetic drugs fulfilled the PICO criteria (ESGPHAN-2018). This study expands the phenotype of ARSs and suggests including mt-ARS defects as a new cause of mitochondrial PICO."

Clinical • Cardiomyopathy • Cardiovascular • Constipation • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hepatology • Metabolic Disorders • Myositis • Pediatrics • NARS2

Design and preparation of novel domperidone loaded polymeric blend electrospun nanofibers for improved oral pharmacodynamic activity. (PubMed, Drug Deliv Transl Res) - "The superior in vitro dissolution and in vivo prokinetic activity proved the promising potential of polymeric NFs to improve the oral delivery of DOM. The optimized DOM-loaded EL-100/PVA NFs may allow for dose reduction and low cardiovascular risk compared to conventional DOM tablets."

Journal • PK/PD data • Cardiovascular

Recurred pantoprazole anaphylaxis: a rare case report from Nepal. (PubMed, Ann Med Surg (Lond)) - "A 57-year-old woman presented to the emergency department with an acute onset of generalized rashes and chest tightness after intake of an over-the-counter oral pantoprazole and domperidone combination tablet. Physicians should be aware of cross-hypersensitivity among PPIs, and a safe alternative should be decided after a skin allergy workup. It is necessary to extensively extract drug and allergy history, and even the most commonly used drugs with rarely any side effects should also be used cautiously."

Journal • Allergy • Dermatology • Hypotension • Immunology • Pain • Urticaria

An Intriguing Case of Hypermobile Ehlers-Danlos Syndrome Presenting With Severe Gut Dysmotility and Refractory Gastroparesis (ACG 2025) - "Full-thickness biopsy via laparoscopic gastric pacemaker placement revealed fibrosis of the myenteric plexus with sparse ganglion cells. Despite trials of metoclopramide, erythromycin, domperidone, and prucalopride, the patient exhibited minimal clinical improvement. Early recognition, combined with integrative care, is critical. As awareness of hEDS-related GI dysfunction grows, more systematic investigation is needed to inform targeted therapies and long-term outcomes."

Clinical • Fibrosis • Gastrointestinal Disorder • Genetic Disorders • Immunology • Rheumatology

The Nausea Atlas: Identifying and Characterizing Nausea Subtypes Using Patient-Reported Information (ACG 2025) - "Ondansetron was the most effective anti-nausea medication, followed by promethazine, lorazepam, prochlorperazine, and domperidone. Marijuana was the most effective non-medication treatment, outperforming dronabinol... 745 participants (77% Female; 19% Male), reporting 1200 distinct nausea types/experiences were evaluated. The most represented age range was 31–40 years. 22% of respondents reported their nausea as severely or completely debilitating."

Clinical • Gastrointestinal Disorder • Mood Disorders • Psychiatry

Comparative Efficacy of Pharmacologic Therapies for Gastroparesis: A Systematic Review and Network Meta-Analysis (ACG 2025) - "Interventions included prucalopride, cisapride, revexepride, metoclopramide, relamorelin, TZP-102, aprepitant, tradipitant, cannabidiol (CBD), and domperidone. A total of 21 trials comprising 2,452 patients were included in the study. For symptom improvement, 19 studies that compared 10 treatments contributed to the network. Cisapride (SMD, 1.88; 95% CI –2.71 to –1.06; SUCRA=0.98), relamorelin (SMD, 1.15; 95% CI –2.15 to –0.16; SUCRA=0.86), and aprepitant (SMD: 0.60; 95% CI –0.88 –0.32; SUCRA=0.76) significantly outperformed the placebo."

