sodium deoxycholate / Generic mfg. - LARVOL DELTA

Comparison of Patient Reviews for Submental Liposuction and Kybella Using Deep Learning and Natural Language Processing: Is There a Superior Intervention for Submental Adiposity? (PubMed, Aesthet Surg J) - "This study applied NLP to extract structured sentiment from unstructured reviews RealSelf. Our findings suggest that submental liposuction patients report greater satisfaction and more positive emotional experiences than those who received Kybella."

Journal • Aesthetic Medicine • Obesity

Cryolipolysis Versus ATX-101 (Deoxycholic Acid) for Upper Back Fat (clinicaltrials.gov) - P=N/A | N=8 | Terminated | Sponsor: Northwestern University | N=34 ➔ 8 | Active, not recruiting ➔ Terminated; Unable to enroll participants for analysis.

Enrollment change • Trial termination • Aesthetic Medicine

A Phase I Study of HY-2003 in the Subjects With Excessive Submental Fat Accumulation (clinicaltrials.gov) - P1 | N=30 | Recruiting | Sponsor: Sichuan Huiyu Pharmaceutical Co., Ltd | Not yet recruiting ➔ Recruiting

Enrollment open

Selecting the Right Technique for the Treatment of Submental Adiposity. (PubMed, Facial Plast Surg) - "Percutaneous treatments include Kybella or enzymatic mixture injection and transcutaneous energy delivery. Liposuction with or without adjunctive treatments and deep neck lifts are the subcutaneous and structural options.Submental interventions, whether percutaneous, transcutaneous, or subcutaneous, amplify the natural characteristics and beauty of the patient. Aligning the proper technique with the proper patient is the mark of a perceptive surgeon who accounts for underlying anatomy and treatment goals."

Journal • Aesthetic Medicine • Infectious Disease • Obesity

Tolerability of Device Based Therapies for Neurofibromatosis Type 1 Cutaneous Neurofibromas (clinicaltrials.gov) - P1 | N=34 | Completed | Sponsor: Massachusetts General Hospital | Active, not recruiting ➔ Completed | N=20 ➔ 34 | Trial completion date: Dec 2024 ➔ Apr 2024 | Trial primary completion date: Dec 2024 ➔ Apr 2024

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Genetic Disorders • Neurofibromatosis • Solid Tumor

Dosing and Tolerability of Deoxycholic Acid Vs. Polidocanol in the Treatment of Neurofibromatosis Type 1 Cutaneous Neurofibromas (clinicaltrials.gov) - P1 | N=20 | Completed | Sponsor: Massachusetts General Hospital | Recruiting ➔ Completed | Trial completion date: Sep 2024 ➔ Jan 2025 | Trial primary completion date: Apr 2024 ➔ Jan 2025

Trial completion • Trial completion date • Trial primary completion date • Genetic Disorders • Neurofibromatosis • Solid Tumor • NF1

US Harmony: A Study to Evaluate Patient Satisfaction With the Overall Face and Neck Appearance After Combined Treatment of OnabotulinumtoxinA, JUVÉDERM® Products, KYBELLA, CoolSculpting Elite and SkinMedica Products (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: AbbVie

New P4 trial

A Phase I Study of HY-2003 in the Subjects With Excessive Submental Fat Accumulation (clinicaltrials.gov) - P1 | N=30 | Not yet recruiting | Sponsor: Sichuan Huiyu Pharmaceutical Co., Ltd

New P1 trial

Accessory Axillary Breast Management: Is Primary Skin Excision Necessary? (PubMed, Indian J Plast Surg) - "While modalities like CoolScupting™, Kybella™ injections, and BodyTite™ have been used by surgeons for management of axillary breasts, the most effective treatment for this condition remains surgical management involving a combination of liposuction of the axillary breast with excision of the gland and skin...Any skin excess is best dealt with secondarily. The author uses a modified protocol without any primary skin excision in axillary breast management to achieve excellent results with minimal scars."

Journal • Aesthetic Medicine

Aesthetic Facial Surgery: a Systematic Review. (PubMed, Clin Ter) - "In order to do this, common nonsurgical treatments including threaded processes, Botox injections Kybella, filler substances, micro-focused ultrasound, and pharmacologic hair transplantation will be examined in contrast to common surgical treatments like face lifts, blepharoplasty, rhinoplasty procedure and transplantation of hair. This study examines the latest advancements and patterns in medical practitioners' methods to bolster the expansion of cosmetic face surgery in India. It also seeks to solve the inadequacies in the current administration and close the gaps that can be found in the realm of cosmetic surgery."

Journal • Review • Surgery • Aesthetic Medicine • Pain • Transplantation

Deoxycholic Acid for Submental Convexity: A MAUDE Database Analysis. (PubMed, Craniomaxillofac Trauma Reconstr) - "The MAUDE database was queried for all reports related to adverse events involving deoxycholic acid using the search terms "KYBELLA" and "deoxycholic acid." Reports were individually reviewed by 2 reviewers and categorized with special attention to adverse events...Adverse events following DOC injections included excessive swelling, dysphagia, numbness, infection, unsatisfactory aesthetic outcome, facial nerve weakness, and skin necrosis requiring hospitalization and/or surgery. Patient counseling regarding these adverse events should be discussed when offering DOC injections for submental convexity."

Journal • Aesthetic Medicine • Gastrointestinal Disorder • Infectious Disease

Assessing the Efficacy of Repeat, Monthly Treatments of Cutaneous Neurofibromas (cNFs) (clinicaltrials.gov) - P1 | N=10 | Not yet recruiting | Sponsor: Massachusetts General Hospital

New P1 trial • Fibrosis • Genetic Disorders • Neurofibromatosis • Solid Tumor

Efficacy of Skin Cooling in Reducing Pain Associated With Non-invasive Treatments of Neurofibromatosis Type 1 Cutaneous Neurofibromas (clinicaltrials.gov) - P1 | N=30 | Recruiting | Sponsor: Massachusetts General Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Fibrosis • Genetic Disorders • Neurofibromatosis • Pain • Solid Tumor

Efficacy of Skin Cooling in Reducing Pain Associated With Non-invasive Treatments of Neurofibromatosis Type 1 Cutaneous Neurofibromas (clinicaltrials.gov) - P1 | N=30 | Not yet recruiting | Sponsor: Massachusetts General Hospital

New P1 trial • Fibrosis • Genetic Disorders • Neurofibromatosis • Pain • Solid Tumor

Dosing and Tolerability of Deoxycholic Acid Versus Polidocanol in the Treatment of Neurofibromatosis Type 1 Cutaneous Neurofibromas (clinicaltrials.gov) - P1 | N=20 | Recruiting | Sponsor: Massachusetts General Hospital

New P1 trial • Fibrosis • Genetic Disorders • Neurofibromatosis • Solid Tumor • NF1

Tolerability of Device Based Therapies for Neurofibromatosis Type 1 Cutaneous Neurofibromas (clinicaltrials.gov) - P1 | N=20 | Active, not recruiting | Sponsor: Massachusetts General Hospital | Recruiting ➔ Active, not recruiting | Trial completion date: Dec 2023 ➔ Dec 2024 | Trial primary completion date: Jun 2023 ➔ Dec 2024

Enrollment closed • Trial completion date • Trial primary completion date • Fibrosis • Genetic Disorders • Neurofibromatosis • Solid Tumor

Degradation Therapy with Collagenase and Deoxycholate. (PubMed, Facial Plast Surg Clin North Am) - "This article will discuss the indications for the use of deoxycholic acid, primarily its well-established role in the non-surgical reduction of submental fat, with a focus on patient assessment, procedural technique, risks, pitfalls, and key clinical tips. It will also review the indications for collagenase as a degradation therapy, its mechanism of action, and benefits in the management of wound healing, scarring, and adipose tissue modification."

Journal • Review

Treatment Options for the Clinical Management of Axillary Breast Tissue. (PubMed, Plast Reconstr Surg Glob Open) - "There are nonsurgical options for its removal, such as CoolSculpting and Kybella, and surgical options such as liposuction, BodyTite liposuction, and excision...Nonsurgical and surgical removal of axillary breast tissue is safe and effective. The algorithm presented can be utilized by plastic and reconstructive surgeons to ensure optimal results for axillary breast tissue removal."

