Maxigesic (acetaminophen/ibuprofen) / AFT Pharma, Hyloris Pharma, BioSyent, Hikma - LARVOL DELTA

A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain (clinicaltrials.gov) - P3 | N=60 | Recruiting | Sponsor: AFT Pharmaceuticals, Ltd. | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

Maxigesic for Postoperative Pain Control After Laparoscopic or Robotic Gastrectomy (clinicaltrials.gov) - P2 | N=90 | Active, not recruiting | Sponsor: Seoul National University Bundang Hospital

New P2 trial • Gastric Cancer • Oncology • Pain • Solid Tumor

A Phase IV Randomized Trial of Maxigesic Versus Standard Analgesia After Radical Gastrectomy (clinicaltrials.gov) - P4 | N=160 | Not yet recruiting | Sponsor: Yonsei University

Head-to-Head • New P4 trial • Gastric Cancer • Oncology • Pain • Solid Tumor

A Study of Combogesic IV (Intravenous) in Pediatric Patients With Acute Pain (clinicaltrials.gov) - P3 | N=60 | Not yet recruiting | Sponsor: AFT Pharmaceuticals, Ltd. | Trial completion date: Oct 2026 ➔ Apr 2027 | Initiation date: Feb 2026 ➔ Sep 2026 | Trial primary completion date: Oct 2026 ➔ Mar 2027

Trial completion date • Trial initiation date • Trial primary completion date • Pain

A Study of Combogesic 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery (clinicaltrials.gov) - P3 | N=180 | Not yet recruiting | Sponsor: AFT Pharmaceuticals, Ltd. | Trial completion date: Oct 2026 ➔ Oct 2027 | Initiation date: Feb 2026 ➔ Oct 2026 | Trial primary completion date: Oct 2026 ➔ Oct 2027

Trial completion date • Trial initiation date • Trial primary completion date • Pain

AFT-MXIV-08p: A clinical study to investigate the absorption, distribution, and elimination of Combogesic IV, and to evaluate its safety in pediatric patients with acute pain. (clinicaltrialsregister.eu) - P2/3 | N=40 | Not yet recruiting | Sponsor: Aft Pharmaceuticals Limited

New P2/3 trial • Pain • Pediatrics

A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain (clinicaltrials.gov) - P3 | N=60 | Not yet recruiting | Sponsor: AFT Pharmaceuticals, Ltd.

New P3 trial • Pain • Pediatrics

A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery (clinicaltrials.gov) - P3 | N=180 | Not yet recruiting | Sponsor: AFT Pharmaceuticals, Ltd.

New P3 trial • Orthopedics • Pain

The Effect of Preoperative Maxigesic® on Intraoperative Remifentanil Requirement (clinicaltrials.gov) - P=N/A | N=96 | Recruiting | Sponsor: Ajou University School of Medicine | Not yet recruiting ➔ Recruiting | Trial completion date: Dec 2024 ➔ Dec 2026 | Trial primary completion date: Aug 2024 ➔ Aug 2026

Enrollment open • Trial completion date • Trial primary completion date • Pain

IV meloxicam returns for treatment of pain. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Pain

Preemptive and Preventive Acetaminophen/Ibuprofen Fixed-dose Combination After Robot-assisted Radical Prostatectomy (clinicaltrials.gov) - P=N/A | N=154 | Completed | Sponsor: Seoul National University Hospital | Active, not recruiting ➔ Completed

Trial completion • Pain

Impact of Maxigesic on Delirium After Minimally Invasive Lung Surgery in Elderly Patients (clinicaltrials.gov) - P4 | N=25 | Terminated | Sponsor: Korea University Guro Hospital | N=176 ➔ 25 | Trial completion date: Dec 2025 ➔ Jan 2025 | Recruiting ➔ Terminated | Trial primary completion date: Dec 2025 ➔ Jan 2025; The study was terminated early owing to challenges in completing the research registration process.