Retrospective data • Review • Gastrointestinal Disorder

Simple spectrophotometric methods for the quantitative analysis of two binary mixtures containing paracetamol as a major component. (PubMed, BMC Chem) - "This work demonstrates simple and reliable spectrophotometric methods for the simultaneous determination of paracetamol (PAR) and meloxicam (MEL) in mixture I as well as PAR and domperidone (DOM) in mixture II in bulk form and laboratory-made tablets. With regard to mixture I, the calibration curves showed linearity in the ranges of 3-30 µg/mL for MEL (zero-order method) and 2.5-30 and 3-15 µg/mL for MEL and PAR, respectively (first-order method), with correlation values of at least 0.9991.Whereas for mixture II, with correlation coefficients of 0.9999, the calibration curves for PAR and DOM were linear in the ranges of 3-70 and 2.5-15 µg/mL, respectively.The established procedures were used to analyze the combinations in the lab-prepared pills, and assay results were compared with reported methods. Greenness of the devised spectrophotometric procedures was assessed using the Analytical Eco-Scale and the Analytical Greenness metric (AGREE)."

Journal

Sunshine Biopharma Gains FDA-Equivalent Clearance in Canada for Domperidone to Treat Cancer-related Nausea (ACCESS Newswire) - "Domperidone is often used for chemotherapy-induced nausea and vomiting, especially when patients cannot tolerate other antiemetics which may cause extrapyramidal side effects. Domperidone works by blocking dopamine receptors in the gut, helping reduce nausea and improve gastric motility."

Canada approval • Chemotherapy-Induced Nausea and Vomiting

Domperidone in Treating Patients With Gastrointestinal Disorders (clinicaltrials.gov) - P3 | N=200 | Recruiting | Sponsor: M.D. Anderson Cancer Center | Trial completion date: Oct 2025 ➔ Oct 2027 | Trial primary completion date: Oct 2025 ➔ Oct 2027

Trial completion date • Trial primary completion date • Dyspepsia • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder

Microbiological and Physical Stability of Extemporaneous Oral Suspensions Compounded with SyrSpend® SF PH4. (PubMed, Int J Pharm Compd) - "This study evaluates the microbiological and physical stability of oral suspensions compounded with SyrSpend® SF PH4, containing a range of active pharmaceutical ingredients (APIs) including propranolol, domperidone, ondansetron, dexamethasone, tacrolimus, allopurinol, clopidogrel, and folic acid. albicans, A. brasiliensis, E. coli, P. aeruginosa, and S. aureus), with counts reduced to below detectable limits by day 14 and maintained through day 28. These findings confirm the intrinsic preservative properties of SyrSpend® SF PH4 and support its use as a safe and effective vehicle for extemporaneous compounding, particularly when intended for vulnerable populations."

Journal • Pediatrics

Linalool exerts antiemetic effects via dopaminergic and serotonergic pathways: Evidence from chick model and molecular docking. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Its effects were compared against the standard antiemetics domperidone (DOM, 7 mg/kg) and ondansetron (OND, 5 mg/kg). Molecular docking studies revealed a strong binding affinity of LIN to the dopamine D2 receptor (- 6.4 kcal/mol) and moderate binding to the 5-HT3 receptor (- 5.3 kcal/mol), suggesting involvement of both dopaminergic and serotonergic mechanisms. These findings collectively indicate that LIN possesses significant antiemetic activity and may offer a plant-derived alternative for emesis control."

Journal • DRD2

Assessment of antiemetic potential of schaftoside through modulation of dopaminergic, serotonergic and muscarinic signaling pathways: in vivo and in silico investigations. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "SCF was tested at doses of 5, 10, and 20 mg/kg and compared to standard antiemetics domperidone (DOM-6 mg/kg), ondansetron (OND-5 mg/kg), and hyoscine (HYO-21 mg/kg). PKs and toxicity profiling revealed that SCF possesses favorable drug-likeness characteristics, good water solubility, moderate skin permeability, favorable metabolic and excretory characteristics as well as promising safety profile. Despite some lacking in PKs properties, its safety profile and efficacy in behavioral models support SCF as a promising candidate for antiemetic drug."

Journal • Preclinical

Efficacy and safety of pharmacological therapies for functional constipation in children: a systematic review and meta-analysis. (PubMed, Lancet Child Adolesc Health) - "Polyethylene glycol is probably more effective than placebo and key comparator therapies and should be considered the standard of first-line care. Future studies should consider polyethylene glycol as an index therapy, and clearly describe methods, patient characteristics, and previous therapeutics."

