amiodarone / Generic mfg. - LARVOL DELTA

FLECA-ED: Flecainide Versus Amiodarone in the Cardioversion of Paroxysmal Atrial Fibrillation at the Emergency Department, in Patients With Coronary Artery Disease Without Residual Ischemia (clinicaltrials.gov) - P3 | N=80 | Recruiting | Sponsor: Hippocration General Hospital | N=200 ➔ 80 | Trial completion date: Nov 2024 ➔ Jan 2026 | Trial primary completion date: Oct 2024 ➔ Dec 2025

Enrollment change • Trial completion date • Trial primary completion date • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease

Therapeutic plasmapheresis in the management of thyrotoxicosis: a-retrospective study with emphasis on critically ill patients. (PubMed, Endocrine) - "Our study is among the largest series in the literature. Consistent with existing literature, it has been demonstrated that TPE was reliable and effective in establishing rapid and effective euthyroid state not only in cases of antithyroid drug side effects, ineffectiveness, and thyroid storm but also before non-thyroidal emergency surgeries."

Journal • Retrospective data • Endocrine Disorders • Grave’s Disease

Refractory supraventricular tachycardia from a coronary sinus diverticulum leading to cardiogenic shock: a challenging ablation case. (PubMed, Monaldi Arch Chest Dis) - "Despite boluses of adenosine and amiodarone perfusion, the patient experienced recurrent supraventricular tachycardia (SVT), leading to cardiogenic shock...Successful radiofrequency ablation was performed, resulting in clinical and left ventricular ejection fraction improvement. This case highlights the challenges in managing incessant SVT with cardiogenic shock and complex ablation procedures."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Ventricular Tachycardia

A single center experience of concomitant administration of sofosbuvir/velpatasvir and amiodarone after heart and lung transplantation. (PubMed, JHLT Open) - "Episodes of bradycardia were transient, resolved with intervention, and did not require the discontinuation of SOF/VEL. In patients requiring the combination of SOF/VEL and amiodarone, consideration of therapeutic options is warranted prior to the addition of other bradycardia-inducing medications."

Journal • Cardiovascular • Hepatitis C • Infectious Disease • Inflammation • Transplantation

Plasmapheresis as a Life-Saving Intervention in Amiodarone-Induced Thyroid Storm (ERA 2025) - "Amiodarone was discontinued, thiamazole and prednisolone were started...Postoperatively, the patient recovered without complications and was transitioned to lifelong levothyroxine therapy... This case highlights the efficacy of plasmapheresis in managing refractory AIT, particularly in patients with critically thyrotoxicosis and severe clinical instability. Plasmapheresis offers rapid hormonal control by removing protein-bound thyroid hormones, bridging the gap between medical therapy and surgical intervention. Early recognition and initiation of plasmapheresis in high-risk patients, especially when standard therapies fail to control symptoms, could improve outcomes and reduce morbidity associated with AITS."

Cardiovascular

Amiodarone and Ravuconazole Combination Potentiates Chemotherapy against Drug-Resistant Trypanosoma cruzi Strains. (PubMed, ACS Omega) - "These findings demonstrate a positive in vivo interaction between ravuconazole and amiodarone against T. cruzi infection. Furthermore, they highlight the relevance of the host genetic background and parasite strain on treatment outcomes."

Journal • Infectious Disease • IL10

Exploring Public Interest in Atrial Fibrillation and Its Treatment Measures: A Google Trends Analysis. (PubMed, Cureus) - " This study demonstrates a rising public interest in AF. Searches related to medications such as amiodarone, metoprolol, diltiazem, and flecainide, as well as procedures including cardioversion, artificial cardiac pacemaker, and left atrial appendage occlusion, have all shown increasing trends."

