domperidone / Generic mfg. - LARVOL DELTA

Rapid Clinical Improvement Temporally Associated with Off-Label LetiFend® Vaccination in Canine Leishmaniasis: A Case Report. (PubMed, Vaccines (Basel)) - "Domperidone was subsequently introduced as long-term immunomodulatory follow-up, and allopurinol was temporarily reintroduced after transient laboratory deterioration in 2024; the dog remained clinically healthy through July 2026. The close temporal association is clinically noteworthy but cannot establish causality. This hypothesis-generating observation supports controlled investigation of therapeutic vaccination as a potential complementary approach in canine leishmaniasis."

Journal • Hematological Disorders • Infectious Disease • Thrombocytopenia

Domperidone in Treating Patients With Gastrointestinal Disorders (clinicaltrials.gov) - P3 | N=96 | Active, not recruiting | Sponsor: M.D. Anderson Cancer Center | Recruiting ➔ Active, not recruiting | N=200 ➔ 96

Enrollment change • Enrollment closed • Dyspepsia • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder

Management of Acute Diarrhea in Children after Implementing the Thai Clinical Practice Guideline. (PubMed, Pediatr Gastroenterol Hepatol Nutr) - "PGs were more likely to have experiences using adjunctive therapy, such as racecadotril and diosmectite (aOR, 7.86; 95% CI, 1.69-36.52; p=0.009 and aOR, 15.42; 95% CI, 2.90-33.63; p<0.001, consecutively). Domperidone was mostly used for patients with the first vomiting episode (52.4%). This survey provides insight into the practices of Thai pediatricians for the management of acute diarrhea in children. Variations in the use of oral antibiotics, antiemetics, adjunctive drugs, electrolyte supplementation, and feeding were observed, which may not align with the guideline."

Clinical guideline • Journal • Pediatrics

A pilot study evaluating the tolerability and effectiveness of miltefosine and sodium stibogluconate for the treatment of cutaneous leishmaniasis in Kandahar, Afghanistan. (PubMed, Trop Med Health) - "SSG was effective by both routes, but partially supervised MF was ineffective. More work is needed to determine factors affecting MF effectiveness against L. tropica in Kandahar. Clinical trial number The clinical trial number is TCTR20180710007, dated 10/07/2018."

Journal • Acute Kidney Injury • Dermatology • Infectious Disease • Inflammation • Nephrology • Renal Disease

Domperidone and the Risk of Serious Adverse Events (clinicaltrials.gov) - P=N/A | N=15000 | Active, not recruiting | Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Completed ➔ Active, not recruiting | Trial completion date: Oct 2024 ➔ Dec 2027

Adverse events • Enrollment closed • Serious adverse event • Trial completion date • Chronic Kidney Disease • Nephrology • Renal Disease

Proton Pump Inhibitor (PPI)-Domperidone Induced Anemia and Galactorrhea: A Case Report. (PubMed, EJIFCC) - "This case underscores the importance of meticulous history taking, appropriate diagnostic evaluation, and rational test utilization in identifying uncommon medication-related adverse effects. Clinicians should consider prolonged PPI use as a potential contributing factor when evaluating unexplained iron deficiency anemia, particularly in young individuals receiving long-term therapy."

Journal • Anemia • Fatigue • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hematological Disorders • Pain • PRL

The evaluation of body surface gastric mapping for the assessment of patients with gastrointestinal symptoms in New Zealand (ANZCTR) - P=N/A | N=200 | Completed | Sponsor: Alimetry Ltd. | Active, not recruiting ➔ Completed

Trial completion • Dyspepsia • Gastroenterology • Gastrointestinal Disorder

DOMPERIDONE VERSUS PLACEBO FOR NON-EROSIVE REFLUX DISEASE IN SYSTEMIC SCLEROSIS: A PRELIMINARY REPORT OF A RANDOMIZED CONTROLLED TRIAL (UEGW 2026) - No abstract available

Clinical • Gastroesophageal Reflux Disease • Immunology • Scleroderma • Systemic Sclerosis

Psychoactive drug effects on melanin production and melanocyte gene expression in zebrafish larvae (WFSBP 2026) - "Objective: This study examines how opioid use disorder–related compounds (morphine, MK801, and domperidone) affect melanogenesis and melanocyte gene expression in developing zebrafish (Danio rerio) to determine whether pigmentation biology is altered through pathways relevant to opioid exposure. Opioid use disorder–related compounds significantly modulate pigmentation biology in zebrafish by altering melanin production and melanocyte gene expression. These findings highlight links between opioid-related signaling and melanogenesis, supporting the use of zebrafish as a sensitive model for studying pigmentation changes associated with opioid exposure."