Journal • Retrospective data • Constipation • Gastroenterology • Gastrointestinal Disorder

SL-START: A Multicentre Observational Study of Sublingual Apomorphine Titration and Usage Schemes in Routine Practice (MDS Congress 2025) - "Details of the SL-APO regimen, use of domperidone, and other PD medications will be documented... SL-START will inform on the factors of SL-APO titration that are important for patient retention and guide best practice for SL-APO titration strategies in real-world practice."

Clinical • Observational data • CNS Disorders • Movement Disorders • Parkinson's Disease

THE FRENCH CONSENSUS ON IDIOPATHIC GASTROPARESIS IN ADULTS AND CHILDREN (UEGW 2025) - "A blood test and screening for Helicobacter pylori were supported before diagnosing IG.Regarding the management, like in recent guidelines, the panel supported a first-line therapy using dietary advice and dopamine antagonists (metoclopramide or domperidone). The panel supported the efficacy of intravenous erythromycin, but not oral erythromycin. Agreement on the efficacy of other drugs, including prucalopride, antiemetics, or neuromodulators, was not reached... This consensus shows that the diagnostic modalities for IG are similar in France as compared to international guidelines, but highlights differences in the management of refractory gastroparesis, supporting endoscopic pyloromyotomy or the implantation of gastric electrical stimulation."

Clinical • Constipation • Gastrointestinal Disorder • Infectious Disease • Pediatrics

ITOPRIDE'S ROLE IN FUNCTIONAL DYSPEPSIA: A META-ANALYSIS OF PLACEBO-CONTROLLED AND PROKINETIC-CONTROLLED TRIALS (UEGW 2025) - "Aims & This meta-analysis evaluates the therapeutic efficacy of Itopride compared to placebo and other prokinetic agents in managing FD symptoms.A total of 19 randomized controlled trials were included in the analysis, comprising six placebo-controlled studies (n=1981, 976 on placebo and 1005 on Itopride) and 13 trials comparing Itopride to another prokinetic (n=1077, 515 on Itopride and 562 on control prokinetics including mosapride citrate, levosulpiride, metoclopramide, domperidone, and cisapride). This meta-analysis suggests that Itopride provides significant symptom relief in patients with FD compared to placebo, particularly in overall responder rates. While Itopride's benefits over other prokinetics were modest in general symptom relief, it demonstrated a statistically significant advantage over domperidone for early satiation."

Retrospective data • Dyspepsia • DRD2

MENTAL HEALTH CONSEQUENCES OF PRESSURE TO BREASTFEED (WPA-WCP 2025) - "In Canada, they may be prescribed Domperidone which has the side effect of increasing breast milk...Is this harassment of women based on scientific evidence? This presentation will discuss the evidence and care of postpartum women who wish to breast feed."

CNS Disorders • Depression • Mood Disorders • Psychiatry

Effect of Six Months of Gallbladder Flush on Size and Symptoms of A Patient With Cholelithiasis: A Case Report. (PubMed, Adv Mind Body Med) - "He was on conventional medications (Pantoprazole (40 mg), Domperidone (10 mg) twice a day before food, Biscodyl (5 mg) at night, and Urocidol (150 mg) twice a day, after food). Further clinical trials with a larger sample size are recommended to validate the study's results and assess its applicability in a broader population. cholelithiasis, gallstones, gallbladder flush, naturopathy, case report."

Journal • Constipation • Gastroenterology • Gastrointestinal Disorder • Hepatology

AGA Clinical Practice Guideline on Management of Gastroparesis. (PubMed, Gastroenterology) - "The diagnosis of gastroparesis requires the use of 4-hour gastric emptying tests. Metoclopramide or erythromycin is appropriate for initial pharmacologic treatment. Other treatment recommendations require shared patient-physician decision making. There are still considerable unmet needs in the treatment of gastroparesis."

Clinical guideline • Journal • Diabetes • Gastrointestinal Disorder • Metabolic Disorders