Journal • Aesthetic Medicine

CONTOUR Australia: Condition of Submental Fullness and Treatment Outcomes with Belkyra Registry. (PubMed, Plast Reconstr Surg Glob Open) - "Adverse events were all mild and mostly related to the injection site (ie, bruising and swelling). CONTOUR Australia observed clinically meaningful and significant outcomes and further supports ATX-101 as a well-tolerated and effective treatment for SMF reduction."

Journal • Obesity

URBANIZATION ALTERS GUT VIROME AND ITS CORRELATIONS WITH INTESTINAL BACTERIOME AND ASSOCIATED METABOLITES (DDW 2023) - "In addition, VC209 was positively correlated with cholic acid (CA) metabolites, and VC371 was associated strongly with deoxycholic acid ( DCA ) and ursodeoxycholic acid ( UDCA)...In conclusion, our findings indicate that the gut virome is distinct in healthy adults living in rural and urban areas of South Africa. Ongoing urbanization with increased consumption of meat, fat and calories and reduced high fiber foods may be partly responsible for changes in associations between gut phages, bacteria, and their metabolites, possibly affecting gastrointestinal health."

Colorectal Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Obesity • Oncology • Solid Tumor

Evolution and Trends of Facial Plastic Surgery and Facial Aesthetic Procedures in India: From Awakening to Revival. (PubMed, Aesthet Surg J Open Forum) - "This study aims to study past practices and current trends in facial plastic surgery and aesthetic procedures in India by individually addressing commonly performed nonsurgical procedures (Botox, Kybella [Allergan, Irvine, CA], fillers, threads, micro-focused ultrasound, and nonsurgical hair restoration), and surgical procedures (rhinoplasty, blepharoplasty, hair transplant, and facelift). This article affirms the growth of facial aesthetic surgery in India by highlighting the recent development and trends in the practices of surgeons. It also addresses the shortcomings in the current administration and makes recommendations to fill the existing loopholes in plastic surgery."

Journal • Review • Surgery • Aesthetic Medicine • Transplantation

Cryolipolysis Versus ATX-101 (Deoxycholic Acid) for Upper Back Fat (clinicaltrials.gov) - P=N/A | N=34 | Active, not recruiting | Sponsor: Northwestern University | Trial completion date: Dec 2022 ➔ Dec 2025 | Trial primary completion date: Dec 2022 ➔ Dec 2025

Trial completion date • Trial primary completion date • Aesthetic Medicine

Tolerability of Device Based Therapies for Neurofibromatosis Type 1 Cutaneous Neurofibromas (clinicaltrials.gov) - P1 | N=20 | Recruiting | Sponsor: Massachusetts General Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Fibrosis • Genetic Disorders • Neurofibromatosis • Solid Tumor

HIGH FAT DIET SHAPES GUT MICROBIOME AND ACCELERATES PROGRESSION FROM BARRETT ESOPHAGUS TO ADENOCARCINOMA VIA SYSTEMIC BILE ACIDS (DDW 2022) - "We assessed the effect of bile acids on the EAC pathological progression and we focused on farnesoid-X-receptor (FXR), a nuclear BA receptor and an important modulator in BA metabolism, and on obeticholic acid (OCA), a selective FXR agonist...We suggest that this leads to an acceleration of carcinogenesis via FXR signaling specifically on progenitor cells. FXR-upregulation in BE tissue appears to be protective against effects of BA in the esophageal microenvironment since it ameliorates the dysplastic phenotype and could be a potential preventive target."

Barrett Esophagus • Esophageal Adenocarcinoma • Esophageal Cancer • Gastroesophageal Reflux Disease • Gastrointestinal Cancer • Gastrointestinal Disorder • Genetic Disorders • Immunology • Inflammation • Obesity • Oncology • IL1B

The Role of Fat Reducing Agents on Adipocyte Death and Adipose Tissue Inflammation. (PubMed, Front Endocrinol (Lausanne)) - "Initially, it was used as a solvent for Phosphatidylcholine (PDC), which was thought to promote lipolysis, but it was later proven to be the bioactive component of the formula and is currently widely used as Kybella...Additional papers have suggested a synergistic effect between the two compounds. Our review integrates the findings of this growing body of literature into a proposed mechanism of fat reduction and provides direction for further studies."

Journal • Review • Fibrosis • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Lipodystrophy • Metabolic Disorders • TNFA