Enrollment change • Trial completion date • Trial primary completion date • Trial termination • CNS Disorders • Geriatric Disorders • Lung Cancer • Oncology • Solid Tumor

Analgesic Efficacy of Maxigesic in Breast Cancer Surgery (clinicaltrials.gov) - P=N/A | N=84 | Recruiting | Sponsor: Yonsei University | Trial completion date: Feb 2025 ➔ Dec 2025 | Trial primary completion date: Feb 2025 ➔ Dec 2025

Trial completion date • Trial primary completion date • Breast Cancer • Oncology • Pain • Solid Tumor

Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean Section (clinicaltrials.gov) - P4 | N=84 | Recruiting | Sponsor: Seoul National University Hospital | Not yet recruiting ➔ Recruiting | Trial completion date: Aug 2025 ➔ Aug 2026 | Trial primary completion date: Jun 2025 ➔ Jun 2026

Enrollment open • Trial completion date • Trial primary completion date • Pain

Preemptive and Preventive Acetaminophen/Ibuprofen Fixed-dose Combination After Robot-assisted Radical Prostatectomy (clinicaltrials.gov) - P=N/A | N=154 | Active, not recruiting | Sponsor: Seoul National University Hospital | Recruiting ➔ Active, not recruiting | Trial completion date: Sep 2024 ➔ Jul 2025 | Trial primary completion date: Aug 2024 ➔ Feb 2025

Enrollment closed • Trial completion date • Trial primary completion date • Pain

Drugs in Development to Manage Acute Pain. (PubMed, Drugs) - "These agents include VX-548 (Suzetrigine), Cebranopadol, AAT-076, Combogesic intravenous (IV), sublingual ketamine, XG004 (naproxen/pregabalin conjugate), and HTX-011 (Zynrelef). We analyze the pharmacodynamics, pharmacokinetics, development status, and clinical implications of these drugs, emphasizing the importance of finding an agent that provides both a strong safety profile and effective relief from acute pain. Our findings show promise but also highlight the need for further large-scale research to allow these drugs to be utilized in a clinical context for patients experiencing acute pain."

Journal • Review • Pain

A Pharmacokinetic study evaluating the pharmacokinetic parameters of different doses of Maxigesic® IV (intravenous paracetamol + intravenous ibuprofen) in healthy Japanese volunteers and Caucasian volunteers (ANZCTR) - P1 | N=24 | Completed | Sponsor: AFT Pharmaceuticals Ltd | Recruiting ➔ Completed

Trial completion

Seroma and Hematoma Rates: MAXIGESIC IV vs. Ketorolac in Breast Cancer Surgery (clinicaltrials.gov) - P=N/A | N=60 | Not yet recruiting | Sponsor: Seoul National University Hospital

New trial • Surgery • Breast Cancer • Oncology • Solid Tumor

Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean Section (clinicaltrials.gov) - P4 | N=84 | Not yet recruiting | Sponsor: Seoul National University Hospital

New P4 trial • Pain

A Pharmacokinetic study evaluating the pharmacokinetic parameters of different doses of Maxigesic® IV (intravenous paracetamol + intravenous ibuprofen) in healthy Japanese volunteers and Caucasian volunteers (ANZCTR) - P1 | N=24 | Recruiting | Sponsor: AFT Pharmaceuticals Ltd | Not yet recruiting ➔ Recruiting | Initiation date: Apr 2024

Enrollment open • Trial initiation date

Intravenous acetaminophen/ibuprofen (Combogesic IV). (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Pain

Hikma announces US launch of COMBOGESIC IV (PRNewswire) - "Hikma Pharmaceuticals PLC...announces the launch of COMBOGESIC IV (acetaminophen and ibuprofen) injection in the US."

Launch US • CNS Disorders • Pain

A Pharmacokinetic study evaluating the pharmacokinetic parameters of different doses of Maxigesic® IV (intravenous paracetamol + intravenous ibuprofen) in healthy Japanese volunteers and Caucasian volunteers (ANZCTR) - P1 | N=24 | Not yet recruiting | Sponsor: AFT Pharmaceuticals Ltd

New P1 trial

Analgesic Efficacy of Maxigesic in Breast Cancer Surgery (clinicaltrials.gov) - P=N/A | N=84 | Recruiting | Sponsor: Yonsei University

New trial • Surgery • Breast Cancer • Oncology • Pain • Solid Tumor

Maxigesic_Lung: Intravenous Acetaminophen/Ibuprofen Fixed-dose Combination on Postoperative Opioid Consumption (clinicaltrials.gov) - P=N/A | N=96 | Completed | Sponsor: Seoul National University Hospital | Recruiting ➔ Completed

Trial completion • Pain