amiodarone / Generic mfg. - LARVOL DELTA

Real-world efficacy and safety of carfilzomib-based combination regimens in patients with multiple myeloma (ASH 2025) - "Only 3 patients were newly diagnosed MM, among the remaining 100 patients, 99 (99.0%) had prior exposure to bortezomib, 41.0% had received prior anti-CD38 monoclonal antibody (mAb), and 10 patients had undergone prior autologous stem cell transplantation (ASCT)...16 (15.5%) patients received carfilzomib and dexamethasone (Kd) based therapy with or without anti-CD38 mAb, 46 (44.7%) received Kd combined with an immunomodulatory agent (IMiD) with or without anti-CD38 mAb, 33 (32.0%) received Kd combined with chemotherapy with or without anti-CD38 mAb, and 8 (7.8%) received Kd combined with other regimens...Among these, two patients experienced grade ≥3 CVAEs, one developed atrial fibrillation, which improved following amiodarone administration, and the other experienced heart failure, which was alleviated with diuretic and coronary vasodilator therapy...Conclusion Carfilzomib-based combination regimens demonstrated encouraging efficacy and manageable safety profiles in..."

Clinical • IO biomarker • Real-world • Real-world effectiveness • Real-world evidence • Acute Kidney Injury • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Dermatitis • Dermatology • Heart Failure • Hypertension • Immunology • Infectious Disease • Leukopenia • Multiple Myeloma • Nephrology • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Thrombocytopenia

Thyrotoxicosis-Induced Chordal Rupture Causing Severe Mitral Regurgitation: Surgical Management and Outpatient Recovery. (PubMed, JACC Case Rep) - "Thyrotoxicosis can cause chordal rupture and flail leaflet. Repair is preferred, but replacement is appropriate when repair is not durable. Management requires endocrine-cardiac coordination and individualized antithrombotic therapy. Expect early ejection-fraction decline after surgical correction."

Journal • Atrial Fibrillation • Cardiovascular • Endocrine Cancer • Heart Failure

Erythrocyte aggregability as a hemodynamic marker in paroxysmal atrial fibrillation (ASH 2025) - "RESULTS Studies have been conducted during paroxysm and after restoration of sinus rhythm, cardioversion was achieved via electrical stimulation (n=2), electrolyte correction (n=4), or pharmacological treatment with amiodarone (n=15)...Restoration of sinus rhythm improves blood flow characteristics by reducing erythrocyte aggregation. These findings underscore the importance of considering rheological parameters in the management and treatment of AF, and suggest a novel therapeutic target for both cardiology and clinical rheology."

Atrial Fibrillation • Cardiovascular

Risk of serious bleeding with concomitant use of apixaban or rivaroxaban with amiodarone compared to flecainide or sotalol in patients with atrial fibrillation (ASH 2025) - "Covariates were well balanced post-matching (standardized differences <0.1).After matching, 253 patients in the amiodarone group experienced serious bleeding (25.8 events per1,000 person-years) compared to 175 in the comparator group (16.4 events per 1,000 person-years) (HR,1.53; 95% CI, 1.26 to 1.86).CONCLUSIONIn this comparative safety study, among patients with AF treated with apixaban or rivaroxaban,concomitant use of amiodarone was associated with a higher risk of serious bleeding compared to use offlecainide or sotalol. These findings highlight the importance of considering drug-drug interactions whenmanaging anticoagulated patients with AF to promote safe prescribing and minimize the risk of seriousbleeding complications."

Clinical • Asthma • Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • Hepatology • Immunology • Nephrology • CYP3A4 • PER1

Inactivation of the High-Affinity Ca2+ Uptake System Delays the Amiodarone-Induced Ca2+ Influx in Yeast Ogataea parapolymorpha. (PubMed, Int J Mol Sci) - "Similarly to sodium dodecyl sulfate, which has also been shown to increase [Ca2+]cyt, amiodarone causes activation of the Hog1 protein kinase involved in the cell cycle regulation. The role of HACS in the amiodarone-induced Ca2+ influx is discussed."

Journal

Dose Optimization of Rivaroxaban in Elderly Chinese Patients with Non-Valvular Atrial Fibrillation: Analysis of Populations Pharmacokinetics and Exposure-Response Relationships. (PubMed, Drug Des Devel Ther) - "For elderly Chinese NVAF patients, a reduced-dose rivaroxaban regimen, specifically 10 mg once daily with amiodarone, is recommended for all patients regardless of renal function, whereas 15 mg once daily is a more optimal option for those not taking amiodarone. Based on the risk-benefit assessment, maintaining AUC24,ss above 2840 ng·h/mL does not yield additional clinical benefit."

Journal • Observational data • PK/PD data • Atrial Fibrillation • Cardiovascular • Renal Disease

Ivabradine in the treatment of congenital junctional ectopic tachycardia: a case report and review of the literature. (PubMed, Cardiol Young) - "This report presents a case of neonatal-onset congenital junctional ectopic tachycardia treated with cedilanid, amiodarone, and propafenone but persisted in episodes. The review of the literature indicates that ivabradine demonstrates efficacy in the treatment of paediatric junctional ectopic tachycardia, particularly in refractory cases, without significant side effects. These findings suggest that ivabradine has broad applications in the treatment of refractory arrhythmias."

Journal • Cardiovascular • Pediatrics

Multi-Modality Imaging for Accurate Valvular Lesion Diagnosis: A Case Report of Catastrophic Outcomes From Unrecognized Severe Aortic Regurgitation. (PubMed, J Med Cases) - "During hospital stay, he developed thyrotoxicosis secondary to amiodarone. This case demonstrates the discrepancy in assessing severity between different imaging techniques and highlights the potential complications in delayed intervention in AR."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Imaging evaluation of amiodarone-induced thyroid dysfunction: ultrasonographic and radionuclide findings with clinical correlation. (PubMed, Quant Imaging Med Surg) - "A combination of radionuclide imaging and ultrasound is recommended for accurately determining the type of thyrotoxicosis. Early diagnosis and precise classification are essential for timely and appropriate treatment."

Journal • Cardiovascular • Endocrine Disorders

Atrial overdrive pacing in drug-refractory postinfarction electrical storm case report. (PubMed, Medicine (Baltimore)) - "AOP demonstrates dual therapeutic efficacy in refractory post-AMI ES: (1) physiological conduction restoration suppressing ectopic triggers and (2) avoidance of ventricular pacing-induced dyssynchrony. Fluoroscopic guidance ensures lead stability, positioning AOP as a hemodynamically favorable intervention in ES management."

Journal • Cardiovascular • Congestive Heart Failure • Diabetes • Heart Failure • Hepatology • Hypertension • Liver Failure • Metabolic Disorders • Myocardial Infarction • Type 2 Diabetes Mellitus • Ventricular Tachycardia

BEAT-AF: BiodEgradable Soaked Amiodarone paTch Use for the Prevention of Atrial Fibrillation After Cardiac Surgery (clinicaltrials.gov) - P3 | N=500 | Recruiting | Sponsor: Jilin Heart Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Atrial Fibrillation • Cardiovascular

Out-of-hospital cardiac arrest in alpine and urban terrain: a five-year retrospective analysis of 11,315 Austrian HEMS missions. (PubMed, Resusc Plus) - "Mixed-effects logistic regression (clustered by base) was used to examine the association of terrain with ROSC, adjusting for age, sex, initial rhythm, bystander CPR/AED, response and on-scene times, and adrenaline/amiodarone...Yet once rhythm and other factors were considered, alpine missions required more time on scene and this delay translated into lower odds of ROSC. Terrain-specific strategies-routine mCPR devices access, structured hypothermia management, and improved logistics-are needed to improve outcomes in these settings."

Journal • Retrospective data • Cardiovascular

Primary graft dysfunction prevention strategies in the perioperative period. (PubMed, JHLT Open) - "In heart transplantation, modifiable factors such as pre-transplant amiodarone exposure and donor-recipient mismatch increase PGD risk...Every step of the transplant process is important in reducing the risk of PGD. Emerging machine perfusion technologies represent a promising advancement to enhance graft utilization, reduce PGD incidence, and improve overall outcomes following heart and lung transplantation."

Journal • Cardiovascular • Reperfusion Injury • Transplantation

Indian Experience with Cryoablation for Paroxysmal and Persistent Atrial Fibrillation. (PubMed, Indian Pacing Electrophysiol J) - "Cryoballoon ablation demonstrated efficiency, safety, and effectiveness in treating patients with paroxysmal and persistent AF. 12-month atrial arrhythmia-free survival rates were significantly higher in patients with PAF compared to those with PsAF. Pre-procedural atrial arrhythmias and post-procedural atrial arrhythmias requiring cardioversion are associated with a higher risk of recurrence. Major procedural adverse effects were comparable to those reported in global standards."

Journal • Atrial Fibrillation • Cardiovascular

Cardioprotective effects of Sodium-Glucose cotransporter-2 inhibitors in patients undergoing ventricular tachycardia (VT) ablation: a propensity-matched cohort study. (PubMed, J Interv Card Electrophysiol) - "SGLT2i non-user group was associated with significantly higher risks of several adverse outcomes following ablation, including a 42% increase in all-cause mortality and a 41% increase in cardiac arrest. Non-users also had higher rates of post-ablation cardioversion and amiodarone use. However, no significant differences were found in redo ablation, ICD adjustments, or the use of other antiarrhythmics. These findings suggest a potential protective role of SGLT2 inhibitors in selective cardiovascular outcomes. Further studies are warranted to confirm these associations and investigate the underlying mechanisms."

Journal • Cardiovascular • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus • Ventricular Tachycardia

A Pharmaco-surgical Approach to Reduce Postoperative Atrial Fibrillation After Cardiac Surgery (clinicaltrials.gov) - P=N/A | N=242 | Completed | Sponsor: Massachusetts General Hospital | Active, not recruiting ➔ Completed | Trial completion date: Dec 2024 ➔ Mar 2025

Trial completion • Trial completion date • Atrial Fibrillation • Cardiovascular

Stability of emergency medications during extreme cold: a controlled environmental study. (PubMed, Scand J Trauma Resusc Emerg Med) - "Emergency medications can remain chemically stable under extreme cold conditions when stored in sealed, insulated packaging. While our study simulated prehospital conditions without direct environmental exposure, these findings support the feasibility of extended storage and transport of emergency medications in challenging field settings. Further research should assess the impact of direct environmental exposure and evaluate additional stability parameters to optimize storage protocols in real-world scenarios."

Journal

Polymorphic Ventricular Tachycardia After Cardioversion for AF with Tachycardia-induced Cardiomyopathy. (PubMed, Arrhythm Electrophysiol Rev) - "Most of these arrhythmias are related to QT prolongation, resulting from marked and sudden slowing of heart rates, treatment with Class III antiarrhythmic drugs or other QT-prolonging medications, and the ventricular repolarisation remodelling effect of electrical cardioversion. A case of polymorphic ventricular tachycardia post-cardioversion of rapid AF in a patient with tachycardia-induced cardiomyopathy and the use of amiodarone is reported."

Journal • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Ventricular Tachycardia

PATRONUS: Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery (clinicaltrials.gov) - P4 | N=242 | Not yet recruiting | Sponsor: Massachusetts General Hospital | Trial completion date: Dec 2025 ➔ Dec 2027 | Trial primary completion date: Jul 2025 ➔ Jan 2027

Trial completion date • Trial primary completion date • Atrial Fibrillation • Cardiovascular

The Role of Quinine to Prevent Ventricular Fibrillation and ICD Shocks in Early Repolarization Syndrome. (PubMed, JACC Case Rep) - "This case highlights the possible role of quinine in suppression of short-coupled premature ventricular complexes and ventricular fibrillation in patients with ERS."