Journal • Atrial Fibrillation • Cardiovascular • Respiratory Syncytial Virus Infections

Non-operation room anesthesia during polypectomy in colonoscopy for a patient with pattern of Wolff-Parkinson White (Euroanaesthesia 2025) - "He was treated in that period with atenolol 50mg x 2 and denied ablation...We used dexmedetomidine 3 mcg/kg + ketamine 2 mg/kg i/v for NORA. Adenosine, procainamide, and amiodarone were kept on standby...Our case aims to highlight that proper medical knowledge combined with appropriate precautions can avoid sympathetic stimulation. They are the key to a successful outcome in patients with WPW syndrome undergoing sedation during colonoscopy."

Clinical • Aesthetic Medicine • Anesthesia • Cardiovascular • CNS Disorders • Movement Disorders

Ventricular tachycardia refractory to cardioversion in a pediatric patient without congenital cardiac anomaly: case report (Euroanaesthesia 2025) - "There was no response and a diagnosis of a ventricular tachycardia was made and initially intravenous amiodarone was tried and synchronized cardioversion was planned...It can occur in children with cardiomyopathy, following some heart surgeries, and with inherited diseases that affect the heart's electrical system (e.g. Long QT syndrome, Brugada's syndrome), also metabolic or electrolyte abnormalities and medication toxicity. In the case of our patient on futher investigation Human coronavirus OC43 infection was detected with molecular PCR testing and the patient was discharged with oral beta blocker for rhythm control."

Case report • Clinical • Cardiomyopathy • Cardiovascular • Genetic Disorders • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Pediatrics • Ventricular Tachycardia

Stellate ganglion block: the future treatment for electrical cardiac storms – case report (Euroanaesthesia 2025) - "Current pharmacological treatment (amiodarone, beta-blockers) have limitations regarding their effectiveness[1,2]...We presente a case of a patient with electrical storm treated with stellate ganglion block.Case Report: A 69-year-old male patient with a past medical history of atrial fibrillation (on dabigatran anticoagulation), heart insufficiency (EF 49%), alcohol and tobacco consumption, type II diabetes mellitus and benign prostatic hyperplasia (BPH), was admitted for revascularization angioplasty after an inferolateral STEMI...Three VT episodes were recorded within 24 hours after the SGB, hemodynamic stability was achieved and no further dysrhythmic episodes were observed subsequently. SGB is an effective, minimally invasive and with low risk of complications technique for recurrent VT/VF. Currently, it's not included in the guidelines, with the potential to be part of the treatment for refractory VT/VF[1,2]."

Case report • Clinical • Anesthesia • Atrial Fibrillation • Benign Prostatic Hyperplasia • Cardiovascular • Congestive Heart Failure • Diabetes • Heart Failure • Metabolic Disorders • Ophthalmology • Type 2 Diabetes Mellitus • Ventricular Tachycardia

Acute right heart failure in a patient with undiagnosed pulmonary hypertension following spinal surgery: a case report (Euroanaesthesia 2025) - "This significantly raises morbidity, mortality and challenging perioperative management in major surgeries.Case Report: A 72-year-old woman with hypertension, chronic bronchitis, chronic kidney disease, and previous spinal surgeries was scheduled for spinal arthrodesis (T3-Sacro) due to failed prior instrumentation.Anesthesia was initiated with intrathecal morphine, followed by general anesthesia...During surgery, the patient experienced hypotension, 900 mL blood loss, and ventricular tachycardia, which were managed with fluid resuscitation, blood transfusion, vasopressors, and amiodarone.Postoperatively, she was transferred to the ICU...Treatment with vasopressors and milrinone stabilized her within 72 hours...Echocardiography and AngioCT were key in excluding pulmonary embolism and identifying right ventricular dysfunction.Learning Points: PH enhances the risk of perioperative complications, particularly right heart failure. Early detection, hemodynamic stability, and..."

Case report • Clinical • Surgery • Anesthesia • Cardiovascular • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Heart Failure • Hypertension • Hypotension • Nephrology • Pulmonary Arterial Hypertension • Pulmonary Disease • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Ventricular Tachycardia

The dilemma of choosing safe anaesthetic medicines for a patient with Brugada syndrome needing vitrectomy! If the same patient needs a laparotomy, what pharmacological agents should you choose? (Euroanaesthesia 2025) - "Lignocaine, Amiodarone, Tramadol, Metoclopramide and Ketamine are on the orange list (preferably avoid)2. Caution with Vagotonic manoeuvres (e.g pneumoperitoneum, neck surgery) bradycardia precipitates VT/VF. Avoid hyperthermia3.If GA is necessary (e.g. laparotomy), safer drugs are Thiopentone, Fentanyl, Sevoflurane, NDMR, Paracetamol, NSAIDs, Dexamethasone, Ondansetron and Sugammadex."

Clinical • Aesthetic Medicine • Anesthesia • Cardiovascular • Dyslipidemia • Genetic Disorders • Hypertension • Metabolic Disorders

The phenomena of arrhythmia-induced cardiomyopathies (AICM): what comes first, the chicken or the egg? (Euroanaesthesia 2025) - "Consequently, a therapy with amiodarone and beta blocker was gradually designed to control the arrhythmic pattern. After the decrease of heart rate, we continued to treat the heart failure with beta blocker carvedilol, digoxin, ACE inhibitor and diuretics...Even if the causative arrhythmia is apparent, the clarification of a cause-effect relationship sometimes provokes a diagnostic "headache" for the treating physician, since diagnosis may be confirmed only retrospectively. Raising awareness of the difficulties of diagnosis and all available treatment options is essential for a better management of dysrhythmia in children."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fatigue • Heart Failure • Infectious Disease • Pain • Pediatrics

Predicting drug-drug interactions and optimal dosing of betrixaban with physiologically based pharmacokinetic modeling in patients with renal impairment who were coadministered with P-glycoprotein inhibitors. (PubMed, J Int Med Res) - "ObjectiveTo optimize dosing adjustments in patients with renal impairment who were coadministered with P-glycoprotein inhibitors-verapamil or amiodarone-using a physiologically based pharmacokinetic model.MethodsThe developed physiologically based pharmacokinetic model was corroborated using previously reported pharmacokinetic parameters across multiple doses, ratio values in drug-drug interactions, and pharmacokinetic ratio values in patients with renal impairment.ResultsThe physiologically based pharmacokinetic model exhibited fold errors between 0.7 and 1.3 and effectively illustrated changes in pharmacokinetic ratios in patients with renal impairment. For patients with severe renal impairment, it may be reasonable to avoid concurrent use of betrixaban with P-glycoprotein inhibitors.ConclusionsThe coadministration of P-glycoprotein inhibitors elevates the exposure of betrixaban and may heighten the risk of major bleeding. Reduced dosing regimens are recommended for..."

Journal • PK/PD data • Renal Disease

Amiodarone-Induced Pulmonary Toxicity Presenting as Hypoxemic Respiratory Failure in a Patient With Ventricular Tachycardia: A Case Report. (PubMed, Cureus) - "Following the prompt discontinuation of amiodarone and the initiation of systemic corticosteroids, the patient exhibited marked clinical and radiological improvement. This case underscores the importance of maintaining a high index of suspicion for APT in patients on long-term amiodarone therapy presenting with new respiratory symptoms."

Journal • Cardiovascular • Infectious Disease • Interstitial Lung Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Ventricular Tachycardia

Corrigendum to "Ventricular fibrillation likely resulting from electrocautery and amiodarone: a rare clinical case report". (PubMed, J Int Med Res) - No abstract available

Journal • Cardiovascular

Effect of Amiodarone on Apixaban Exposure in Patients after Cardiac Surgery-A Population Pharmacokinetic Study. (PubMed, Clin Pharmacokinet) - "Concomitant amiodarone therapy reduced apixaban CL/F and increased the risk of high exposure in patients with impaired renal function. A dose of 2.5 mg apixaban b.i.d. for a CrCL range of 30-50 mL/min under concomitant amiodarone therapy was identified as a new dosing option."

Journal • PK/PD data • Atrial Fibrillation • Cardiovascular

Heart Ventricular Function In Hospitalized Patients With Severe Hypothyroidism (ENDO 2025) - "Exclusion criteria included ischemic coronary artery disease, cardiac arrest, implanted cardiac device, atrial fibrillation, amiodarone treatment, receiving hemodialysis, history of cardiotoxic chemotherapy, alcohol withdrawal, urgent surgery, or septic shock at admission... Severe hypothyroidism is associated with heart ventricular muscle dysfunction manifested by a high prevalence of patients (>70%) with increased GLS and, clinically, with low LVEF."

Clinical • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease • Endocrine Disorders • Septic Shock

Iodine-Induced Thyrotoxicosis Leading to Severe Osteoporosis: A Case Report (ENDO 2025) - "Common sources include iodized salt, amiodarone, and seaweed-based supplements such as kelp. We report a case of iodine-induced thyrotoxicosis secondary to kelp consumption, resulting in severe osteoporosis, emphasizing the importance of dietary awareness in thyroid management.CaseA 58-year-old woman with osteoporosis, low BMI, and premature ovarian insufficiency (POI) was evaluated for worsening bone density despite prior treatment with alendronate...She was advised to avoid excessive iodine and was treated with prednisone. She also started denosumab but was lost to follow-up...Kelp and similar supplements can exceed the recommended iodine intake of 1,100 mcg/day, necessitating dietary education.This case highlights the difficulty of managing iodine-induced thyrotoxicosis, especially when unrecognized supplement intake is involved. Comprehensive care should include dietary counseling and, when needed, psychiatric evaluation to address behavioral patterns contributing to..."

Case report • Clinical • Cardiovascular • Endocrine Disorders • Movement Disorders • Musculoskeletal Diseases • Orthopedics • Osteoporosis • Psychiatry • Rheumatology • Women's Health

Amiodarone induced thyroiditis (ENDO 2025) - "He was initially diagnosed with suspected type 2 amiodarone induced thyroiditis and treated with a course of prednisone for 10 days...The rhabdomyolysis could be precipitated by the prolonged usage of amiodarone and atorvastatin which could have been worsened by prolonged amiodarone induced thyroiditis... Type 1 AIT is usually treated with thioamides, enhanced by potassium perchlorate to block iodine uptake, while type 2 AIT is best treated with oral glucocorticoids. Mixed forms may require a combination of these therapies. In refractory cases, thyroidectomy can be considered."

Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • Dyslipidemia • Endocrine Disorders • Fatigue • Hypertension • Musculoskeletal Pain • Myositis • Nephrology • Pain • Renal Disease

Severe Hypothyroidism with Impending Myxedema Coma after Pembrolizumab Therapy (ENDO 2025) - "This is the case of a 72 y/o male with history of hypertension, atrial fibrillation on apixaban and amiodarone, chronic obstructive pulmonary disease GOLD 2A, hyperlipidemia, chronic kidney disease stage 2, seizures, oropharyngeal dysphagia, and stage IV lung squamous cell carcinoma with metastasis to the brain that failed to conventional therapy and was started on pembrolizumab 6 weeks ago...Patient was initially managed with IV bolus of hydrocortisone 100 mg and then started on IV levothyroxine (100 mcg once then 50 mcg daily) and Hydrocortisone IV drip for 3 days...The occurrence of anti-PD-1–induced thyroid irAEs is high, although the underlying mechanism is not completely understood. Therefore, it is important to monitor thyroid function test closely in patients receiving these therapies for prompt recognition and treatment."

Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • CNS Disorders • Dyslipidemia • Endocrine Disorders • Epilepsy • Gastrointestinal Disorder • Heart Failure • Hypertension • Immunology • Nephrology • Non Small Cell Lung Cancer • Oncology • Otorhinolaryngology • Pulmonary Disease • Renal Disease • Respiratory Diseases

Unexpected New Onset of Grave's Disease in an 80 Year Old Female (ENDO 2025) - "She denied exposure to amiodarone, iodine, or recent viral illnesses...After 4 weeks, methimazole was reduced to 5 mg daily with normalization of her FT3 and FT4. Our case further illustrates the unexpected diagnosis of late-onset GD, given the patient's advanced age...GD in the elderly may accelerate the occurrence of cataracts, age-related hearing impairment, COPD, and sarcopenia. The absence of classical symptoms and signs in older adults presents a diagnostic challenge and may lead to delay in treatment and poor outcome if not recognized."

Anorexia • Atrial Fibrillation • Cardiovascular • Cataract • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Endocrine Disorders • Geriatric Disorders • Grave’s Disease • Heart Failure • Hypertension • Immunology • Infectious Disease • Movement Disorders • Ophthalmology • Osteoporosis • Pain • Respiratory Diseases • Rheumatology • Sarcopenia

Navigating Metastatic Thyroid Cancer in the Context of Amiodarone Induced Iodine Overload (ENDO 2025) - "Post-thyroidectomy hypothyroidism was treated with levothyroxine (175 mcg/day), maintaining TSH <0.1 mIU/L due to metastatic disease.Diagnostic RAI imaging was contraindicated by iodine saturation...Discontinuing amiodarone and initiating dofetilide to facilitate iodine clearance.2...Considering tyrosine kinase inhibitors if disease progressed while awaiting RAI eligibility.Currently, she remains clinically stable without significant progression, and future RAI eligibility is under reassessment.Clinical Lessons:This case highlights the unique complexities of managing metastatic PTC in the context of iodine excess from chronic amiodarone use. Key clinical lessons include:• Chronic amiodarone-induced iodine overload demands strategic tapering of amiodarone and the use of alternative antiarrhythmics.• Maintaining TSH suppression is critical to limiting tumor growth in metastatic PTC.• Close collaboration among endocrinology, cardiology, and oncology balances arrhythmia..."

Metastases • Atrial Fibrillation • Cardiovascular • Endocrine Cancer • Endocrine Disorders • Oncology • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma • NKX2-1 • PAX8

Thyroid Function Testing Patterns in Newly Diagnosed Heart Failure (ENDO 2025) - "Main exclusions included receipt of amiodarone, dronedarone, lithium, anti-thyroid, or thyroid replacement medication within 1 year prior to hospitalization and lack of follow-up data through 90 days after discharge. Thyroid testing among patients with new-onset HF was inconsistent in a real-world setting. Testing was more prevalent among patients with HF with reduced ejection fraction, atrial fibrillation, and those receiving guideline directed medical therapy. In-hospital TSH testing resulted in changes in management for a small subset of patients, though the clinical validity and implications of this is uncertain."

Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Endocrine Disorders • Heart Failure

Challenging the Paradigm: IV Amiodarone in Thyroid Storm Without Worsening Thyrotoxicosis (ENDO 2025) - "He was started on IV esmolol and digoxin. Due to persistent tachycardia and hypotension precluding diltiazem use, an IV amiodarone drip was started as per cardiology recommendation...Hydrocortisone was tapered with the continual improvement of FT4, and methimazole was continued for new-onset hyperthyroidism, with outpatient follow-up planned for further workup.Conclusion This case highlights the potential use of IV amiodarone in thyroid storm for refractory arrhythmia despite maximal conventional management without worsening of thyrotoxicosis, as the patient's thyrotoxic symptoms and thyroid function improved despite IV amiodarone. IV amiodarone inhibits peripheral T4 to T3 conversion which in combination with anti-thyroid medications, preferably started before amiodarone to suppress new hormone synthesis, may help control thyrotoxicosis symptoms in the short term. However, data remain limited due to the absence of randomized controlled trials and their known..."

Ataxia • Atrial Fibrillation • Cardiovascular • Endocrine Disorders • Friedreich ataxia • Gastroenterology • Hepatology • Hypotension • Movement Disorders • Pulmonary Embolism • Respiratory Diseases • Septic Shock