Advantan (methylprednisolone aceponate) / Bayer - LARVOL DELTA

Revisiting methylprednisolone aceponate: efficacy, safety and current positioning. (PubMed, Drugs Context) - "Long-term use is associated with a low risk of skin atrophy or hypothalamic-pituitary-adrenal axis suppression, and allergic sensitization is rare. MPA offers an effective and well-tolerated option for acute and maintenance management of inflammatory skin diseases."

Journal • Review • Atopic Dermatitis • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Pruritus • Seborrheic Dermatitis

Delayed Type Hypersensitivity Injection Site Reaction Induced By Liraglutide (EAACI 2026) - "Symptomatic treatment with topical methylprednisolone aceponate 0,1% was administered twice daily for two weeks, followed by once-daily application for 30 days, with continuation of liraglutide therapy...While injection-site reactions are known adverse effects, the distinction between immediate and delayed hypersensitivity reactions is not clearly defined in current product information. Increased awareness and appropriate diagnostic evaluation are essential to ensure safe long-term treatment."

Late-breaking abstract • Immunology

Ocrelizumab-Induced Atopic Dermatitis-like Drug Eruption: A Case Report (EADV-Sp 2026) - "The patient was prescribed emollients, topical methylprednisolone aceponate, and oral bilastine. The pathophysiological mechanism may involve B-cell depletion induced by ocrelizumab, resulting in subsequent immune dysregulation. Although further investigation is warranted to elucidate this association, clinicians should maintain heightened vigilance for cutaneous manifestations when administering novel biological agents."

Case report • Clinical • Alopecia • Ataxia • Atopic Dermatitis • CNS Disorders • Dermatitis • Dermatology • Immunology • Movement Disorders • Multiple Sclerosis • Psoriasis • Pyoderma Gangrenosum • Vasculitis

Modulating the Skin Microbiome in Atopic Dermatitis: A Six-Month Comparative Study of JAK Inhibitors, Dupilumab, Cyclosporine A, and Topical Corticosteroids (EADV-Sp 2026) - "Materials and Methods This prospective pilot study included 60 patients with atopic dermatitis treated with Janus kinase (JAK) inhibitors, dupilumab, cyclosporine A, or topical corticosteroids (intermittently used methylprednisolone aceponate). Overall, these findings suggest that targeting type 2 inflammation with biologic or small-molecule therapies can shift the skin bacteriome toward a healthier balance, whereas traditional anti-inflammatory treatments show limited effects. These observations are exploratory and underscore the need for larger, longitudinal studies to clarify which cytokines, pathways, and mechanisms are most important for modulating the skin microbiome in atopic dermatitis."

Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • IL13 • IL4

Graham-Little-Piccardi-Lassueur syndrome and its relation to Antigen mimicry (EADV-Sp 2026) - "These findings were consistent with lichen planus hypertrophicus 2a: cicatricial alopecia HE x 40 2b: Lichen planus hypertrophicus HE x 40 2c: Lichen hypertrophicus HE x 100 Results Initial therapy included loratadine and topical clobetasol propionate. Due to the suspicion of possible drug-induced autoimmunity, the antihypertensive therapy, which consisted of valsartan, bisoprolol, spironolactone, and chlorthalidone, was discontinued and replaced with moxonidine...Prescribed outpatient treatment included acitretin, bilastine, and topical prednisolone for the scalp. Improvement was observed in the lesions located on the trunk and upper and lower extremities following betamethasone/salicylic acid ointment was prescribed, and methylprednisolone aceponate cream...It is this fact that suggests that polymedication could also be considered as a trigger of lichen planus and its subforms such as GLPLS. Conclusions The hypothesis about antigen / molecular mimicry, based on the..."

Alopecia • Dermatopathology • Immunology • Infectious Disease • Lichen Planus • Urology

Development and validation of a method to quantify methylprednisolone aceponate in cream by micellar liquid chromatography. (PubMed, Anal Bioanal Chem) - "Additionally, the retention mechanism was investigated by determining the constants of the partition equilibria occurring in the column and demonstrating that both surfactant and organic solvent contribute similarly to elution strength. The method was safe and ecofriendly, due to the low volume of toxic and volatile organic solvents employed, easy to handle, cost-effective, semi-automated, and with a high sample throughput, making it well suited for routine pharmaceutical quality control."

Journal • Dermatology

Generalized pustular psoriasis: a rare entity in pediatrics (PubMed, Bol Med Hosp Infant Mex) - "Treatment included methotrexate at 12 mg/m²/week, folic acid, 1% methylprednisolone aceponate cream, 0.005% calcipotriol, urea-based emollient at 10%, and antihistamines. Generalized pustular psoriasis in pediatrics requires comprehensive care, considering not only dermatological aspects but also psychosocial factors. Successful management of pediatric cases, as described, highlights the importance of a personalized approach tailored to each patient's needs to achieve long-term satisfactory outcomes."

