amiodarone / Generic mfg. - LARVOL DELTA

Total Thyroidectomy for Amiodarone-Induced Thyrotoxicosis in Advanced Heart Disease (ATA 2026) - No abstract available

Metastases • Cardiovascular • Heart Failure

Recurrent Atrial Fibrillation Post-Ablation Secondary to Late-Onset Type 2 Amiodarone-Induced Thyrotoxicosis (ATA 2026) - No abstract available

Atrial Fibrillation • Cardiovascular

Late Onset Amiodarone Induced Thyrotoxicosis in Advanced Age (ATA 2026) - No abstract available

Metastases

Single Pass Albumin Dialysis for Refractory Amiodarone-Induced Thyrotoxicosis (ATA 2026) - No abstract available

Thyroidectomy for Amiodarone-Induced Thyrotoxicosis: Surgical Rescue after Medical Failure (ATA 2026) - No abstract available

Contribution of Amiodarone Lymphocyte Proliferation Test to Diagnostic Confidence in Suspected Amiodarone Pulmonary Toxicity (ERS 2026) - "LPT significantly improved diagnostic confidence in suspected APT, particularly in uncertain cases. Although causality cannot be established in the absence of an exposed control group, the positive LPT prevalence of nearly 40% may point towards a hypersensitivity mechanism."

Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Amiodarone dose to treat ventricular tachycardia in Chagas cardiomyopathy. (PubMed, Europace) - No abstract available

Journal • Cardiomyopathy • Cardiovascular • Ventricular Tachycardia

Myxedema Coma with Cardiogenic Shock: Diagnostic Challenges and Risks of Amiodarone in Acute Thyroid Failure. (PubMed, HCA Healthc J Med) - "She subsequently experienced worsening encephalopathy, hypotension, and bradyarrhythmia, which required intubation, multiple vasopressors, IV levothyroxine, hydrocortisone, fludrocortisone, and mechanical ventilation. Although amiodarone is commonly used for ventricular arrhythmia management due to its acute electrical stabilizing properties, its effects on thyroid hormone metabolism warrant caution in patients with underlying thyroid disease. Early recognition and coordinated endocrine cardiac management are critical to improving outcomes in this high-risk population."

Journal • Breast Cancer • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Congestive Heart Failure • Endocrine Cancer • Endocrine Disorders • Heart Failure • Hypotension • Nephrology • Oncology • Pulmonary Disease • Renal Disease • Solid Tumor • Ventricular Tachycardia

The protective effect of chemical and natural compounds against amiodarone induced toxicity: A systematic review. (PubMed, Biochem Biophys Rep) - "No protective adjunct can presently be recommended for routine use with amiodarone. Independent replication, clinically relevant exposure schedules, pharmacokinetic-interaction testing, and rigorously designed human studies are required."

Clinical • Journal • Review • Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases • TGFB1

Leveraging neural network models for drug repurposing: a case study on cardiac hypertrophy. (PubMed, Sci Rep) - "Leveraging the model, we identified potential drug candidates, such as lapatinib and amiodarone showing promise in mitigating proBNP concentration associated with cardiac hypertrophy. This study demonstrates the power of deep learning of human transcriptomic mechanisms in swiftly identifying new therapeutic potentials for existing drugs, highlighting the pivotal role of artificial intelligence technologies in accelerating drug development for other complex medical conditions."

Journal • EDN1

FATAL STEROID-REFRACTORY PNEUMONITIS FOLLOWING TRANSITION TO EXTENDED-INTERVAL NIVOLUMAB IN A PATIENT WITH ANTECEDENT AMIODARONE EXPOSURE (CHEST 2026) - No abstract available

Clinical • Inflammation • Pneumonia

Functional perturbation reveals context-dependent contributions of nuclear receptors to drug-induced hepatic steatosis. (PubMed, Toxicol Lett) - "Stable short hairpin RNA-mediated knockdown of individual nuclear receptors was established in HepG2 and differentiated HepaRG cells, followed by exposure to representative steatogenic drugs, including valproic acid, amiodarone, tamoxifen, and rifampicin. These findings demonstrate that the contribution of individual nuclear receptors to drug-induced hepatic steatosis is highly compound- and context-dependent and cannot be explained by a single conserved receptor pathway. This study provides functional evidence from complementary human-relevant hepatic models that supports refinement of hepatic steatosis adverse outcome pathways and highlights the value of targeted perturbation strategies for mechanistic toxicology."

