IMM-H012
/ Shanxi Zhendong Group
- LARVOL DELTA
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January 28, 2026
Revitalizing PI3K Inhibitors for PET/CT Imaging and Radionuclide Therapy of Multiple Cancers.
(PubMed, J Med Chem)
- "Herein, we rationally designed and synthesized four bifunctional radiolabeled small-molecule chimeras based on the PI3K inhibitor IMM-H012, denoted as [68Ga]Ga/[177Lu]Lu-P(1-4)...The mechanistic study suggested a novel radiosensitization mechanism of 177Lu to PI3K inhibitors by downregulating fatty acid oxidase expression. These findings reposition PI3K as a versatile theranostic target while providing an effective repurposing strategy for PI3K inhibitors."
Journal • Cutaneous Melanoma • Melanoma • Oncology • Solid Tumor
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