levosulpiride / Generic mfg. - LARVOL DELTA

Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular Edema (clinicaltrials.gov) - P2 | N=120 | Recruiting | Sponsor: Carmen Clapp | Trial completion date: Jun 2026 ➔ Jun 2027 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Trial completion date • Trial primary completion date • Breast Cancer • Diabetic Macular Edema • Diabetic Retinopathy • Ophthalmology • Retinal Disorders • PRL

Striatal Overload Causing Motor Crisis: Extrapyramidal Manifestations of Antipsychotic Excess in Clinical Profiles (Neuroscience 2025) - "Patients were observed in inpatient settings for 10-14 days, and clinical progress was documented.RESULTSCase 1: A 32-year-old received 60 mg of Risperidone along with Levosulpiride, resulting in pronounced rigidity and oculogyric crisis...Case 3: A 35-year-old showed tremors, drooling, and stiffness after consuming an estimated 50 mg of RISPERIDONE and 30 mg of Olanzapine...Timely identification and intervention are critical to reducing associated morbidity. Preventive strategies, including caregiver education and medication safety protocols, are essential to avoid such clinical emergencies."

Clinical • CNS Disorders • Dystonia • Movement Disorders • Psychiatry • Schizophrenia

Gastric Emptying Patterns in Type 2 Diabetes Mellitus Patients with Symptoms of Gastroparesis and the Impact of Levosulpiride on These Patterns. (PubMed, J Assoc Physicians India) - "Levosulpiride significantly alleviated symptoms of diabetic gastroparesis, as evidenced by reduced GCSI scores and improvements in gastric scintigraphy patterns. Despite minimal changes in delayed gastric emptying, the drug's effect on motility dysfunction highlights its therapeutic potential. This study underscores the importance of focusing on motility patterns in symptom management, suggesting levosulpiride as a promising option for targeted treatment of diabetic gastroparesis."

Journal • Observational data • Diabetes • Gastrointestinal Disorder • Metabolic Disorders • Type 2 Diabetes Mellitus

ITOPRIDE'S ROLE IN FUNCTIONAL DYSPEPSIA: A META-ANALYSIS OF PLACEBO-CONTROLLED AND PROKINETIC-CONTROLLED TRIALS (UEGW 2025) - "Aims & This meta-analysis evaluates the therapeutic efficacy of Itopride compared to placebo and other prokinetic agents in managing FD symptoms.A total of 19 randomized controlled trials were included in the analysis, comprising six placebo-controlled studies (n=1981, 976 on placebo and 1005 on Itopride) and 13 trials comparing Itopride to another prokinetic (n=1077, 515 on Itopride and 562 on control prokinetics including mosapride citrate, levosulpiride, metoclopramide, domperidone, and cisapride). This meta-analysis suggests that Itopride provides significant symptom relief in patients with FD compared to placebo, particularly in overall responder rates. While Itopride's benefits over other prokinetics were modest in general symptom relief, it demonstrated a statistically significant advantage over domperidone for early satiation."

Retrospective data • Dyspepsia • DRD2

POTENTIALLY INAPPROPRIATE MEDICATION USE IN PATIENTS WITH PARKINSON'S DISEASE: KOREAN NATIONAL HEALTH INSURANCE CLAIMS DATA ANALYSIS (WCN 2025) - "Excluding the mainstay PD treatments, amitriptyline was the most commonly prescribed PIM. The prevalence and overall utilization of PIMs were notably high in Korean patients with PD, and the use of PIMPDs persisted throughout the study period. These findings highlight the importance of establishing evidence-based strategies for managing polypharmacy and optimizing medication safety in patients with PD."

Clinical • Reimbursement • US reimbursement • CNS Disorders • Movement Disorders • Parkinson's Disease

Potentially Inappropriate Medication Use in Patients With Parkinson's Disease: Analysis of Korean National Health Insurance Claims Data. (PubMed, J Clin Neurol) - "The prevalence and usage of PIMs were high in Korean PD patients during 2014-2019, and the utilization of PIMPDs persisted throughout this period. These findings can be used to develop evidence-based guidelines for robust polypharmacy management strategies to ensure the safety of medications used by PD patients."

Journal • Reimbursement • US reimbursement • CNS Disorders • Movement Disorders • Parkinson's Disease

Development of novel electrospun nanofibers loaded with Levosulpiride and Cannabidiol encapsulated in cyclodextrin-phospholipid inclusion complex for ameliorated treatment of anxiety and depression. (PubMed, Int J Pharm) - "The biochemical profile of the treated group further corroborated the formulation's improved therapeutic potential. In conclusion, the Levo-CBD-C-P-IC-loaded nanofiber system offers a promising approach for the targeted management of depression and anxiety by addressing limitations in drug bioavailability and delivery."

Journal • CNS Disorders • Depression • Inflammation • Mood Disorders • Psychiatry

Electrochemical Sensor for Levosulpiride Detection and Its Adsorptive Removal from Wastewater. (PubMed, ACS Omega) - "Results revealed that adsorption occurred in accordance with the Langmuir model, while the kinetics of adsorption adhered to pseudo-second order kinetics. Thermodynamic parameters such as negative ΔG and positive ΔS revealed the spontaneous nature of the entropy-driven process of adsorption."

Journal • CNS Disorders

Movement Disorders Associated with Levosulpiride: A Systematic Review of Prevalence, Risk Factors, and Therapeutic Approaches. (PubMed, Neurol India) - "PROSPERO: CRD42024553156."

Journal • Movement Disorders

Drug repurposing: Identification and X-ray crystallographic analyses of US-FDA approved drugs against carbonic anhydrase-II. (PubMed, Int J Biol Macromol) - "From in vivo studies, we found that carbonic anhydrase activity was significantly inhibited by the intraperitoneal administration of levosulpiride for up to 5 h. Our findings provide comprehensive insights for the optimization of the pharmacological profile of these drugs, and provide avenues for the exploration of different derivatives of these drugs with enhanced efficacy and fewer adverse effects."

FDA event • Journal • Glaucoma • Ophthalmology

Updated document on the management of functional dyspepsia by the Asociación Española de Neurogastroenterologia y Motilidad (ASENEM) and Sociedad Española de Medicina Familiar y Comunitaria (semFYC). (PubMed, Rev Esp Enferm Dig) - "Second-line therapy includes neuromodulating agents, among which tricyclic antidepressants and atypical antipsychotics such as levosulpiride stand out...Other therapy alternatives include phytotherapy using STW5 or peppermint/caraway oil, which have shown their superiority over placebo in controlled studies. Concurrently, dietary and lifestyle counseling, as well as psychological interventions such as cognitive-behavioral therapy, when available, may represent a therapeutic alternative worth considering for some patients."

Journal • CNS Disorders • Dyspepsia • Gastroenterology • Infectious Disease • Pain

Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular Edema (clinicaltrials.gov) - P2 | N=120 | Recruiting | Sponsor: Carmen Clapp | Trial completion date: Jun 2025 ➔ Jun 2026 | Trial primary completion date: Jun 2025 ➔ Dec 2025

Trial completion date • Trial primary completion date • Diabetic Macular Edema • Diabetic Retinopathy • Ophthalmology • Retinal Disorders • PRL

Nanostructured lipid carriers as a strategy to enhance oral levosulpiride delivery: An in vitro and ex vivo assessment. (PubMed, Int J Pharm) - "The reversible effect on integrity was associated with altered cell morphology confirmed by occludin and f-actin localization with insignificant effect on metabolic activity. These results suggest that the NLCs and/or components thereof can mediate improved absorption of drugs by increasing the permeability of the intestinal epithelial membrane, further facilitated by increased drug solubilization."

Journal • Preclinical • CNS Disorders

Exploring the potential of a pH-sensitive hydrogel sponge: interpenetrating network of tragacanth and pectin for controlled delivery of levosulpiride. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Drug release kinetics was observed to be in zero order. The findings of this study highlight the promising potential of the tragacanth/pectin hydrogel sponge as a pH-sensitive dais for the controlled delivery of levosulpiride, emphasizing its potential application in personalized drug therapy and the treatment of gastrointestinal disorders."

Journal • Gastroenterology • Gastrointestinal Disorder

Prevalence and comparative analysis of potential drug-drug interactions among hospitalized patients at a tertiary care cardiac institute in Pakistan: Findings from a single centre. (PubMed, Pak J Pharm Sci) - "Class C interactions were the most frequent (62.1%), followed by Classes B, D and X. Additionally, the study identified unique pDDIs from Lexicomp, including Ipratropium-Orphenadrine and Furosemide-Levosulpiride, not listed in Micromedex. The findings highlight the high prevalence of pDDIs in this population, emphasizing the need for regular monitoring. Using pDDI screening tools, clinical pharmacists can be crucial in mitigating these risks, particularly in high-risk patients."

Clinical • Journal • Observational data • Cardiovascular

In silico studies, synthesis, characterization and in vitro studies of levosulpiride derivatives. (PubMed, Future Med Chem) - "Most of the derivatives showed strong pharmacokinetic profiles while no drug crossed blood-brain barrier. The newly synthesized L1 and L3 levosulpiride-derived compounds have demonstrated promising anticancer properties against breast cancer cells."

Journal • Preclinical • Breast Cancer • Oncology • Solid Tumor

Gastroparesis associated to isoniazid. First description. (PubMed, Rev Med Chil) - "Gastroparesis improved with discontinuation of isoniazid and levosulpiride, reappeared with re-exposure, and improved with definitive withdrawal of isoniazid...Gastroparesis associated with isoniazid should be added to the list of adverse effects associated with this drug, even in patients receiving pyridoxine supplementation. Its recognition is initially clinical, can be confirmed with nuclear medicine studies, and affects the eradication of Mycobacterium tuberculosis."

Journal • Gastrointestinal Disorder • Hepatology • Infectious Disease • Inflammation • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Development and validation of a reversed-phase HPLC-UV method for simultaneous determination of levosulpiride and omeprazole in human plasma: Applicability of the method for evaluation of pharmacokinetic drug-drug interactions. (PubMed, PLoS One) - "In the presented study, a reversed-phase HPLC-UV method was developed for the simultaneous determination of levosulpiride and omeprazole using pantoprazole as the internal standard. Both the changes were insignificant. Similarly, no significant change in the pharmacokinetic parameters of omeprazole was observed with co-administration of levosulpiride."

Journal • PK/PD data • CNS Disorders • Depression • Gastroenterology • Gastrointestinal Disorder • Mood Disorders • Psychiatry

Tritium decay catastrophe. (PubMed, Appl Radiat Isot) - "The phenomenon of tritium decay catastrophe is introduced. A technical example is provided regarding the radioligand [methoxy-3H] levosulpiride whose long-term behavior is consistent with the concept of tritium decay catastrophe."

Journal

Stimuli-responsive glucuronoxylan polysaccharide from quince seeds for biomedical, food packaging, and environmental applications. (PubMed, Int J Biol Macromol) - "In tablet formulations, modified and unmodified QSM as a binder sustained the release of various drugs such as cefixime, capecitabine, diclofenac sodium, theophylline, levosulpiride, diphenhydramine, metoprolol tartrate, and acyclovir sodium. The present review discussed the extraction optimization, chemical composition, stimuli-responsiveness, and viscoelastic properties of mucilage. The potential of mucilage in edible films, tissue engineering, and water purification will also be discussed."

Journal • Review

Efficacy of Pistacia lentiscus Plant (Rumi Mastagi) in Comparison to Levosulpiride in Patients with Diabetic Gastroparesis: A Double-Blind Non-Inferior Randomised Control Trial Study. (PubMed, Indian J Endocrinol Metab) - "To our knowledge, this is the first study to compare the effect of levosulpiride with mastic gum concerning improvement in diabetic gastroparesis (DG) using GES. In the study, mastic gum was found to have great properties to improve DG with many important pleiotropic effects."

Journal • Diabetes • Dyslipidemia • Gastroenterology • Gastrointestinal Disorder • Hepatology • Immunology • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Solid Tumor

Dopaminergic Drugs and Valproate-associated Refractory Hyponatremia Over Levosulpiride-induced Parkinsonism in an Elderly Female Patient When Deprescribing was the Only Therapy. (PubMed, Curr Drug Saf) - "The case highlights the need to be vigilant for adverse consequences of the prescribing cascade, especially for antiemetic drugs, such as levosulpiride, because of its propensity to induce extrapyramidal reactions in older patients. In cases of refractory hyponatremia, a trial of de-challenge of valproate and dopaminergic drugs should be considered. In addition, the identification and removal of the culprit drugs can rescue the patient from a disabling cycle of adverse drug reactions."

Journal • Cardiovascular • CNS Disorders • Heart Failure • Movement Disorders • Parkinson's Disease • Psychiatry

Fixed drug combination (levosulpiride and rabeprazole)-induced atypical Parkinsonian's disorders with associated anxiety and low-lying depression. (PubMed, Indian J Pharmacol) - "We hereby describe a rare case of levosulpiride-induced atypical parkinsonism presenting with sluggish movements, atypical kinetic tremors (tremors with voluntary movement), periorbital tremors, dystonia, difficulty in speech and coordination, postural imbalance, with additional features of difficulty in swallowing and drooling with associated recent onset psychiatric disturbances such as anxiety and low-lying depression. The dechallenge of levosulpiride and medications for associated anxiety and low-lying depression caused a complete remission of the disease within 2 ½ months."

Journal • CNS Disorders • Depression • Dystonia • Mental Retardation • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry

Real-world safety and effectiveness of Pistacia lentiscus (mastic gum) in patients with diabetic gastroparesis: 24-week interim analysis postintervention. (PubMed, Indian J Pharmacol) - "Six-month (24-week) interim analysis of patients suggests that mastic gum gives a sustainable improvement in DG symptoms without any obvious adverse effects as compared to levosulpiride."

Journal • Real-world • Real-world evidence • Diabetes • Gastrointestinal Disorder • Metabolic Disorders • Solid Tumor

Efficacy of prokinetic agents in diabetic gastroparesis comparing symptomatology and scintigraphy - An open-label trial. (PubMed, Caspian J Intern Med) - "Levosulpiride was significantly more effective than Cinitapride in improving individual symptoms like nausea, vomiting, stomach fullness, and early satiety. Levosulpiride is better than Cinitapride in improving the symptoms of diabetic gastroparesis but no significant effect on gastric scintigraphy."

Journal • Diabetes • Gastrointestinal Disorder • Metabolic Disorders • Type 2 Diabetes Mellitus