Journal • Cardiovascular • Dermatitis • Dermatology • Immunology • Inflammation • Pediatrics • Pruritus • Psoriasis • Pustular Psoriasis

Penile porokeratosis successfully treated with diagnostic and curative punch excision: a case report (EADV 2025) - "Topical miconazole 2% and topical methylprednisolone aceponate 0.1% ointment were trialled without success... Penoscrotal porokeratosis, though uncommon, can present as asymptomatic and persistent lesions. This highlights the importance of dermoscopy in diagnosing genital lesions in younger men. Complete surgical removal may be considered for small solitary lesions; however, it remains essential to take an individualised approach to patient care."

Case report • Clinical • Rare Diseases

Randomized clinical trial comparing removal followed by topical imiquimod versus removal followed by topical methylprednisolone in the treatment of keloids. (PubMed, Acta Cir Bras) - "Surgical removal plus application of topical imiquimod was shown as safe, and its efficacy was not statistically inferior for the treatment of keloids as compared to methylprednisolone. Due to the lack of efficacy in most therapeutic modalities, surgical removal plus topical imiquimod could be recommended as an additional first line therapy and especially for recurrent keloids. Studies with larger samples are necessary to evaluatre therapies for keloids."

Clinical • Journal • Dermatology • Fibrosis

EFFECT OF SYSTEMIC THERAPIES ON SKIN BACTERIOME IN PATIENTS WITH ATOPIC DERMATITIS: A PILOT PROSPECTIVE STUDY. (PubMed, J Invest Dermatol) - "Here, we aimed to investigate the effects of four different therapies on clinical outcomes and skin bacteriome in patients with atopic dermatitis, namely: Janus kinase inhibitors, dupilumab, cyclosporine A, and topical corticosteroids (intermittently used methylprednisolone aceponate). While overall bacteriome alpha diversity remained unchanged, the ratio of Staphylococcus to Corynebacterium and Cutibacterium decreased significantly after Janus kinase inhibitors as well as dupilumab treatment but remained stable with cyclosporine A and topical corticosteroids. These results indicate that addressing type 2 inflammation by targeted drugs alters the skin bacteriome towards a healthy balance, while traditional anti-inflammatory treatments have minimal impact on microbial composition."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation

Severe atopic dermatitis poorly controlled, or something else? (EAACI 2025) - "Chronic eczema of hands from 1 year of evolution with poor control with topical treatment with methylprednisolone aceponate and tachromilium. propolis (10% in vaseline) (++), with relevance present after being found in the list of ingredients of topical tacrólimus as white wax. Improvement in lesions after changing tacrólimus for pimecrolimus Results The forms of clinical presentation of AD are very variable, but usually includes eczema. ACD is a delayed hypersensitivity reaction to contact allergens."

Atopic Dermatitis • Dermatitis • Immunology

Analgesia in radical mastectomy. Before and after erector spinalis plane block (Euroanaesthesia 2025) - "Background and Goal of Study: In our hospital, analgesia for breast surgery has traditionally been performed using a combination of NSAIDs and morphine, obtaining acceptable results. Specifically, the erector spinae block (ESP) has meant a significant change in the way of approaching this type of surgery, improving the anesthetic and analgesic quality.Materials and We performed a retrospective analysis of 40 patients undergoing radical mastectomy.The common procedure for both groups was:- Premedication: Midazolam 2 mg, Ranitidine 50 mg, Dexamethasone 8 mg.- Induction and maintenance: sevoflurane + fentanyl + rocuronium.- Postoperative analgesia: Paracetamol 1 g alternating with Dexketoprofen.- Rescues with Tramadol 100 mg and Dolantine 50 mg.The difference between groups was that half of them received ESP at T4 level with 25 ml of 0.5% ropivacaine 20 minutes before the intervention.We evaluated: hemodynamic stability during surgery, the dose of fentanyl administered,..."

Anesthesia • Pain

GRAHAM-LITTLE-PICCARDI-LASSEUR SYNDROME IN A BULGARIAN PATIENT: CASE REPORT AND SHORT PATHOGENETIC UPDATE IN RELATION TO THE CONNECTION TO ANTIGEN/ MOLECULAR MIMICRY. (PubMed, Georgian Med News) - "Initial therapy included loratadine and topical clobetasol propionate. Due to the suspicion of possible drug-induced reaction, the antihypertensive therapy, which consisted of valsartan, bisoprolol, spironolactone, and chlorthalidone, was discontinued and replaced with moxonidine...Prescribed outpatient treatment included acitretin, bilastine, and topical prednisolone for the scalp. Improvement was observed in the lesions located on the trunk and upper and lower extremities following betamethasone/salicylic acid ointment was prescribed, and methylprednisolone aceponate cream...It is this fact that suggests that polymedication could also be considered as a trigger of lichen planus and its subforms such as GLPLS. The hypothesis surrounding alterations in tissue homeostasis as a potential trigger factor for autoimmunity is being discussed, with a specific focus on infectious and drug-induced forms of lichen planus, as well as Graham-Little-Lasseur syndrome."

Journal • Alopecia • Dermatology • Dermatopathology • Immunology • Infectious Disease • Lichen Planus • Urology

Drug-Induced Subacute Cutaneous Lupus Erythematosus Associated with Fenofibrate Lipid Lowering Agent. (PubMed, Skinmed) - "Her treatment for the past 4 years included metformin, saxagliptin, atorvastatin, vitamin B12, vitamin D, lansoprazole, and aspirin. Methylprednisolone aceponate ointment, pimecrolimus ointment 0.1%, and sunblock were prescribed. Her facial eruption was only minimally lessened, while the dermatitis worsened on the trunk, arms, and legs."

Journal • Cutaneous Lupus Erythematosus • Dermatitis • Dermatology • Diabetes • Dyslipidemia • Immunology • Inflammatory Arthritis • Lupus • Metabolic Disorders

Improvement of Fox-Fordyce disease with botulinum toxin type A (EADV 2024) - "Treatment with methylprednisolone aceponate 1mg/g ointment and clindamycin 1% gel yielded no improvement after 3 months. Due to concomitant hyperhidrosis, she received one session of intradermal injection of 75 U botulinum toxin type A (BTX-A, Botox®, Allergan, Inc) into each axilla...Other modalities with varying success rates include topical calcineurin inhibitors, tretinoin, clindamycin, oral contraceptives, laser therapy, surgical excision, and phototherapy... A 36-year-old pre-menopausal woman presented with a four-year history of multiple mildly itchy papules in both axillae. She had no significant medical history and denied previous laser hair removal or use of topical products/fragrances. Physical examination revealed multiple firm, non-tender, skin-colored follicular papules grouped in the bilateral axilla."

Aesthetic Medicine • Dermatology • Pruritus

Case report: reticular erythematous mucinosis spontaneously resolved after melanoma excision (EADV 2024) - "The patient was recommended to use topical steroids, avoiding Hydroxychloroquine because of planning for pregnancy. Patient used Methylprednisolone aceponate cream during 14 days with minor changes of the lesion color, then no treatment has been performed... Malignant tumours of the skin could be considered as one of REM underlying causes. Further clinical trials needed."

Case report • Clinical • Diabetes • Endocrine Disorders • Immunology • Inflammatory Arthritis • Lupus • Melanoma • Metabolic Disorders • Oncology • Pruritus • Solid Tumor • Systemic Lupus Erythematosus • Thyroid Gland Carcinoma

Functional and clinic evaluation in dermatomyositis (EADV 2024) - "The variation of biologic parameters and the functional tests aspect are very important for the prognostic of the disease."

Dermatomyositis • Fatigue • Immunology • Musculoskeletal Pain • Myositis • Pain • Rheumatoid Arthritis

Lupus erythematosus tumidus (EADV 2024) - "Description of patients Patient 1 Patient 2 Sex / Age Male / 30 yo Male / 53 yo Medical history of interest Hepatomegaly Hypertension, dyslipidemia, smoking Time from outbreak to diagnosis 6 months 2 years Geographical location Central Asia North-Western region of Russia Season N/A Spring-Summer Trigger factors Sun exposure, doxycycline (2 months) Sun exposure, alcohol, ACE inhibitor (3 years) Previous diagnoses Dermatitis, JLIS, Rosacea, cutaneous sarcoidosis Dermatitis, Urticaria, Rosacea Clinical manifestation 3 round shape urticarial-like erythematous-violaceous plaques (oedematous erythema) with clearly defined boundaries Multiple annular and semi annular urticarial-like erythematous- violaceus plaques (oedematous erythema) and succulent papules Localisation Face Face, neck, chest, back Itch No Yes Indirect immunofluorescence ANA < 160 dsDNA – 1,3 IU/ml ANA < 160 dsDNA 0,02 IU/ml Histology Focal perivascular and pronounced perifollicular lympocytic..."

Cardiovascular • Cutaneous Lupus Erythematosus • Dermatitis • Dermatology • Dermatopathology • Dyslipidemia • Hepatology • Hypertension • Immunology • Inflammatory Arthritis • Lupus • Metabolic Disorders • Rosacea • Sarcoidosis • Tobacco Cessation • Urticaria • Vasculitis

Chronic cutaneous lupus erythematosus in a patient with a history of Kikuchi–Fujimoto disease (EADV 2024) - "A diagnosis of CCLE was made and the patient received hydroxychloroquine 200 mg/d, methylprednisolone aceponate topically, with good tolerance and improvement within a month. I present this case to highlight the rare clinical entity of KFD in the Caucasian population, the need for a long-term follow-up, and the high risk of associated autoimmune diseases such as SLE. Our patient only developed symptoms of chronic lupus, approximately 7 years after the symptoms of KFD disappeared. Therefore, long-term follow-up of patients with this syndrome seems necessary."

Clinical • Cutaneous Lupus Erythematosus • Epstein-Barr Virus Infections • Fatigue • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Inflammatory Arthritis • Leukopenia • Lupus • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology

Pilot study of a branded (marketed) formulation methylprednisolone aceponate called Advantan ointment applied to the skin in healthy male and female volunteers to determine the appropriate dose duration (ED50) for use in a pivotal in vivo bioequivalence study. (ANZCTR) - P4 | N=12 | Completed | Sponsor: Zenith Technology Corporation Limited | Not yet recruiting ➔ Completed

Trial completion • Atopic Dermatitis • Dermatology • Immunology • Psoriasis

Pilot study of a branded (marketed) formulation methylprednisolone aceponate called Advantan fatty ointment applied to the skin in healthy male and female volunteers to determine the appropriate dose duration (ED50) for use in a pivotal in vivo bioequivalence study. (ANZCTR) - P4 | N=12 | Completed | Sponsor: Zenith Technology Corporation Limited | Not yet recruiting ➔ Completed

Trial completion • Atopic Dermatitis • Dermatology • Immunology • Psoriasis

INTERESTING FACT: Delayed systemic allergic reactions to corticosteroids: Clinical symptoms y cross-reactivity (EAACI 2024) - "The ST were diagnostic in 37% of cases, two patients by PT with positive readings at D2 and D4 for the culprit drugs (hydrocortisone, budesonide, and methylprednisolone aceponate respectively), IDT were positive in only one patient with the culprit drug (dexamethasone)...The most commonly was intravenous hydrocortisone and oral methylprednisolone, both belonging to group 1...We considered necessary to prove CS from different groups to offer safe alternatives to the patients. None of them presented reactions to two or more groups of CS and although cross-reactivity exists between CS of the same group, all of our patients presented good tolerance."

Clinical • Allergy • Dermatitis • Immunology

Patch testing findings in children with suspected Allergy Contact Dermatitis at a tertiary Hospital (EAACI 2024) - "In some cases, additional batteries such as the standard series of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) was applied, as were the patient's own product and additional allergens (chlorhexidine, latex, methylprednisolone aceponate, prednicarbate) based on clinical suspicion...In 61.5% (8) of the cases, the sensitization was considered relevant. It is important to carry out an exhaustive clinical history, to orientate the test according to the clinical suspicion and to carry out a patch test for atopic dermatitis with a poor evolution or atypical location."

Clinical • Allergy • Atopic Dermatitis • Dermatitis • Immunology

Patch testing findings in children with suspected Allergy Contact Dermatitis at a tertiary Hospital (EAACI 2024) - "In some cases, additional batteries such as the standard series of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) was applied, as were the patient's own product and additional allergens (chlorhexidine, latex, methylprednisolone aceponate, prednicarbate) based on clinical suspicion...In 61.5% (8) of the cases, the sensitization was considered relevant. It is important to carry out an exhaustive clinical history, to orientate the test according to the clinical suspicion and to carry out a patch test for atopic dermatitis with a poor evolution or atypical location."

Clinical • Allergy • Atopic Dermatitis • Dermatitis • Immunology

Care and medical costs of urticaria in children in Germany : Drugs, medical and inpatient services (PubMed, Dermatologie (Heidelb)) - "The lack of guidelines for the standardization of treatment in children still leads to ambiguities and different treatment concepts among the specialist groups, which must be eliminated in order to enable more efficient therapies. The treatment of chronic urticaria in children and adolescents is mainly carried out by pediatricians, general practitioners and dermatologists. Systemic and topical medications as well as inpatient services are the most important cost factors."

HEOR • Journal • Dermatology • Dermatopathology • Immunology • Pediatrics • Urticaria