Addiction (Opioid and Alcohol) • CNS Disorders • Substance Abuse • SOX10

Domperidone plus pinaverium bromide and itopride for functional dyspepsia in the elderly: efficacy, symptom improvement, and gastric function panel. (PubMed, Am J Transl Res) - "The triple therapy (DPD+PB+ITP) demonstrates high therapeutic efficacy on elderly FD patients, helps improve symptoms, and actively up-regulates GF panel levels."

Journal • Dyspepsia • GAST

Practice of obstetric medicine in neurological disorders: towards evidence-based shared decision-making (SDM) (PubMed, Rinsho Shinkeigaku) - "We present evidence from an integrated database of 12,971 pregnancy cases, encompassing findings on various medications such as domperidone, fluoroquinolones, and triptans, among others...Through the Japan Association of Medical Sciences' TEAM project, cross-cutting guidelines have been developed to support patients' reproductive goals. We aim for a society where patients can make informed, autonomous choices through shared decision-making with healthcare providers regarding their treatment and pregnancy."

Journal • CNS Disorders • Multiple Sclerosis • Obstetrics • Small for Gestational Age

Evaluation of Compatibility of Domperidone with Selected Excipients used in Preparation of Orally Disintegrating Tablets. (PubMed, Drug Dev Ind Pharm) - "While excipient hygroscopicity varied significantly, no incompatibilities were detected that would limit formulation development of ODTs. It is recommended to use moisture protective packaging when highly hygroscopic excipients are included in formulation of ODTs."

Journal

In Vivo Evaluation of Psoralen in a Copper Sulfate-Induced Chick (Gallus gallus domesticus) Emesis Model and In Silico Analysis of Its Interaction With D2, 5-HT3 A, and Muscarinic Receptors. (PubMed, ChemistryOpen) - "A dose-dependent experimental design was employed with PSN (5, 10, and 20 mg/kg), alongside standard antiemetics (domperidone 6 mg/kg, ondansetron (OND) 5 mg/kg, and hyoscine 21 mg/kg) and combination treatments. PSN demonstrates significant antiemetic activity in a validated chick emesis model, supported by moderate binding affinity toward key emesis-related receptors. While docking findings suggest possible receptor interactions, further mechanistic and translational studies are required to confirm the molecular basis of its activity."

Journal • Preclinical

Artificial propagation, embryonic development and early larval growth of Triplophysa strauchii. (PubMed, J Fish Biol) - "Fertilized eggs were obtained using a combined domperidone (DOM) and luteinizing hormone-releasing hormone analogue (LHRH-A2) injection protocol (8 mg/kg + 18 μg/kg for females, half dosage for males) at a water temperature of (19 ± 1)°C...The relatively stable growth of head length and interorbital width reflects an adaptive strategy prioritizing the development of sensory and feeding organs. This study is the first to systematically establish an artificial propagation system for T. strauchii, clarify the timing of embryonic development and the patterns of larval growth, and fill the research gap in artificial propagation and early development of this species, providing a scientific basis and technical support for germplasm conservation, wild population restoration and large-scale artificial breeding of T. strauchii."

Journal

Cardiovascular pharmacology of dopaminergic agents in humans: a review. (PubMed, Clin Auton Res) - "The cardiovascular response to dopaminergic agents depends on receptor selectivity, intrinsic activity, and baroreflex integrity. The discrepancy between murine-knockout-predicted hypertension and human pharmacological neutrality with antagonists, and the hypertensive effects of dopamine D1 positive allosteric modulators, represent key unresolved questions."

Journal • Review • Cardiovascular • CNS Disorders • Hypertension • Hypotension • Mental Retardation • Movement Disorders • Parkinson's Disease • Psychiatry

Lactation Induction in a Transgender Woman With Electrocardiogram Abnormalities. (PubMed, J Hum Lact) - "Domperidone can be safely deployed for lactation induction in transgender women, but monitoring for potential cardiac adverse events is essential. We encourage clinicians lacking experience in lactation induction to engage with transgender patients seeking this type of care in a collaborative manner, rather than refusing outright to provide care."