Journal • Cardiovascular • Genetic Disorders

Narrow Complex Tachycardia Is Not Always a Supraventricular Tachycardia: A Case of Ventricular Tachycardia Presenting as a Narrow Complex Tachycardia. (PubMed, Cureus) - "Herein, we report the case of an 18-month-old toddler who presented with sudden-onset, narrow complex tachycardia at a heart rate of 240 bpm following an upper respiratory tract infection. Initial management, including multiple doses of adenosine and amiodarone, was unsuccessful...Given the refractory nature of the tachycardia, an emergency electrophysiological (EP) study was performed, which revealed atrioventricular (AV) dissociation, confirming the diagnosis of VT despite the narrow QRS morphology. This case highlights the importance of considering VT in cases of refractory tachycardia, even when ECG findings suggest supraventricular tachycardia."

Journal • Cardiovascular • Infectious Disease • Pediatrics • Respiratory Diseases • Ventricular Tachycardia

Refractory ventricular arrhythmia in a patient with suspected immune checkpoint inhibitor-related myocarditis: a case report. (PubMed, Eur Heart J Case Rep) - "We report a 65-year-old male with oesophageal cancer who developed refractory ventricular tachycardia three months after initiating toripalimab, a PD-1 inhibitor...Treatment with high-dose methylprednisolone, immunoglobulin, and anti-arrhythmic drugs (amiodarone, esmolol) yielded limited success, with recurrent arrhythmias requiring multiple cardioversions. Following the family's thoughtful decision to forgo extracorporeal membrane oxygenation, the patient passed away shortly after discharge. This case underscores the diagnostic complexity of suspected ICI-related myocarditis and the critical need for early recognition of immune-mediated cardiac toxicity in immunotherapy patients, emphasizing the role of clinical vigilance when definitive diagnostics are unavailable."

Checkpoint inhibition • Journal • Cardiovascular • Esophageal Cancer • Inflammation • Oncology • Ventricular Tachycardia

A Novel Method Using Dual-Energy Computed Tomography for Detecting Amiodarone-Induced Lung Injury: A Cohort Pilot Study. (PubMed, Respirology) - "DECT facilitated detection of iodine deposition in AILD-associated lung abnormalities and in the liver. Radiological evaluation of AILD using DECT showed substantial correlation with clinical AILD and may help in difficult diagnoses."

Journal • Pulmonary Disease • Respiratory Diseases

Catheter Ablation vs. Anti-Arrhythmic Drug Therapy for Ventricular Tachycardia in Ischemic Heart Disease: A Meta-Analysis of Randomized Controlled Trials. (PubMed, Europace) - "In ischemic heart disease and VT, catheter ablation compared with anti-arrhythmic drugs is associated with a reduction of appropriate ICD therapy, cardiovascular rehospitalization and adverse events with benefits most evident versus sotalol."

Journal • Retrospective data • Cardiomyopathy • Cardiovascular • Coronary Artery Disease • Heart Failure • Ventricular Tachycardia

Amiodarone Improves Locomotor Function in Experimental Spinal Cord Injury by Reducing Secondary Axonal Degeneration and White Matter Atrophy. (PubMed, J Neurotrauma) - "Interestingly, long-term amiodarone-mediated axonoprotection was accompanied by a reduction of SAD at early time points, measured by counting axonal spheroids 24 h after SCI in fluorescently labeled corticospinal tract axons imaged with light sheet imaging. Overall, these data identify amiodarone as a potentially axonoprotective agent that could be repurposed to treat secondary injury after SCI."

Journal • CNS Disorders • Orthopedics • NEFH