CarneVal-M (valproic acid/acetyl-L-carnitine)
/ BioLink Life Sci
- LARVOL DELTA
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September 21, 2020
"Awake Resection of Insular Glioma https://t.co/UjMRLzIZ3Z via @YouTube Thx to @JCarnevaleMD for fantastic editing! @NeuroOnc @NSTumorSection"
(@drRohanR)
Glioma • Oncology • Solid Tumor
July 23, 2013
Pharmacological and neuroethological studies of three antiepileptic drugs in the Genetic Audiogenic Seizure Hamster (GASH:Sal)
(Epilepsy Behav)
- PMID: 23872084; “The intraperitoneal administration of PB (5-20mg/kg) and VPA (100-300mg/kg) produced a dose-dependent decrease in GASH:Sal audiogenic seizure severity scores….Valproic acid acted only at high concentrations and was the AED with the most ataxic effects….We conclude that the GASH:Sal is a reliable genetic model of epilepsy suitable to evaluate AEDs.”
Preclinical • Epilepsy
October 04, 2013
Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy
(Neurology)
- PMID: 24089388; "More subjects receiving valproic acid (49%) had attention deficits than subjects receiving ethosuximide (32%) or lamotrigine (24%) (p = 0.0006). Parental assessment did not reliably detect attention deficits before or after treatment (p < 0.0001)...This study provides Class I evidence that valproic acid is associated with more significant attentional dysfunction than ethosuximide or lamotrigine in children with newly diagnosed CAE."
Adverse events • Epilepsy
October 05, 2013
The effect of antiepileptic drugs on thyroid function in children
(Seizure)
- PMID: 24091037; P=NA, N=223; "Valproate-treated patients had decreased fT4 and increased TSH levels at months 1, 6, and 12. Carbamazepine-treated patients had decreased fT4 levels at months 1, 6, and 12 and increased TSH levels at months 1, and 6...The frequency of subclinical hypothyroidism at month 12 was 28% in valproate, 21.4% in oxcarbazepine, 18.2% in phenobarbital, 13.9% in carbamazepine, and 0% in levetiracetam groups."
Adverse events
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