Journal

UNMASKING THE CULPRIT: TRASTUZUMAB ASSOCIATED INTERSTITIAL LUNG DISEASE IN A PATIENT ON CHRONIC AMIODARONE THERAPY (CHEST 2026) - No abstract available

Clinical • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases

DISPROPORTIONATE REPORTING OF THYROTOXIC CRISIS WITH AMIODARONE: AN FDA ADVERSE EVENT REPORTING SYSTEM PHARMACOVIGILANCE ANALYSIS (CHEST 2026) - No abstract available

Adverse events

AMIODARONE-INDUCED PULMONARY TOXICITY: A CASE REPORT (CHEST 2026) - No abstract available

Case report • Clinical

A DOUBLE-EDGED SWORD: CONCOMITANT AMIODARONE-INDUCED THYROTOXICOSIS AND HEPATOTOXICITY (CHEST 2026) - No abstract available

Hepatology

Are beta-blockers safe early after heart transplantation? (TTS 2026) - "This includes excess bradycardia and hypotension, especially if previous amiodarone was given prior to HTx. This study confirms that BB therapy used early after heart transplant must be used with caution, as exaggerated responses are experienced."

Cardiovascular • Congestive Heart Failure • Heart Failure • Hypotension • Transplantation

DIGOXIN VS AMIODARONE IN PATIENTS WITH ATRIAL FIBRILLATION AND HEART FAILURE WITH REDUCED EJECTION FRACTION NOT UNDERGOING CATHETER ABLATION: A MULTICENTER STUDY (CHEST 2026) - No abstract available

Clinical • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Heart Failure

ACUTE RESPIRATORY FAILURE FOLLOWING RECENT ORAL AMIODARONE INITIATION: A DIAGNOSTIC CHALLENGE (CHEST 2026) - No abstract available

Respiratory Diseases

AMIODARONE-INDUCED DIFFUSE ALVEOLAR HEMORRHAGE IN A PATIENT WITH INTERSTITIAL LUNG DISEASE AND RECENT CORONARY ARTERY BYPASS GRAFTING: A RARE BUT LIFE-THREATENING SIDE EFFECT (CHEST 2026) - No abstract available

Adverse events • Clinical • Hematological Disorders • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases

EARLY-ONSET AMIODARONE-INDUCED PULMONARY TOXICITY PRESENTING WITH DIFFUSE ALVEOLAR HEMORRHAGE AND RAPID RESPIRATORY FAILURE (CHEST 2026) - No abstract available

Hematological Disorders • Respiratory Diseases

BEYOND MEDICATIONS: PLASMAPHERESIS AS A LIFESAVING INTERVENTION FOR AMIODARONE-INDUCED FULMINANT MULTIORGAN FAILURE IN AN ADULT - A CASE REPORT (CHEST 2026) - No abstract available

Case report • Clinical • Critical care • Endocrine Disorders

Refractory Amiodarone-Induced Thyrotoxicosis Requiring the Consideration of Thyroidectomy: A Case Report and Review of Management Challenges. (PubMed, Cureus) - "Carbimazole therapy was initiated, but persistent thyrotoxicosis necessitated dose escalation, discontinuation of amiodarone, and commencement of prednisolone for suspected AIT. Although thyroid function tests initially improved with combined medical therapy, biochemical response later plateaued with a fT4 level of 52 pmol/L at the end of month 8, prompting referral for thyroidectomy. This case describes a challenging presentation of AIT with an incomplete response to conventional medical management and progression to consideration of definitive surgical treatment."

Journal • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Diabetes • Genetic Disorders • Heart Failure • Metabolic Disorders • Obesity

ReCAST AF: Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation (clinicaltrials.gov) - P4 | N=988 | Recruiting | Sponsor: Universitaire Ziekenhuizen KU Leuven | Not yet recruiting ➔ Recruiting

Enrollment open • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease

Thyroid Storm Presenting With Refractory Atrial Arrhythmia and Tachycardia-Induced Dilated Cardiomyopathy: A Case Report. (PubMed, Cureus) - "Multiple rhythm-control and rate-control strategies were required, including direct-current cardioversion, adenosine, magnesium, digoxin, beta-blockers and escalating infusions. Amiodarone was discontinued following multidisciplinary review due to concerns regarding iodine-induced exacerbation of thyrotoxicosis. Thyroid storm was treated with propylthiouracil, Lugol's iodine, hydrocortisone, propranolol and cholestyramine. Serial echocardiography demonstrated interval improvement in left ventricular systolic function, supporting a reversible tachycardia-mediated mechanism. This case highlights the diagnostic and therapeutic complexity of thyroid storm with refractory arrhythmia and underscores the importance of early recognition, multidisciplinary management and careful selection of antiarrhythmic therapy."

Journal • Cardiomyopathy • Cardiovascular • Cognitive Disorders • Congestive Heart Failure • Endocrine Disorders • Grave’s Disease • Heart Failure • Hypertension • Metabolic Disorders • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases