amiodarone / Generic mfg. - LARVOL DELTA

Iodine and Thyroid Dysfunction in Ageing: Nutritional, Pharmacologic, and Microbial Modifiers in Older Adults. (PubMed, Geriatrics (Basel)) - "Polypharmacy, including amiodarone, lithium, and proton pump inhibitors, further destabilizes thyroid function... Overall, variations in iodine intake emerge as one of the main determinants of thyroid dysfunction in ageing with nutritional, pharmacologic, and other modifiers primarily influencing iodine-related thyroid vulnerability. The adoption of age-adjusted thyroid reference ranges and preventive monitoring can reduce overtreatment and improve metabolic resilience in later life."

Journal • Review • Endocrine Disorders • Inflammation

Recurrent syncope due to ischemic ventricular tachycardia masquerading as a seizure disorder treated with coronary revascularization: a case report. (PubMed, Oxf Med Case Reports) - "Improvement was observed after revascularization, though the mechanism remains inferred and may have been influenced by concomitant amiodarone. Clinicians should consider cardiac arrhythmias in atypical seizure-like episodes, especially in adults with cardiovascular risk factors."

Journal • Cardiovascular • CNS Disorders • Coronary Artery Disease • Epilepsy • Heart Failure • Ventricular Tachycardia

Comparing Liquid Vortex Capture & the Rapid Droplet Sampling Interface for Single Cell Mass Spectrometry. (PubMed, J Am Soc Mass Spectrom) - "RDSI demonstrated up to 100-fold improvements in sensitivity for drugs and lipids such as propranolol, amiodarone, atorvastatin, and phosphocholines in water and phosphate-buffered solutions. Single-cell uptake of atorvastatin incubated for 10 min, or amiodarone incubated for 24 h in HepG2 cells, similarly revealed up to 85-fold enhancement in sensitivity by RDSI for drugs and lipids. These findings highlight the potential of RDSI for enhancing sensitivity in single-cell drug monitoring and lipidomics."

Journal

Evaluating the Impact of Posterior Pericardiotomy on Reducing Postoperative Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Grafting in an LMIC (STS 2026) - "Preoperative beta-blockers were used in 61.6%, postoperative in 82.5%, and amiodarone in 13.9%...Larger prospective studies could validate these findings and inform practice in resource-limited cardiac surgery settings. Table Image"

Clinical • Atrial Fibrillation • Cardiovascular

Five-year Outcomes of Robotic versus Sternotomy Cryothermic Cox Maze III (STS 2026) - "All patients were discharged on postoperative oral amiodarone prophylaxis for 3 months...Robotic CMIII may provide a safe minimally invasive alternative with augmented lesion precision enabling longitudinal efficacy. Table Image"

Atrial Fibrillation • Cardiovascular • Hematological Disorders • Ischemic stroke

Isolating the Independent Impact of Posterior Pericardiotomy and Amiodarone for Prophylaxis Against Postoperative Atrial Fibrillation: A Posthoc Analysis of the PAPPA Trial (STS 2026) - "These findings suggest a potential synergistic effect between the two interventions, underscoring the importance of a combined pharmacosurgical strategy for POAF prevention in cardiac surgery. Table Image"

Retrospective data • Atrial Fibrillation • Cardiovascular

Amiodarone-Induced Thyrotoxicosis Presenting as Refractory Atrial Fibrillation in Hypertrophic Cardiomyopathy: A Case Report. (PubMed, Cureus) - "The patient continued to experience recurrent arrhythmic episodes despite withdrawal of amiodarone and aggressive pharmacological management, highlighting the complex bidirectional relationship between thyroid dysfunction and cardiac arrhythmias. This case underscores the importance of early recognition of AIT in patients with difficult-to-control atrial fibrillation and emphasizes the need for a multidisciplinary approach involving cardiology and endocrinology."

Journal • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Endocrine Disorders • Heart Failure • Hypertrophic Cardiomyopathy • Non-obstructive Hypertrophic Cardiomyopathy

Analysis of interstitial lung disease in pharmacovigilance databases: Coding challenges and interpretation biases-An update. (PubMed, Br J Clin Pharmacol) - "Our analysis highlights the substantial variability in MedDRA coding that may affect the reliability of drug safety analyses. Moreover, studies conducted on PV databases do not sufficiently assess the relevance of query criteria and their impact on the results. We propose a few practical recommendations."

Adverse events • Journal • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases

ReCAST AF: Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation (clinicaltrials.gov) - P4 | N=988 | Not yet recruiting | Sponsor: Universitaire Ziekenhuizen KU Leuven

New P4 trial • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease

Amiodarone-induced hyperthyroidism : complex diagnosis and treatment (PubMed, Rev Med Liege) - "Two main subtypes have been identified - Type 1 and Type 2 - along with mixed forms, whose diagnosis may be challenging but remains essential, as therapeutic strategies vary significantly according to the underlying pathophysiology. Through the presentation of a clinical case, this article examines the different forms of amiodarone-induced thyrotoxicosis, their clinical manifestations, the diagnostic workup required to distinguish them, and the appropriate management strategies."

Journal • Atrial Fibrillation • Cardiovascular • Endocrine Cancer • Endocrine Disorders

Amiodarone-Induced Pneumonia Without Foamy Macrophages in the BALF: A Diagnostic Challenge Unveiled by Cryobiopsy. (PubMed, Respirol Case Rep) - "After discontinuation of amiodarone, the patient's symptoms and radiographic abnormalities improved. This case highlights that the absence of foamy macrophages in BALF should not preclude amiodarone-induced pneumonia, and that histological evaluation plays a pivotal role in establishing an accurate diagnosis."

Journal • Cough • Infectious Disease • Interstitial Lung Disease • Pneumonia • Respiratory Diseases

Evaluating the Reliability of Virtual Screening: Experimental Insights From Flavonoid Library Screen Targeting Caspase-3. (PubMed, FASEB J) - "Out of which, in both cell lines (HepG2 & Huh-7), Okanin showed significant protection against amiodarone, while Okanin, Irigenin, and Isoliquiritigenin provided substantial protection against oleic acid-induced cell death. The findings highlight the limitations of individual docking programs and emphasize the utility of an integrated approach to enhance the effectiveness of predictions for virtual screening. Furthermore, this study provides a robust framework for the rational design of flavonoid-based caspase inhibitors with optimized efficacy and pharmacological profiles."

Journal • Preclinical • Hepatology • CASP3

Rare Chromosome 18q Rearrangements and Hypoplastic Right Heart Syndrome: A Case Report and Genetic Insights (ACMG 2026) - "Outcome and Follow-Up At reporting, she was discharged with nasogastric tube feeding and continuation of Enalapril and Amiodarone for tachycardia and Lovenox for thrombus. Conclusion This case broadens the clinical spectrum of chromosome 18q rearrangements by identifying a potential association with HRHS, a phenotype not previously reported. Recognition of this correlation may enhance understanding of cardiac developmental pathways, inform genotype–phenotype research, and improve genetic counseling for families."

Case report • Clinical • Cardiovascular • Gynecology • Hematological Disorders • Hypertension • Thrombosis • DSG2 • ZKSCAN1 • ZNF23

Drug-Induced Thyroid Dysfunctions (AACE 2026) - "This lecture reviews the spectrum of drug-induced thyroid dysfunctions, including hypothyroidism, hyperthyroidism, and thyroiditis caused by commonly used medications such as amiodarone, immune checkpoint inhibitors, and tyrosine kinase inhibitors...Identify which medications and supplements can cause lab interference and which can cause clinically relevant thyroid hormone dysfunction. Understand how to workup, manage, monitor, and treat drug-induced thyroid disorders."

Endocrine Disorders

Histology of amiodarone-induced liver injury revisited: A retrospective morphologic analysis. (PubMed, Ann Diagn Pathol) - "While AILI shares features with the more generally known metabolic dysfunction-associated steatotic liver disease, our findings indicate that a prominence of periportal distribution of ballooned hepatocytes and Mallory-Denk bodies despite a minimum of macrovesicular steatosis are characteristic of AILI. Furthermore, cholestasis in biopsy samples may suggest a poorer prognosis in patients on amiodarone."

Journal • Retrospective data • Cholestasis • Fibrosis • Hepatology • Immunology • Inflammation • Liver Failure • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease

OUTCOME OF HEART TRANSPLANT PATIENTS WITH PACEMAKERS PLACED AFTER 1-YEAR POST-TRANSPLANT (WRMC 2026) - "Purpose of Study: Patients after heart transplantation (HTx) may require a permanent pacemaker (PPM) within one month after transplant, due to edema or trauma to the donor heart or the preoperative use of amiodarone which can cause relative bradycardia in the donor heart... Patients who receive a PPM more than one year after HTx are at increased risk for 3-year mortality and warrant close monitoring after PPM placement. PPM placement for Unknown cause compared to those with Known cause appears to have less adverse outcomes which may represent more benign cardiac nerve conduction abnormality."

Clinical • Post-transplantation • Antibody-mediated Rejection • Cardiovascular • Congestive Heart Failure • Heart Failure • Mood Disorders • Myocardial Infarction • Transplantation

DOAC Pharmacologic Interactions in Acute Ischemic/TIA vs Hemorrhagic Stroke: Findings from a 77-Hospital Telestroke Program (ISC 2026) - "DOAC distribution: rivaroxaban 314/446 (70.4%) , apixaban 101/446 (22.6%) , edoxaban 17/446 (3.8%) , dabigatran 14/446 (3.1%) . Cerebrovascular presentations: ischemic stroke 381/446 (85.4%) , non-SAH hemorrhagic stroke 41/446 (9.2%) , SAH 18/446 (4.0%) , TIA 6/446 (1.3%) .Interaction prevalence by event group (pre-specified comparison of ischemic/TIA vs hemorrhagic:Ischemic/TIA (n=387): – PD (bleeding-risk): 130/387 (33.6%) – PK inhibitors (↑ exposure): 37/387 (9.6%) – PK inducers (↓ exposure): 18/387 (4.7%) Hemorrhagic (n=59): – PD (bleeding-risk): 15/59 (25.4%) – PK inhibitors (↑ exposure): 7/59 (11.9%) – PK inducers (↓ exposure): 6/59 (10.2%) PD combinations consistently exceeded PK DDIs overall, driven primarily by acetylsalicylic acid/aspirin and clopidogrel; heparins were less frequent. Among PK interactions, amiodarone predominated as an inhibitor and phenytoin as an inducer. The relative excess of PD DDIs in ischemic/TIA and the higher proportions of PK..."

Clinical • Cardiovascular • Cerebral Hemorrhage • Hematological Disorders • Ischemic stroke

Medication-associated thyroid eye disease: a review. (PubMed, Graefes Arch Clin Exp Ophthalmol) - "Medication-associated TED is an important differential consideration in the work-up of orbital inflammatory disease. The clinico-radiological manifestations and the principles of management of medication-associated TED were similar to that of de novo TED. Certain medications, such as various ICIs, may demonstrate different clinical phenotypes of orbital inflammation, inciting either TED or a "TED-like" orbitopathy without evidence of underlying thyroid dysfunction."

Journal • Review • Endocrine Disorders • Grave’s Disease • Inflammation • Ocular Inflammation • Oncology • Ophthalmology • Thyroid Eye Disease

Survival with one versus three centimeters of active decompression during automated head-up CPR in a porcine cardiac arrest model. (PubMed, Resusc Plus) - "Epinephrine and amiodarone were administered after 19 min of CPR with defibrillation 1 min later. 24-h survival rates were significantly higher with AL-3 cm vs AL-1 cm during AHUP-CPR. Together with improved hemodynamics observed with AL-3 cm, these outcomes underscore the critical importance of AL-3 cm to optimize AHUP-CPR."

Journal • Preclinical • Anesthesia • Cardiovascular

Bleeding risk of rivaroxaban and edoxaban with and without amiodarone in atrial fibrillation patients: a prospective cohort study. (PubMed, Eur J Clin Pharmacol) - No abstract available

Journal • Atrial Fibrillation • Cardiovascular

Left Atrial Thrombus and Cardioembolic Stroke in Chagas Cardiomyopathy Presenting with Atrial Flutter: A Case Report. (PubMed, J Clin Med) - "Intravenous thrombolysis with alteplase (0.9 mg/kg) was administered within 4.5 h of symptom onset. Pharmacologic rhythm control was achieved using intravenous and oral amiodarone, followed by oral anticoagulation with warfarin (target INR 2.0-3.0) after excluding hemorrhagic transformation...Early recognition, adherence to evidence-based guidelines, and multidisciplinary management were key to achieving a favorable outcome. Timely diagnosis and intervention remain crucial to preventing severe complications in patients with Chagas disease."