Journal • Cardiovascular

A Study to Evaluate the Efficacy and Safety of CIN-102 (Deudomperidone) in Adult Subjects With Idiopathic Gastroparesis. (clinicaltrials.gov) - P2 | N=416 | Completed | Sponsor: CinDome Pharma, Inc. | Active, not recruiting ➔ Completed

Trial completion • Gastrointestinal Disorder

Serum angiogenesis-hypoxia biomarkers in relapsing-remitting multiple sclerosis. (PubMed, Mult Scler Relat Disord) - "Hypoxic factors are upregulated in RRMS serum and CNS, while angiogenesis factors are unchanged. This may suggest preservation of the hypoxia-angiogenic axis in RRMS as compared to the dysregulation seen in progressive MS."

Biomarker • Journal • CNS Disorders • Multiple Sclerosis • BDNF • HIF1A • HMOX1

Galactagogue activity of shalukam (Nelumbium speciosum Willd rhizome) compared to domperidone in Wistar albino rats. (PubMed, Front Pharmacol) - "Commonly used galactagogues include domperidone, metoclopramide, chlorpromazine, and sulpiride. The results suggest that the trial drug double-dose group demonstrated better galactagogue activity than the standard drug domperidone group in parameters serum prolactin and cortisol levels and trial drug single dose group demonstrated better galactagogue activity than the standard drug domperidone group in parameters serum prolactin and milk yield of 10 days. The findings suggests that the double dose group demonstrates stronger galactagogue potential."

Journal • Preclinical • Anesthesia • Cardiovascular • Dental Disorders • Gastroenterology • Gastrointestinal Disorder • Hypertension • Mood Disorders • Pain • Psychiatry • Xerostomia • PRL

Pituitary apoplexy in pregnancy with threatened vision (ENDO 2026) - "She was unable to breastfeed due to inappropriately low-normal postpartum prolactin and did not respond to a domperidone trial...Clinicians should anticipate possible post-operative hypopituitarism and lactation failure. Given the increased recurrence risk of apoplexy in future pregnancies, preconception counseling with neurosurgery, endocrinology, and obstetrics is recommended."

Late-breaking abstract • Endocrine Disorders • Hematological Disorders • Metabolic Disorders • Nephrology • Obstetrics • Ophthalmology • Renal Disease

Gastroparesis syndrome following thoracoscopic diaphragmatic hernia repair in a pediatric patient: a case report and literature review. (PubMed, Front Pediatr) - "The child was given continuous nasogastric suction, prokinetic therapy with domperidone, and acupressure massage at the Zusanli (ST36) acupoint...The occurrence of PGS following CDH repair is exceedingly rare. This report reviews the relevant literature to enhance clinicians' awareness of this complication and improve patient outcomes."

Journal • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hypertension • Pain • Pediatrics • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Pharmacological pitfalls in inpatient lung transplant care and management of medication risks. (PubMed, Front Pharmacol) - "Tacrolimus was the most commonly commented on drug, often due to interactions with metamizole/dipyrone, resulting in fluctuating tacrolimus levels. Other frequent issues included QTc-prolonging combinations (e.g., domperidone with escitalopram or amiodarone in addition to itraconazole) and reduced levothyroxine absorption due to divalent cations. Only five comments reflected actual adverse outcomes, indicating overall high drug safety. These findings are consistent with the literature describing the importance of systematic pharmacological review and interdisciplinary collaboration to improve medication safety and standardise care in lung transplant recipients."

Journal • Transplantation

MORDOR: REALITY MONITORING AND DOPAMINE (clinicaltrials.gov) - P=N/A | N=39 | Recruiting | Sponsor: Hôpital le Vinatier | Trial primary completion date: Jun 2026 ➔ Jan 2027

Trial primary completion date

Tail-Suspension Model of Simulated Microgravity-Induced Functional Dyspepsia in Rats: Behavioral, Motility, and Brain-Gut Peptide Alterations. (PubMed, Int J Mol Sci) - "These findings demonstrate that the rat tail-suspension model provides a reproducible platform for studying microgravity-induced FD, implicating brain-gut axis dysregulation. Domperidone's therapeutic effects highlight the model's utility for evaluating countermeasures against spaceflight-associated digestive dysfunction."

Journal • Preclinical • CNS Disorders • Depression • Dyspepsia • Gastrointestinal Disorder • Mood Disorders • Psychiatry • BDNF • GAST

Impact of different domperidone dosages on reflux esophagitis treated with esomeprazole: a randomized controlled trial. (PubMed, Dis Esophagus) - "Although overall adverse event rates did not differ significantly among groups, a dose-dependent trend was observed. Higher doses offer no additional benefit and may increase safety concerns."

Clinical • Journal • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder