IPD (suplatast tosilate) / Senju, Otsuka - LARVOL DELTA

Efficacy and Safety of ME-015 (Suplatast Tosilate) in Cough Related to Idiopathic Pulmonary Fibrosis (COSMIC-IPF) (clinicaltrials.gov) - P2 | N=40 | Active, not recruiting | Sponsor: Melius Pharma AB | Recruiting ➔ Active, not recruiting

Enrollment closed • Chronic Cough • Cough • Idiopathic Pulmonary Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases

Efficacy and Safety of ME-015 (Suplatast Tosilate) in Cough Related to Idiopathic Pulmonary Fibrosis (COSMIC-IPF) (clinicaltrials.gov) - P2 | N=40 | Recruiting | Sponsor: Melius Pharma AB | Not yet recruiting ➔ Recruiting | Trial completion date: Mar 2025 ➔ Sep 2025 | Trial primary completion date: Mar 2025 ➔ Aug 2025

Enrollment open • Trial completion date • Trial primary completion date • Chronic Cough • Cough • Idiopathic Pulmonary Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases

Efficacy and Safety of ME-015 (Suplatast Tosilate) in Cough Related to Idiopathic Pulmonary Fibrosis (COSMIC-IPF) (clinicaltrials.gov) - P2 | N=40 | Not yet recruiting | Sponsor: Melius Pharma AB

New P2 trial • Cough • Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases

Inhibition of suplatast tosilate on EPSC in the single paratracheal ganglion neurons attached with presynaptic boutons. (PubMed, J Neurophysiol) - "Using single neurons of rat paratracheal ganglia (PTG) attached with presynaptic boutons, the effects of suplatast tosilate on excitatory postsynaptic currents (EPSC) were investigated with nystatin-perforated patch-clamp recording technique. Suplatast also inhibited the EPSCs potentiated by bradykinin (BK), but it did not affect the potentiation itself by BK. Thus, suplatast inhibited the EPSC of PTG neurons attached with presynaptic boutons at both of presynaptic and postsynaptic sites."

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Prevention of Renal Interstitial Fibrosis by Suplatast in a Mouse Model. (PubMed, Biol Pharm Bull) - "Furthermore, STAT3 phosphorylation, which was stimulated by UUO, was also significantly decreased by suplatast. Collectively, these data show that suplatast reduces UUO-induced renal interstitial fibrosis via mechanisms including a reduction of phosphorylation of ERK and JAK/STAT pathway signaling."

Journal • Preclinical • Fibrosis • Immunology • IL4 • JAK1 • KIM1 • TGFB1

Pharmaceutical targeting Th2-mediated immunity enhances immunotherapy response in breast cancer. (PubMed, J Transl Med) - "Our findings demonstrate that pharmaceutical inhibition of Th2 cell function improves ICB response via remodeling immune landscape of TME, which illustrates a promising combinatorial immunotherapy."

Journal • Breast Cancer • Immune Modulation • Inflammation • Oncology • Solid Tumor • CD4 • CD8 • IL4

Sulfonium Ligands of the α7 nAChR. (PubMed, Molecules) - "Amongst them, we found that there is a wide range of ability to induce α7 desensitization, with 4-hydroxyphenyldimethylsulfonium and suplatast sulfonium salts being the most desensitizing...Molecular docking into the α7 receptor extracellular domain revealed preferred poses in the orthosteric binding site for all but one compound, with typical cation-pi interactions as seen with traditional ammonium compounds. A number of the compounds tested may serve as useful platforms for further development of α7 desensitizing ability and for receptor subtype selectivity."

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Successful use of montelukast in eosinophilic gastroenteritis: a case report and a literature review. (PubMed, BMC Gastroenterol) - "Montelukast may be an effective treatment for eosinophilic gastroenteritis, either alone or in combination with systemic steroids or ketotifen. Our patient is the second reported adult case of eosinophilic gastroenteritis who responded to montelukast alone as a first line therapy. Further studies and clinical trials are required to confirm efficacy compared to standard therapy."

Clinical • Journal • Review • Allergy • Eosinophilia • Eosinophilic Esophagitis • Gastroenterology • Gastrointestinal Disorder • Immunology • Pain • IL4 • IL5

The effect on patient life quality of prophylactic treatment to seasonal allergic rhinitis and related transcriptomics research (PubMed, Zhonghua Yu Fang Yi Xue Za Zhi) - "Polymerase Chain Reaction (PCR) verification of differentially expressed genes indicated that the relative expression level of HLA-G in prophylactic group was significantly lower than that in control group (0.23±0.19 vs 1.00±0.49,t=4.016, P=0.006). The prophylactic treatment of suplatast tosilate showed some benefit to the life quality of seasonal AR patients during the pollen season, and the potential mechanism might be related with the downregulation of IL-12 and IL-23 pathways and decreased expression of HLA-G."

Clinical • Journal • Allergic Rhinitis • Allergy • Conjunctivitis • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology • IL12A • PCR

Suplatast tosilate in patients with interstitial cystitis: Efficacy and treatment possibilities, with suggestions for future assessments. (PubMed, Int J Urol) - "Comparison of interstitial cystitis symptom score changes suggested that the placebo effect was very small. Use of diagnostic hydrodistention was considered to be a major difference in the population characteristics of the studies and may have resulted in different observed efficacies. Diagnostic hydrodistention, which potentially influences the treatment effect, is probably not essential for trials of suplatast in interstitial cystitis patients."

Clinical • Journal • Interstitial Cystitis

Suplatast tosilate reduces radiation-induced lung injury in mice through suppression of oxidative stress. (PubMed, Free Radic Biol Med) - "These findings demonstrate that suplatast tosilate could be a useful lung-protective agent that acts via suppression of oxidative stress associated with thoracic radiotherapy."

Journal • Preclinical • Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Respiratory Diseases • Thoracic Cancer

Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals. (PubMed) - Free Radic Biol Med - "These results suggest that suplatast tosilate protects the lung against hyperoxic lung injury by decreasing the degree of oxidative stress induced by ROS, particularly by scavenging hydroxyl radicals. Suplatast tosilate might become a potential therapeutic for hyperoxic lung injury."

Journal • Asthma • Biosimilar • Fibrosis • Immunology

Oral suplatast tosilate for the treatment of urticaria pigmentosa, skin lesion in mastocytosis. (PubMed, Int J Dermatol) - No abstract available.

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