Journal • Cardiomyopathy • Cardiovascular • Hematological Disorders • Infectious Disease • Ischemic stroke • Pain • Pulmonary Disease • Thrombosis

Chronic obstructive pulmonary disease (COPD) and cardiovascular comorbidities: Shedding light on key interactions and therapeutic approaches. (PubMed, Eur J Intern Med) - "Chronic obstructive pulmonary disease (COPD) is often associated with cardiovascular disease and the both conditions share common risk factors (smoke), associated pathophysiological mechanisms (pulmonary hyperinflation and vasoconstriction, systemic inflammation and sympathetic activation) and drug use (beta agonists and/or antagonists, steroids, amiodarone)...Recent improvement in the knowledge of molecular basis of COPD, heart diseases and PAD have pointed out a strong, complex and fascinating relationship linking these conditions, not simply definable as comorbidities. From these premises, we here aim at discussing on the novel and emerging integrated therapeutic perspectives, in some instances exploited from immune-oncology, which strongly deserve a multidisciplinary clinical management."

Journal • Review • Cardiovascular • Chronic Obstructive Pulmonary Disease • Heart Failure • Immunology • Oncology • Peripheral Arterial Disease • Pulmonary Disease • Respiratory Diseases

MANAGEMENT OF ATRIAL FIBRILLATION DURING THE PERI-TRANSPLANT PERIOD IN ELDERLY AML PATIENTS UNDERGOING ALLO-HSCT BASED ON EBMT GUIDELINES: A CASE STUDY OF NURSING CARE (EBMT 2026) - "Precision medication nursing: Oral propafenone hydrochloride + intravenous amiodarone (collaborative with physicians), with 30-minute blood pressure/heart rate monitoring to control ventricular rate at 60–80 bpm and prevent hypotension.3. The occurrence of AF in elderly AML patients during the peri-transplant period of allo-HSCT is closely related to the toxicity of conditioning regimens, underlying heart disease, and decreased physiological reserve. The integrated nursing model of "evidence-based monitoring - precision medication - complication prevention and control - psychological support and health education" constructed in accordance with EBMT guidelines has been proven to effectively control AF episodes, reduce related risks, and thus ensure the smooth progress of transplantation. This model emphasizes the special nursing needs of elderly patients undergoing allo-HSCT, refines the guideline measures by optimizing the intervention plan, and demonstrates..."

Case study • Clinical • Acute Myelogenous Leukemia • Atrial Fibrillation • Bone Marrow Transplantation • Cardiovascular • CNS Disorders • General Anxiety Disorder • Heart Failure • Hematological Disorders • Hematological Malignancies • Hypotension • Leukemia • Mood Disorders • Transplantation

Reversible Atrial Fibrillation and Cardiogenic Shock Following Acute Aluminum Phosphide Poisoning: A Case Report and Literature Review. (PubMed, Clin Med Insights Case Rep) - "Key learning points include recognition of ALP ingestion in shock, vigilance for life-threatening arrhythmias, and tailored management (eg, use of amiodarone and careful fluid and pressor support). The patient's full recovery underscores that even severe ALP cardiotoxicity can be reversible with appropriate care."

Journal • Atrial Fibrillation • Cardiovascular • Critical care • Heart Failure • Hypotension • Metabolic Disorders

AAA: Oral Amiodarone for Acute Cardioversion of Atrial Fibrillation Study (clinicaltrials.gov) - P4 | N=3 | Terminated | Sponsor: University of Calgary | N=42 ➔ 3 | Trial completion date: Dec 2027 ➔ Jan 2026 | Recruiting ➔ Terminated | Trial primary completion date: Dec 2027 ➔ Jan 2026; we couldn't recruit enough participants

Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Atrial Fibrillation • Cardiovascular